-
1
-
-
63849118178
-
Role of nitric oxide, superoxide, peroxynitrite and poly(ADPribose) polymerase in diabetic retinopathy
-
Zheng L, Kern T (2009) Role of nitric oxide, superoxide, peroxynitrite and poly(ADPribose) polymerase in diabetic retinopathy. Front Biosci 14:3974-3987.
-
(2009)
Front Biosci
, vol.14
, pp. 3974-3987
-
-
Zheng, L.1
Kern, T.2
-
2
-
-
79960190061
-
Inflammation in diabetic retinopathy
-
Tang J, Kern TS (2011) Inflammation in diabetic retinopathy. Prog Retin Eye Res 30(5): 343-358.
-
(2011)
Prog Retin Eye Res
, vol.30
, Issue.5
, pp. 343-358
-
-
Tang, J.1
Kern, T.S.2
-
3
-
-
0035434119
-
Abnormalities of retinal metabolism in diabetes and experimental galactosemia. VII. Effect of long-term administration of antioxidants on the development of retinopathy
-
Kowluru RA, Tang J, Kern TS (2001) Abnormalities of retinal metabolism in diabetes and experimental galactosemia. VII. Effect of long-term administration of antioxidants on the development of retinopathy. Diabetes 50(8):1938-1942.
-
(2001)
Diabetes
, vol.50
, Issue.8
, pp. 1938-1942
-
-
Kowluru, R.A.1
Tang, J.2
Kern, T.S.3
-
4
-
-
34648825492
-
Oxidative damage in the retinal mitochondria of diabetic mice: Possible protection by superoxide dismutase
-
Kanwar M, Chan PS, Kern TS, Kowluru RA (2007) Oxidative damage in the retinal mitochondria of diabetic mice: Possible protection by superoxide dismutase. Invest Ophthalmol Vis Sci 48(8):3805-3811.
-
(2007)
Invest Ophthalmol Vis Sci
, vol.48
, Issue.8
, pp. 3805-3811
-
-
Kanwar, M.1
Chan, P.S.2
Kern, T.S.3
Kowluru, R.A.4
-
5
-
-
34547674399
-
Critical role of inducible nitric oxide synthase in degeneration of retinal capillaries in mice with streptozotocin-induced diabetes
-
Zheng L, et al. (2007) Critical role of inducible nitric oxide synthase in degeneration of retinal capillaries in mice with streptozotocin-induced diabetes. Diabetologia 50(9): 1987-1996.
-
(2007)
Diabetologia
, vol.50
, Issue.9
, pp. 1987-1996
-
-
Zheng, L.1
-
6
-
-
48449097142
-
5-Lipoxygenase, but not 12/15-lipoxygenase, contributes to degeneration of retinal capillaries in a mouse model of diabetic retinopathy
-
Gubitosi-Klug RA, Talahalli R, Du Y, Nadler JL, Kern TS (2008) 5-Lipoxygenase, but not 12/15-lipoxygenase, contributes to degeneration of retinal capillaries in a mouse model of diabetic retinopathy. Diabetes 57(5):1387-1393.
-
(2008)
Diabetes
, vol.57
, Issue.5
, pp. 1387-1393
-
-
Gubitosi-Klug, R.A.1
Talahalli, R.2
Du, Y.3
Nadler, J.L.4
Kern, T.S.5
-
7
-
-
65549157077
-
Retinal ion regulation in a mouse model of diabetic retinopathy: Natural history and the effect of Cu/Zn superoxide dismutase overexpression
-
Berkowitz BA, Gradianu M, Bissig D, Kern TS, Roberts R (2009) Retinal ion regulation in a mouse model of diabetic retinopathy: Natural history and the effect of Cu/Zn superoxide dismutase overexpression. Invest Ophthalmol Vis Sci 50(5):2351-2358.
-
(2009)
Invest Ophthalmol Vis Sci
, vol.50
, Issue.5
, pp. 2351-2358
-
-
Berkowitz, B.A.1
Gradianu, M.2
Bissig, D.3
Kern, T.S.4
Roberts, R.5
-
8
-
-
33744468523
-
Exercise and hormesis: Activation of cellular antioxidant signaling pathway
-
Ji LL, Gomez-Cabrera MC, Vina J (2006) Exercise and hormesis: Activation of cellular antioxidant signaling pathway. Ann N Y Acad Sci 1067:425-435.
-
(2006)
Ann N y Acad Sci
, vol.1067
, pp. 425-435
-
-
Ji, L.L.1
Gomez-Cabrera, M.C.2
Vina, J.3
-
9
-
-
0036751978
-
A review of specific dietary antioxidants and the effects on biochemical mechanisms related to neurodegenerative processes
-
Esposito E, et al. (2002) A review of specific dietary antioxidants and the effects on biochemical mechanisms related to neurodegenerative processes. Neurobiol Aging 23(5):719-735.
-
(2002)
Neurobiol Aging
, vol.23
, Issue.5
, pp. 719-735
-
-
Esposito, E.1
-
10
-
-
0031757934
-
Nuclear factor kappa B: Important transcription factor and therapeutic target
-
Lee JI, Burckart GJ (1998) Nuclear factor kappa B: Important transcription factor and therapeutic target. J Clin Pharmacol 38(11):981-993.
-
(1998)
J Clin Pharmacol
, vol.38
, Issue.11
, pp. 981-993
-
-
Lee, J.I.1
Burckart, G.J.2
-
11
-
-
0344012015
-
Hyperglycemia increases mitochondrial superoxide in retina and retinal cells
-
Du Y, Miller CM, Kern TS (2003) Hyperglycemia increases mitochondrial superoxide in retina and retinal cells. Free Radic Biol Med 35(11):1491-1499.
-
(2003)
Free Radic Biol Med
, vol.35
, Issue.11
, pp. 1491-1499
-
-
Du, Y.1
Miller, C.M.2
Kern, T.S.3
-
12
-
-
78649887659
-
PP2A contributes to endothelial death in high glucose: Inhibition by benfotiamine
-
Du Y, Kowluru A, Kern TS (2010) PP2A contributes to endothelial death in high glucose: Inhibition by benfotiamine. Am J Physiol Regul Integr Comp Physiol 299(6): R1610-R1617.
-
(2010)
Am J Physiol Regul Integr Comp Physiol
, vol.299
, Issue.6
-
-
Du, Y.1
Kowluru, A.2
Kern, T.S.3
-
13
-
-
0035086992
-
The absence of diabetic retinopathy in patients with retinitis pigmentosa: Implications for pathophysiology and possible treatment
-
Arden GB (2001) The absence of diabetic retinopathy in patients with retinitis pigmentosa: Implications for pathophysiology and possible treatment. Br J Ophthalmol 85(3):366-370.
-
(2001)
Br J Ophthalmol
, vol.85
, Issue.3
, pp. 366-370
-
-
Arden, G.B.1
-
14
-
-
20344391160
-
Spare the rod and spoil the eye
-
Arden GB, Sidman RL, Arap W, Schlingemann RO (2005) Spare the rod and spoil the eye. Br J Ophthalmol 89(6):764-769.
-
(2005)
Br J Ophthalmol
, vol.89
, Issue.6
, pp. 764-769
-
-
Arden, G.B.1
Sidman, R.L.2
Arap, W.3
Schlingemann, R.O.4
-
15
-
-
34248215127
-
Retinopathy is reduced during experimental diabetes in a mouse model of outer retinal degeneration
-
de Gooyer TE, et al. (2006) Retinopathy is reduced during experimental diabetes in a mouse model of outer retinal degeneration. Invest Ophthalmol Vis Sci 47(12): 5561-5568.
-
(2006)
Invest Ophthalmol Vis Sci
, vol.47
, Issue.12
, pp. 5561-5568
-
-
De Gooyer, T.E.1
-
16
-
-
77951214647
-
Effects of p38 MAPK inhibition on early stages of diabetic retinopathy and sensory nerve function
-
Du Y, et al. (2010) Effects of p38 MAPK inhibition on early stages of diabetic retinopathy and sensory nerve function. Invest Ophthalmol Vis Sci 51(4):2158-2164.
-
(2010)
Invest Ophthalmol Vis Sci
, vol.51
, Issue.4
, pp. 2158-2164
-
-
Du, Y.1
-
17
-
-
0034643340
-
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
-
Nishikawa T, et al. (2000) Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 404(6779):787-790.
-
(2000)
Nature
, vol.404
, Issue.6779
, pp. 787-790
-
-
Nishikawa, T.1
-
18
-
-
79955528923
-
Alternative mitochondrial electron transfer as a novel strategy for neuroprotection
-
Wen Y, et al. (2011) Alternative mitochondrial electron transfer as a novel strategy for neuroprotection. J Biol Chem 286(18):16504-16515.
-
(2011)
J Biol Chem
, vol.286
, Issue.18
, pp. 16504-16515
-
-
Wen, Y.1
-
19
-
-
84863116088
-
Mechanism of all-trans-retinal toxicity with implications for Stargardt disease and age-related macular degeneration
-
Chen Y, et al. (2012) Mechanism of all-trans-retinal toxicity with implications for Stargardt disease and age-related macular degeneration. J Biol Chem 287(7): 5059-5069.
-
(2012)
J Biol Chem
, vol.287
, Issue.7
, pp. 5059-5069
-
-
Chen, Y.1
-
21
-
-
7044228789
-
A central role for inflammation in the pathogenesis of diabetic retinopathy
-
Joussen AM, et al. (2004) A central role for inflammation in the pathogenesis of diabetic retinopathy. FASEB J 18(12):1450-1452.
-
(2004)
FASEB J
, vol.18
, Issue.12
, pp. 1450-1452
-
-
Joussen, A.M.1
-
22
-
-
77954734475
-
A preliminary trial to determine whether prevention of dark adaptation affects the course of early diabetic retinopathy
-
Arden GB, et al. (2010) A preliminary trial to determine whether prevention of dark adaptation affects the course of early diabetic retinopathy. Eye (Lond) 24(7): 1149-1155.
-
(2010)
Eye (Lond)
, vol.24
, Issue.7
, pp. 1149-1155
-
-
Arden, G.B.1
-
23
-
-
80053526640
-
Regression of early diabetic macular oedema is associated with prevention of dark adaptation
-
Arden GB, Jyothi S, Hogg CH, Lee YF, Sivaprasad S (2011) Regression of early diabetic macular oedema is associated with prevention of dark adaptation. Eye (Lond) 25(12): 1546-1554.
-
(2011)
Eye (Lond)
, vol.25
, Issue.12
, pp. 1546-1554
-
-
Arden, G.B.1
Jyothi, S.2
Hogg, C.H.3
Lee, Y.F.4
Sivaprasad, S.5
-
24
-
-
84883563790
-
Low-intensity far-red light inhibits early lesions that contribute to diabetic retinopathy: In vivo and in vitro
-
Tang J, et al. (2013) Low-intensity far-red light inhibits early lesions that contribute to diabetic retinopathy: In vivo and in vitro. Invest Ophthalmol Vis Sci 54(5):3681-3690.
-
(2013)
Invest Ophthalmol Vis Sci
, vol.54
, Issue.5
, pp. 3681-3690
-
-
Tang, J.1
-
25
-
-
0032102336
-
Does dark adaptation exacerbate diabetic retinopathy? Evidence and a linking hypothesis
-
Arden GB, Wolf JE, Tsang Y (1998) Does dark adaptation exacerbate diabetic retinopathy? Evidence and a linking hypothesis. Vision Res 38(11):1723-1729.
-
(1998)
Vision Res
, vol.38
, Issue.11
, pp. 1723-1729
-
-
Arden, G.B.1
Wolf, J.E.2
Tsang, Y.3
-
26
-
-
0023023438
-
Effects of light and darkness on oxygen distribution and consumption in the cat retina
-
Linsenmeier RA (1986) Effects of light and darkness on oxygen distribution and consumption in the cat retina. J Gen Physiol 88(4):521-542.
-
(1986)
J Gen Physiol
, vol.88
, Issue.4
, pp. 521-542
-
-
Linsenmeier, R.A.1
-
27
-
-
0025209796
-
Mathematical models of the spatial distribution of retinal oxygen tension and consumption, including changes upon illumination
-
Haugh LM, Linsenmeier RA, Goldstick TK (1990) Mathematical models of the spatial distribution of retinal oxygen tension and consumption, including changes upon illumination. Ann Biomed Eng 18(1):19-36.
-
(1990)
Ann Biomed Eng
, vol.18
, Issue.1
, pp. 19-36
-
-
Haugh, L.M.1
Linsenmeier, R.A.2
Goldstick, T.K.3
-
28
-
-
0035136729
-
Oxygen distribution and consumption within the retina in vascularised and avascular retinas and in animal models of retinal disease
-
Yu DY, Cringle SJ (2001) Oxygen distribution and consumption within the retina in vascularised and avascular retinas and in animal models of retinal disease. Prog Retin Eye Res 20(2):175-208.
-
(2001)
Prog Retin Eye Res
, vol.20
, Issue.2
, pp. 175-208
-
-
Yu, D.Y.1
Cringle, S.J.2
-
29
-
-
82955213965
-
Early inner retinal astrocyte dysfunction during diabetes and development of hypoxia, retinal stress, and neuronal functional loss
-
Ly A, et al. (2011) Early inner retinal astrocyte dysfunction during diabetes and development of hypoxia, retinal stress, and neuronal functional loss. Invest Ophthalmol Vis Sci 52(13):9316-9326.
-
(2011)
Invest Ophthalmol Vis Sci
, vol.52
, Issue.13
, pp. 9316-9326
-
-
Ly, A.1
-
30
-
-
33745667365
-
Reexamining the hyperglycemic pseudohypoxia hypothesis of diabetic oculopathy
-
Diederen RM, Starnes CA, Berkowitz BA, Winkler BS (2006) Reexamining the hyperglycemic pseudohypoxia hypothesis of diabetic oculopathy. Invest Ophthalmol Vis Sci 47(6):2726-2731.
-
(2006)
Invest Ophthalmol Vis Sci
, vol.47
, Issue.6
, pp. 2726-2731
-
-
Diederen, R.M.1
Starnes, C.A.2
Berkowitz, B.A.3
Winkler, B.S.4
-
31
-
-
80055046898
-
Oxygen consumption and distribution in the diabetic rat retina
-
(ARVO abstract)
-
Lau JC, Linsenmeier RA (2010) Oxygen consumption and distribution in the diabetic rat retina. Invest Ophthalmol Vis Sci 51:5644 (ARVO abstract).
-
(2010)
Invest Ophthalmol Vis Sci
, vol.51
, pp. 5644
-
-
Lau, J.C.1
Linsenmeier, R.A.2
-
32
-
-
77649189113
-
Hypoxia and the expression of HIF-1alpha and HIF-2alpha in the retina of streptozotocin-injected mice and rats
-
Wright WS, McElhatten RM, Messina JE, Harris NR (2010) Hypoxia and the expression of HIF-1alpha and HIF-2alpha in the retina of streptozotocin-injected mice and rats. Exp Eye Res 90(3):405-412.
-
(2010)
Exp Eye Res
, vol.90
, Issue.3
, pp. 405-412
-
-
Wright, W.S.1
McElhatten, R.M.2
Messina, J.E.3
Harris, N.R.4
-
33
-
-
80055030000
-
Increase in retinal hypoxia-inducible factor-2α, but not hypoxia, early in the progression of diabetes in the rat
-
Wright WS, McElhatten RM, Harris NR (2011) Increase in retinal hypoxia-inducible factor-2α, but not hypoxia, early in the progression of diabetes in the rat. Exp Eye Res 93(4):437-441.
-
(2011)
Exp Eye Res
, vol.93
, Issue.4
, pp. 437-441
-
-
Wright, W.S.1
McElhatten, R.M.2
Harris, N.R.3
-
34
-
-
84855855169
-
Physiological effects of superoxide dismutase on altered visual function of retinal ganglion cells in db/db mice
-
Xiao C, et al. (2012) Physiological effects of superoxide dismutase on altered visual function of retinal ganglion cells in db/db mice. PLoS ONE 7(1):e30343.
-
(2012)
PLoS ONE
, vol.7
, Issue.1
-
-
Xiao, C.1
-
35
-
-
0036010223
-
Outer retinal anoxia during dark adaptation is not a general property of mammalian retinas
-
Yu DY, Cringle SJ (2002) Outer retinal anoxia during dark adaptation is not a general property of mammalian retinas. Comp Biochem Physiol A Mol Integr Physiol 132(1): 47-52.
-
(2002)
Comp Biochem Physiol A Mol Integr Physiol
, vol.132
, Issue.1
, pp. 47-52
-
-
Yu, D.Y.1
Cringle, S.J.2
-
36
-
-
0037390258
-
Retinal oxygen: Fundamental and clinical aspects
-
Wangsa-Wirawan ND, Linsenmeier RA (2003) Retinal oxygen: Fundamental and clinical aspects. Arch Ophthalmol 121(4):547-557.
-
(2003)
Arch Ophthalmol
, vol.121
, Issue.4
, pp. 547-557
-
-
Wangsa-Wirawan, N.D.1
Linsenmeier, R.A.2
-
37
-
-
57649201567
-
ATP consumption by mammalian rod photoreceptors in darkness and in light
-
Okawa H, Sampath AP, Laughlin SB, Fain GL (2008) ATP consumption by mammalian rod photoreceptors in darkness and in light. Curr Biol 18(24):1917-1921.
-
(2008)
Curr Biol
, vol.18
, Issue.24
, pp. 1917-1921
-
-
Okawa, H.1
Sampath, A.P.2
Laughlin, S.B.3
Fain, G.L.4
-
38
-
-
0033857531
-
The missing link: A single unifying mechanism for diabetic complications
-
Nishikawa T, Edelstein D, Brownlee M (2000) The missing link: A single unifying mechanism for diabetic complications. Kidney Int Suppl 77:S26-S30.
-
(2000)
Kidney Int Suppl
, vol.77
-
-
Nishikawa, T.1
Edelstein, D.2
Brownlee, M.3
-
39
-
-
0037228626
-
Mitochondrial reactive oxygen species reduce insulin secretion by pancreatic beta-cells
-
Sakai K, et al. (2003) Mitochondrial reactive oxygen species reduce insulin secretion by pancreatic beta-cells. Biochem Biophys Res Commun 300(1):216-222.
-
(2003)
Biochem Biophys Res Commun
, vol.300
, Issue.1
, pp. 216-222
-
-
Sakai, K.1
-
40
-
-
0141755317
-
Reactive oxygen species from mitochondria induce cyclooxygenase-2 gene expression in human mesangial cells: Potential role in diabetic nephropathy
-
Kiritoshi S, et al. (2003) Reactive oxygen species from mitochondria induce cyclooxygenase-2 gene expression in human mesangial cells: Potential role in diabetic nephropathy. Diabetes 52(10):2570-2577.
-
(2003)
Diabetes
, vol.52
, Issue.10
, pp. 2570-2577
-
-
Kiritoshi, S.1
-
41
-
-
78650018920
-
Cellular and molecular actions of Methylene Blue in the nervous system
-
Oz M, Lorke DE, Hasan M, Petroianu GA (2011) Cellular and molecular actions of Methylene Blue in the nervous system. Med Res Rev 31(1):93-117.
-
(2011)
Med Res Rev
, vol.31
, Issue.1
, pp. 93-117
-
-
Oz, M.1
Lorke, D.E.2
Hasan, M.3
Petroianu, G.A.4
-
42
-
-
34247249752
-
Photoreceptor mitochondrial oxidative stress in early experimental autoimmune uveoretinitis
-
Rajendram R, Saraswathy S, Rao NA (2007) Photoreceptor mitochondrial oxidative stress in early experimental autoimmune uveoretinitis. Br J Ophthalmol 91(4): 531-537.
-
(2007)
Br J Ophthalmol
, vol.91
, Issue.4
, pp. 531-537
-
-
Rajendram, R.1
Saraswathy, S.2
Rao, N.A.3
-
43
-
-
48249134698
-
Role of NADPH oxidase in retinal vascular inflammation
-
Al-Shabrawey M, et al. (2008) Role of NADPH oxidase in retinal vascular inflammation. Invest Ophthalmol Vis Sci 49(7):3239-3244.
-
(2008)
Invest Ophthalmol Vis Sci
, vol.49
, Issue.7
, pp. 3239-3244
-
-
Al-Shabrawey, M.1
-
44
-
-
42649146197
-
Long-term cellular and regional specificity of the photoreceptor toxin, iodoacetic acid (IAA), in the rabbit retina
-
Liang L, et al. (2008) Long-term cellular and regional specificity of the photoreceptor toxin, iodoacetic acid (IAA), in the rabbit retina. Vis Neurosci 25(2):167-177.
-
(2008)
Vis Neurosci
, vol.25
, Issue.2
, pp. 167-177
-
-
Liang, L.1
-
45
-
-
67249123818
-
Depleting Rac1 in mouse rod photoreceptors protects them from photo-oxidative stress without affecting their structure or function
-
Haruta M, et al. (2009) Depleting Rac1 in mouse rod photoreceptors protects them from photo-oxidative stress without affecting their structure or function. Proc Natl Acad Sci USA 106(23):9397-9402.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, Issue.23
, pp. 9397-9402
-
-
Haruta, M.1
-
46
-
-
77952299343
-
Rod and cone photoreceptor cells produce ROS in response to stress in a live retinal explant system
-
Bhatt L, Groeger G, McDermott K, Cotter TG (2010) Rod and cone photoreceptor cells produce ROS in response to stress in a live retinal explant system. Mol Vis 16:283-293.
-
(2010)
Mol Vis
, vol.16
, pp. 283-293
-
-
Bhatt, L.1
Groeger, G.2
McDermott, K.3
Cotter, T.G.4
-
47
-
-
67650505494
-
NADPH oxidase plays a central role in cone cell death in retinitis pigmentosa
-
Usui S, et al. (2009) NADPH oxidase plays a central role in cone cell death in retinitis pigmentosa. J Neurochem 110(3):1028-1037.
-
(2009)
J Neurochem
, vol.110
, Issue.3
, pp. 1028-1037
-
-
Usui, S.1
-
48
-
-
77952028243
-
Overexpression of Bcl-2 in vascular endothelium inhibits the microvascular lesions of diabetic retinopathy
-
Kern TS, Du Y, Miller CM, Hatala DA, Levin LA (2010) Overexpression of Bcl-2 in vascular endothelium inhibits the microvascular lesions of diabetic retinopathy. Am J Pathol 176(5):2550-2558.
-
(2010)
Am J Pathol
, vol.176
, Issue.5
, pp. 2550-2558
-
-
Kern, T.S.1
Du, Y.2
Miller, C.M.3
Hatala, D.A.4
Levin, L.A.5
-
49
-
-
33847028707
-
Topical administration of nepafenac inhibits diabetes-induced retinal microvascular disease and underlying abnormalities of retinal metabolism and physiology
-
Kern TS, et al. (2007) Topical administration of nepafenac inhibits diabetes-induced retinal microvascular disease and underlying abnormalities of retinal metabolism and physiology. Diabetes 56(2):373-379.
-
(2007)
Diabetes
, vol.56
, Issue.2
, pp. 373-379
-
-
Kern, T.S.1
|