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Volumn 125, Issue 5, 2018, Pages 781-795

The IL-1β phenomena in neuroinflammatory diseases

Author keywords

Alzheimer s disease; Diabetic retinopathy; IL 1 ; Microglia; Multiple sclerosis; Neuroinflammation

Indexed keywords

CANAKINUMAB; INTERLEUKIN 1BETA;

EID: 85019858241     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-017-1732-9     Document Type: Review
Times cited : (183)

References (137)
  • 1
    • 0024368359 scopus 로고
    • Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype
    • Ando DG, Clayton J, Kono D, Urban JL, Sercarz EE (1989) Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype. Cell Immunol 124(1):132–143. doi:10.1016/0008-8749(89)90117-2
    • (1989) Cell Immunol , vol.124 , Issue.1 , pp. 132-143
    • Ando, D.G.1    Clayton, J.2    Kono, D.3    Urban, J.L.4    Sercarz, E.E.5
  • 2
    • 84859012407 scopus 로고    scopus 로고
    • Diabetic retinopathy
    • Antonetti DA, Klein R, Gardner TW (2012) Diabetic retinopathy. N Engl J Med 366(13):1227–1239. doi:10.1056/NEJMra1005073
    • (2012) N Engl J Med , vol.366 , Issue.13 , pp. 1227-1239
    • Antonetti, D.A.1    Klein, R.2    Gardner, T.W.3
  • 6
    • 85015637535 scopus 로고    scopus 로고
    • Therapeutic targeting of the pathological triad of extrasynaptic NMDA receptor signaling in neurodegenerations
    • COI: 1:CAS:528:DC%2BC2sXhtV2ju7jE, PID: 28209726
    • Bading H (2017) Therapeutic targeting of the pathological triad of extrasynaptic NMDA receptor signaling in neurodegenerations. J Exp Med 214(3):569
    • (2017) J Exp Med , vol.214 , Issue.3 , pp. 569
    • Bading, H.1
  • 8
    • 85002412707 scopus 로고    scopus 로고
    • Cytokine networks in neuroinflammation
    • Becher B, Spath S, Goverman J (2017) Cytokine networks in neuroinflammation. Nat Rev Immunol 17(1):49–59. doi:10.1038/nri.2016.123
    • (2017) Nat Rev Immunol , vol.17 , Issue.1 , pp. 49-59
    • Becher, B.1    Spath, S.2    Goverman, J.3
  • 9
    • 24144453087 scopus 로고    scopus 로고
    • Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism
    • Block ML, Hong J-S (2005) Microglia and inflammation-mediated neurodegeneration: multiple triggers with a common mechanism. Prog Neurobiol 76(2):77–98. doi:10.1016/j.pneurobio.2005.06.004
    • (2005) Prog Neurobiol , vol.76 , Issue.2 , pp. 77-98
    • Block, M.L.1    Hong, J.-S.2
  • 10
    • 0029417080 scopus 로고
    • Interleukin-1β and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer’s and de novo Parkinson’s disease patients
    • Blum-Degena D, Müller T, Kuhn W, Gerlach M, Przuntek H, Riederer P (1995) Interleukin-1β and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer’s and de novo Parkinson’s disease patients. Neurosci Lett 202(1):17–20
    • (1995) Neurosci Lett , vol.202 , Issue.1 , pp. 17-20
    • Blum-Degena, D.1    Müller, T.2    Kuhn, W.3    Gerlach, M.4    Przuntek, H.5    Riederer, P.6
  • 11
    • 63149114677 scopus 로고    scopus 로고
    • Glatiramer acetate increases IL-1 receptor antagonist but decreases T cell-induced IL-1β in human monocytes and multiple sclerosis
    • Burger D, Molnarfi N, Weber MS, Brandt KJ, Benkhoucha M, Gruaz L, Chofflon M, Zamvil SS, Lalive PH (2009) Glatiramer acetate increases IL-1 receptor antagonist but decreases T cell-induced IL-1β in human monocytes and multiple sclerosis. Proc Natl Acad Sci USA 106(11):4355–4359. doi:10.1073/pnas.0812183106
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.11 , pp. 4355-4359
    • Burger, D.1    Molnarfi, N.2    Weber, M.S.3    Brandt, K.J.4    Benkhoucha, M.5    Gruaz, L.6    Chofflon, M.7    Zamvil, S.S.8    Lalive, P.H.9
  • 14
    • 0028941871 scopus 로고
    • The adhesion molecule and cytokine profile of multiple sclerosis lesions
    • Cannella B, Raine CS (1995) The adhesion molecule and cytokine profile of multiple sclerosis lesions. Ann Neurol 37(4):424–435. doi:10.1002/ana.410370404
    • (1995) Ann Neurol , vol.37 , Issue.4 , pp. 424-435
    • Cannella, B.1    Raine, C.S.2
  • 15
    • 84946204508 scopus 로고    scopus 로고
    • Disruption of fractalkine signaling leads to microglial activation and neuronal damage in the diabetic retina
    • Cardona SM, Mendiola AS, Yang Y-C, Adkins SL, Torres V, Cardona AE (2015) Disruption of fractalkine signaling leads to microglial activation and neuronal damage in the diabetic retina. ASN Neuro 7(5). doi:10.1177/1759091415608204
    • (2015) ASN Neuro , vol.7 , Issue.5
    • Cardona, S.M.1    Mendiola, A.S.2    Yang, Y.-C.3    Adkins, S.L.4    Torres, V.5    Cardona, A.E.6
  • 16
    • 0034531053 scopus 로고    scopus 로고
    • Effect of cyclosporin-A on the blood–retinal barrier permeability in streptozotocin-induced diabetes
    • Carmo A, Cunha-Vaz JG, Carvalho AP, Lopes MC (2000) Effect of cyclosporin-A on the blood–retinal barrier permeability in streptozotocin-induced diabetes. Mediat Inflamm 9(5):243–248. doi:10.1080/09629350020025764
    • (2000) Mediat Inflamm , vol.9 , Issue.5 , pp. 243-248
    • Carmo, A.1    Cunha-Vaz, J.G.2    Carvalho, A.P.3    Lopes, M.C.4
  • 17
    • 0036847841 scopus 로고    scopus 로고
    • Microglia as liaisons between the immune and central nervous systems: functional implications for multiple sclerosis
    • Carson MJ (2002) Microglia as liaisons between the immune and central nervous systems: functional implications for multiple sclerosis. Glia 40(2):218–231. doi:10.1002/glia.10145
    • (2002) Glia , vol.40 , Issue.2 , pp. 218-231
    • Carson, M.J.1
  • 20
    • 84946398388 scopus 로고    scopus 로고
    • + microglia reduce Abeta plaque deposition during IL-1beta-dependent neuroinflammation
    • + microglia reduce Abeta plaque deposition during IL-1beta-dependent neuroinflammation. J Neuroinflammation 12:203. doi:10.1186/s12974-015-0411-8
    • (2015) J Neuroinflammation , vol.12 , pp. 203
    • Cherry, J.D.1    Olschowka, J.A.2    O’Banion, M.K.3
  • 22
    • 79956116032 scopus 로고    scopus 로고
    • ROR[gamma]t drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation
    • Codarri L, Gyulveszi G, Tosevski V, Hesske L, Fontana A, Magnenat L, Suter T, Becher B (2011) ROR[gamma]t drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation. Nat Immunol 12(6):560–567. doi:10.1038/ni.2027
    • (2011) Nat Immunol , vol.12 , Issue.6 , pp. 560-567
    • Codarri, L.1    Gyulveszi, G.2    Tosevski, V.3    Hesske, L.4    Fontana, A.5    Magnenat, L.6    Suter, T.7    Becher, B.8
  • 23
    • 84937113148 scopus 로고    scopus 로고
    • Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques
    • Condello C, Yuan P, Schain A, Grutzendler J (2015) Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques. Nat Commun 6:6176. doi:10.1038/ncomms7176
    • (2015) Nat Commun , vol.6 , pp. 6176
    • Condello, C.1    Yuan, P.2    Schain, A.3    Grutzendler, J.4
  • 25
    • 84869178487 scopus 로고    scopus 로고
    • Microglia and neurodegeneration: the role of systemic inflammation
    • Cunningham C (2013) Microglia and neurodegeneration: the role of systemic inflammation. Glia 61(1):71–90. doi:10.1002/glia.22350
    • (2013) Glia , vol.61 , Issue.1 , pp. 71-90
    • Cunningham, C.1
  • 27
    • 84859715302 scopus 로고    scopus 로고
    • Fibrinogen as a key regulator of inflammation in disease
    • Davalos D, Akassoglou K (2012) Fibrinogen as a key regulator of inflammation in disease. Semin Immunopathol 34(1):43–62. doi:10.1007/s00281-011-0290-8
    • (2012) Semin Immunopathol , vol.34 , Issue.1 , pp. 43-62
    • Davalos, D.1    Akassoglou, K.2
  • 28
    • 79953046719 scopus 로고    scopus 로고
    • The inflammasome NLRs in immunity, inflammation, and associated diseases
    • COI: 1:CAS:528:DC%2BC3MXltlKnsLY%3D, PID: 21219188
    • Davis BK, Wen H, Ting JP (2011) The inflammasome NLRs in immunity, inflammation, and associated diseases. Annu Rev Immunol 29:707
    • (2011) Annu Rev Immunol , vol.29 , pp. 707
    • Davis, B.K.1    Wen, H.2    Ting, J.P.3
  • 30
    • 33845546564 scopus 로고    scopus 로고
    • Determination of vitreous interleukin-1 (IL-1) and tumour necrosis factor (TNF) levels in proliferative diabetic retinopathy
    • Demircan N, Safran BG, Soylu M, Ozcan AA, Sizmaz S (2005) Determination of vitreous interleukin-1 (IL-1) and tumour necrosis factor (TNF) levels in proliferative diabetic retinopathy. Eye 20(12):1366–1369. doi:10.1038/sj.eye.6702138
    • (2005) Eye , vol.20 , Issue.12 , pp. 1366-1369
    • Demircan, N.1    Safran, B.G.2    Soylu, M.3    Ozcan, A.A.4    Sizmaz, S.5
  • 31
    • 84940453103 scopus 로고    scopus 로고
    • Immunopathology of multiple sclerosis
    • Dendrou CA, Fugger L, Friese MA (2015) Immunopathology of multiple sclerosis. Nat Rev Immunol 15(9):545–558. doi:10.1038/nri3871
    • (2015) Nat Rev Immunol , vol.15 , Issue.9 , pp. 545-558
    • Dendrou, C.A.1    Fugger, L.2    Friese, M.A.3
  • 32
    • 62649139025 scopus 로고    scopus 로고
    • Immunological and inflammatory functions of the interleukin-1 family
    • Dinarello CA (2009) Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol 27(1):519–550. doi:10.1146/annurev.immunol.021908.132612
    • (2009) Annu Rev Immunol , vol.27 , Issue.1 , pp. 519-550
    • Dinarello, C.A.1
  • 33
    • 79953813107 scopus 로고    scopus 로고
    • Interleukin-1 in the pathogenesis and treatment of inflammatory diseases
    • Dinarello CA (2011) Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood 117(14):3720–3732. doi:10.1182/blood-2010-07-273417
    • (2011) Blood , vol.117 , Issue.14 , pp. 3720-3732
    • Dinarello, C.A.1
  • 34
    • 84864545087 scopus 로고    scopus 로고
    • Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases
    • Dinarello CA, Simon A, van der Meer JWM (2012) Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases. Nat Rev Drug Discov 11(8):633–652. doi:10.1038/nrd3800
    • (2012) Nat Rev Drug Discov , vol.11 , Issue.8 , pp. 633-652
    • Dinarello, C.A.1    Simon, A.2    van der Meer, J.W.M.3
  • 36
    • 84885357617 scopus 로고    scopus 로고
    • Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina
    • Du Y, Veenstra A, Palczewski K, Kern TS (2013) Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina. Proc Natl Acad Sci USA 110(41):16586–16591. doi:10.1073/pnas.1314575110
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.41 , pp. 16586-16591
    • Du, Y.1    Veenstra, A.2    Palczewski, K.3    Kern, T.S.4
  • 38
    • 79956152607 scopus 로고    scopus 로고
    • The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF
    • El-Behi M, Ciric B, Dai H, Yan Y, Cullimore M, Safavi F, Zhang G-X, Dittel BN, Rostami A (2011) The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF. Nat Immunol 12(6):568–575. doi:10.1038/ni.2031
    • (2011) Nat Immunol , vol.12 , Issue.6 , pp. 568-575
    • El-Behi, M.1    Ciric, B.2    Dai, H.3    Yan, Y.4    Cullimore, M.5    Safavi, F.6    Zhang, G.-X.7    Dittel, B.N.8    Rostami, A.9
  • 39
    • 84956596401 scopus 로고    scopus 로고
    • The pathogenic role of the inflammasome in neurodegenerative diseases
    • Freeman LC, Ting JP (2016) The pathogenic role of the inflammasome in neurodegenerative diseases. J Neurochem 136(Suppl 1):29–38. doi:10.1111/jnc.13217
    • (2016) J Neurochem , vol.136 , pp. 29-38
    • Freeman, L.C.1    Ting, J.P.2
  • 44
    • 84952922436 scopus 로고    scopus 로고
    • Retinal failure in diabetes: a feature of retinal sensory neuropathy
    • Gray EJ, Gardner TW (2015) Retinal failure in diabetes: a feature of retinal sensory neuropathy. Curr Diabetes Rep 15(12):107. doi:10.1007/s11892-015-0683-5
    • (2015) Curr Diabetes Rep , vol.15 , Issue.12 , pp. 107
    • Gray, E.J.1    Gardner, T.W.2
  • 46
    • 0001360461 scopus 로고
    • Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease
    • COI: 1:STN:280:DyaK3c%2FhslGhug%3D%3D, PID: 2529544
    • Griffin W, Stanley L, Ling C, White L, MacLeod V, Perrot L, White C, Araoz C (1989) Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc Natl Acad Sci USA 86(19):7611–7615
    • (1989) Proc Natl Acad Sci USA , vol.86 , Issue.19 , pp. 7611-7615
    • Griffin, W.1    Stanley, L.2    Ling, C.3    White, L.4    MacLeod, V.5    Perrot, L.6    White, C.7    Araoz, C.8
  • 51
    • 84862649049 scopus 로고    scopus 로고
    • Toll-like receptor (TLR) and inflammasome actions in the central nervous system
    • COI: 1:CAS:528:DC%2BC38XlvFyrtbw%3D, PID: 22521509
    • Hanamsagar R, Hanke ML, Kielian T (2012) Toll-like receptor (TLR) and inflammasome actions in the central nervous system. Trends Immunol 33(7):333–342
    • (2012) Trends Immunol , vol.33 , Issue.7 , pp. 333-342
    • Hanamsagar, R.1    Hanke, M.L.2    Kielian, T.3
  • 54
    • 84929921146 scopus 로고    scopus 로고
    • Immune attack: the role of inflammation in Alzheimer disease
    • Heppner FL, Ransohoff RM, Becher B (2015) Immune attack: the role of inflammation in Alzheimer disease. Nat Rev Neurosci 16(6):358–372. doi:10.1038/nrn3880
    • (2015) Nat Rev Neurosci , vol.16 , Issue.6 , pp. 358-372
    • Heppner, F.L.1    Ransohoff, R.M.2    Becher, B.3
  • 57
    • 84862988248 scopus 로고    scopus 로고
    • NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis
    • Inoue M, Williams KL, Gunn MD, Shinohara ML (2012) NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis. Proc Natl Acad Sci USA 109(26):10480–10485. doi:10.1073/pnas.1201836109
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.26 , pp. 10480-10485
    • Inoue, M.1    Williams, K.L.2    Gunn, M.D.3    Shinohara, M.L.4
  • 58
    • 0025856061 scopus 로고
    • Experimental autoimmune encephalomyelitis is exacerbated by IL-1 alpha and suppressed by soluble IL-1 receptor
    • COI: 1:CAS:528:DyaK3MXlvVWhs78%3D, PID: 1826702
    • Jacobs CA, Baker PE, Roux ER, Picha KS, Toivola B, Waugh S, Kennedy MK (1991) Experimental autoimmune encephalomyelitis is exacerbated by IL-1 alpha and suppressed by soluble IL-1 receptor. J Immunol 146(9):2983–2989
    • (1991) J Immunol , vol.146 , Issue.9 , pp. 2983-2989
    • Jacobs, C.A.1    Baker, P.E.2    Roux, E.R.3    Picha, K.S.4    Toivola, B.5    Waugh, S.6    Kennedy, M.K.7
  • 59
    • 73349109145 scopus 로고    scopus 로고
    • Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes
    • Jäger A, Dardalhon V, Sobel RA, Bettelli E, Kuchroo VK (2009) Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes. J Immunol 183(11):7169–7177. doi:10.4049/jimmunol.0901906
    • (2009) J Immunol , vol.183 , Issue.11 , pp. 7169-7177
    • Jäger, A.1    Dardalhon, V.2    Sobel, R.A.3    Bettelli, E.4    Kuchroo, V.K.5
  • 61
    • 85015675626 scopus 로고    scopus 로고
    • Epac1 blocks NLRP3 inflammasome to reduce IL-1β in retinal endothelial cells and mouse retinal vasculature
    • Jiang Y, Liu L, Curtiss E, Steinle JJ (2017) Epac1 blocks NLRP3 inflammasome to reduce IL-1β in retinal endothelial cells and mouse retinal vasculature. Mediat Inflamm. doi:10.1155/2017/2860956
    • (2017) Mediat Inflamm
    • Jiang, Y.1    Liu, L.2    Curtiss, E.3    Steinle, J.J.4
  • 62
    • 34648825492 scopus 로고    scopus 로고
    • Oxidative damage in the retinal mitochondria of diabetic mice: possible protection by superoxide dismutase
    • Kanwar M, Chan P-S, Kern TS, Kowluru RA (2007) Oxidative damage in the retinal mitochondria of diabetic mice: possible protection by superoxide dismutase. Invest Ophthalmol Vis Sci 48(8):3805–3811. doi:10.1167/iovs.06-1280
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , Issue.8 , pp. 3805-3811
    • Kanwar, M.1    Chan, P.-S.2    Kern, T.S.3    Kowluru, R.A.4
  • 64
    • 84890843069 scopus 로고    scopus 로고
    • Reactive astrocytes and perivascular macrophages express NLRP3 inflammasome in active demyelinating lesions of multiple sclerosis and necrotic lesions of neuromyelitis optica and cerebral infarction
    • Kawana N, Yamamoto Y, Ishida T, Saito Y, Konno H, Arima K, Ji Satoh (2013) Reactive astrocytes and perivascular macrophages express NLRP3 inflammasome in active demyelinating lesions of multiple sclerosis and necrotic lesions of neuromyelitis optica and cerebral infarction. Clin Exp Neuroimmunol 4(3):296–304. doi:10.1111/cen3.12068
    • (2013) Clin Exp Neuroimmunol , vol.4 , Issue.3 , pp. 296-304
    • Kawana, N.1    Yamamoto, Y.2    Ishida, T.3    Saito, Y.4    Konno, H.5    Arima, K.6    Ji, S.7
  • 66
    • 83755183781 scopus 로고    scopus 로고
    • Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer’s disease model
    • Kitazawa M, Cheng D, Tsukamoto MR, Koike MA, Wes PD, Vasilevko V, Cribbs DH, LaFerla FM (2011) Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer’s disease model. J Immunol 187(12):6539–6549. doi:10.4049/jimmunol.1100620
    • (2011) J Immunol , vol.187 , Issue.12 , pp. 6539-6549
    • Kitazawa, M.1    Cheng, D.2    Tsukamoto, M.R.3    Koike, M.A.4    Wes, P.D.5    Vasilevko, V.6    Cribbs, D.H.7    LaFerla, F.M.8
  • 67
    • 84878264043 scopus 로고    scopus 로고
    • Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal
    • Kohno H, Chen Y, Kevany BM, Pearlman E, Miyagi M, Maeda T, Palczewski K, Maeda A (2013) Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal. J Biol Chem 288(21):15326–15341. doi:10.1074/jbc.M112.448712
    • (2013) J Biol Chem , vol.288 , Issue.21 , pp. 15326-15341
    • Kohno, H.1    Chen, Y.2    Kevany, B.M.3    Pearlman, E.4    Miyagi, M.5    Maeda, T.6    Palczewski, K.7    Maeda, A.8
  • 68
    • 6944233576 scopus 로고    scopus 로고
    • Role of interleukin-1β in the development of retinopathy in rats: effect of antioxidants
    • Kowluru RA, Odenbach S (2004) Role of interleukin-1β in the development of retinopathy in rats: effect of antioxidants. Invest Ophthalmol Vis Sci 45(11):4161–4166. doi:10.1167/iovs.04-0633
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , Issue.11 , pp. 4161-4166
    • Kowluru, R.A.1    Odenbach, S.2
  • 69
    • 17844392902 scopus 로고    scopus 로고
    • Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy
    • Krady JK, Basu A, Allen CM, Xu Y, LaNoue KF, Gardner TW, Levison SW (2005) Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy. Diabetes 54(5):1559–1565. doi:10.2337/diabetes.54.5.1559
    • (2005) Diabetes , vol.54 , Issue.5 , pp. 1559-1565
    • Krady, J.K.1    Basu, A.2    Allen, C.M.3    Xu, Y.4    LaNoue, K.F.5    Gardner, T.W.6    Levison, S.W.7
  • 73
    • 69549105888 scopus 로고    scopus 로고
    • Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes
    • Larsen CM, Faulenbach M, Vaag A, Ehses JA, Donath MY, Mandrup-Poulsen T (2009) Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes. Diabetes Care 32(9):1663–1668. doi:10.2337/dc09-0533
    • (2009) Diabetes Care , vol.32 , Issue.9 , pp. 1663-1668
    • Larsen, C.M.1    Faulenbach, M.2    Vaag, A.3    Ehses, J.A.4    Donath, M.Y.5    Mandrup-Poulsen, T.6
  • 74
    • 0028675319 scopus 로고
    • GM-CSF promotes proliferation of human fetal and adult microglia in primary cultures
    • COI: 1:STN:280:DyaK2M7pslWqtA%3D%3D, PID: 7890333
    • Lee SC, Liu W, Brosnan CF, Dickson DW (1994) GM-CSF promotes proliferation of human fetal and adult microglia in primary cultures. Glia 12(4):309–318
    • (1994) Glia , vol.12 , Issue.4 , pp. 309-318
    • Lee, S.C.1    Liu, W.2    Brosnan, C.F.3    Dickson, D.W.4
  • 76
    • 84861212022 scopus 로고    scopus 로고
    • IL-1β is upregulated in the diabetic retina and retinal vessels: cell-specific effect of high glucose and IL-1β autostimulation
    • Liu Y, Biarnés Costa M, Gerhardinger C (2012) IL-1β is upregulated in the diabetic retina and retinal vessels: cell-specific effect of high glucose and IL-1β autostimulation. PLoS One 7(5):e36949. doi:10.1371/journal.pone.0036949
    • (2012) PLoS One , vol.7 , Issue.5
    • Liu, Y.1    Biarnés Costa, M.2    Gerhardinger, C.3
  • 78
    • 70349562400 scopus 로고    scopus 로고
    • Enhanced experimental corneal neovascularization along with aberrant angiogenic factor expression in the absence of IL-1 receptor antagonist
    • Lu P, Li L, Liu G, Zhang X, Mukaida N (2009) Enhanced experimental corneal neovascularization along with aberrant angiogenic factor expression in the absence of IL-1 receptor antagonist. Invest Ophthalmol Vis Sci 50(10):4761–4768. doi:10.1167/iovs.08-2732
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , Issue.10 , pp. 4761-4768
    • Lu, P.1    Li, L.2    Liu, G.3    Zhang, X.4    Mukaida, N.5
  • 79
    • 84991107707 scopus 로고    scopus 로고
    • Mechanisms of glutamate toxicity in multiple sclerosis: biomarker and therapeutic opportunities
    • Macrez R, Stys PK, Vivien D, Lipton SA, Docagne F (2016) Mechanisms of glutamate toxicity in multiple sclerosis: biomarker and therapeutic opportunities. Lancet Neurol 15(10):1089–1102. doi:10.1016/S1474-4422(16)30165-X
    • (2016) Lancet Neurol , vol.15 , Issue.10 , pp. 1089-1102
    • Macrez, R.1    Stys, P.K.2    Vivien, D.3    Lipton, S.A.4    Docagne, F.5
  • 82
    • 85014032657 scopus 로고    scopus 로고
    • The NLRP3 inflammasome is involved in the pathogenesis of Parkinson’s disease in rats
    • Mao Z, Liu C, Ji S, Yang Q, Ye H, Han H, Xue Z (2017) The NLRP3 inflammasome is involved in the pathogenesis of Parkinson’s disease in rats. Neurochem Res 42(4):1104–1115. doi:10.1007/s11064-017-2185-0
    • (2017) Neurochem Res , vol.42 , pp. 1104-1115
    • Mao, Z.1    Liu, C.2    Ji, S.3    Yang, Q.4    Ye, H.5    Han, H.6    Xue, Z.7
  • 83
    • 33845890803 scopus 로고    scopus 로고
    • Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation
    • COI: 1:CAS:528:DC%2BD28XhtlChtL7M, PID: 17186029
    • Mariathasan S, Monack DM (2007) Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation. Nat Rev Immunol 7(1):31–40
    • (2007) Nat Rev Immunol , vol.7 , Issue.1 , pp. 31-40
    • Mariathasan, S.1    Monack, D.M.2
  • 84
    • 0028828583 scopus 로고
    • Protective effect of the interleukin-1 receptor antagonist (IL-1ra) on experimental allergic encephalomyelitis in rats
    • Martin D, Near SL (1995) Protective effect of the interleukin-1 receptor antagonist (IL-1ra) on experimental allergic encephalomyelitis in rats. J Neuroimmunol 61(2):241–245. doi:10.1016/0165-5728(95)00108-E
    • (1995) J Neuroimmunol , vol.61 , Issue.2 , pp. 241-245
    • Martin, D.1    Near, S.L.2
  • 86
    • 84991098162 scopus 로고    scopus 로고
    • Distinct inflammatory phenotypes of microglia and monocyte-derived macrophages in Alzheimer’s disease models: effects of aging and amyloid pathology
    • Martin E, Boucher C, Fontaine B, Delarasse C (2017) Distinct inflammatory phenotypes of microglia and monocyte-derived macrophages in Alzheimer’s disease models: effects of aging and amyloid pathology. Aging Cell 16(1):27–38. doi:10.1111/acel.12522
    • (2017) Aging Cell , vol.16 , Issue.1 , pp. 27-38
    • Martin, E.1    Boucher, C.2    Fontaine, B.3    Delarasse, C.4
  • 87
    • 0035883161 scopus 로고    scopus 로고
    • Interleukin-1β promotes repair of the CNS
    • COI: 1:CAS:528:DC%2BD3MXmvFWhtLY%3D, PID: 11549714
    • Mason JL, Suzuki K, Chaplin DD, Matsushima GK (2001) Interleukin-1β promotes repair of the CNS. J Neurosci 21(18):7046–7052
    • (2001) J Neurosci , vol.21 , Issue.18 , pp. 7046-7052
    • Mason, J.L.1    Suzuki, K.2    Chaplin, D.D.3    Matsushima, G.K.4
  • 88
    • 84860751910 scopus 로고    scopus 로고
    • Chronic IL-1β-mediated neuroinflammation mitigates amyloid pathology in a mouse model of Alzheimer’s disease without inducing overt neurodegeneration
    • PID: 22173340
    • Matousek SB, Ghosh S, Shaftel SS, Kyrkanides S, Olschowka JA, O’Banion MK (2012) Chronic IL-1β-mediated neuroinflammation mitigates amyloid pathology in a mouse model of Alzheimer’s disease without inducing overt neurodegeneration. J Neuroimmune Pharmacol 7(1):156–164
    • (2012) J Neuroimmune Pharmacol , vol.7 , Issue.1 , pp. 156-164
    • Matousek, S.B.1    Ghosh, S.2    Shaftel, S.S.3    Kyrkanides, S.4    Olschowka, J.A.5    O’Banion, M.K.6
  • 89
    • 76449087805 scopus 로고    scopus 로고
    • Natalizumab treatment in multiple sclerosis: marked decline of chemokines and cytokines in cerebrospinal fluid
    • Mellergård J, Edström M, Vrethem M, Ernerudh J, Dahle C (2010) Natalizumab treatment in multiple sclerosis: marked decline of chemokines and cytokines in cerebrospinal fluid. Mult Scler 16(2):208–217. doi:10.1177/1352458509355068
    • (2010) Mult Scler , vol.16 , Issue.2 , pp. 208-217
    • Mellergård, J.1    Edström, M.2    Vrethem, M.3    Ernerudh, J.4    Dahle, C.5
  • 90
    • 85010747987 scopus 로고    scopus 로고
    • Fractalkine signaling attenuates perivascular clustering of microglia and fibrinogen leakage during systemic inflammation in mouse models of diabetic retinopathy
    • Mendiola AS, Garza R, Cardona SM, Mythen SA, Lira SA, Akassoglou K, Cardona AE (2017) Fractalkine signaling attenuates perivascular clustering of microglia and fibrinogen leakage during systemic inflammation in mouse models of diabetic retinopathy. Front Cell Neurosci 10:303. doi:10.3389/fncel.2016.00303
    • (2017) Front Cell Neurosci , vol.10 , pp. 303
    • Mendiola, A.S.1    Garza, R.2    Cardona, S.M.3    Mythen, S.A.4    Lira, S.A.5    Akassoglou, K.6    Cardona, A.E.7
  • 91
    • 0036224782 scopus 로고    scopus 로고
    • Caspase activation in retinas of diabetic and galactosemic mice and diabetic patients
    • Mohr S, Xi X, Tang J, Kern TS (2002) Caspase activation in retinas of diabetic and galactosemic mice and diabetic patients. Diabetes 51(4):1172–1179. doi:10.2337/diabetes.51.4.1172
    • (2002) Diabetes , vol.51 , Issue.4 , pp. 1172-1179
    • Mohr, S.1    Xi, X.2    Tang, J.3    Kern, T.S.4
  • 94
    • 60149098421 scopus 로고    scopus 로고
    • Debris clearance by microglia: an essential link between degeneration and regeneration
    • Neumann H, Kotter MR, Franklin RJM (2009) Debris clearance by microglia: an essential link between degeneration and regeneration. Brain 132(2):288–295. doi:10.1093/brain/awn109
    • (2009) Brain , vol.132 , Issue.2 , pp. 288-295
    • Neumann, H.1    Kotter, M.R.2    Franklin, R.J.M.3
  • 95
    • 18144410635 scopus 로고    scopus 로고
    • Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer’s disease
    • Patel NS, Paris D, Mathura V, Quadros AN, Crawford FC, Mullan MJ (2005) Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer’s disease. J Neuroinflammation 2(1):1
    • (2005) J Neuroinflammation , vol.2 , Issue.1 , pp. 1
    • Patel, N.S.1    Paris, D.2    Mathura, V.3    Quadros, A.N.4    Crawford, F.C.5    Mullan, M.J.6
  • 96
    • 39449133026 scopus 로고    scopus 로고
    • Concentration of haemodynamic and inflammatory related cytokines in diabetic retinopathy
    • Patel JI, Saleh GM, Hykin PG, Gregor ZJ, Cree IA (2006) Concentration of haemodynamic and inflammatory related cytokines in diabetic retinopathy. Eye 22(2):223–228. doi:10.1038/sj.eye.6702584
    • (2006) Eye , vol.22 , Issue.2 , pp. 223-228
    • Patel, J.I.1    Saleh, G.M.2    Hykin, P.G.3    Gregor, Z.J.4    Cree, I.A.5
  • 97
    • 34547791784 scopus 로고    scopus 로고
    • Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer’s disease
    • Paul J, Strickland S, Melchor JP (2007) Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer’s disease. J Exp Med 204(8):1999. doi:10.1084/jem.20070304
    • (2007) J Exp Med , vol.204 , Issue.8 , pp. 1999
    • Paul, J.1    Strickland, S.2    Melchor, J.P.3
  • 98
    • 84912033385 scopus 로고    scopus 로고
    • Increased inflammasome related gene expression profile in PBMC may facilitate T helper 17 cell induction in multiple sclerosis
    • Peelen E, Damoiseaux J, Muris AH, Knippenberg S, Smolders J, Hupperts R, Thewissen M (2015) Increased inflammasome related gene expression profile in PBMC may facilitate T helper 17 cell induction in multiple sclerosis. Mol Immunol 63(2):521–529. doi:10.1016/j.molimm.2014.10.008
    • (2015) Mol Immunol , vol.63 , Issue.2 , pp. 521-529
    • Peelen, E.1    Damoiseaux, J.2    Muris, A.H.3    Knippenberg, S.4    Smolders, J.5    Hupperts, R.6    Thewissen, M.7
  • 99
    • 80053233055 scopus 로고    scopus 로고
    • Heterogeneity of CNS myeloid cells and their roles in neurodegeneration
    • Prinz M, Priller J, Sisodia SS, Ransohoff RM (2011) Heterogeneity of CNS myeloid cells and their roles in neurodegeneration. Nat Neurosci 14(10):1227–1235. doi:10.1038/nn.2923
    • (2011) Nat Neurosci , vol.14 , Issue.10 , pp. 1227-1235
    • Prinz, M.1    Priller, J.2    Sisodia, S.S.3    Ransohoff, R.M.4
  • 100
    • 84885444054 scopus 로고    scopus 로고
    • Microglia actions in Alzheimer’s disease
    • Prokop S, Miller KR, Heppner FL (2013) Microglia actions in Alzheimer’s disease. Acta Neuropathol 126(4):461–477. doi:10.1007/s00401-013-1182-x
    • (2013) Acta Neuropathol , vol.126 , Issue.4 , pp. 461-477
    • Prokop, S.1    Miller, K.R.2    Heppner, F.L.3
  • 101
    • 84884281404 scopus 로고    scopus 로고
    • Using EAE to better understand principles of immune function and autoimmune pathology
    • Rangachari M, Kuchroo VK (2013) Using EAE to better understand principles of immune function and autoimmune pathology. J Autoimmun 45:31–39. doi:10.1016/j.jaut.2013.06.008
    • (2013) J Autoimmun , vol.45 , pp. 31-39
    • Rangachari, M.1    Kuchroo, V.K.2
  • 102
    • 84930178921 scopus 로고    scopus 로고
    • T cell subsets and their signature cytokines in autoimmune and inflammatory diseases
    • Raphael I, Nalawade S, Eagar TN, Forsthuber TG (2015) T cell subsets and their signature cytokines in autoimmune and inflammatory diseases. Cytokine 74(1):5–17. doi:10.1016/j.cyto.2014.09.011
    • (2015) Cytokine , vol.74 , Issue.1 , pp. 5-17
    • Raphael, I.1    Nalawade, S.2    Eagar, T.N.3    Forsthuber, T.G.4
  • 105
    • 72849106266 scopus 로고    scopus 로고
    • A leaky blood–brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer’s disease brain
    • Ryu JK, McLarnon JG (2009) A leaky blood–brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer’s disease brain. J Cell Mol Med 13(9a):2911–2925. doi:10.1111/j.1582-4934.2008.00434.x
    • (2009) J Cell Mol Med , vol.13 , Issue.9a , pp. 2911-2925
    • Ryu, J.K.1    McLarnon, J.G.2
  • 106
    • 0035932121 scopus 로고    scopus 로고
    • Interleukin-1[beta]-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity
    • Samad TA, Moore KA, Sapirstein A, Billet S, Allchorne A, Poole S, Bonventre JV, Woolf CJ (2001) Interleukin-1[beta]-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity. Nature 410(6827):471–475. doi:10.1038/35068566
    • (2001) Nature , vol.410 , Issue.6827 , pp. 471-475
    • Samad, T.A.1    Moore, K.A.2    Sapirstein, A.3    Billet, S.4    Allchorne, A.5    Poole, S.6    Bonventre, J.V.7    Woolf, C.J.8
  • 108
    • 0034028453 scopus 로고    scopus 로고
    • The induction of EAE is only partially dependent on TNF receptor signaling but requires the IL-1 type I receptor
    • Schiffenbauer J, Streit WJ, Butfiloski E, LaBow M, Edwards C, Moldawer LL (2000) The induction of EAE is only partially dependent on TNF receptor signaling but requires the IL-1 type I receptor. Clin Immunol 95(2):117–123. doi:10.10006/clim.2000.4851
    • (2000) Clin Immunol , vol.95 , Issue.2 , pp. 117-123
    • Schiffenbauer, J.1    Streit, W.J.2    Butfiloski, E.3    LaBow, M.4    Edwards, C.5    Moldawer, L.L.6
  • 109
    • 84930475910 scopus 로고    scopus 로고
    • Different retinal expression patterns of IL-1α, IL-1β, and their receptors in a rat model of type 1 STZ-induced diabetes
    • Scuderi S, D’amico AG, Federico C, Saccone S, Magro G, Bucolo C, Drago F, D’Agata V (2015) Different retinal expression patterns of IL-1α, IL-1β, and their receptors in a rat model of type 1 STZ-induced diabetes. J Mol Neurosci 56(2):431–439. doi:10.1007/s12031-015-0505-x
    • (2015) J Mol Neurosci , vol.56 , Issue.2 , pp. 431-439
    • Scuderi, S.1    D’amico, A.G.2    Federico, C.3    Saccone, S.4    Magro, G.5    Bucolo, C.6    Drago, F.7    D’Agata, V.8
  • 110
    • 84898792270 scopus 로고    scopus 로고
    • Cerebrospinal fluid IL-1β correlates with cortical pathology load in multiple sclerosis at clinical onset
    • Seppi D, Puthenparampil M, Federle L, Ruggero S, Toffanin E, Rinaldi F, Perini P, Gallo P (2014) Cerebrospinal fluid IL-1β correlates with cortical pathology load in multiple sclerosis at clinical onset. J Neuroimmunol 270(1–2):56–60. doi:10.1016/j.jneuroim.2014.02.014
    • (2014) J Neuroimmunol , vol.270 , Issue.1-2 , pp. 56-60
    • Seppi, D.1    Puthenparampil, M.2    Federle, L.3    Ruggero, S.4    Toffanin, E.5    Rinaldi, F.6    Perini, P.7    Gallo, P.8
  • 111
    • 34548434392 scopus 로고    scopus 로고
    • Chronic interleukin-1β expression in mouse brain leads to leukocyte infiltration and neutrophil-independent blood–brain barrier permeability without overt neurodegeneration
    • Shaftel SS, Carlson TJ, Olschowka JA, Kyrkanides S, Matousek SB, O’Banion MK (2007a) Chronic interleukin-1β expression in mouse brain leads to leukocyte infiltration and neutrophil-independent blood–brain barrier permeability without overt neurodegeneration. J Neurosci 27(35):9301–9309. doi:10.1523/jneurosci.1418-07.2007
    • (2007) J Neurosci , vol.27 , Issue.35 , pp. 9301-9309
    • Shaftel, S.S.1    Carlson, T.J.2    Olschowka, J.A.3    Kyrkanides, S.4    Matousek, S.B.5    O’Banion, M.K.6
  • 112
    • 34249899174 scopus 로고    scopus 로고
    • Sustained hippocampal IL-1β overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology
    • COI: 1:CAS:528:DC%2BD2sXmsVWkurg%3D, PID: 17549256
    • Shaftel SS, Kyrkanides S, Olschowka JA, Jen-nie HM, Johnson RE, O’Banion MK (2007b) Sustained hippocampal IL-1β overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology. J Clin Invest 117(6):1595–1604
    • (2007) J Clin Invest , vol.117 , Issue.6 , pp. 1595-1604
    • Shaftel, S.S.1    Kyrkanides, S.2    Olschowka, J.A.3    Jen-nie, H.M.4    Johnson, R.E.5    O’Banion, M.K.6
  • 113
    • 42649084052 scopus 로고    scopus 로고
    • The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective
    • Shaftel SS, Griffin WST, O’Banion MK (2008) The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective. J Neuroinflammation 5(1):1
    • (2008) J Neuroinflammation , vol.5 , Issue.1 , pp. 1
    • Shaftel, S.S.1    Griffin, W.S.T.2    O’Banion, M.K.3
  • 114
    • 0030757323 scopus 로고    scopus 로고
    • Neuritic plaque evolution in Alzheimer’s disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms
    • COI: 1:STN:280:DyaK2szmslyhsg%3D%3D, PID: 9224523
    • Sheng JG, Mrak RE, Griffin WST (1997) Neuritic plaque evolution in Alzheimer’s disease is accompanied by transition of activated microglia from primed to enlarged to phagocytic forms. Acta Neuropathol 94(1):1–5
    • (1997) Acta Neuropathol , vol.94 , Issue.1 , pp. 1-5
    • Sheng, J.G.1    Mrak, R.E.2    Griffin, W.S.T.3
  • 115
    • 32344440522 scopus 로고    scopus 로고
    • Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD28XhvFyjsbs%3D, PID: 16476660
    • Simard AR, Soulet D, Gowing G, Julien J-P, Rivest S (2006) Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer’s disease. Neuron 49(4):489–502
    • (2006) Neuron , vol.49 , Issue.4 , pp. 489-502
    • Simard, A.R.1    Soulet, D.2    Gowing, G.3    Julien, J.-P.4    Rivest, S.5
  • 116
    • 79955823910 scopus 로고    scopus 로고
    • Retinal ganglion cell death is induced by microglia derived pro-inflammatory cytokines in the hypoxic neonatal retina
    • Sivakumar V, Foulds WS, Luu CD, Ling E-A, Kaur C (2011) Retinal ganglion cell death is induced by microglia derived pro-inflammatory cytokines in the hypoxic neonatal retina. J Pathol 224(2):245–260. doi:10.1002/path.2858
    • (2011) J Pathol , vol.224 , Issue.2 , pp. 245-260
    • Sivakumar, V.1    Foulds, W.S.2    Luu, C.D.3    Ling, E.-A.4    Kaur, C.5
  • 118
    • 84957631835 scopus 로고    scopus 로고
    • SYSTEMIC INTERLEUKIN 1β INHIBITION IN PROLIFERATIVE DIABETIC RETINOPATHY: a prospective open-label study using canakinumab
    • Stahel M, Becker M, Graf N, Michels S (2016) SYSTEMIC INTERLEUKIN 1β INHIBITION IN PROLIFERATIVE DIABETIC RETINOPATHY: a prospective open-label study using canakinumab. Retina 36(2):385–391. doi:10.1097/IAE.0000000000000701
    • (2016) Retina , vol.36 , Issue.2 , pp. 385-391
    • Stahel, M.1    Becker, M.2    Graf, N.3    Michels, S.4
  • 119
    • 33745873727 scopus 로고    scopus 로고
    • A crucial role for interleukin (IL)-1 in the induction of IL-17–producing T cells that mediate autoimmune encephalomyelitis
    • Sutton C, Brereton C, Keogh B, Mills KHG, Lavelle EC (2006) A crucial role for interleukin (IL)-1 in the induction of IL-17–producing T cells that mediate autoimmune encephalomyelitis. J Exp Med 203(7):1685–1691. doi:10.1084/jem.20060285
    • (2006) J Exp Med , vol.203 , Issue.7 , pp. 1685-1691
    • Sutton, C.1    Brereton, C.2    Keogh, B.3    Mills, K.H.G.4    Lavelle, E.C.5
  • 120
    • 0038416100 scopus 로고    scopus 로고
    • Interleukin-1β promotes oligodendrocyte death through glutamate excitotoxicity
    • Takahashi JL, Giuliani F, Power C, Imai Y, Yong VW (2003) Interleukin-1β promotes oligodendrocyte death through glutamate excitotoxicity. Ann Neurol 53(5):588–595. doi:10.1002/ana.10519
    • (2003) Ann Neurol , vol.53 , Issue.5 , pp. 588-595
    • Takahashi, J.L.1    Giuliani, F.2    Power, C.3    Imai, Y.4    Yong, V.W.5
  • 121
    • 79960190061 scopus 로고    scopus 로고
    • Inflammation in diabetic retinopathy
    • Tang J, Kern TS (2011) Inflammation in diabetic retinopathy. Prog Retin Eye Res 30(5):343–358. doi:10.1016/j.preteyeres.2011.05.002
    • (2011) Prog Retin Eye Res , vol.30 , Issue.5 , pp. 343-358
    • Tang, J.1    Kern, T.S.2
  • 122
    • 84983262175 scopus 로고    scopus 로고
    • Photoreceptor cells produce inflammatory mediators that contribute to endothelial cell death in diabetes-induced inflammation in photoreceptors
    • Tonade D, Liu H, Kern TS (2016) Photoreceptor cells produce inflammatory mediators that contribute to endothelial cell death in diabetes-induced inflammation in photoreceptors. Invest Ophthalmol Vis Sci 57(10):4264–4271. doi:10.1167/iovs.16-19859
    • (2016) Invest Ophthalmol Vis Sci , vol.57 , Issue.10 , pp. 4264-4271
    • Tonade, D.1    Liu, H.2    Kern, T.S.3
  • 123
    • 48249139449 scopus 로고    scopus 로고
    • Multiple sclerosis: an immune or neurodegenerative disorder?
    • Trapp BD, Nave K-A (2008) Multiple sclerosis: an immune or neurodegenerative disorder? Annu Rev Neurosci 31(1):247–269. doi:10.1146/annurev.neuro.30.051606.094313
    • (2008) Annu Rev Neurosci , vol.31 , Issue.1 , pp. 247-269
    • Trapp, B.D.1    Nave, K.-A.2
  • 124
    • 84924331611 scopus 로고    scopus 로고
    • The interleukin-1 receptor antagonist anakinra improves endothelial dysfunction in streptozotocin-induced diabetic rats
    • Vallejo S, Palacios E, Romacho T, Villalobos L, Peiró C, Sánchez-Ferrer CF (2014) The interleukin-1 receptor antagonist anakinra improves endothelial dysfunction in streptozotocin-induced diabetic rats. Cardiovasc Diabetol 13(1):1. doi:10.1186/s12933-014-0158-z
    • (2014) Cardiovasc Diabetol , vol.13 , Issue.1 , pp. 1
    • Vallejo, S.1    Palacios, E.2    Romacho, T.3    Villalobos, L.4    Peiró, C.5    Sánchez-Ferrer, C.F.6
  • 126
    • 0036353262 scopus 로고    scopus 로고
    • Interleukin-1 regulates proliferation and differentiation of oligodendrocyte progenitor cells
    • Vela JM, Molina-Holgado E, Arévalo-Martín Á, Almazán G, Guaza C (2002) Interleukin-1 regulates proliferation and differentiation of oligodendrocyte progenitor cells. Mol Cell Neurosci 20(3):489–502. doi:10.1006/mcne.2002.1127
    • (2002) Mol Cell Neurosci , vol.20 , Issue.3 , pp. 489-502
    • Vela, J.M.1    Molina-Holgado, E.2    Arévalo-Martín, Á.3    Almazán, G.4    Guaza, C.5
  • 127
    • 33847048626 scopus 로고    scopus 로고
    • Inhibition of caspase-1/interleukin-1β signaling prevents degeneration of retinal capillaries in diabetes and galactosemia
    • Vincent JA, Mohr S (2007) Inhibition of caspase-1/interleukin-1β signaling prevents degeneration of retinal capillaries in diabetes and galactosemia. Diabetes 56(1):224–230. doi:10.2337/db06-0427
    • (2007) Diabetes , vol.56 , Issue.1 , pp. 224-230
    • Vincent, J.A.1    Mohr, S.2
  • 131
    • 79955038882 scopus 로고    scopus 로고
    • Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling
    • Wen H, Gris D, Lei Y, Jha S, Zhang L, Huang MT-H, Brickey WJ, Ting JPY (2011) Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat Immunol 12(5):408–415. doi:10.1038/ni.2022
    • (2011) Nat Immunol , vol.12 , Issue.5 , pp. 408-415
    • Wen, H.1    Gris, D.2    Lei, Y.3    Jha, S.4    Zhang, L.5    Huang, M.T.-H.6    Brickey, W.J.7    Ting, J.P.Y.8
  • 132
    • 84920990887 scopus 로고    scopus 로고
    • Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome
    • Yan Y, Jiang W, Liu L, Wang X, Ding C, Tian Z, Zhou R (2015) Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome. Cell 160(1–2):62–73. doi:10.1016/j.cell.2014.11.047
    • (2015) Cell , vol.160 , Issue.1-2 , pp. 62-73
    • Yan, Y.1    Jiang, W.2    Liu, L.3    Wang, X.4    Ding, C.5    Tian, Z.6    Zhou, R.7
  • 134
    • 84878767675 scopus 로고    scopus 로고
    • IL-1β and TNF-α induce neurotoxicity through glutamate production: a potential role for neuronal glutaminase
    • Ye L, Huang Y, Zhao L, Li Y, Sun L, Zhou Y, Qian G, Zheng JC (2013) IL-1β and TNF-α induce neurotoxicity through glutamate production: a potential role for neuronal glutaminase. J Neurochem 125(6):897–908. doi:10.1111/jnc.12263
    • (2013) J Neurochem , vol.125 , Issue.6 , pp. 897-908
    • Ye, L.1    Huang, Y.2    Zhao, L.3    Li, Y.4    Sun, L.5    Zhou, Y.6    Qian, G.7    Zheng, J.C.8
  • 135
    • 85014128859 scopus 로고    scopus 로고
    • NLRP3 inflammasome inhibitor ameliorates amyloid pathology in a mouse model of Alzheimer’s disease
    • Yin J, Zhao F, Chojnacki JE, Fulp J, Klein WL, Zhang S, Zhu X (2017) NLRP3 inflammasome inhibitor ameliorates amyloid pathology in a mouse model of Alzheimer’s disease. Mol Neurobiol. doi:10.1007/s12035-017-0467-9
    • (2017) Mol Neurobiol
    • Yin, J.1    Zhao, F.2    Chojnacki, J.E.3    Fulp, J.4    Klein, W.L.5    Zhang, S.6    Zhu, X.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.