메뉴 건너뛰기




Volumn 34, Issue 1, 2012, Pages 43-62

Fibrinogen as a key regulator of inflammation in disease

Author keywords

Alzheimer's disease; Anticoagulant therapy; Atherosclerosis; Autoimmunity; Blood brain barrier; CD11b CD18; Complement receptor 3; Inflammatory disease; Macrophages; Microglia; Multiple sclerosis; Plasminogen; Rheumatoid arthritis; Stroke

Indexed keywords

CD11B ANTIGEN; CD18 ANTIGEN; FIBRIN; FIBRINOGEN; GAMMA INTERFERON; INTEGRIN RECEPTOR; INTERLEUKIN 1BETA; INTERLEUKIN 6; PLASMINOGEN ACTIVATOR; TISSUE PLASMINOGEN ACTIVATOR; TUMOR NECROSIS FACTOR ALPHA; THROMBIN; THROMBOPLASTIN;

EID: 84859715302     PISSN: 18632297     EISSN: 18632300     Source Type: Journal    
DOI: 10.1007/s00281-011-0290-8     Document Type: Review
Times cited : (727)

References (212)
  • 1
    • 0032697068 scopus 로고    scopus 로고
    • Hemostatic factors and inflammatory disease
    • Degen JL (1999) Hemostatic factors and inflammatory disease. Thromb Haemost 82(2):858-864
    • (1999) Thromb Haemost , vol.82 , Issue.2 , pp. 858-864
    • Degen, J.L.1
  • 3
    • 77957736600 scopus 로고    scopus 로고
    • Step-by-step evolution of vertebrate blood coagulation
    • Spring Harb Symp Quant Biol
    • Doolittle RF (2009) Step-by-step evolution of vertebrate blood coagulation. Cold Spring Harb Symp Quant Biol 74:35-40
    • (2009) Cold , vol.74 , pp. 35-40
    • Doolittle, R.F.1
  • 4
    • 37049242417 scopus 로고
    • Waterfall sequence for intrinsic blood clotting
    • Davie EW, Ratnoff OD (1964) Waterfall sequence for intrinsic blood clotting. Science 145:1310-1312
    • (1964) Science , vol.145 , pp. 1310-1312
    • Davie, E.W.1    Ratnoff, O.D.2
  • 5
    • 37049044629 scopus 로고
    • An enzyme cascade in the blood clotting mechanism, and its function as a biochemical amplifier
    • Macfarlane RG (1964) An enzyme cascade in the blood clotting mechanism, and its function as a biochemical amplifier. Nature 202:498-499
    • (1964) Nature , vol.202 , pp. 498-499
    • Macfarlane, R.G.1
  • 7
    • 68349116208 scopus 로고    scopus 로고
    • Review article: Coagulation cascade and therapeutics update: Relevance to nephrology. Part 1: Overview of coagulation, thrombophilias and history of anticoagulants
    • (Carlton)
    • Adams RL, Bird RJ (2009) Review article: coagulation cascade and therapeutics update: relevance to nephrology. Part 1: overview of coagulation, thrombophilias and history of anticoagulants. Nephrology (Carlton) 14(5):462-470
    • (2009) Nephrology , vol.14 , Issue.5 , pp. 462-470
    • Adams, R.L.1    Bird, R.J.2
  • 9
    • 67849130574 scopus 로고    scopus 로고
    • The many faces of tissue factor
    • Mackman N (2009) The many faces of tissue factor. J Thromb Haemost 7(Suppl 1):136-139
    • (2009) J Thromb Haemost , vol.7 , Issue.SUPPL. 1 , pp. 136-139
    • Mackman, N.1
  • 10
    • 79955495447 scopus 로고    scopus 로고
    • The missing link between atherosclerosis, inflammation and thrombosis: Is it tissue factor?
    • Cimmino G, D'Amico C, Vaccaro V, D'Anna M, Golino P (2011) The missing link between atherosclerosis, inflammation and thrombosis: is it tissue factor? Expert Rev Cardiovasc Ther 9 (4):517-523
    • (2011) Expert Rev Cardiovasc Ther , vol.9 , Issue.4 , pp. 517-523
    • Cimmino, G.1    D'Amico, C.2    Vaccaro, V.3    D'Anna, M.4    Golino, P.5
  • 11
    • 0035235956 scopus 로고    scopus 로고
    • Thrombin as a regulator of inflammation and reparative processes in tissues
    • (Mosc)
    • Strukova SM (2001) Thrombin as a regulator of inflammation and reparative processes in tissues. Biochemistry (Mosc) 66 (1):8-18
    • (2001) Biochemistry , vol.66 , Issue.1 , pp. 8-18
    • Strukova, S.M.1
  • 12
    • 61449161131 scopus 로고    scopus 로고
    • Thrombin physiology and pathophysiology
    • (San Antonio)
    • Licari LG, Kovacic JP (2009) Thrombin physiology and pathophysiology. J Vet Emerg Crit Care (San Antonio) 19(1):11-22
    • (2009) J Vet Emerg Crit Care , vol.19 , Issue.1 , pp. 11-22
    • Licari, L.G.1    Kovacic, J.P.2
  • 13
    • 0026462843 scopus 로고
    • Thrombin enhancement of interleukin-1 and tumor necrosis factor-alpha induced polymorphonuclear leukocyte migration
    • Drake WT, Lopes NN, Fenton JW 2nd, Issekutz AC (1992) Thrombin enhancement of interleukin-1 and tumor necrosis factor-alpha induced polymorphonuclear leukocyte migration. Lab Invest 67(5):617-627
    • (1992) Lab Invest , vol.67 , Issue.5 , pp. 617-627
    • Drake, W.T.1    Lopes, N.N.2    Fenton II, J.W.3    Issekutz, A.C.4
  • 14
    • 0029011957 scopus 로고
    • Thrombin induces IL-6 production in fibroblasts and epithelial cells. Evidence for the involvement of the seven-transmembrane domain (STD) receptor for alpha-thrombin
    • Sower LE, Froelich CJ, Carney DH, Fenton JW 2nd, Klimpel GR (1995) Thrombin induces IL-6 production in fibroblasts and epithelial cells. Evidence for the involvement of the seven-transmembrane domain (STD) receptor for alpha-thrombin. J Immunol 155(2):895-901
    • (1995) J Immunol , vol.155 , Issue.2 , pp. 895-901
    • Sower, L.E.1    Froelich, C.J.2    Carney, D.H.3    Fenton II, J.W.4    Klimpel, G.R.5
  • 16
    • 0036464689 scopus 로고    scopus 로고
    • Roles for thrombin and fibrin(ogen) in cytokine/chemokine production and macrophage adhesion in vivo
    • DOI 10.1182/blood.V99.3.1053
    • Szaba FM, Smiley ST (2002) Roles for thrombin and fibrin (ogen) in cytokine/chemokine production and macrophage adhesion in vivo. Blood 99(3):1053-1059 (Pubitemid 34525570)
    • (2002) Blood , vol.99 , Issue.3 , pp. 1053-1059
    • Szaba, F.M.1    Smiley, S.T.2
  • 17
    • 0034492763 scopus 로고    scopus 로고
    • Mechanism underlying acute resident leukocyte disappearance induced by immunological and non-immunological stimuli in rats: Evidence for a role for the coagulation system
    • DOI 10.1007/s000110050650
    • Serra MF, Diaz BL, Barreto EO, Cordeiro RS, Nazare Meirelles MN, Williams TJ, Martins MA, Silva PM (2000) Mechanism underlying acute resident leukocyte disappearance induced by immunological and non-immunological stimuli in rats: evidence for a role for the coagulation system. Inflamm Res 49(12):708-713 (Pubitemid 32097087)
    • (2000) Inflammation Research , vol.49 , Issue.12 , pp. 708-713
    • Serra, M.F.1    Diaz, B.L.2    Barreto, E.O.3    Cordeiro, R.S.B.4    Nazare, M.M.N.S.L.5    Williams, T.J.6    Martins, M.A.7    Silva, P.M.R.8
  • 19
    • 45949100430 scopus 로고    scopus 로고
    • Role of protease-activated receptors in inflammatory responses, innate and adaptive immunity
    • DOI 10.1189/jlb.0108001
    • Shpacovitch V, Feld M, Hollenberg MD, Luger TA, Steinhoff M (2008) Role of protease-activated receptors in inflammatory responses, innate and adaptive immunity. J Leukoc Biol 83 (6):1309-1322 (Pubitemid 351960309)
    • (2008) Journal of Leukocyte Biology , vol.83 , Issue.6 , pp. 1309-1322
    • Shpacovitch, V.1    Feld, M.2    Hollenberg, M.D.3    Luger, T.A.4    Steinhoff, M.5
  • 20
    • 17444392120 scopus 로고    scopus 로고
    • Fibrinogen and fibrin
    • Weisel JW (2005) Fibrinogen and fibrin. Adv Protein Chem 70:247-299
    • (2005) Adv Protein Chem , vol.70 , pp. 247-299
    • Weisel, J.W.1
  • 21
    • 33847341323 scopus 로고    scopus 로고
    • Human plasma fibrinogen is synthesized in the liver
    • DOI 10.1182/blood-2006-08-040956
    • Tennent GA, Brennan SO, Stangou AJ, O'Grady J, Hawkins PN, Pepys MB (2007) Human plasma fibrinogen is synthesized in the liver. Blood 109(5):1971-1974 (Pubitemid 46348194)
    • (2007) Blood , vol.109 , Issue.5 , pp. 1971-1974
    • Tennent, G.A.1    Brennan, S.O.2    Stangou, A.J.3    O'Grady, J.4    Hawkins, P.N.5    Pepys, M.B.6
  • 22
    • 36749054336 scopus 로고
    • The dominant role of the liver in plasma protein synthesis; a direct study of the isolated perfused rat liver with the aid of lysine-epsilon-C14
    • Miller LL, Bly CG, Watson ML, Bale WF (1951) The dominant role of the liver in plasma protein synthesis; a direct study of the isolated perfused rat liver with the aid of lysine-epsilon-C14. J Exp Med 94(5):431-453
    • (1951) J Exp Med , vol.94 , Issue.5 , pp. 431-453
    • Miller, L.L.1    Bly, C.G.2    Watson, M.L.3    Bale, W.F.4
  • 23
    • 70249091771 scopus 로고
    • The fibrinogen molecule: Its size, shape, and mode of polymerization
    • Hall CE, Slayter HS (1959) The fibrinogen molecule: its size, shape, and mode of polymerization. J Biophys Biochem Cytol 5 (1):11-16
    • (1959) J Biophys Biochem Cytol , vol.5 , Issue.1 , pp. 11-16
    • Hall, C.E.1    Slayter, H.S.2
  • 26
    • 0032441774 scopus 로고    scopus 로고
    • Three-dimensional structural studies on fragments of fibrinogen and fibrin
    • DOI 10.1016/S0959-440X(98)80100-0
    • Doolittle RF, Spraggon G, Everse SJ (1998) Three-dimensional structural studies on fragments of fibrinogen and fibrin. Curr Opin Struct Biol 8(6):792-798 (Pubitemid 29004678)
    • (1998) Current Opinion in Structural Biology , vol.8 , Issue.6 , pp. 792-798
    • Doolittle, R.F.1    Spraggon, G.2    Everse, S.J.3
  • 30
    • 67849121525 scopus 로고    scopus 로고
    • Fibrinogen signal transduction in the nervous system
    • Ryu JK, Davalos D, Akassoglou K (2009) Fibrinogen signal transduction in the nervous system. J Thromb Haemost 7(Suppl 1):151-154
    • (2009) J Thromb Haemost , vol.7 , Issue.SUPPL. 1 , pp. 151-154
    • Ryu, J.K.1    Davalos, D.2    Akassoglou, K.3
  • 32
    • 21344463591 scopus 로고    scopus 로고
    • Platelet aggregation: Involvement of thrombin and fibrin(ogen)
    • Lisman T, Weeterings C, de Groot PG (2005) Platelet aggregation: involvement of thrombin and fibrin(ogen). Front Biosci 10:2504-2517 (Pubitemid 40905255)
    • (2005) Frontiers in Bioscience , vol.10 , Issue.SUPPL. 2 , pp. 2504-2517
    • Lisman, T.1    Weeterings, C.2    De Groot, P.G.3
  • 33
  • 34
  • 35
    • 0028052961 scopus 로고
    • Binding of recombinant fibrinogen mutants to platelets
    • Farrell DH, Thiagarajan P (1994) Binding of recombinant fibrinogen mutants to platelets. J Biol Chem 269(1):226-231 (Pubitemid 24026648)
    • (1994) Journal of Biological Chemistry , vol.269 , Issue.1 , pp. 226-231
    • Farrell, D.H.1    Thiagarajan, P.2
  • 36
    • 0029978277 scopus 로고    scopus 로고
    • Dissecting clot retraction and platelet aggregation: Clot retraction does not require an intact fibrinogen gamma chain C terminus
    • DOI 10.1074/jbc.271.15.8553
    • Rooney MM, Parise LV, Lord ST (1996) Dissecting clot retraction and platelet aggregation. Clot retraction does not require an intact fibrinogen gamma chain C terminus. J Biol Chem 271(15):8553-8555 (Pubitemid 26125946)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.15 , pp. 8553-8555
    • Rooney, M.M.1    Parise, L.V.2    Lord, S.T.3
  • 37
    • 0030584083 scopus 로고    scopus 로고
    • Loss of fibrinogen rescues mice from the pleiotropic effects of plasminogen deficiency
    • DOI 10.1016/S0092-8674(00)81390-2
    • Bugge TH, Kombrinck KW, Flick MJ, Daugherty CC, Danton MJ, Degen JL (1996) Loss of fibrinogen rescues mice from the pleiotropic effects of plasminogen deficiency. Cell 87(4):709-719 (Pubitemid 26386944)
    • (1996) Cell , vol.87 , Issue.4 , pp. 709-719
    • Bugge, T.H.1    Kombrinck, K.W.2    Flick, M.J.3    Daugherty, C.C.4    Danton, M.J.S.5    Degen, J.L.6
  • 38
    • 0034969433 scopus 로고    scopus 로고
    • Elements of the fibrinolytic system
    • Lijnen HR (2001) Elements of the fibrinolytic system. Ann N Y Acad Sci 936:226-236
    • (2001) Ann N Y Acad Sci , vol.936 , pp. 226-236
    • Lijnen, H.R.1
  • 40
    • 0032765219 scopus 로고    scopus 로고
    • Dysfibrinogenemia and thrombosis
    • Mosesson MW (1999) Dysfibrinogenemia and thrombosis. Semin Thromb Hemost 25(3):311-319
    • (1999) Semin Thromb Hemost , vol.25 , Issue.3 , pp. 311-319
    • Mosesson, M.W.1
  • 41
    • 33748752527 scopus 로고    scopus 로고
    • The molecular basis of quantitative fibrinogen disorders
    • DOI 10.1111/j.1538-7836.2006.02094.x
    • Asselta R, Duga S, Tenchini ML (2006) The molecular basis of quantitative fibrinogen disorders. J Thromb Haemost 4 (10):2115-2129 (Pubitemid 44400283)
    • (2006) Journal of Thrombosis and Haemostasis , vol.4 , Issue.10 , pp. 2115-2129
    • Asselta, R.1    Duga, S.2    Tenchini, M.L.3
  • 42
    • 0028920904 scopus 로고
    • Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction
    • Bugge TH, Flick MJ, Daugherty CC, Degen JL (1995) Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction. Genes Dev 9(7):794-807
    • (1995) Genes Dev , vol.9 , Issue.7 , pp. 794-807
    • Bugge, T.H.1    Flick, M.J.2    Daugherty, C.C.3    Degen, J.L.4
  • 44
    • 0034729210 scopus 로고    scopus 로고
    • Tissue plasminogen activator-mediated fibrinolysis protects against axonal degeneration and demyelination after sciatic nerve injury
    • DOI 10.1083/jcb.149.5.1157
    • Akassoglou K, Kombrinck KW, Degen JL, Strickland S (2000) Tissue plasminogen activator-mediated fibrinolysis protects against axonal degeneration and demyelination after sciatic nerve injury. J Cell Biol 149(5):1157-1166 (Pubitemid 30354264)
    • (2000) Journal of Cell Biology , vol.149 , Issue.5 , pp. 1157-1166
    • Akassoglou, K.1    Kombrinck, K.W.2    Degen, J.L.3    Strickland, S.4
  • 45
    • 36749051730 scopus 로고    scopus 로고
    • Fibrinogen signal transduction as a mediator and therapeutic target in inflammation: Lessons from multiple sclerosis
    • DOI 10.2174/092986707782360015
    • Adams RA, Schachtrup C, Davalos D, Tsigelny I, Akassoglou K (2007) Fibrinogen signal transduction as a mediator and therapeutic target in inflammation: lessons from multiple sclerosis. Curr Med Chem 14(27):2925-2936 (Pubitemid 350201659)
    • (2007) Current Medicinal Chemistry , vol.14 , Issue.27 , pp. 2925-2936
    • Adams, R.A.1    Schachtrup, C.2    Davalos, D.3    Tsigelny, I.4    Akassoglou, K.5
  • 46
    • 28344452909 scopus 로고    scopus 로고
    • Circulating inflammatory markers and risks of cardiovascular and non-cardiovascular disease
    • Lowe GD (2005) Circulating inflammatory markers and risks of cardiovascular and non-cardiovascular disease. J Thromb Haemost 3(8):1618-1627
    • (2005) J Thromb Haemost , vol.3 , Issue.8 , pp. 1618-1627
    • Lowe, G.D.1
  • 47
    • 0023934344 scopus 로고
    • Fibrinogen-derived peptide B beta 1-42 is a multidomained neutrophil chemoattractant
    • Skogen WF, Senior RM, Griffin GL, Wilner GD (1988) Fibrinogen-derived peptide B beta 1-42 is a multidomained neutrophil chemoattractant. Blood 71(5):1475-1479
    • (1988) Blood , vol.71 , Issue.5 , pp. 1475-1479
    • Skogen, W.F.1    Senior, R.M.2    Griffin, G.L.3    Wilner, G.D.4
  • 48
    • 12544252996 scopus 로고    scopus 로고
    • Distinct roles for the alpha and beta subunits in the functions of integrin alphaMbeta2
    • Solovjov DA, Pluskota E, Plow EF (2005) Distinct roles for the alpha and beta subunits in the functions of integrin alphaMbeta2. J Biol Chem 280(2):1336-1345
    • (2005) J Biol Chem , vol.280 , Issue.2 , pp. 1336-1345
    • Solovjov, D.A.1    Pluskota, E.2    Plow, E.F.3
  • 51
    • 0035889160 scopus 로고    scopus 로고
    • The alternatively spliced alpha(E)C domain of human fibrinogen-420 is a novel ligand for leukocyte integrins alpha(M)beta(2) and alpha(X)beta(2)
    • Lishko VK, Yakubenko VP, Hertzberg KM, Grieninger G, Ugarova TP (2001) The alternatively spliced alpha(E)C domain of human fibrinogen-420 is a novel ligand for leukocyte integrins alpha(M)beta(2) and alpha(X)beta(2). Blood 98 (8):2448-2455
    • (2001) Blood , vol.98 , Issue.8 , pp. 2448-2455
    • Lishko, V.K.1    Yakubenko, V.P.2    Hertzberg, K.M.3    Grieninger, G.4    Ugarova, T.P.5
  • 53
    • 0037195265 scopus 로고    scopus 로고
    • 2 in the gammaC-domain of fibrinogen
    • DOI 10.1021/bi026324c
    • Lishko VK, Kudryk B, Yakubenko VP, Yee VC, Ugarova TP (2002) Regulated unmasking of the cryptic binding site for integrin alpha M beta 2 in the gamma C-domain of fibrinogen. Biochemistry 41(43):12942-12951 (Pubitemid 35215777)
    • (2002) Biochemistry , vol.41 , Issue.43 , pp. 12942-12951
    • Lishko, V.K.1    Kudryk, B.2    Yakubenko, V.P.3    Yee, V.C.4    Ugarova, T.P.5
  • 54
    • 0027212363 scopus 로고
    • Integrin regulation of leukocyte inflammatory functions. CD11b/CD18 enhancement of the tumor necrosis factor-alpha responses of monocytes
    • Fan ST, Edgington TS (1993) Integrin regulation of leukocyte inflammatory functions. CD11b/CD18 enhancement of the tumor necrosis factor-alpha responses of monocytes. J Immunol 150 (7):2972-2980
    • (1993) J Immunol , vol.150 , Issue.7 , pp. 2972-2980
    • Fan, S.T.1    Edgington, T.S.2
  • 55
    • 0028814602 scopus 로고
    • Fibrin enhances the expression of IL- 1 beta by human peripheral blood mononuclear cells.Implications in pulmonary inflammation
    • Perez RL, Roman J (1995) Fibrin enhances the expression of IL- 1 beta by human peripheral blood mononuclear cells.Implications in pulmonary inflammation. J Immunol 154 (4):1879-1887
    • (1995) J Immunol , vol.154 , Issue.4 , pp. 1879-1887
    • Perez, R.L.1    Roman, J.2
  • 56
    • 0033129378 scopus 로고    scopus 로고
    • Transcriptional regulation of the interleukin-1beta promoter via fibrinogen engagement of the CD18 integrin receptor
    • Perez RL, Ritzenthaler JD, Roman J (1999) Transcriptional regulation of the interleukin-1beta promoter via fibrinogen engagement of the CD18 integrin receptor. Am J Respir Cell Mol Biol 20(5):1059-1066 (Pubitemid 129540865)
    • (1999) American Journal of Respiratory Cell and Molecular Biology , vol.20 , Issue.5 , pp. 1059-1066
    • Perez, R.L.1    Ritzenthaler, J.D.2    Roman, J.3
  • 60
    • 33947363967 scopus 로고    scopus 로고
    • 377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease
    • DOI 10.1084/jem.20061931
    • Adams RA, Bauer J, Flick MJ, Sikorski SL, Nuriel T, Lassmann H, Degen JL, Akassoglou K (2007) The fibrin-derived gamma377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease. J Exp Med 204(3):571-582 (Pubitemid 46457080)
    • (2007) Journal of Experimental Medicine , vol.204 , Issue.3 , pp. 571-582
    • Adams, R.A.1    Bauer, J.2    Flick, M.J.3    Sikorski, S.L.4    Nuriel, T.5    Lassmann, H.6    Degen, J.L.7    Akassoglou, K.8
  • 63
    • 0033517847 scopus 로고    scopus 로고
    • Characteristics of fibrinogen binding to the domain of CD11c, an alpha subunit of p150,95
    • Nham SU (1999) Characteristics of fibrinogen binding to the domain of CD11c, an alpha subunit of p150,95. Biochem Biophys Res Commun 264(3):630-634
    • (1999) Biochem Biophys Res Commun , vol.264 , Issue.3 , pp. 630-634
    • Nham, S.U.1
  • 66
    • 71649101901 scopus 로고    scopus 로고
    • Mechanisms of fibrinogen-induced microvascular dysfunction during cardiovascular disease
    • (Oxf)
    • Lominadze D, Dean WL, Tyagi SC, Roberts AM (2010) Mechanisms of fibrinogen-induced microvascular dysfunction during cardiovascular disease. Acta Physiol (Oxf) 198 (1):1-13
    • (2010) Acta Physiol , vol.198 , Issue.1 , pp. 1-13
    • Lominadze, D.1    Dean, W.L.2    Tyagi, S.C.3    Roberts, A.M.4
  • 67
    • 0035451118 scopus 로고    scopus 로고
    • Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4
    • Smiley ST, King JA, Hancock WW (2001) Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4. J Immunol 167(5):2887-2894 (Pubitemid 32768923)
    • (2001) Journal of Immunology , vol.167 , Issue.5 , pp. 2887-2894
    • Smiley, S.T.1    King, J.A.2    Hancock, W.W.3
  • 68
    • 48949097129 scopus 로고    scopus 로고
    • Functional Toll-like receptor 4 mutations modulate the response to fibrinogen
    • Hodgkinson CP, Patel K, Ye S (2008) Functional Toll-like receptor 4 mutations modulate the response to fibrinogen. Thromb Haemost 100(2):301-307
    • (2008) Thromb Haemost , vol.100 , Issue.2 , pp. 301-307
    • Hodgkinson, C.P.1    Patel, K.2    Ye, S.3
  • 69
    • 79951669207 scopus 로고    scopus 로고
    • The immune system in atherosclerosis
    • Hansson GK, Hermansson A (2011) The immune system in atherosclerosis. Nat Immunol 12(3):204-212
    • (2011) Nat Immunol , vol.12 , Issue.3 , pp. 204-212
    • Hansson, G.K.1    Hermansson, A.2
  • 70
    • 79955031204 scopus 로고    scopus 로고
    • Regulation of VSMC behavior by the cadherin-catenin complex
    • Lyon C, Mill C, Tsaousi A, Williams H, George S (2011) Regulation of VSMC behavior by the cadherin-catenin complex. Front Biosci 16:644-657
    • (2011) Front Biosci , vol.16 , pp. 644-657
    • Lyon, C.1    Mill, C.2    Tsaousi, A.3    Williams, H.4    George, S.5
  • 71
    • 42949172414 scopus 로고    scopus 로고
    • The role of fibrinogen and fibrinolysis in peripheral arterial disease
    • DOI 10.1016/j.thromres.2007.06.003, PII S0049384807002411
    • Paraskevas KI, Baker DM, Vrentzos GE, Mikhailidis DP (2008) The role of fibrinogen and fibrinolysis in peripheral arterial disease. Thromb Res 122(1):1-12 (Pubitemid 351618332)
    • (2008) Thrombosis Research , vol.122 , Issue.1 , pp. 1-12
    • Paraskevas, K.I.1    Baker, D.M.2    Vrentzos, G.E.3    Mikhailidis, D.P.4
  • 72
    • 30944466704 scopus 로고    scopus 로고
    • Overview of hemostatic factors involved in atherosclerotic cardiovascular disease
    • Kannel WB (2005) Overview of hemostatic factors involved in atherosclerotic cardiovascular disease. Lipids 40(12):1215-1220
    • (2005) Lipids , vol.40 , Issue.12 , pp. 1215-1220
    • Kannel, W.B.1
  • 73
    • 0042887139 scopus 로고    scopus 로고
    • Endothdial dysfunction in peripheral arterial disease is related to increase in plasma markers of inflammation and severity of peripheral circulatory impairment but not to classic risk factors and atherosclerotic burden
    • DOI 10.1016/S0741-5214(03)00124-1
    • Brevetti G, Silvestro A, Di Giacomo S, Bucur R, Di Donato A, Schiano V, Scopacasa F (2003) Endothelial dysfunction in peripheral arterial disease is related to increase in plasma markers of inflammation and severity of peripheral circulatory impairment but not to classic risk factors and atherosclerotic burden. J Vasc Surg 38(2):374-379 (Pubitemid 41123265)
    • (2003) Journal of Vascular Surgery , vol.38 , Issue.2 , pp. 374-379
    • Brevetti, G.1    Silvestro, A.2    Di, G.S.3    Bucur, R.4    Di, D.A.5    Schiano, V.6    Scopacasa, F.7
  • 74
    • 23644444800 scopus 로고    scopus 로고
    • Patterns of inflammation associated with peripheral arterial disease: The InCHIANTI study
    • DOI 10.1016/j.ahj.2004.09.032, PII S0002870304006647
    • McDermott MM, Guralnik JM, Corsi A, Albay M, Macchi C, Bandinelli S, Ferrucci L (2005) Patterns of inflammation associated with peripheral arterial disease: the InCHIANTI study. Am Heart J 150(2):276-281 (Pubitemid 41116253)
    • (2005) American Heart Journal , vol.150 , Issue.2 , pp. 276-281
    • McDermott, M.M.1    Guralnik, J.M.2    Corsi, A.3    Albay, M.4    Macchi, C.5    Bandinelli, S.6    Ferrucci, L.7
  • 75
    • 33846968816 scopus 로고    scopus 로고
    • Inflammatory, haemostatic, and rheological markers for incident peripheral arterial disease: Edinburgh Artery Study
    • Tzoulaki I, Murray GD, Lee AJ, Rumley A, Lowe GD, Fowkes FG (2007) Inflammatory, haemostatic, and rheological markers for incident peripheral arterial disease: Edinburgh Artery Study. Eur Heart J 28(3):354-362
    • (2007) Eur Heart J , vol.28 , Issue.3 , pp. 354-362
    • Tzoulaki, I.1    Murray, G.D.2    Lee, A.J.3    Rumley, A.4    Lowe, G.D.5    Fowkes, F.G.6
  • 76
    • 0027404171 scopus 로고
    • The human beta fibrinogen promoter contains a hepatocyte nuclear factor 1- dependent interleukin-6-responsive element
    • Dalmon J, Laurent M, Courtois G (1993) The human beta fibrinogen promoter contains a hepatocyte nuclear factor 1- dependent interleukin-6-responsive element. Mol Cell Biol 13 (2):1183-1193 (Pubitemid 23040285)
    • (1993) Molecular and Cellular Biology , vol.13 , Issue.2 , pp. 1183-1193
    • Dalmon, J.1    Laurent, M.2    Courtois, G.3
  • 77
    • 0027217386 scopus 로고
    • The two C/EBP isoforms, IL-6DBP/NF-IL6 and C/EBPdelta/NF-IL6beta, are induced by IL-6 to promote acute phase gene transcription via different mechanisms
    • Ramji DP, Vitelli A, Tronche F, Cortese R, Ciliberto G (1993) The two C/EBP isoforms, IL-6DBP/NF-IL6 and C/EBP delta/ NF-IL6 beta, are induced by IL-6 to promote acute phase gene transcription via different mechanisms. Nucleic Acids Res 21 (2):289-294 (Pubitemid 23151900)
    • (1993) Nucleic Acids Research , vol.21 , Issue.2 , pp. 289-294
    • Ramji, D.P.1    Vitelli, I.2    Tronche, I.3    Cortese, R.4    Ciliberto, G.5
  • 78
    • 0025190892 scopus 로고
    • Interleukin-6 and the acute phase response
    • Heinrich PC, Castell JV, Andus T (1990) Interleukin-6 and the acute phase response. Biochem J 265(3):621-636 (Pubitemid 20053863)
    • (1990) Biochemical Journal , vol.265 , Issue.3 , pp. 621-636
    • Heinrich, P.C.1    Castell, J.V.2    Andus, T.3
  • 80
    • 28344448202 scopus 로고    scopus 로고
    • Fibrinogen and fibrin structure and functions
    • Mosesson MW (2005) Fibrinogen and fibrin structure and functions. J Thromb Haemost 3(8):1894-1904
    • (2005) J Thromb Haemost , vol.3 , Issue.8 , pp. 1894-1904
    • Mosesson, M.W.1
  • 81
    • 0037395239 scopus 로고    scopus 로고
    • Fibrin(ogen) in cardiovascular disease: An update
    • Koenig W (2003) Fibrin(ogen) in cardiovascular disease: an update. Thromb Haemost 89(4):601-609
    • (2003) Thromb Haemost , vol.89 , Issue.4 , pp. 601-609
    • Koenig, W.1
  • 83
    • 0023932819 scopus 로고
    • Blood rheology in patients with transient ischemic attacks
    • Ernst E, Matrai A, Marshall M (1988) Blood rheology in patients with transient ischemic attacks. Stroke 19(5):634-636
    • (1988) Stroke , vol.19 , Issue.5 , pp. 634-636
    • Ernst, E.1    Matrai, A.2    Marshall, M.3
  • 84
    • 0025971739 scopus 로고
    • Chronic blood hyperviscosity in subjects with acute stroke, transient ischemic attack, and risk factors for stroke
    • Coull BM, Beamer N, de Garmo P, Sexton G, Nordt F, Knox R, Seaman GV (1991) Chronic blood hyperviscosity in subjects with acute stroke, transient ischemic attack, and risk factors for stroke. Stroke 22(2):162-168
    • (1991) Stroke , vol.22 , Issue.2 , pp. 162-168
    • Coull, B.M.1    Beamer, N.2    De Garmo, P.3    Sexton, G.4    Nordt, F.5    Knox, R.6    Seaman, G.V.7
  • 85
    • 0031015612 scopus 로고    scopus 로고
    • Blood viscosity and risk of cardiovascular events: The Edinburgh artery study
    • Lowe GD, Lee AJ, Rumley A, Price JF, Fowkes FG (1997) Blood viscosity and risk of cardiovascular events: the Edinburgh artery study. Br J Haematol 96(1):168-173
    • (1997) Br J Haematol , vol.96 , Issue.1 , pp. 168-173
    • Lowe, G.D.1    Lee, A.J.2    Rumley, A.3    Price, J.F.4    Fowkes, F.G.5
  • 86
    • 0036843301 scopus 로고    scopus 로고
    • Role of integrins in endothelial mechanosensing of shear stress
    • DOI 10.1161/01.RES.0000038487.19924.18
    • Shyy JY, Chien S (2002) Role of integrins in endothelial mechanosensing of shear stress. Circ Res 91(9):769-775 (Pubitemid 35285073)
    • (2002) Circulation Research , vol.91 , Issue.9 , pp. 769-775
    • Shyy, J.Y.-J.1    Chien, S.2
  • 87
    • 0027321023 scopus 로고
    • Mechanisms of shear-induced platelet adhesion and aggregation
    • Ruggeri ZM (1993) Mechanisms of shear-induced platelet adhesion and aggregation. Thromb Haemost 70(1):119-123
    • (1993) Thromb Haemost , vol.70 , Issue.1 , pp. 119-123
    • Ruggeri, Z.M.1
  • 88
    • 78751652828 scopus 로고    scopus 로고
    • Effects of disturbed flow on vascular endothelium: Pathophysiological basis and clinical perspectives
    • Chiu JJ, Chien S (2011) Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives. Physiol Rev 91(1):327-387
    • (2011) Physiol Rev , vol.91 , Issue.1 , pp. 327-387
    • Chiu, J.J.1    Chien, S.2
  • 89
    • 77954096910 scopus 로고    scopus 로고
    • Role of plasma proteins in whole blood viscosity: A brief clinical review
    • Kwaan HC (2010) Role of plasma proteins in whole blood viscosity: a brief clinical review. Clin Hemorheol Microcirc 44 (3):167-176
    • (2010) Clin Hemorheol Microcirc , vol.44 , Issue.3 , pp. 167-176
    • Kwaan, H.C.1
  • 93
    • 0024531616 scopus 로고
    • Identification and distribution of fibrinogen, fibrin, and fibrin(ogen) degradation products in atherosclerosis. Use of monoclonal antibodies
    • Bini A, Fenoglio JJ Jr, Mesa-Tejada R, Kudryk B, Kaplan KL (1989) Identification and distribution of fibrinogen, fibrin, and fibrin(ogen) degradation products in atherosclerosis. Use of monoclonal antibodies. Arteriosclerosis 9(1):109-121 (Pubitemid 19046097)
    • (1989) Arteriosclerosis , vol.9 , Issue.1 , pp. 109-121
    • Bini, A.1    Fenoglio Jr., J.J.2    Mesa-Tejada, R.3    Kudryk, B.4    Kaplan, K.L.5
  • 94
    • 79955524130 scopus 로고    scopus 로고
    • Proinflammatory effect of fibrinogen and FDP on vascular smooth muscle cells by IL-6, TNF-alpha and iNOS
    • Lu PP, Liu JT, Liu N, Guo F, Ji YY, Pang X (2011) Proinflammatory effect of fibrinogen and FDP on vascular smooth muscle cells by IL-6, TNF-alpha and iNOS. Life Sci 88:839-845
    • (2011) Life Sci , vol.88 , pp. 839-845
    • Lu, P.P.1    Liu, J.T.2    Liu, N.3    Guo, F.4    Ji, Y.Y.5    Pang, X.6
  • 95
    • 0026646590 scopus 로고
    • Substrate-bound fibrinogen, fibrin and other cell attachment-promoting proteins as a scaffold for cultured vascular smooth muscle cells
    • Naito M, Funaki C, Hayashi T, Yamada K, Asai K, Yoshimine N, Kuzuya F (1992) Substrate-bound fibrinogen, fibrin and other cell attachment-promoting proteins as a scaffold for cultured vascular smooth muscle cells. Atherosclerosis 96(2-3):227-234
    • (1992) Atherosclerosis , vol.96 , Issue.2-3 , pp. 227-234
    • Naito, M.1    Funaki, C.2    Hayashi, T.3    Yamada, K.4    Asai, K.5    Yoshimine, N.6    Kuzuya, F.7
  • 96
    • 0022180156 scopus 로고
    • Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation
    • Shattil SJ, Hoxie JA, Cunningham M, Brass LF (1985) Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation. J Biol Chem 260(20):11107-11114 (Pubitemid 16253272)
    • (1985) Journal of Biological Chemistry , vol.260 , Issue.20 , pp. 11107-11114
    • Shattil, S.J.1    Hoxie, J.A.2    Cunningham, M.3    Brass, L.F.4
  • 97
    • 77953865873 scopus 로고    scopus 로고
    • High-density lipoproteins, platelets and the pathogenesis of atherosclerosis
    • Nofer JR, Brodde MF, Kehrel BE (2010) High-density lipoproteins, platelets and the pathogenesis of atherosclerosis. Clin Exp Pharmacol Physiol 37(7):726-735
    • (2010) Clin Exp Pharmacol Physiol , vol.37 , Issue.7 , pp. 726-735
    • Nofer, J.R.1    Brodde, M.F.2    Kehrel, B.E.3
  • 99
    • 34447324354 scopus 로고    scopus 로고
    • Platelet integrins and immunoreceptors
    • DOI 10.1111/j.1600-065X.2007.00532.x
    • Kasirer-Friede A, Kahn ML, Shattil SJ (2007) Platelet integrins and immunoreceptors. Immunol Rev 218:247-264 (Pubitemid 47052302)
    • (2007) Immunological Reviews , vol.218 , Issue.1 , pp. 247-264
    • Kasirer-Friede, A.1    Kahn, M.L.2    Shattil, S.J.3
  • 101
    • 33646570250 scopus 로고    scopus 로고
    • A fibrinogen deficiency accelerates the initiation of LDL cholesterol-driven atherosclerosis via thrombin generation and platelet activation in genetically predisposed mice
    • DOI 10.1182/blood-2005-09-3780
    • Iwaki T, Sandoval-Cooper MJ, Brechmann M, Ploplis VA, Castellino FJ (2006) A fibrinogen deficiency accelerates the initiation of LDL cholesterol-driven atherosclerosis via thrombin generation and platelet activation in genetically predisposed mice. Blood 107(10):3883-3891 (Pubitemid 43726792)
    • (2006) Blood , vol.107 , Issue.10 , pp. 3883-3891
    • Iwaki, T.1    Sandoval-Cooper, M.J.2    Brechmann, M.3    Ploplis, V.A.4    Castellino, F.J.5
  • 104
    • 0035799376 scopus 로고    scopus 로고
    • RANTES deposition by platelets triggers monocyte arrest on inflamed and atherosclerotic endothelium
    • von Hundelshausen P, Weber KS, Huo Y, Proudfoot AE, Nelson PJ, Ley K, Weber C (2001) RANTES deposition by platelets triggers monocyte arrest on inflamed and atherosclerotic endothelium. Circulation 103(13):1772-1777
    • (2001) Circulation , vol.103 , Issue.13 , pp. 1772-1777
    • Von Hundelshausen, P.1    Weber, K.S.2    Huo, Y.3    Proudfoot, A.E.4    Nelson, P.J.5    Ley, K.6    Weber, C.7
  • 106
    • 0037109144 scopus 로고    scopus 로고
    • 3) on platelets upregulates CD40L and triggers CD40L-dependent matrix degradation by endothelial cells
    • DOI 10.1161/01.CIR.0000033597.45947.0F
    • May AE, Kalsch T, Massberg S, Herouy Y, Schmidt R, Gawaz M (2002) Engagement of glycoprotein IIb/IIIa (alpha(IIb)beta3) on platelets upregulates CD40L and triggers CD40L-dependent matrix degradation by endothelial cells. Circulation 106(16):2111-2117 (Pubitemid 35192818)
    • (2002) Circulation , vol.106 , Issue.16 , pp. 2111-2117
    • May, A.E.1    Kalsch, T.2    Massberg, S.3    Herouy, Y.4    Schmidt, R.5    Gawaz, M.6
  • 107
    • 0037126048 scopus 로고    scopus 로고
    • Deposition of platelet RANTES triggering monocyte recruitment requires P-selectin and is involved in neointima formation after arterial injury
    • Schober A, Manka D, von Hundelshausen P, Huo Y, Hanrath P, Sarembock IJ, Ley K, Weber C (2002) Deposition of platelet RANTES triggering monocyte recruitment requires P-selectin and is involved in neointima formation after arterial injury. Circulation 106(12):1523-1529
    • (2002) Circulation , vol.106 , Issue.12 , pp. 1523-1529
    • Schober, A.1    Manka, D.2    Von Hundelshausen, P.3    Huo, Y.4    Hanrath, P.5    Sarembock, I.J.6    Ley, K.7    Weber, C.8
  • 108
    • 33744469804 scopus 로고    scopus 로고
    • Fibrin(ogen) and its fragments in the pathophysiology and treatment of myocardial infarction
    • DOI 10.1007/s00109-006-0051-7
    • Zacharowski K, Zacharowski P, Reingruber S, Petzelbauer P (2006) Fibrin(ogen) and its fragments in the pathophysiology and treatment of myocardial infarction. J Mol Med 84 (6):469-477 (Pubitemid 43801325)
    • (2006) Journal of Molecular Medicine , vol.84 , Issue.6 , pp. 469-477
    • Zacharowski, K.1    Zacharowski, P.2    Reingruber, S.3    Petzelbauer, P.4
  • 109
  • 110
    • 0027318675 scopus 로고
    • Fibrinogen mediates leukocyte adhesion to vascular endothelium through an ICAM-1-dependent pathway
    • DOI 10.1016/0092-8674(93)90367-Y
    • Languino LR, Plescia J, Duperray A, Brian AA, Plow EF, Geltosky JE, Altieri DC (1993) Fibrinogen mediates leukocyte adhesion to vascular endothelium through an ICAM-1-dependent pathway. Cell 73(7):1423-1434 (Pubitemid 23201154)
    • (1993) Cell , vol.73 , Issue.7 , pp. 1423-1434
    • Languino, L.R.1    Plescia, J.2    Duperray, A.3    Brian, A.A.4    Plow, E.F.5    Geltosky, J.E.6    Altieri, D.C.7
  • 111
    • 0028957672 scopus 로고
    • Regulation of leukocyte-endothelium interaction and leukocyte transendothelial migration by intercellular adhesion molecule 1-fibrinogen recognition
    • Languino LR, Duperray A, Joganic KJ, Fornaro M, Thornton GB, Altieri DC (1995) Regulation of leukocyte-endothelium interaction and leukocyte transendothelial migration by intercellular adhesion molecule 1-fibrinogen recognition. Proc Natl Acad Sci USA 92(5):1505-1509
    • (1995) Proc Natl Acad Sci USA , vol.92 , Issue.5 , pp. 1505-1509
    • Languino, L.R.1    Duperray, A.2    Joganic, K.J.3    Fornaro, M.4    Thornton, G.B.5    Altieri, D.C.6
  • 112
    • 0037177243 scopus 로고    scopus 로고
    • 2-terminal portions of the fibrin beta chains
    • DOI 10.1021/bi0160314
    • Gorlatov S, Medved L (2002) Interaction of fibrin(ogen) with the endothelial cell receptor VE-cadherin: mapping of the receptor-binding site in the NH2-terminal portions of the fibrin beta chains. Biochemistry 41(12):4107-4116 (Pubitemid 34251050)
    • (2002) Biochemistry , vol.41 , Issue.12 , pp. 4107-4116
    • Gorlatov, S.1    Medved, L.2
  • 114
  • 119
    • 0035883897 scopus 로고    scopus 로고
    • Rheumatoid arthritis
    • DOI 10.1016/S0140-6736(01)06075-5
    • Lee DM, Weinblatt ME (2001) Rheumatoid arthritis. Lancet 358 (9285):903-911 (Pubitemid 32900579)
    • (2001) Lancet , vol.358 , Issue.9285 , pp. 903-911
    • Lee, D.M.1    Weinblatt, M.E.2
  • 120
    • 50849086145 scopus 로고    scopus 로고
    • Inflammatory and prothrombotic biomarkers in patients with rheumatoid arthritis: Effects of tumor necrosis factor-alpha blockade
    • Ingegnoli F, Fantini F, Favalli EG, Soldi A, Griffini S, Galbiati V, Meroni PL, Cugno M (2008) Inflammatory and prothrombotic biomarkers in patients with rheumatoid arthritis: effects of tumor necrosis factor-alpha blockade. J Autoimmun 31(2):175-179
    • (2008) J Autoimmun , vol.31 , Issue.2 , pp. 175-179
    • Ingegnoli, F.1    Fantini, F.2    Favalli, E.G.3    Soldi, A.4    Griffini, S.5    Galbiati, V.6    Meroni, P.L.7    Cugno, M.8
  • 122
    • 0025741206 scopus 로고
    • Extravascular fibrin formation and dissolution in synovial tissue of patients with osteoarthritis and rheumatoid arthritis
    • Weinberg JB, Pippen AM, Greenberg CS (1991) Extravascular fibrin formation and dissolution in synovial tissue of patients with osteoarthritis and rheumatoid arthritis. Arthritis Rheum 34 (8):996-1005
    • (1991) Arthritis Rheum , vol.34 , Issue.8 , pp. 996-1005
    • Weinberg, J.B.1    Pippen, A.M.2    Greenberg, C.S.3
  • 123
    • 0037242708 scopus 로고    scopus 로고
    • Fibrin generated in the synovial fluid activates intimal cells from their apical surface: A sequential morphological study in antigen-induced arthritis
    • DOI 10.1093/rheumatology/keg021
    • Sanchez-Pernaute O, Lopez-Armada MJ, Calvo E, Diez-Ortego I, Largo R, Egido J, Herrero-Beaumont G (2003) Fibringenerated in the synovial fluid activates intimal cells from their apical surface: a sequential morphological study in antigen-induced arthritis. Rheumatology (Oxford) 42(1):19-25 (Pubitemid 36131562)
    • (2003) Rheumatology , vol.42 , Issue.1 , pp. 19-25
    • Sanchez-Pernaute, O.1    Lopezmada, M.J.2    Calvo, E.3    Diez-Ortego, I.4    Largo, R.5    Egido, J.6    Herrero-Beaumont, G.7
  • 124
    • 0034326635 scopus 로고    scopus 로고
    • Fibrin(ogen)-induced expression of ICAM-1 and chemokines in human synovial fibroblasts
    • Liu X, Piela-Smith TH (2000) Fibrin(ogen)-induced expression of ICAM-1 and chemokines in human synovial fibroblasts. J Immunol 165(9):5255-5261
    • (2000) J Immunol , vol.165 , Issue.9 , pp. 5255-5261
    • Liu, X.1    Piela-Smith, T.H.2
  • 125
  • 127
    • 80052218979 scopus 로고    scopus 로고
    • Targeting the coagulation factor fibrinogen for arthritis therapy
    • in press
    • Raghu H, Flick MJ (2011) Targeting the coagulation factor fibrinogen for arthritis therapy. Curr Pharm Biotechnol (in press)
    • (2011) Curr Pharm Biotechnol
    • Raghu, H.1    Flick, M.J.2
  • 128
    • 73249145617 scopus 로고    scopus 로고
    • Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis
    • Wegner N, Lundberg K, Kinloch A, Fisher B, Malmstrom V, Feldmann M, Venables PJ (2010) Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis. Immunol Rev 233(1):34-54
    • (2010) Immunol Rev , vol.233 , Issue.1 , pp. 34-54
    • Wegner, N.1    Lundberg, K.2    Kinloch, A.3    Fisher, B.4    Malmstrom, V.5    Feldmann, M.6    Venables, P.J.7
  • 130
    • 33746572741 scopus 로고    scopus 로고
    • Citrullinated fibrinogen detected as a soluble citrullinated autoantigen in rheumatoid arthritis synovial fluids
    • DOI 10.1136/ard.2005.044743
    • Takizawa Y, Suzuki A, Sawada T, Ohsaka M, Inoue T, Yamada R, Yamamoto K (2006) Citrullinated fibrinogen detected as a soluble citrullinated autoantigen in rheumatoid arthritis synovial fluids. Ann Rheum Dis 65(8):1013-1020 (Pubitemid 44133262)
    • (2006) Annals of the Rheumatic Diseases , vol.65 , Issue.8 , pp. 1013-1020
    • Takizawa, Y.1    Suzuki, A.2    Sawada, T.3    Ohsaka, M.4    Inoue, T.5    Yamada, R.6    Yamamoto, K.7
  • 131
    • 33750991895 scopus 로고    scopus 로고
    • Serum autoantibodies that bind citrullinated fibrinogen are frequently found in patients with rheumatoid arthritis
    • Hill JA, Al-Bishri J, Gladman DD, Cairns E, Bell DA (2006) Serum autoantibodies that bind citrullinated fibrinogen are frequently found in patients with rheumatoid arthritis. J Rheumatol 33(11):2115-2119 (Pubitemid 44749766)
    • (2006) Journal of Rheumatology , vol.33 , Issue.11 , pp. 2115-2119
    • Hill, J.A.1    Al-Bishri, J.2    Gladman, D.D.3    Cairns, E.4    Bell, D.A.5
  • 136
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions at the blood-brain barrier
    • DOI 10.1038/nrn1824
    • Abbott NJ, Ronnback L, Hansson E (2006) Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci 7(1):41-53 (Pubitemid 41828930)
    • (2006) Nature Reviews Neuroscience , vol.7 , Issue.1 , pp. 41-53
    • Abbott, N.J.1    Ronnback, L.2    Hansson, E.3
  • 137
    • 80053924042 scopus 로고    scopus 로고
    • Extracellular matrix and matrix receptors in blood-brain barrier formation and stroke
    • Baeten KM, Akassoglou K (2011) Extracellular matrix and matrix receptors in blood-brain barrier formation and stroke. Dev Neurobiol 71(11):1018-1039
    • (2011) Dev Neurobiol , vol.71 , Issue.11 , pp. 1018-1039
    • Baeten, K.M.1    Akassoglou, K.2
  • 138
    • 84859806772 scopus 로고    scopus 로고
    • Imaging microglia in the central nervous system: Past, present and future
    • Lane TE, Carson M, Bergmann C, Wyss-Coray T (eds) Springer, USA
    • Davalos D, Akassoglou K (2008) Imaging microglia in the central nervous system: past, present and future. In: Lane TE, Carson M, Bergmann C, Wyss-Coray T (eds) Central nervous system diseases and inflammation. Springer, USA, pp 45-57
    • (2008) Central Nervous System Diseases and Inflammation , pp. 45-57
    • Davalos, D.1    Akassoglou, K.2
  • 139
    • 22944483792 scopus 로고    scopus 로고
    • The blood-brain barrier/neurovascular unit in health and disease
    • DOI 10.1124/pr.57.2.4
    • Hawkins BT, Davis TP (2005) The blood-brain barrier/neurovascular unit in health and disease. Pharmacol Rev 57(2):173-185 (Pubitemid 41043883)
    • (2005) Pharmacological Reviews , vol.57 , Issue.2 , pp. 173-185
    • Hawkins, B.T.1    Davis, T.P.2
  • 140
    • 0036005958 scopus 로고    scopus 로고
    • Nervous system pathology: The fibrin perspective
    • DOI 10.1515/BC.2002.004
    • Akassoglou K, Strickland S (2002) Nervous system pathology: the fibrin perspective. Biol Chem 383(1):37-45 (Pubitemid 34224026)
    • (2002) Biological Chemistry , vol.383 , Issue.1 , pp. 37-45
    • Akassoglou, K.1    Strickland, S.2
  • 141
    • 0035186465 scopus 로고    scopus 로고
    • Characteristics of sustained blood-brain barrier opening and tissue injury in a model for focal trauma in the rat
    • Preston E, Webster J, Small D (2001) Characteristics of sustained blood-brain barrier opening and tissue injury in a model for focal trauma in the rat. J Neurotrauma 18(1):83-92 (Pubitemid 32055458)
    • (2001) Journal of Neurotrauma , vol.18 , Issue.1 , pp. 83-92
    • Preston, E.1    Webster, J.2    Small, D.3
  • 145
    • 0032821690 scopus 로고    scopus 로고
    • Acute inflammatory responses to mechanical lesions in the CNS: Differences between brain and spinal cord
    • DOI 10.1046/j.1460-9568.1999.00792.x
    • Schnell L, Fearn S, Klassen H, Schwab ME, Perry VH (1999) Acute inflammatory responses to mechanical lesions in the CNS: differences between brain and spinal cord. Eur J Neurosci 11 (10):3648-3658 (Pubitemid 29484261)
    • (1999) European Journal of Neuroscience , vol.11 , Issue.10 , pp. 3648-3658
    • Schnell, L.1
  • 146
    • 0037075577 scopus 로고    scopus 로고
    • Fibrin inhibits peripheral nerve remyelination by regulating Schwann cell differentiation
    • DOI 10.1016/S0896-6273(02)00617-7
    • Akassoglou K, Yu WM, Akpinar P, Strickland S (2002) Fibrin inhibits peripheral nerve remyelination by regulating Schwann cell differentiation. Neuron 33(6):861-875 (Pubitemid 34246353)
    • (2002) Neuron , vol.33 , Issue.6 , pp. 861-875
    • Akassoglou, K.1    Yu, W.-M.2    Akpinar, P.3    Strickland, S.4
  • 147
    • 48449086316 scopus 로고    scopus 로고
    • TGF-beta: A master of all T cell trades
    • Li MO, Flavell RA (2008) TGF-beta: a master of all T cell trades. Cell 134(3):392-404
    • (2008) Cell , vol.134 , Issue.3 , pp. 392-404
    • Li, M.O.1    Flavell, R.A.2
  • 148
    • 77953695161 scopus 로고    scopus 로고
    • Cellular and molecular basis for the regulation of inflammation by TGF-beta
    • Yoshimura A, Wakabayashi Y, Mori T (2010) Cellular and molecular basis for the regulation of inflammation by TGF-beta. J Biochem 147(6):781-792
    • (2010) J Biochem , vol.147 , Issue.6 , pp. 781-792
    • Yoshimura, A.1    Wakabayashi, Y.2    Mori, T.3
  • 150
    • 14044251499 scopus 로고    scopus 로고
    • Transforming growth factor-beta differentially inhibits MyD88-dependent, but not TRAM- and TRIF-dependent, lipopolysaccharide-induced TLR4 signaling
    • DOI 10.1074/jbc.C400503200
    • Naiki Y, Michelsen KS, Zhang W, Chen S, Doherty TM, Arditi M (2005) Transforming growth factor-beta differentially inhibits MyD88-dependent, but not TRAM- and TRIF-dependent, lipopolysaccharide-induced TLR4 signaling. J Biol Chem 280 (7):5491-5495 (Pubitemid 40280025)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.7 , pp. 5491-5495
    • Naiki, Y.1    Michelsen, K.S.2    Zhang, W.3    Chen, S.4    Doherty, T.M.5    Arditi, M.6
  • 152
    • 74849096979 scopus 로고    scopus 로고
    • Current and future recanalization strategies for acute ischemic stroke
    • Alexandrov AV (2010) Current and future recanalization strategies for acute ischemic stroke. J Intern Med 267 (2):209-219
    • (2010) J Intern Med , vol.267 , Issue.2 , pp. 209-219
    • Alexandrov, A.V.1
  • 153
    • 0033302248 scopus 로고    scopus 로고
    • Engineering design of optimal strategies for blood clot dissolution
    • Diamond SL (1999) Engineering design of optimal strategies for blood clot dissolution. Annu Rev Biomed Eng 1:427-462
    • (1999) Annu Rev Biomed Eng , vol.1 , pp. 427-462
    • Diamond, S.L.1
  • 154
    • 77953002524 scopus 로고    scopus 로고
    • Embolus extravasation is an alternative mechanism for cerebral
    • Lam CK, Yoo T, Hiner B, Liu Z, Grutzendler J (2010) Embolus extravasation is an alternative mechanism for cerebral microvascular recanalization. Nature 465(7297):478-482
    • (2010) Nature , vol.465 , Issue.7297 , pp. 478-482
    • Lam, C.K.1    Yoo, T.2    Hiner, B.3    Liu, Z.4    Grutzendler, J.5
  • 155
    • 0742321910 scopus 로고    scopus 로고
    • Triggers and Mediators of Hemorrhagic Transformation in Cerebral Ischemia
    • DOI 10.1385/MN:28:3:229
    • Wang X, Lo EH (2003) Triggers and mediators of hemorrhagic transformation in cerebral ischemia. Mol Neurobiol 28 (3):229-244 (Pubitemid 38156421)
    • (2003) Molecular Neurobiology , vol.28 , Issue.3 , pp. 229-244
    • Wang, X.1    Lo, E.H.2
  • 156
    • 0027932440 scopus 로고
    • Fibrin contributes to microvascular obstructions and parenchymal changes during early focal cerebral ischemia and reperfusion
    • discussion 1853-1844
    • Okada Y, Copeland BR, Fitridge R, Koziol JA, del Zoppo GJ (1994) Fibrin contributes to microvascular obstructions and parenchymal changes during early focal cerebral ischemia and reperfusion. Stroke 25(9):1847-1853, discussion 1853-1844
    • (1994) Stroke , vol.25 , Issue.9 , pp. 1847-1853
    • Okada, Y.1    Copeland, B.R.2    Fitridge, R.3    Koziol, J.A.4    Del Zoppo, G.J.5
  • 157
    • 0034095812 scopus 로고    scopus 로고
    • Brain injury and cerebrovascular fibrin deposition correlate with reduced antithrombotic brain capillary functions in a hypertensive stroke model
    • Ninomia T, Wang L, Kumar SR, Kim A, Zlokovic BV (2000) Brain injury and cerebrovascular fibrin deposition correlate with reduced antithrombotic brain capillary functions in a hypertensive stroke model. J Cereb Blood Flow Metab 20(6):998-1009 (Pubitemid 30413683)
    • (2000) Journal of Cerebral Blood Flow and Metabolism , vol.20 , Issue.6 , pp. 998-1009
    • Ninomia, T.1    Wang, L.2    Kumar, S.R.3    Kim, A.4    Zlokovic, B.V.5
  • 158
    • 67349280915 scopus 로고    scopus 로고
    • Post-ischemic hypothermia attenuates loss of the vascular basement membrane proteins, agrin and SPARC, and the blood-brain barrier disruption after global cerebral ischemia
    • Baumann E, Preston E, Slinn J, Stanimirovic D (2009) Post-ischemic hypothermia attenuates loss of the vascular basement membrane proteins, agrin and SPARC, and the blood-brain barrier disruption after global cerebral ischemia. Brain Res 1269:185-197
    • (2009) Brain Res , vol.1269 , pp. 185-197
    • Baumann, E.1    Preston, E.2    Slinn, J.3    Stanimirovic, D.4
  • 159
    • 23844506444 scopus 로고    scopus 로고
    • Multiple sclerosis pathology: Evolution of pathogenetic concepts
    • Lassmann H (2005) Multiple sclerosis pathology: evolution of pathogenetic concepts. Brain Pathol 15(3):217-222
    • (2005) Brain Pathol , vol.15 , Issue.3 , pp. 217-222
    • Lassmann, H.1
  • 160
    • 0035096330 scopus 로고    scopus 로고
    • Heterogeneity of multiple sclerosis pathogenesis: Implications for diagnosis and therapy
    • DOI 10.1016/S1471-4914(00)01909-2, PII S1471491400019092
    • Lassmann H, Bruck W, Lucchinetti C (2001) Heterogeneity of multiple sclerosis pathogenesis: implications for diagnosis and therapy. Trends Mol Med 7(3):115-121 (Pubitemid 32201673)
    • (2001) Trends in Molecular Medicine , vol.7 , Issue.3 , pp. 115-121
    • Lassmann, H.1    Bruck, W.2    Lucchinetti, C.3
  • 162
    • 0024990661 scopus 로고
    • Breakdown of the blood-brain barrier precedes symptoms and other MRI signs of new lesions in multiple sclerosis. Pathogenic and clinical implications
    • Kermode AG, Thompson AJ, Tofts P, MacManus DG, Kendall BE, Kingsley DP, Moseley IF, Rudge P, McDonald WI (1990) Breakdown of the blood-brain barrier precedes symptoms and other MRI signs of new lesions in multiple sclerosis. Pathogenetic and clinical implications. Brain 113 (Pt 5):1477-1489 (Pubitemid 20385925)
    • (1990) Brain , vol.113 , Issue.5 , pp. 1477-1489
    • Kermode, A.G.1    Thompson, A.J.2    Tofts, P.3    MacManus, D.G.4    Kendall, B.E.5    Kingsley, D.P.E.6    Moseley, I.F.7    Rudge, P.8    McDonald, W.I.9
  • 163
    • 0028089844 scopus 로고
    • Blood-brain barrier abnormalities in longstanding multiple sclerosis lesions. An immunohistochemical study
    • Kwon EE, Prineas JW (1994) Blood-brain barrier abnormalities in longstanding multiple sclerosis lesions. An immunohistochemical study. J Neuropathol Exp Neurol 53(6):625-636 (Pubitemid 24333022)
    • (1994) Journal of Neuropathology and Experimental Neurology , vol.53 , Issue.6 , pp. 625-636
    • Kwon, E.E.1    Prineas, J.W.2
  • 166
    • 0017106754 scopus 로고
    • Experimental allergic encephalomyelitis: Role of fibrin deposition in immunopathogenesis of inflammation in rats
    • Paterson PY (1976) Experimental allergic encephalomyelitis: role of fibrin deposition in immunopathogenesis of inflammation in rats. Fed Proc 35(13):2428-2434
    • (1976) Fed Proc , vol.35 , Issue.13 , pp. 2428-2434
    • Paterson, P.Y.1
  • 167
    • 0030561019 scopus 로고    scopus 로고
    • Suppression of cell-transferred experimental autoimmune encephalomyelitis in defibrinated Lewis rats
    • DOI 10.1016/S0165-5728(96)00150-6, PII S0165572896001506
    • Inoue A, Koh CS, Shimada K, Yanagisawa N, Yoshimura K (1996) Suppression of cell-transferred experimental autoimmune encephalomyelitis in defibrinated Lewis rats. J Neuroimmunol 71(1-2):131-137 (Pubitemid 26413265)
    • (1996) Journal of Neuroimmunology , vol.71 , Issue.1-2 , pp. 131-137
    • Inoue, A.1    Koh, C.-S.2    Shimada, K.3    Yanagisawa, N.4    Yoshimura, K.5
  • 168
    • 0031659763 scopus 로고    scopus 로고
    • Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: Models for multiple sclerosis with primary oligodendrogliopathy
    • Akassoglou K, Bauer J, Kassiotis G, Pasparakis M, Lassmann H, Kollias G, Probert L (1998) Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy. Am J Pathol 153(3):801-813 (Pubitemid 28419033)
    • (1998) American Journal of Pathology , vol.153 , Issue.3 , pp. 801-813
    • Akassoglou, K.1    Bauer, J.2    Kassiotis, G.3    Pasparakis, M.4    Lassmann, H.5    Kollias, G.6    Probert, L.7
  • 169
    • 0028864801 scopus 로고
    • Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha
    • Probert L, Akassoglou K, Pasparakis M, Kontogeorgos G, Kollias G (1995) Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha. Proc Natl Acad Sci USA 92(24):11294-11298
    • (1995) Proc Natl Acad Sci USA , vol.92 , Issue.24 , pp. 11294-11298
    • Probert, L.1    Akassoglou, K.2    Pasparakis, M.3    Kontogeorgos, G.4    Kollias, G.5
  • 171
    • 1842367972 scopus 로고    scopus 로고
    • The application of multifactorial cluster analysis in the staging of plaques in early multiple sclerosis. Identification and characterization of the primary demyelinating lesion
    • Gay FW, Drye TJ, Dick GW, Esiri MM (1997) The application of multifactorial cluster analysis in the staging of plaques in early multiple sclerosis. Identification and characterization of the primary demyelinating lesion. Brain 120(Pt 8):1461-1483
    • (1997) Brain , vol.120 , Issue.PART 8 , pp. 1461-1483
    • Gay, F.W.1    Drye, T.J.2    Dick, G.W.3    Esiri, M.M.4
  • 172
    • 35649018602 scopus 로고    scopus 로고
    • Lesion genesis in a subset of patients with multiple sclerosis: A role for innate immunity?
    • DOI 10.1093/brain/awm236
    • Marik C, Felts PA, Bauer J, Lassmann H, Smith KJ (2007) Lesion genesis in a subset of patients with multiple sclerosis: a role for innate immunity? Brain 130(Pt 11):2800-2815 (Pubitemid 350033973)
    • (2007) Brain , vol.130 , Issue.11 , pp. 2800-2815
    • Marik, C.1    Felts, P.A.2    Bauer, J.3    Lassmann, H.4    Smith, K.J.5
  • 173
    • 27744504478 scopus 로고    scopus 로고
    • Blood-brain barrier alterations in both focal and diffuse abnormalities on postmortem MRI in multiple sclerosis
    • DOI 10.1016/j.nbd.2005.06.012, PII S0969996105001658
    • Vos CM, Geurts JJ, Montagne L, van Haastert ES, Bo L, van der Valk P, Barkhof F, de Vries HE (2005) Blood-brain barrier alterations in both focal and diffuse abnormalities on postmortem MRI in multiple sclerosis. Neurobiol Dis 20(3):953-960 (Pubitemid 41619370)
    • (2005) Neurobiology of Disease , vol.20 , Issue.3 , pp. 953-960
    • Vos, C.M.P.1    Geurts, J.J.G.2    Montagne, L.3    Van Haastert, E.S.4    Bo, L.5    Van Der, V.P.6    Barkhof, F.7    De Vries, H.E.8
  • 174
    • 19744380563 scopus 로고    scopus 로고
    • Neuroscience: Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • DOI 10.1126/science.1110647
    • Nimmerjahn A, Kirchhoff F, Helmchen F (2005) Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308(5726):1314-1318 (Pubitemid 40746128)
    • (2005) Science , vol.308 , Issue.5726 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 176
    • 33644853531 scopus 로고    scopus 로고
    • Metabolism of amyloid beta peptide and pathogenesis of Alzheimer's disease: Towards presymptomatic diagnosis, prevention and therapy
    • DOI 10.1016/j.neures.2005.12.015, PII S0168010205003330
    • Saido TC, Iwata N (2006) Metabolism of amyloid beta peptide and pathogenesis of Alzheimer's disease. Towards presymptomatic diagnosis, prevention and therapy. Neurosci Res 54(4):235-253 (Pubitemid 43374441)
    • (2006) Neuroscience Research , vol.54 , Issue.4 , pp. 235-253
    • Saido, T.C.1    Iwata, N.2
  • 177
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • DOI 10.1126/science.1072994
    • Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297(5580):353-356 (Pubitemid 34790756)
    • (2002) Science , vol.297 , Issue.5580 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 178
    • 33745893209 scopus 로고    scopus 로고
    • Amyloid at the blood vessel wall
    • DOI 10.1038/nm0706-756, PII NM0706756
    • Hardy J, Cullen K (2006) Amyloid at the blood vessel wall. Nat Med 12(7):756-757 (Pubitemid 44050057)
    • (2006) Nature Medicine , vol.12 , Issue.7 , pp. 756-757
    • Hardy, J.1    Cullen, K.2
  • 179
    • 79956365897 scopus 로고    scopus 로고
    • Cerebral amyloid angiopathy: A systematic review
    • Biffi A, Greenberg SM (2011) Cerebral amyloid angiopathy: a systematic review. J Clin Neurol 7(1):1-9
    • (2011) J Clin Neurol , vol.7 , Issue.1 , pp. 1-9
    • Biffi, A.1    Greenberg, S.M.2
  • 180
    • 77956410028 scopus 로고    scopus 로고
    • The vascular contribution to Alzheimer's disease
    • (Lond)
    • Altman R, Rutledge JC (2010) The vascular contribution to Alzheimer's disease. Clin Sci (Lond) 119(10):407-421
    • (2010) Clin Sci , vol.119 , Issue.10 , pp. 407-421
    • Altman, R.1    Rutledge, J.C.2
  • 181
    • 0033391684 scopus 로고    scopus 로고
    • The blood-brain barrier and cerebrovascular pathology in Alzheimer's disease
    • Kalaria RN (1999) The blood-brain barrier and cerebrovascular pathology in Alzheimer's disease. Ann N Y Acad Sci 893:113-125
    • (1999) Ann N Y Acad Sci , vol.893 , pp. 113-125
    • Kalaria, R.N.1
  • 182
    • 34249040510 scopus 로고    scopus 로고
    • Blood-brain barrier impairment in Alzheimer disease: Stability and functional significance
    • DOI 10.1212/01.wnl.0000262031.18018.1a, PII 0000611420070522000008
    • Bowman GL, Kaye JA, Moore M, Waichunas D, Carlson NE, Quinn JF (2007) Blood-brain barrier impairment in Alzheimer disease: stability and functional significance. Neurology 68 (21):1809-1814 (Pubitemid 46791393)
    • (2007) Neurology , vol.68 , Issue.21 , pp. 1809-1814
    • Bowman, G.L.1    Kaye, J.A.2    Moore, M.3    Waichunas, D.4    Carlson, N.E.5    Quinn, J.F.6
  • 183
    • 67349142021 scopus 로고    scopus 로고
    • Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease
    • Bell RD, Zlokovic BV (2009) Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease. Acta Neuropathol 118(1):103-113
    • (2009) Acta Neuropathol , vol.118 , Issue.1 , pp. 103-113
    • Bell, R.D.1    Zlokovic, B.V.2
  • 185
    • 3442894794 scopus 로고    scopus 로고
    • Blood-brain barrier permeability precedes senile plaque formation in an Alzheimer disease model
    • DOI 10.1038/sj.mn.7800212
    • Ujiie M, Dickstein DL, Carlow DA, Jefferies WA (2003) Blood-brain barrier permeability precedes senile plaque formation in an Alzheimer disease model. Microcirculation 10(6):463-470 (Pubitemid 39004272)
    • (2003) Microcirculation , vol.10 , Issue.6 , pp. 463-470
    • Ujiie, M.1    Dickstein, D.L.2    Carlow, D.A.3    Jefferies, W.A.4
  • 187
    • 34547791784 scopus 로고    scopus 로고
    • Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease
    • DOI 10.1084/jem.20070304
    • Paul J, Strickland S, Melchor JP (2007) Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease. J Exp Med 204 (8):1999-2008 (Pubitemid 47236333)
    • (2007) Journal of Experimental Medicine , vol.204 , Issue.8 , pp. 1999-2008
    • Paul, J.1    Strickland, S.2    Melchor, J.P.3
  • 188
    • 72849106266 scopus 로고    scopus 로고
    • A leaky blood-brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer's disease brain
    • Ryu JK, McLarnon JG (2008) A leaky blood-brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer's disease brain. J Cell Mol Med 13:2911-2925
    • (2008) J Cell Mol Med , vol.13 , pp. 2911-2925
    • Ryu, J.K.1    McLarnon, J.G.2
  • 189
    • 33644663637 scopus 로고    scopus 로고
    • Fibrinogen is associated with an increased risk of Alzheimer disease and vascular dementia
    • van Oijen M, Witteman JC, Hofman A, Koudstaal PJ, Breteler MM (2005) Fibrinogen is associated with an increased risk of Alzheimer disease and vascular dementia. Stroke 36(12):2637-2641
    • (2005) Stroke , vol.36 , Issue.12 , pp. 2637-2641
    • Van Oijen, M.1    Witteman, J.C.2    Hofman, A.3    Koudstaal, P.J.4    Breteler, M.M.5
  • 190
    • 44849095467 scopus 로고    scopus 로고
    • Plasma fibrinogen is associated with cognitive decline and risk for dementia in patients with mild cognitive impairment
    • DOI 10.1111/j.1742-1241.2007.01268.x
    • Xu G, Zhang H, Zhang S, Fan X, Liu X (2008) Plasma fibrinogen is associated with cognitive decline and risk for dementia in patients with mild cognitive impairment. Int J Clin Pract 62(7):1070-1075 (Pubitemid 351793581)
    • (2008) International Journal of Clinical Practice , vol.62 , Issue.7 , pp. 1070-1075
    • Xu, G.1    Zhang, H.2    Zhang, S.3    Fan, X.4    Liu, X.5
  • 194
    • 78149488153 scopus 로고    scopus 로고
    • Amyloid-independent mechanisms in Alzheimer's disease pathogenesis
    • Pimplikar SW, Nixon RA, Robakis NK, Shen J, Tsai LH (2010) Amyloid-independent mechanisms in Alzheimer's disease pathogenesis. J Neurosci 30(45):14946-14954
    • (2010) J Neurosci , vol.30 , Issue.45 , pp. 14946-14954
    • Pimplikar, S.W.1    Nixon, R.A.2    Robakis, N.K.3    Shen, J.4    Tsai, L.H.5
  • 195
    • 78650850292 scopus 로고    scopus 로고
    • Is brain amyloid production a cause or a result of dementia of the Alzheimer's type?
    • Struble RG, Ala T, Patrylo PR, Brewer GJ, Yan XX (2010) Is brain amyloid production a cause or a result of dementia of the Alzheimer's type? J Alzheimers Dis 22(2):393-399
    • (2010) J Alzheimers Dis , vol.22 , Issue.2 , pp. 393-399
    • Struble, R.G.1    Ala, T.2    Patrylo, P.R.3    Brewer, G.J.4    Yan, X.X.5
  • 196
    • 79551713201 scopus 로고    scopus 로고
    • Brain microbleeds and Alzheimer's disease: Innocent observation or key player?
    • Cordonnier C, van der Flier WM (2011) Brain microbleeds and Alzheimer's disease: innocent observation or key player? Brain 134(Pt 2):335-344
    • (2011) Brain , vol.134 , Issue.PART 2 , pp. 335-344
    • Cordonnier, C.1    Van Der Flier, W.M.2
  • 197
    • 67849133379 scopus 로고    scopus 로고
    • Fibrinogen, a possible key player in Alzheimer's disease
    • Cortes-Canteli M, Strickland S (2009) Fibrinogen, a possible key player in Alzheimer's disease. J Thromb Haemost 7(Suppl 1):146-150
    • (2009) J Thromb Haemost , vol.7 , Issue.SUPPL. 1 , pp. 146-150
    • Cortes-Canteli, M.1    Strickland, S.2
  • 198
    • 2342614850 scopus 로고    scopus 로고
    • Neurovascular regulation in the normal brain and in Alzheimer's disease
    • Iadecola C (2004) Neurovascular regulation in the normal brain and in Alzheimer's disease. Nat Rev Neurosci 5(5):347-360
    • (2004) Nat Rev Neurosci , vol.5 , Issue.5 , pp. 347-360
    • Iadecola, C.1
  • 200
    • 40049091475 scopus 로고    scopus 로고
    • Cancer in inflammatory bowel disease
    • DOI 10.3748/wjg.14.378
    • Xie J, Itzkowitz SH (2008) Cancer in inflammatory bowel disease. World J Gastroenterol 14(3):378-389 (Pubitemid 351320846)
    • (2008) World Journal of Gastroenterology , vol.14 , Issue.3 , pp. 378-389
    • Xie, J.1    Itzkowitz, S.H.2
  • 201
    • 0034669975 scopus 로고    scopus 로고
    • Fibrinogen is an important determinant of the metastatic potential of circulating tumor cells
    • Palumbo JS, Kombrinck KW, Drew AF, Grimes TS, Kiser JH, Degen JL, Bugge TH (2000) Fibrinogen is an important determinant of the metastatic potential of circulating tumor cells. Blood 96(10):3302-3309
    • (2000) Blood , vol.96 , Issue.10 , pp. 3302-3309
    • Palumbo, J.S.1    Kombrinck, K.W.2    Drew, A.F.3    Grimes, T.S.4    Kiser, J.H.5    Degen, J.L.6    Bugge, T.H.7
  • 202
    • 0036894405 scopus 로고    scopus 로고
    • Spontaneous hematogenous and lymphatic metastasis, but not primary tumor growth or angiogenesis, is diminished in fibrinogen-deficient mice
    • Palumbo JS, Potter JM, Kaplan LS, Talmage K, Jackson DG, Degen JL (2002) Spontaneous hematogenous and lymphatic metastasis, but not primary tumor growth or angiogenesis, is diminished in fibrinogen-deficient mice. Cancer Res 62 (23):6966-6972 (Pubitemid 35424088)
    • (2002) Cancer Research , vol.62 , Issue.23 , pp. 6966-6972
    • Palumbo, J.S.1    Potter, J.M.2    Kaplan, L.S.3    Talmage, K.4    Jackson, D.G.5    Degen, J.L.6
  • 203
    • 34347385401 scopus 로고    scopus 로고
    • Tumor cell-associated tissue factor and circulating hemostatic factors cooperate to increase metastatic potential through natural killer cell-dependent and -independent mechanisms
    • DOI 10.1182/blood-2007-01-065995
    • Palumbo JS, Talmage KE, Massari JV, La Jeunesse CM, Flick MJ, Kombrinck KW, Hu Z, Barney KA, Degen JL (2007) Tumor cell-associated tissue factor and circulating hemostatic factors cooperate to increasemetastatic potential through natural killer cell-dependent and-independent mechanisms. Blood 110 (1):133-141 (Pubitemid 47026828)
    • (2007) Blood , vol.110 , Issue.1 , pp. 133-141
    • Palumbo, J.S.1    Talmage, K.E.2    Massari, J.V.3    La, J.C.M.4    Flick, M.J.5    Kombrinck, K.W.6    Hu, Z.7    Barney, K.A.8    Degen, J.L.9
  • 204
    • 11144230059 scopus 로고    scopus 로고
    • Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells
    • DOI 10.1182/blood-2004-06-2272
    • Palumbo JS, Talmage KE, Massari JV, La Jeunesse CM, Flick MJ, Kombrinck KW, Jirouskova M, Degen JL (2005) Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells. Blood 105(1):178-185 (Pubitemid 40053080)
    • (2005) Blood , vol.105 , Issue.1 , pp. 178-185
    • Palumbo, J.S.1    Talmage, K.E.2    Massari, J.V.3    La, J.C.M.4    Flick, M.J.5    Kombrinck, K.W.6    Jirouskova, M.7    Degen, J.L.8
  • 205
    • 77955481551 scopus 로고    scopus 로고
    • Mechanisms coupling the hemostatic system to colitis-associated cancer
    • Palumbo JS, Degen JL (2010) Mechanisms coupling the hemostatic system to colitis-associated cancer. Thromb Res 125 (Suppl 2):S39-S43
    • (2010) Thromb Res , vol.125 , Issue.SUPPL. 2
    • Palumbo, J.S.1    Degen, J.L.2
  • 206
    • 36048969746 scopus 로고    scopus 로고
    • Mechanisms linking tumor cell-associated procoagulant function to tumor metastasis
    • DOI 10.1016/S0049-3848(07)70127-5, PII S0049384807701275
    • Palumbo JS, Degen JL (2007) Mechanisms linking tumor cell-associated procoagulant function to tumor metastasis. Thromb Res 120(Suppl 2):S22-S28 (Pubitemid 350101770)
    • (2007) Thrombosis Research , vol.120 , Issue.SUPPL. 2
    • Palumbo, J.S.1    Degen, J.L.2
  • 210
    • 33750529958 scopus 로고    scopus 로고
    • Delayed inflammatory responses to endotoxin in fibrinogen-deficient mice
    • DOI 10.1002/path.2060
    • Cruz-Topete D, Iwaki T, Ploplis VA, Castellino FJ (2006) Delayed inflammatory responses to endotoxin in fibrinogen-deficient mice. J Pathol 210(3):325-333 (Pubitemid 44660511)
    • (2006) Journal of Pathology , vol.210 , Issue.3 , pp. 325-333
    • Cruz-Topete, D.1    Iwaki, T.2    Ploplis, V.A.3    Castellino, F.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.