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Volumn 36, Issue 5, 2017, Pages 583-603

Young microglia restore amyloid plaque clearance of aged microglia

Author keywords

Alzheimer's disease; amyloid plaque clearance; microglia; neurodegeneration

Indexed keywords

AMYLOID BETA PROTEIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; CONDITIONED MEDIUM;

EID: 85016586166     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201694591     Document Type: Article
Times cited : (129)

References (135)
  • 1
    • 84893579839 scopus 로고    scopus 로고
    • Innate and adaptive immune responses in neurodegeneration and repair
    • Amor S, Woodroofe MN (2014) Innate and adaptive immune responses in neurodegeneration and repair. Immunology 141: 287–291
    • (2014) Immunology , vol.141 , pp. 287-291
    • Amor, S.1    Woodroofe, M.N.2
  • 3
    • 0030038809 scopus 로고    scopus 로고
    • Scavenging of Alzheimer's amyloid beta-protein by microglia in culture
    • Ard MD, Cole GM, Wei J, Mehrle AP, Fratkin JD (1996) Scavenging of Alzheimer's amyloid beta-protein by microglia in culture. J Neurosci Res 43: 190–202
    • (1996) J Neurosci Res , vol.43 , pp. 190-202
    • Ard, M.D.1    Cole, G.M.2    Wei, J.3    Mehrle, A.P.4    Fratkin, J.D.5
  • 4
    • 77953675879 scopus 로고    scopus 로고
    • Probing the biology of Alzheimer's disease in mice
    • Ashe KH, Zahs KR (2010) Probing the biology of Alzheimer's disease in mice. Neuron 66: 631–645
    • (2010) Neuron , vol.66 , pp. 631-645
    • Ashe, K.H.1    Zahs, K.R.2
  • 5
    • 0035106780 scopus 로고    scopus 로고
    • Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy
    • Bacskai BJ, Kajdasz ST, Christie RH, Carter C, Games D, Seubert P, Schenk D, Hyman BT (2001) Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy. Nat Med 7: 369–372
    • (2001) Nat Med , vol.7 , pp. 369-372
    • Bacskai, B.J.1    Kajdasz, S.T.2    Christie, R.H.3    Carter, C.4    Games, D.5    Seubert, P.6    Schenk, D.7    Hyman, B.T.8
  • 7
    • 84904957734 scopus 로고    scopus 로고
    • Accelerated microglial pathology is associated with Abeta plaques in mouse models of Alzheimer's disease
    • Baron R, Babcock AA, Nemirovsky A, Finsen B, Monsonego A (2014) Accelerated microglial pathology is associated with Abeta plaques in mouse models of Alzheimer's disease. Aging Cell 13: 584–595
    • (2014) Aging Cell , vol.13 , pp. 584-595
    • Baron, R.1    Babcock, A.A.2    Nemirovsky, A.3    Finsen, B.4    Monsonego, A.5
  • 9
    • 41149149333 scopus 로고    scopus 로고
    • The role of the immune system in clearance of Abeta from the brain
    • Boche D, Nicoll JA (2008) The role of the immune system in clearance of Abeta from the brain. Brain Pathol 18: 267–278
    • (2008) Brain Pathol , vol.18 , pp. 267-278
    • Boche, D.1    Nicoll, J.A.2
  • 10
    • 65249119363 scopus 로고    scopus 로고
    • Powerful beneficial effects of macrophage colony-stimulating factor on beta-amyloid deposition and cognitive impairment in Alzheimer's disease
    • Boissonneault V, Filali M, Lessard M, Relton J, Wong G, Rivest S (2009) Powerful beneficial effects of macrophage colony-stimulating factor on beta-amyloid deposition and cognitive impairment in Alzheimer's disease. Brain 132: 1078–1092.
    • (2009) Brain , vol.132 , pp. 1078-1092
    • Boissonneault, V.1    Filali, M.2    Lessard, M.3    Relton, J.4    Wong, G.5    Rivest, S.6
  • 12
  • 13
    • 84923637515 scopus 로고    scopus 로고
    • Aging and brain rejuvenation as systemic events
    • Bouchard J, Villeda SA (2015) Aging and brain rejuvenation as systemic events. J Neurochem 132: 5–19
    • (2015) J Neurochem , vol.132 , pp. 5-19
    • Bouchard, J.1    Villeda, S.A.2
  • 15
    • 0036807365 scopus 로고    scopus 로고
    • A method for characterising cell death in vitro by combining propidium iodide staining with immunohistochemistry
    • Brana C, Benham C, Sundstrom L (2002) A method for characterising cell death in vitro by combining propidium iodide staining with immunohistochemistry. Brain Res Brain Res Protoc 10: 109–114
    • (2002) Brain Res Brain Res Protoc , vol.10 , pp. 109-114
    • Brana, C.1    Benham, C.2    Sundstrom, L.3
  • 18
    • 79951551206 scopus 로고    scopus 로고
    • Hippocampal expression of murine TNFalpha results in attenuation of amyloid deposition in vivo
    • Chakrabarty P, Herring A, Ceballos-Diaz C, Das P, Golde TE (2011) Hippocampal expression of murine TNFalpha results in attenuation of amyloid deposition in vivo. Mol Neurodegener 6: 16
    • (2011) Mol Neurodegener , vol.6 , pp. 16
    • Chakrabarty, P.1    Herring, A.2    Ceballos-Diaz, C.3    Das, P.4    Golde, T.E.5
  • 21
    • 0033527637 scopus 로고    scopus 로고
    • Uptake, degradation, and release of fibrillar and soluble forms of Alzheimer's amyloid beta-peptide by microglial cells
    • Chung H, Brazil MI, Soe TT, Maxfield FR (1999) Uptake, degradation, and release of fibrillar and soluble forms of Alzheimer's amyloid beta-peptide by microglial cells. J Biol Chem 274: 32301–32308
    • (1999) J Biol Chem , vol.274 , pp. 32301-32308
    • Chung, H.1    Brazil, M.I.2    Soe, T.T.3    Maxfield, F.R.4
  • 22
    • 0033080919 scopus 로고    scopus 로고
    • Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of beta-amyloid and prion proteins
    • Combs CK, Johnson DE, Cannady SB, Lehman TM, Landreth GE (1999) Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of beta-amyloid and prion proteins. J Neurosci 19: 928–939
    • (1999) J Neurosci , vol.19 , pp. 928-939
    • Combs, C.K.1    Johnson, D.E.2    Cannady, S.B.3    Lehman, T.M.4    Landreth, G.E.5
  • 23
    • 2542431100 scopus 로고    scopus 로고
    • The microglial phagocytic role with specific plaque types in the Alzheimer disease brain
    • D'Andrea MR, Cole GM, Ard MD (2004) The microglial phagocytic role with specific plaque types in the Alzheimer disease brain. Neurobiol Aging 25: 675–683
    • (2004) Neurobiol Aging , vol.25 , pp. 675-683
    • D'Andrea, M.R.1    Cole, G.M.2    Ard, M.D.3
  • 25
    • 84906307352 scopus 로고    scopus 로고
    • Microglia as a critical player in both developmental and late-life CNS pathologies
    • Derecki NC, Katzmarski N, Kipnis J, Meyer-Luehmann M (2014) Microglia as a critical player in both developmental and late-life CNS pathologies. Acta Neuropathol 128: 333–345
    • (2014) Acta Neuropathol , vol.128 , pp. 333-345
    • Derecki, N.C.1    Katzmarski, N.2    Kipnis, J.3    Meyer-Luehmann, M.4
  • 26
    • 0023809230 scopus 로고
    • Alzheimer's disease. A double-labeling immunohistochemical study of senile plaques
    • Dickson DW, Farlo J, Davies P, Crystal H, Fuld P, Yen SH (1988) Alzheimer's disease. A double-labeling immunohistochemical study of senile plaques. Am J Pathol 132: 86–101
    • (1988) Am J Pathol , vol.132 , pp. 86-101
    • Dickson, D.W.1    Farlo, J.2    Davies, P.3    Crystal, H.4    Fuld, P.5    Yen, S.H.6
  • 29
    • 34147115541 scopus 로고    scopus 로고
    • Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease
    • El Khoury J, Toft M, Hickman SE, Means TK, Terada K, Geula C, Luster AD (2007) Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease. Nat Med 13: 432–438
    • (2007) Nat Med , vol.13 , pp. 432-438
    • El Khoury, J.1    Toft, M.2    Hickman, S.E.3    Means, T.K.4    Terada, K.5    Geula, C.6    Luster, A.D.7
  • 32
    • 0026783591 scopus 로고
    • Ultrastructure of the microglia that phagocytose amyloid and the microglia that produce beta-amyloid fibrils
    • Frackowiak J, Wisniewski HM, Wegiel J, Merz GS, Iqbal K, Wang KC (1992) Ultrastructure of the microglia that phagocytose amyloid and the microglia that produce beta-amyloid fibrils. Acta Neuropathol 84: 225–233
    • (1992) Acta Neuropathol , vol.84 , pp. 225-233
    • Frackowiak, J.1    Wisniewski, H.M.2    Wegiel, J.3    Merz, G.S.4    Iqbal, K.5    Wang, K.C.6
  • 34
    • 84878427567 scopus 로고    scopus 로고
    • Microglia as dynamic and essential components of the amyloid hypothesis
    • Gandy S, Heppner FL (2013) Microglia as dynamic and essential components of the amyloid hypothesis. Neuron 78: 575–577
    • (2013) Neuron , vol.78 , pp. 575-577
    • Gandy, S.1    Heppner, F.L.2
  • 35
    • 0024211168 scopus 로고
    • Colony-stimulating factors as promoters of ameboid microglia
    • Giulian D, Ingeman JE (1988) Colony-stimulating factors as promoters of ameboid microglia. J Neurosci 8: 4707–4717
    • (1988) J Neurosci , vol.8 , pp. 4707-4717
    • Giulian, D.1    Ingeman, J.E.2
  • 37
    • 84923377359 scopus 로고    scopus 로고
    • Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease
    • Gjoneska E, Pfenning AR, Mathys H, Quon G, Kundaje A, Tsai LH, Kellis M (2015) Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease. Nature 518: 365–369
    • (2015) Nature , vol.518 , pp. 365-369
    • Gjoneska, E.1    Pfenning, A.R.2    Mathys, H.3    Quon, G.4    Kundaje, A.5    Tsai, L.H.6    Kellis, M.7
  • 38
    • 84873324231 scopus 로고    scopus 로고
    • Regulation of microglial proliferation during chronic neurodegeneration
    • Gomez-Nicola D, Fransen NL, Suzzi S, Perry VH (2013) Regulation of microglial proliferation during chronic neurodegeneration. J Neurosci 33: 2481–2493
    • (2013) J Neurosci , vol.33 , pp. 2481-2493
    • Gomez-Nicola, D.1    Fransen, N.L.2    Suzzi, S.3    Perry, V.H.4
  • 39
    • 0028197596 scopus 로고
    • Transforming growth factor beta decreases the rate of proliferation of rat vascular smooth muscle cells by extending the G2 phase of the cell cycle and delays the rise in cyclic AMP before entry into M phase
    • Grainger DJ, Kemp PR, Witchell CM, Weissberg PL, Metcalfe JC (1994) Transforming growth factor beta decreases the rate of proliferation of rat vascular smooth muscle cells by extending the G2 phase of the cell cycle and delays the rise in cyclic AMP before entry into M phase. Biochem J 299(Pt 1): 227–235
    • (1994) Biochem J , vol.299 , pp. 227-235
    • Grainger, D.J.1    Kemp, P.R.2    Witchell, C.M.3    Weissberg, P.L.4    Metcalfe, J.C.5
  • 43
  • 46
    • 33847662852 scopus 로고    scopus 로고
    • Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide
    • Haass C, Selkoe DJ (2007) Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat Rev Mol Cell Biol 8: 101–112
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 101-112
    • Haass, C.1    Selkoe, D.J.2
  • 47
    • 0024573330 scopus 로고
    • Demonstration of microglial cells in and around senile (neuritic) plaques in the Alzheimer brain. An immunohistochemical study using a novel monoclonal antibody
    • Haga S, Akai K, Ishii T (1989) Demonstration of microglial cells in and around senile (neuritic) plaques in the Alzheimer brain. An immunohistochemical study using a novel monoclonal antibody. Acta Neuropathol 77: 569–575
    • (1989) Acta Neuropathol , vol.77 , pp. 569-575
    • Haga, S.1    Akai, K.2    Ishii, T.3
  • 48
    • 35548986304 scopus 로고    scopus 로고
    • Microglia: active sensor and versatile effector cells in the normal and pathologic brain
    • Hanisch UK, Kettenmann H (2007) Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci 10: 1387–1394
    • (2007) Nat Neurosci , vol.10 , pp. 1387-1394
    • Hanisch, U.K.1    Kettenmann, H.2
  • 51
    • 84942945616 scopus 로고    scopus 로고
    • Forebrain microglia from wild-type but not adult 5xFAD mice prevent amyloid-beta plaque formation in organotypic hippocampal slice cultures
    • Hellwig S, Masuch A, Nestel S, Katzmarski N, Meyer-Luehmann M, Biber K (2015) Forebrain microglia from wild-type but not adult 5xFAD mice prevent amyloid-beta plaque formation in organotypic hippocampal slice cultures. Sci Rep 5: 14624
    • (2015) Sci Rep , vol.5 , pp. 14624
    • Hellwig, S.1    Masuch, A.2    Nestel, S.3    Katzmarski, N.4    Meyer-Luehmann, M.5    Biber, K.6
  • 54
    • 51149120624 scopus 로고    scopus 로고
    • Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice
    • Hickman SE, Allison EK, El Khoury J (2008) Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice. J Neurosci 28: 8354–8360
    • (2008) J Neurosci , vol.28 , pp. 8354-8360
    • Hickman, S.E.1    Allison, E.K.2    El Khoury, J.3
  • 55
    • 79953854897 scopus 로고    scopus 로고
    • Alzheimer's disease: the challenge of the second century
    • Holtzman DM, Morris JC, Goate AM (2011) Alzheimer's disease: the challenge of the second century. Sci Transl Med 3: 77sr71
    • (2011) Sci Transl Med , vol.3 , pp. 77sr71
    • Holtzman, D.M.1    Morris, J.C.2    Goate, A.M.3
  • 56
    • 0024436506 scopus 로고
    • Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease
    • Itagaki S, McGeer PL, Akiyama H, Zhu S, Selkoe D (1989) Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease. J Neuroimmunol 24: 173–182
    • (1989) J Neuroimmunol , vol.24 , pp. 173-182
    • Itagaki, S.1    McGeer, P.L.2    Akiyama, H.3    Zhu, S.4    Selkoe, D.5
  • 57
    • 84873497150 scopus 로고    scopus 로고
    • Microglia actively regulate the number of functional synapses
    • Ji K, Akgul G, Wollmuth LP, Tsirka SE (2013) Microglia actively regulate the number of functional synapses. PLoS One 8: e56293
    • (2013) PLoS One , vol.8
    • Ji, K.1    Akgul, G.2    Wollmuth, L.P.3    Tsirka, S.E.4
  • 59
    • 0034028817 scopus 로고    scopus 로고
    • Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion
    • Jung S, Aliberti J, Graemmel P, Sunshine MJ, Kreutzberg GW, Sher A, Littman DR (2000) Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol Cell Biol 20: 4106–4114
    • (2000) Mol Cell Biol , vol.20 , pp. 4106-4114
    • Jung, S.1    Aliberti, J.2    Graemmel, P.3    Sunshine, M.J.4    Kreutzberg, G.W.5    Sher, A.6    Littman, D.R.7
  • 62
    • 0345700737 scopus 로고    scopus 로고
    • The bisphosphonate clodronate depletes microglial cells in excitotoxically injured organotypic hippocampal slice cultures
    • Kohl A, Dehghani F, Korf HW, Hailer NP (2003) The bisphosphonate clodronate depletes microglial cells in excitotoxically injured organotypic hippocampal slice cultures. Exp Neurol 181: 1–11
    • (2003) Exp Neurol , vol.181 , pp. 1-11
    • Kohl, A.1    Dehghani, F.2    Korf, H.W.3    Hailer, N.P.4
  • 64
    • 62149143788 scopus 로고    scopus 로고
    • 2-Arachidonoylglycerol elicits neuroprotective effects on excitotoxically lesioned dentate gyrus granule cells via abnormal-cannabidiol-sensitive receptors on microglial cells
    • Kreutz S, Koch M, Bottger C, Ghadban C, Korf HW, Dehghani F (2009) 2-Arachidonoylglycerol elicits neuroprotective effects on excitotoxically lesioned dentate gyrus granule cells via abnormal-cannabidiol-sensitive receptors on microglial cells. Glia 57: 286–294
    • (2009) Glia , vol.57 , pp. 286-294
    • Kreutz, S.1    Koch, M.2    Bottger, C.3    Ghadban, C.4    Korf, H.W.5    Dehghani, F.6
  • 65
    • 0030222037 scopus 로고    scopus 로고
    • Microglia: a sensor for pathological events in the CNS
    • Kreutzberg GW (1996) Microglia: a sensor for pathological events in the CNS. Trends Neurosci 19: 312–318
    • (1996) Trends Neurosci , vol.19 , pp. 312-318
    • Kreutzberg, G.W.1
  • 66
    • 84858259145 scopus 로고    scopus 로고
    • Clearance of amyloid-beta peptides by microglia and macrophages: the issue of what, when and where
    • Lai AY, McLaurin J (2012) Clearance of amyloid-beta peptides by microglia and macrophages: the issue of what, when and where. Future Neurol 7: 165–176
    • (2012) Future Neurol , vol.7 , pp. 165-176
    • Lai, A.Y.1    McLaurin, J.2
  • 68
    • 0028675319 scopus 로고
    • GM-CSF promotes proliferation of human fetal and adult microglia in primary cultures
    • Lee SC, Liu W, Brosnan CF, Dickson DW (1994) GM-CSF promotes proliferation of human fetal and adult microglia in primary cultures. Glia 12: 309–318
    • (1994) Glia , vol.12 , pp. 309-318
    • Lee, S.C.1    Liu, W.2    Brosnan, C.F.3    Dickson, D.W.4
  • 69
    • 77956955758 scopus 로고    scopus 로고
    • The role of microglia in amyloid clearance from the AD brain
    • Lee CY, Landreth GE (2010) The role of microglia in amyloid clearance from the AD brain. J Neural Transm 117: 949–960
    • (2010) J Neural Transm , vol.117 , pp. 949-960
    • Lee, C.Y.1    Landreth, G.E.2
  • 70
    • 78650338241 scopus 로고    scopus 로고
    • CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-beta phagocytosis
    • Liu Z, Condello C, Schain A, Harb R, Grutzendler J (2010) CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-beta phagocytosis. J Neurosci 30: 17091–17101
    • (2010) J Neurosci , vol.30 , pp. 17091-17101
    • Liu, Z.1    Condello, C.2    Schain, A.3    Harb, R.4    Grutzendler, J.5
  • 71
    • 70349807619 scopus 로고    scopus 로고
    • Immune activation in brain aging and neurodegeneration: too much or too little?
    • Lucin KM, Wyss-Coray T (2009) Immune activation in brain aging and neurodegeneration: too much or too little? Neuron 64: 110–122
    • (2009) Neuron , vol.64 , pp. 110-122
    • Lucin, K.M.1    Wyss-Coray, T.2
  • 73
    • 34247264399 scopus 로고    scopus 로고
    • Activation of microglia acidifies lysosomes and leads to degradation of Alzheimer amyloid fibrils
    • Majumdar A, Cruz D, Asamoah N, Buxbaum A, Sohar I, Lobel P, Maxfield FR (2007) Activation of microglia acidifies lysosomes and leads to degradation of Alzheimer amyloid fibrils. Mol Biol Cell 18: 1490–1496
    • (2007) Mol Biol Cell , vol.18 , pp. 1490-1496
    • Majumdar, A.1    Cruz, D.2    Asamoah, N.3    Buxbaum, A.4    Sohar, I.5    Lobel, P.6    Maxfield, F.R.7
  • 74
    • 70349567912 scopus 로고    scopus 로고
    • Neutralization of granulocyte macrophage colony-stimulating factor decreases amyloid beta 1-42 and suppresses microglial activity in a transgenic mouse model of Alzheimer's disease
    • Manczak M, Mao P, Nakamura K, Bebbington C, Park B, Reddy PH (2009) Neutralization of granulocyte macrophage colony-stimulating factor decreases amyloid beta 1-42 and suppresses microglial activity in a transgenic mouse model of Alzheimer's disease. Hum Mol Genet 18: 3876–3893
    • (2009) Hum Mol Genet , vol.18 , pp. 3876-3893
    • Manczak, M.1    Mao, P.2    Nakamura, K.3    Bebbington, C.4    Park, B.5    Reddy, P.H.6
  • 79
    • 84866290238 scopus 로고    scopus 로고
    • Organotypic brain slice cultures of adult transgenic P301S mice–a model for tauopathy studies
    • Mewes A, Franke H, Singer D (2012) Organotypic brain slice cultures of adult transgenic P301S mice–a model for tauopathy studies. PLoS One 7: e45017
    • (2012) PLoS One , vol.7
    • Mewes, A.1    Franke, H.2    Singer, D.3
  • 81
    • 0242268945 scopus 로고    scopus 로고
    • Immunotherapeutic approaches to Alzheimer's disease
    • Monsonego A, Weiner HL (2003) Immunotherapeutic approaches to Alzheimer's disease. Science 302: 834–838
    • (2003) Science , vol.302 , pp. 834-838
    • Monsonego, A.1    Weiner, H.L.2
  • 82
    • 24644438615 scopus 로고    scopus 로고
    • Dynamic complexity of the microglial activation response in transgenic models of amyloid deposition: implications for Alzheimer therapeutics
    • Morgan D, Gordon MN, Tan J, Wilcock D, Rojiani AM (2005) Dynamic complexity of the microglial activation response in transgenic models of amyloid deposition: implications for Alzheimer therapeutics. J Neuropathol Exp Neurol 64: 743–753
    • (2005) J Neuropathol Exp Neurol , vol.64 , pp. 743-753
    • Morgan, D.1    Gordon, M.N.2    Tan, J.3    Wilcock, D.4    Rojiani, A.M.5
  • 83
    • 84897954445 scopus 로고    scopus 로고
    • Microglial dysfunction in brain aging and Alzheimer's disease
    • Mosher KI, Wyss-Coray T (2014) Microglial dysfunction in brain aging and Alzheimer's disease. Biochem Pharmacol 88: 594–604
    • (2014) Biochem Pharmacol , vol.88 , pp. 594-604
    • Mosher, K.I.1    Wyss-Coray, T.2
  • 84
    • 77249133015 scopus 로고    scopus 로고
    • A new method to isolate microglia from adult mice and culture them for an extended period of time
    • Moussaud S, Draheim HJ (2010) A new method to isolate microglia from adult mice and culture them for an extended period of time. J Neurosci Methods 187: 243–253
    • (2010) J Neurosci Methods , vol.187 , pp. 243-253
    • Moussaud, S.1    Draheim, H.J.2
  • 86
    • 84906229172 scopus 로고    scopus 로고
    • Tumour necrosis factor alpha-induced neuronal loss is mediated by microglial phagocytosis
    • Neniskyte U, Vilalta A, Brown GC (2014) Tumour necrosis factor alpha-induced neuronal loss is mediated by microglial phagocytosis. FEBS Lett 588: 2952–2956
    • (2014) FEBS Lett , vol.588 , pp. 2952-2956
    • Neniskyte, U.1    Vilalta, A.2    Brown, G.C.3
  • 87
    • 0037393454 scopus 로고    scopus 로고
    • Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report
    • Nicoll JA, Wilkinson D, Holmes C, Steart P, Markham H, Weller RO (2003) Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report. Nat Med 9: 448–452
    • (2003) Nat Med , vol.9 , pp. 448-452
    • Nicoll, J.A.1    Wilkinson, D.2    Holmes, C.3    Steart, P.4    Markham, H.5    Weller, R.O.6
  • 91
    • 0030664076 scopus 로고    scopus 로고
    • Slow degradation of aggregates of the Alzheimer's disease amyloid beta-protein by microglial cells
    • Paresce DM, Chung H, Maxfield FR (1997) Slow degradation of aggregates of the Alzheimer's disease amyloid beta-protein by microglial cells. J Biol Chem 272: 29390–29397
    • (1997) J Biol Chem , vol.272 , pp. 29390-29397
    • Paresce, D.M.1    Chung, H.2    Maxfield, F.R.3
  • 94
    • 84938394820 scopus 로고    scopus 로고
    • Antibody drugs for Alzheimer's show glimmers of promise
    • Reardon S (2015) Antibody drugs for Alzheimer's show glimmers of promise. Nature 523: 509–510
    • (2015) Nature , vol.523 , pp. 509-510
    • Reardon, S.1
  • 95
    • 0036849021 scopus 로고    scopus 로고
    • Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide
    • Rogers J, Strohmeyer R, Kovelowski CJ, Li R (2002) Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide. Glia 40: 260–269
    • (2002) Glia , vol.40 , pp. 260-269
    • Rogers, J.1    Strohmeyer, R.2    Kovelowski, C.J.3    Li, R.4
  • 96
    • 0031969223 scopus 로고    scopus 로고
    • Alzheimer's disease as proteolytic disorders: anabolism and catabolism of beta-amyloid
    • Saido TC (1998) Alzheimer's disease as proteolytic disorders: anabolism and catabolism of beta-amyloid. Neurobiol Aging 19: S69–S75
    • (1998) Neurobiol Aging , vol.19 , pp. S69-S75
    • Saido, T.C.1
  • 97
    • 68349127365 scopus 로고    scopus 로고
    • Granulocyte colony stimulating factor decreases brain amyloid burden and reverses cognitive impairment in Alzheimer's mice
    • Sanchez-Ramos J, Song S, Sava V, Catlow B, Lin X, Mori T, Cao C, Arendash GW (2009) Granulocyte colony stimulating factor decreases brain amyloid burden and reverses cognitive impairment in Alzheimer's mice. Neuroscience 163: 55–72
    • (2009) Neuroscience , vol.163 , pp. 55-72
    • Sanchez-Ramos, J.1    Song, S.2    Sava, V.3    Catlow, B.4    Lin, X.5    Mori, T.6    Cao, C.7    Arendash, G.W.8
  • 99
    • 0020044056 scopus 로고
    • Action of cytochalasin D on cytoskeletal networks
    • Schliwa M (1982) Action of cytochalasin D on cytoskeletal networks. J Cell Biol 92: 79–91
    • (1982) J Cell Biol , vol.92 , pp. 79-91
    • Schliwa, M.1
  • 100
    • 0033984235 scopus 로고    scopus 로고
    • The Ki-67 protein: from the known and the unknown
    • Scholzen T, Gerdes J (2000) The Ki-67 protein: from the known and the unknown. J Cell Physiol 182: 311–322
    • (2000) J Cell Physiol , vol.182 , pp. 311-322
    • Scholzen, T.1    Gerdes, J.2
  • 103
    • 0034748924 scopus 로고    scopus 로고
    • GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1
    • Shibata Y, Berclaz PY, Chroneos ZC, Yoshida M, Whitsett JA, Trapnell BC (2001) GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1. Immunity 15: 557–567
    • (2001) Immunity , vol.15 , pp. 557-567
    • Shibata, Y.1    Berclaz, P.Y.2    Chroneos, Z.C.3    Yoshida, M.4    Whitsett, J.A.5    Trapnell, B.C.6
  • 104
    • 34250328818 scopus 로고    scopus 로고
    • Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes
    • Shirotani K, Tomioka M, Kremmer E, Haass C, Steiner H (2007) Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes. Neurobiol Dis 27: 102–107
    • (2007) Neurobiol Dis , vol.27 , pp. 102-107
    • Shirotani, K.1    Tomioka, M.2    Kremmer, E.3    Haass, C.4    Steiner, H.5
  • 105
    • 32344440522 scopus 로고    scopus 로고
    • Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease
    • Simard AR, Soulet D, Gowing G, Julien JP, Rivest S (2006) Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron 49: 489–502
    • (2006) Neuron , vol.49 , pp. 489-502
    • Simard, A.R.1    Soulet, D.2    Gowing, G.3    Julien, J.P.4    Rivest, S.5
  • 108
    • 84864134469 scopus 로고    scopus 로고
    • Microglia function in Alzheimer's disease
    • Solito E, Sastre M (2012) Microglia function in Alzheimer's disease. Front Pharmacol 3: 14
    • (2012) Front Pharmacol , vol.3 , pp. 14
    • Solito, E.1    Sastre, M.2
  • 109
    • 79960298544 scopus 로고    scopus 로고
    • Characterization of cortical neuronal and glial alterations during culture of organotypic whole brain slices from neonatal and mature mice
    • Staal JA, Alexander SR, Liu Y, Dickson TD, Vickers JC (2011) Characterization of cortical neuronal and glial alterations during culture of organotypic whole brain slices from neonatal and mature mice. PLoS One 6: e22040
    • (2011) PLoS One , vol.6
    • Staal, J.A.1    Alexander, S.R.2    Liu, Y.3    Dickson, T.D.4    Vickers, J.C.5
  • 110
    • 0032983536 scopus 로고    scopus 로고
    • Association of microglia with amyloid plaques in brains of APP23 transgenic mice
    • Stalder M, Phinney A, Probst A, Sommer B, Staufenbiel M, Jucker M (1999) Association of microglia with amyloid plaques in brains of APP23 transgenic mice. Am J Pathol 154: 1673–1684
    • (1999) Am J Pathol , vol.154 , pp. 1673-1684
    • Stalder, M.1    Phinney, A.2    Probst, A.3    Sommer, B.4    Staufenbiel, M.5    Jucker, M.6
  • 111
    • 0030897133 scopus 로고    scopus 로고
    • Risk of Alzheimer's disease and duration of NSAID use
    • Stewart WF, Kawas C, Corrada M, Metter EJ (1997) Risk of Alzheimer's disease and duration of NSAID use. Neurology 48: 626–632
    • (1997) Neurology , vol.48 , pp. 626-632
    • Stewart, W.F.1    Kawas, C.2    Corrada, M.3    Metter, E.J.4
  • 112
    • 0025805120 scopus 로고
    • A simple method for organotypic cultures of nervous tissue
    • Stoppini L, Buchs PA, Muller D (1991) A simple method for organotypic cultures of nervous tissue. J Neurosci Methods 37: 173–182
    • (1991) J Neurosci Methods , vol.37 , pp. 173-182
    • Stoppini, L.1    Buchs, P.A.2    Muller, D.3
  • 113
  • 115
    • 14044264203 scopus 로고    scopus 로고
    • Inhibition of granulocyte-macrophage colony-stimulating factor signaling and microglial proliferation by anti-CD45RO: role of Hck tyrosine kinase and phosphatidylinositol 3-kinase/Akt
    • Suh HS, Kim MO, Lee SC (2005) Inhibition of granulocyte-macrophage colony-stimulating factor signaling and microglial proliferation by anti-CD45RO: role of Hck tyrosine kinase and phosphatidylinositol 3-kinase/Akt. J Immunol 174: 2712–2719
    • (2005) J Immunol , vol.174 , pp. 2712-2719
    • Suh, H.S.1    Kim, M.O.2    Lee, S.C.3
  • 116
    • 0027200944 scopus 로고
    • Transforming growth factor-beta suppresses activation and proliferation of microglia in vitro
    • Suzumura A, Sawada M, Yamamoto H, Marunouchi T (1993) Transforming growth factor-beta suppresses activation and proliferation of microglia in vitro. J Immunol 151: 2150–2158
    • (1993) J Immunol , vol.151 , pp. 2150-2158
    • Suzumura, A.1    Sawada, M.2    Yamamoto, H.3    Marunouchi, T.4
  • 123
    • 84939436660 scopus 로고    scopus 로고
    • Immune phenotypes of microglia in human neurodegenerative disease: challenges to detecting microglial polarization in human brains
    • Walker DG, Lue LF (2015) Immune phenotypes of microglia in human neurodegenerative disease: challenges to detecting microglial polarization in human brains. Alzheimers Res Ther 7: 56
    • (2015) Alzheimers Res Ther , vol.7 , pp. 56
    • Walker, D.G.1    Lue, L.F.2
  • 126
    • 0025676284 scopus 로고
    • The complex of microglial cells and amyloid star in three-dimensional reconstruction
    • Wegiel J, Wisniewski HM (1990) The complex of microglial cells and amyloid star in three-dimensional reconstruction. Acta Neuropathol 81: 116–124
    • (1990) Acta Neuropathol , vol.81 , pp. 116-124
    • Wegiel, J.1    Wisniewski, H.M.2
  • 128
    • 84864936920 scopus 로고    scopus 로고
    • A changing perspective on the role of neuroinflammation in Alzheimer's disease
    • Wilcock DM (2012) A changing perspective on the role of neuroinflammation in Alzheimer's disease. Int J Alzheimers Dis 2012: 495243
    • (2012) Int J Alzheimers Dis , vol.2012 , pp. 495243
    • Wilcock, D.M.1
  • 130
    • 84925279976 scopus 로고    scopus 로고
    • Immunotherapeutic approaches for Alzheimer's disease
    • Wisniewski T, Goni F (2015) Immunotherapeutic approaches for Alzheimer's disease. Neuron 85: 1162–1176
    • (2015) Neuron , vol.85 , pp. 1162-1176
    • Wisniewski, T.1    Goni, F.2
  • 131
    • 33748471099 scopus 로고    scopus 로고
    • Inflammation in Alzheimer disease: driving force, bystander or beneficial response?
    • Wyss-Coray T (2006) Inflammation in Alzheimer disease: driving force, bystander or beneficial response? Nat Med 12: 1005–1015
    • (2006) Nat Med , vol.12 , pp. 1005-1015
    • Wyss-Coray, T.1
  • 133
    • 14544306103 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drug use and Alzheimer's disease risk: the MIRAGE Study
    • Yip AG, Green RC, Huyck M, Cupples LA, Farrer LA, Group MS (2005) Nonsteroidal anti-inflammatory drug use and Alzheimer's disease risk: the MIRAGE Study. BMC Geriatr 5: 2
    • (2005) BMC Geriatr , vol.5 , pp. 2
    • Yip, A.G.1    Green, R.C.2    Huyck, M.3    Cupples, L.A.4    Farrer, L.A.5
  • 134
    • 0037167542 scopus 로고    scopus 로고
    • Reduced incidence of AD with NSAID but not H2 receptor antagonists: the Cache County Study
    • Zandi PP, Anthony JC, Hayden KM, Mehta K, Mayer L, Breitner JC, Cache County Study I (2002) Reduced incidence of AD with NSAID but not H2 receptor antagonists: the Cache County Study. Neurology 59: 880–886.
    • (2002) Neurology , vol.59 , pp. 880-886
    • Zandi, P.P.1    Anthony, J.C.2    Hayden, K.M.3    Mehta, K.4    Mayer, L.5    Breitner, J.C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.