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Volumn 17, Issue 1, 2017, Pages 49-59

Cytokine networks in neuroinflammation

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 17; INTERLEUKIN 22; TUMOR NECROSIS FACTOR;

EID: 85002412707     PISSN: 14741733     EISSN: 14741741     Source Type: Journal    
DOI: 10.1038/nri.2016.123     Document Type: Review
Times cited : (480)

References (142)
  • 1
    • 32244442562 scopus 로고    scopus 로고
    • TGFβ in the context ofan inflammatory cytokine milieu supports de novo differentiation of IL 17 producing T cells
    • Veldhoen M, Hocking R. J, Atkins C. J, Locksley R. M, & Stockinger B. TGFβ in the context ofan inflammatory cytokine milieu supports de novo differentiation of IL 17 producing T cells. Immunity. 24, 179-189 (2006).
    • (2006) Immunity , vol.24 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 2
    • 57449112782 scopus 로고    scopus 로고
    • IL 6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells
    • Korn T, et al. IL 6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells. Proc. Natl Acad. Sci. USA 105, 18460-18465 (2008).
    • (2008) Proc. Natl Acad. Sci. US , vol.105 , pp. 18460-18465
    • Korn, T.1
  • 3
    • 67349216357 scopus 로고    scopus 로고
    • Autoimmune T cell responses in the central nervous system
    • Goverman J. Autoimmune T cell responses in the central nervous system. Nat. Rev. Immunol.9 393-407 (2009).
    • (2009) Nat. Rev. Immunol , vol.9 , pp. 393-407
    • Goverman, J.1
  • 4
    • 0142259710 scopus 로고    scopus 로고
    • Three or more routes for leukocyte migration into the central nervous system
    • Ransohoff R. M, Kivisakk P, & Kidd G. Three or more routes for leukocyte migration into the central nervous system. Nat. Rev. Immunol. 3, 569-581 (2003).
    • (2003) Nat. Rev. Immunol , vol.3 , pp. 569-581
    • Ransohoff, R.M.1    Kivisakk, P.2    Kidd, G.3
  • 5
    • 84929921146 scopus 로고    scopus 로고
    • Immune attack: The role of inflammation in Alzheimer disease
    • Heppner F. L, Ransohoff R. M, & Becher B. Immune attack: the role of inflammation in Alzheimer disease. Nat. Rev. Neurosci. 16, 358-372 (2015).
    • (2015) Nat. Rev. Neurosci , vol.16 , pp. 358-372
    • Heppner, F.L.1    Ransohoff, R.M.2    Becher, B.3
  • 6
    • 70349838218 scopus 로고    scopus 로고
    • Cytokines and CNS development
    • Deverman B. E, & Patterson P. H. Cytokines and CNS development. Neuron 64, 61-78 (2009).
    • (2009) Neuro , vol.64 , pp. 61-78
    • Deverman, B.E.1    Patterson, P.H.2
  • 7
    • 0036663074 scopus 로고    scopus 로고
    • The Role of gp130 in cerebral cortical development: In vivo functional analysis in a mouse ex utero system
    • Hatta T, Moriyama K, Nakashima K, Taga T, & Otani H. The Role of gp130 in cerebral cortical development: in vivo functional analysis in a mouse ex utero system. J. Neurosci. 22, 5516-5524 (2002).
    • (2002) J. Neurosci , vol.22 , pp. 5516-5524
    • Hatta, T.1    Moriyama, K.2    Nakashima, K.3    Taga, T.4    Otani, H.5
  • 8
    • 70349794451 scopus 로고    scopus 로고
    • Immune proteins in brain development and synaptic plasticity
    • Boulanger L. M. Immune proteins in brain development and synaptic plasticity. Neuron 64, 93-109 (2009).
    • (2009) Neuro , vol.64 , pp. 93-109
    • Boulanger, L.M.1
  • 9
    • 16444371048 scopus 로고    scopus 로고
    • Influence of LIF and BMP 2 on differentiation and development of glial cells in primary cultures of embryonic rat cerebral hemisphere
    • Adachi T, Takanaga H, Kunimoto M, & Asou H. Influence of LIF and BMP 2 on differentiation and development of glial cells in primary cultures of embryonic rat cerebral hemisphere. J. Neurosci. Res. 79, 608-615 (2005).
    • (2005) J. Neurosci. Res , vol.79 , pp. 608-615
    • Adachi, T.1    Takanaga, H.2    Kunimoto, M.3    Asou, H.4
  • 10
    • 26944448206 scopus 로고    scopus 로고
    • Evidence that embryonic neurons regulate the onset of cortical gliogenesis via cardiotrophin 1
    • Barnabe-Heider F, et al. Evidence that embryonic neurons regulate the onset of cortical gliogenesis via cardiotrophin 1. Neuron 48, 253-265 (2005).
    • (2005) Neuro , vol.48 , pp. 253-265
    • Barnabe-Heider, F.1
  • 11
    • 14044250903 scopus 로고    scopus 로고
    • CNTF/LIF/gp130 receptor complex signaling maintains a VZ precursor differentiation gradient in the developing ventral forebrain
    • Gregg C, & Weiss S. CNTF/LIF/gp130 receptor complex signaling maintains a VZ precursor differentiation gradient in the developing ventral forebrain. Development 132, 565-578 (2005).
    • (2005) Developmen , vol.132 , pp. 565-578
    • Gregg, C.1    Weiss, S.2
  • 12
    • 84870907320 scopus 로고    scopus 로고
    • Stroma-derived interleukin 34 controls the development and maintenance of Langerhans cells and the maintenance of microglia
    • Greter M, et al. Stroma-derived interleukin 34 controls the development and maintenance of Langerhans cells and the maintenance of microglia. Immunity 37, 1050-1060 (2012).
    • (2012) Immunit , vol.37 , pp. 1050-1060
    • Greter, M.1
  • 13
    • 84864152036 scopus 로고    scopus 로고
    • IL 34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia
    • Wang Y, et al. IL 34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia. Nat. Immunol. 13, 753-760 (2012).
    • (2012) Nat. Immunol , vol.13 , pp. 753-760
    • Wang, Y.1
  • 14
    • 80053281065 scopus 로고    scopus 로고
    • Interleukin 34 selectively enhances the neuroprotective effects of microglia to attenuate oligomeric amyloid-beta neurotoxicity
    • Mizuno T, et al. Interleukin 34 selectively enhances the neuroprotective effects of microglia to attenuate oligomeric amyloid-beta neurotoxicity. Am. J. Pathol. 179, 2016-2027 (2011).
    • (2011) Am. J. Pathol , vol.179 , pp. 2016-2027
    • Mizuno, T.1
  • 15
    • 78149360132 scopus 로고    scopus 로고
    • Fate mapping analysis reveals that adult microglia derive from primitive macrophages
    • Ginhoux F, et al. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science 330, 841-845 (2010).
    • (2010) Scienc , vol.330 , pp. 841-845
    • Ginhoux, F.1
  • 16
    • 84919740878 scopus 로고    scopus 로고
    • Interleukin 34 restores blood-brain barrier integrity by upregulating tight junction proteins in endothelial cells
    • Jin S, et al. Interleukin 34 restores blood-brain barrier integrity by upregulating tight junction proteins in endothelial cells. PLoS ONE 9, e115981 (2014).
    • (2014) PLoS on , vol.9 , pp. e115981
    • Jin, S.1
  • 17
    • 0027356664 scopus 로고
    • Heterogeneity of microglial and perivascular cell populations: Insights gained from the facial nucleus paradigm
    • Streit W. J, & Graeber M. B. Heterogeneity of microglial and perivascular cell populations: insights gained from the facial nucleus paradigm. Glia 7, 68-74 (1993).
    • (1993) Gli , vol.7 , pp. 68-74
    • Streit, W.J.1    Graeber, M.B.2
  • 18
    • 84863726869 scopus 로고    scopus 로고
    • The immunology of acute stroke
    • Chamorro A, et al. The immunology of acute stroke. Nat. Rev. Neurol. 8, 401-410 (2012).
    • (2012) Nat. Rev. Neurol , vol.8 , pp. 401-410
    • Chamorro, A.1
  • 19
    • 84939500270 scopus 로고    scopus 로고
    • Innate and adaptive immune responses in the CNS
    • Waisman A, Liblau R. S, & Becher B. Innate and adaptive immune responses in the CNS. Lancet Neurol. 14, 945-955 (2015).
    • (2015) Lancet Neurol , vol.14 , pp. 945-955
    • Waisman, A.1    Liblau, R.S.2    Becher, B.3
  • 21
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer?s disease: Progress and problems on the road to therapeutics
    • Hardy J, & Selkoe D. J. The amyloid hypothesis of Alzheimer?s disease: progress and problems on the road to therapeutics. Science 297, 353-356 (2002).
    • (2002) Scienc , vol.297 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 22
    • 84866246671 scopus 로고    scopus 로고
    • Microglia, Alzheimer?s disease, and complement
    • Crehan H, Hardy J, & Pocock J. Microglia, Alzheimer?s disease, and complement. Int. J. Alzheimers Dis. 2012, 983640 (2012).
    • (2012) Int. J. Alzheimers Dis , vol.2012 , pp. 983640
    • Crehan, H.1    Hardy, J.2    Pocock, J.3
  • 23
    • 0346003785 scopus 로고    scopus 로고
    • A CD36 initiated signaling cascade mediates inflammatory effects of β-Amyloid
    • Moore K. J. et al. A CD36 initiated signaling cascade mediates inflammatory effects of β-Amyloid. J. Biol. Chem. 277, 47373-47379 (2002).
    • (2002) J. Biol. Chem , vol.277 , pp. 47373-47379
    • Moore, K.J.1
  • 24
    • 0034840664 scopus 로고    scopus 로고
    • Involvement of microglial receptor for advanced glycation endproducts (RAGE) in Alzheimer?s disease: Identification of a cellular activation mechanism
    • Lue L. F, et al. Involvement of microglial receptor for advanced glycation endproducts (RAGE) in Alzheimer?s disease: identification of a cellular activation mechanism. Exp. Neurol. 171, 29-45 (2001).
    • (2001) Exp. Neurol , vol.171 , pp. 29-45
    • Lue, L.F.1
  • 25
    • 84866106602 scopus 로고    scopus 로고
    • Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease
    • Hu W. T, et al. Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease. Neurology 79, 897-905 (2012).
    • (2012) Neurolog , vol.79 , pp. 897-905
    • Hu, W.T.1
  • 26
    • 0001360461 scopus 로고
    • Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease
    • Griffin W. S, et al. Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc. Natl Acad. Sci. USA 86, 7611-7615 (1989).
    • (1989) Proc. Natl Acad. Sci. US , vol.86 , pp. 7611-7615
    • Griffin, W.S.1
  • 27
    • 18144410635 scopus 로고    scopus 로고
    • Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer?s disease
    • Patel N. S, et al. Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer?s disease. J. Neuroinflamm. 2, 9 (2005).
    • (2005) J. Neuroinflamm , vol.2 , pp. 9
    • Patel, N.S.1
  • 28
    • 84924988052 scopus 로고    scopus 로고
    • The glia-derived alarmin IL 33 orchestrates the immune response and promotes recovery following CNS injury
    • Gadani S. P, Walsh J. T, Smirnov I, Zheng J, & Kipnis J. The glia-derived alarmin IL 33 orchestrates the immune response and promotes recovery following CNS injury. Neuron 85, 703-709 (2015).
    • (2015) Neuro , vol.85 , pp. 703-709
    • Gadani, S.P.1    Walsh, J.T.2    Smirnov, I.3    Zheng, J.4    Kipnis, J.5
  • 29
    • 84887093048 scopus 로고    scopus 로고
    • How do immune cells support and shape the brain in health, disease, and aging?
    • Schwartz M, Kipnis J, Rivest S, & Prat A. How do immune cells support and shape the brain in health, disease, and aging?. J. Neurosci. 33, 17587-17596 (2013).
    • (2013) J. Neurosci , vol.33 , pp. 17587-17596
    • Schwartz, M.1    Kipnis, J.2    Rivest, S.3    Prat, A.4
  • 30
    • 80053233055 scopus 로고    scopus 로고
    • Heterogeneity of CNS myeloid cells and their roles in neurodegeneration
    • Prinz M, Priller J, Sisodia S. S, & Ransohoff R. M. Heterogeneity of CNS myeloid cells and their roles in neurodegeneration. Nat. Neurosci. 14, 1227-1235 (2011).
    • (2011) Nat. Neurosci , vol.14 , pp. 1227-1235
    • Prinz, M.1    Priller, J.2    Sisodia, S.S.3    Ransohoff, R.M.4
  • 31
    • 76149092520 scopus 로고    scopus 로고
    • Massive gliosis induced by interleukin 6 suppresses Aβ deposition in vivo: Evidence against inflammation as a driving force for amyloid deposition
    • Chakrabarty P, et al. Massive gliosis induced by interleukin 6 suppresses Aβ deposition in vivo: evidence against inflammation as a driving force for amyloid deposition. FASEB J. 24, 548-559 (2010).
    • (2010) FASEB J , vol.24 , pp. 548-559
    • Chakrabarty, P.1
  • 32
    • 79951551206 scopus 로고    scopus 로고
    • Hippocampal expression of murine TNFα results in attenuation of amyloid deposition in vivo
    • Chakrabarty P, Herring A, Ceballos-Diaz C, Das P, & Golde T. E. Hippocampal expression of murine TNFα results in attenuation of amyloid deposition in vivo. Mol. Neurodegener. 6, 16 (2011).
    • (2011) Mol. Neurodegener , vol.6 , pp. 16
    • Chakrabarty, P.1    Herring, A.2    Ceballos-Diaz, C.3    Das, P.4    Golde, T.E.5
  • 33
    • 0025807206 scopus 로고
    • Elevated circulating tumor necrosis factor levels in Alzheimer?s disease
    • Fillit H, et al. Elevated circulating tumor necrosis factor levels in Alzheimer?s disease. Neurosci. Lett. 129, 318-320 (1991).
    • (1991) Neurosci. Lett , vol.129 , pp. 318-320
    • Fillit, H.1
  • 34
    • 77049093949 scopus 로고    scopus 로고
    • Differential activation of tumor necrosis factor receptors distinguishes between brains from Alzheimer?s disease and non-demented patients
    • Cheng X, Yang L, He P, Li R, & Shen Y. Differential activation of tumor necrosis factor receptors distinguishes between brains from Alzheimer?s disease and non-demented patients. J. Alzheimers Dis. 19, 621-630 (2010).
    • (2010) J. Alzheimers Dis , vol.19 , pp. 621-630
    • Cheng, X.1    Yang, L.2    He, P.3    Li, R.4    Shen, Y.5
  • 35
    • 84929937549 scopus 로고    scopus 로고
    • Etanercept in Alzheimer disease: A randomized, placebo-controlled, double-blind, phase 2 trial
    • Butchart J, et al. Etanercept in Alzheimer disease: A randomized, placebo-controlled, double-blind, phase 2 trial. Neurology 84, 2161-2168 (2015).
    • (2015) Neurolog , vol.84 , pp. 2161-2168
    • Butchart, J.1
  • 36
    • 84874882726 scopus 로고    scopus 로고
    • Sustained interleukin 1β overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer?s mouse model
    • Ghosh S, et al. Sustained interleukin 1β overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer?s mouse model. J. Neurosci. 33, 5053-5064 (2013).
    • (2013) J. Neurosci , vol.33 , pp. 5053-5064
    • Ghosh, S.1
  • 37
    • 34548434392 scopus 로고    scopus 로고
    • Chronic interleukin 1β expression in mouse brain leads to leukocyte infiltration and neutrophil-independent blood brain barrier permeability without overt neurodegeneration
    • Shaftel S. S, et al. Chronic interleukin 1β expression in mouse brain leads to leukocyte infiltration and neutrophil-independent blood brain barrier permeability without overt neurodegeneration. J. Neurosci. 27, 9301-9309 (2007).
    • (2007) J. Neurosci , vol.27 , pp. 9301-9309
    • Shaftel, S.S.1
  • 38
    • 83755183781 scopus 로고    scopus 로고
    • Blocking IL 1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer?s disease model
    • Kitazawa M, et al. Blocking IL 1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer?s disease model. J. Immunol. 187, 6539-6549 (2011).
    • (2011) J. Immunol , vol.187 , pp. 6539-6549
    • Kitazawa, M.1
  • 39
    • 34548316575 scopus 로고    scopus 로고
    • Deletion of tumor necrosis factor death receptor inhibits amyloid β generation and prevents learning and memory deficits in Alzheimer?s mice
    • He P, et al. Deletion of tumor necrosis factor death receptor inhibits amyloid β generation and prevents learning and memory deficits in Alzheimer?s mice. J. Cell Biol. 178, 829-841 (2007).
    • (2007) J. Cell Biol , vol.178 , pp. 829-841
    • He, P.1
  • 40
    • 84873087532 scopus 로고    scopus 로고
    • NLRP3 is activated in Alzheimer?s disease and contributes to pathology in APP/PS1 mice
    • Heneka M. T, et al. NLRP3 is activated in Alzheimer?s disease and contributes to pathology in APP/PS1 mice. Nature 493, 674-678 (2013).
    • (2013) Natur , vol.493 , pp. 674-678
    • Heneka, M.T.1
  • 41
    • 84870932482 scopus 로고    scopus 로고
    • Inhibition of IL 12/IL 23 signaling reduces Alzheimer?s disease-like pathology and cognitive decline
    • Vom Berg J, et al. Inhibition of IL 12/IL 23 signaling reduces Alzheimer?s disease-like pathology and cognitive decline. Nat. Med. 18, 1812-1819 (2012).
    • (2012) Nat. Med , vol.18 , pp. 1812-1819
    • Vom Berg, J.1
  • 42
    • 77955883396 scopus 로고    scopus 로고
    • Cytokine polymorphisms and Alzheimer disease: Possible associations
    • Ribizzi G, Fiordoro S, Barocci S, Ferrari E, & Megna M. Cytokine polymorphisms and Alzheimer disease: possible associations. Neurol. Sci. 31, 321-325 (2010).
    • (2010) Neurol. Sci , vol.31 , pp. 321-325
    • Ribizzi, G.1    Fiordoro, S.2    Barocci, S.3    Ferrari, E.4    Megna, M.5
  • 43
    • 0032914896 scopus 로고    scopus 로고
    • A genetic variation of the inflammatory cytokine interleukin 6 delays the initial onset and reduces the risk for sporadic Alzheimer?s disease
    • Papassotiropoulos A, et al. A genetic variation of the inflammatory cytokine interleukin 6 delays the initial onset and reduces the risk for sporadic Alzheimer?s disease. Ann. Neurol. 45, 666-668 (1999).
    • (1999) Ann. Neurol , vol.45 , pp. 666-668
    • Papassotiropoulos, A.1
  • 44
    • 58249130474 scopus 로고    scopus 로고
    • Interleukin 18 promoter polymorphisms and risk of late onset Alzheimer?s disease
    • Yu J. T, et al. Interleukin 18 promoter polymorphisms and risk of late onset Alzheimer?s disease. Brain Res. 1253, 169-175 (2009).
    • (2009) Brain Res , vol.1253 , pp. 169-175
    • Yu, J.T.1
  • 45
    • 0034053173 scopus 로고    scopus 로고
    • Association of interleukin 1 gene polymorphisms with Alzheimer?s disease
    • Nicoll J. A, et al. Association of interleukin 1 gene polymorphisms with Alzheimer?s disease. Ann. Neurol. 47, 365-368 (2000).
    • (2000) Ann. Neurol , vol.47 , pp. 365-368
    • Nicoll, J.A.1
  • 46
    • 0019487117 scopus 로고
    • Vaccination against autoimmune encephalomyelitis with T lymphocyte line cells reactive against myelin basic protein
    • Ben-Nun A, Wekerle H, & Cohen I. R. Vaccination against autoimmune encephalomyelitis with T lymphocyte line cells reactive against myelin basic protein. Nature 292, 60-61 (1981).
    • (1981) Natur , vol.292 , pp. 60-61
    • Ben-Nun, A.1    Wekerle, H.2    Cohen, I.R.3
  • 47
    • 80051684615 scopus 로고    scopus 로고
    • Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
    • The International Multiple Sclerosis Genetics Consortium & The Welcome Trust Case Control Consortium 2
    • The International Multiple Sclerosis Genetics Consortium & The Welcome Trust Case Control Consortium 2. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 476, 214-219 (2011).
    • (2011) Natur , vol.476 , pp. 214-219
  • 48
    • 84948773327 scopus 로고    scopus 로고
    • CSF cytokines/chemokines as biomarkers in neuroinflammatory CNS disorders: A systematic review
    • Kothur K, Wienholt L, Brilot F, & Dale R. C. CSF cytokines/chemokines as biomarkers in neuroinflammatory CNS disorders: a systematic review. Cytokine 77, 227-237 (2016).
    • (2016) Cytokin , vol.77 , pp. 227-237
    • Kothur, K.1    Wienholt, L.2    Brilot, F.3    Dale, R.C.4
  • 49
    • 34248137873 scopus 로고    scopus 로고
    • APC-derived cytokines and T cell polarization in autoimmune inflammation
    • Gutcher I, & Becher B. APC-derived cytokines and T cell polarization in autoimmune inflammation. J. Clin. Invest. 117, 1119-1127 (2007).
    • (2007) J. Clin. Invest , vol.117 , pp. 1119-1127
    • Gutcher, I.1    Becher, B.2
  • 50
    • 0033638507 scopus 로고    scopus 로고
    • Novel p19 protein engages IL 12p40 to form a cytokine, IL 23, with biological activities similar as well as distinct from IL 12
    • Oppmann B, et al. Novel p19 protein engages IL 12p40 to form a cytokine, IL 23, with biological activities similar as well as distinct from IL 12. Immunity. 13, 715-725 (2000).
    • (2000) Immunity , vol.13 , pp. 715-725
    • Oppmann, B.1
  • 51
    • 0029788704 scopus 로고    scopus 로고
    • IL 12 unmasks latent autoimmune disease in resistant mice
    • Segal B. M, & Shevach E. M. IL 12 unmasks latent autoimmune disease in resistant mice. J. Exp. Med. 184, 771-775 (1996).
    • (1996) J. Exp. Med , vol.184 , pp. 771-775
    • Segal, B.M.1    Shevach, E.M.2
  • 52
    • 0036677420 scopus 로고    scopus 로고
    • Experimental autoimmune encephalitis and inflammation in the absence of interleukin 12
    • Becher B, Durell B. G, & Noelle R. J. Experimental autoimmune encephalitis and inflammation in the absence of interleukin 12. J. Clin. Investig. 110, 493-497 (2002).
    • (2002) J. Clin. Investig , vol.110 , pp. 493-497
    • Becher, B.1    Durell, B.G.2    Noelle, R.J.3
  • 53
    • 0037434789 scopus 로고    scopus 로고
    • Interleukin 23 rather than interleukin 12 is the critical cytokine for autoimmune inflammation of the brain
    • Cua D. J, et al. Interleukin 23 rather than interleukin 12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421, 744-748 (2003).
    • (2003) Natur , vol.421 , pp. 744-748
    • Cua, D.J.1
  • 54
    • 33846593869 scopus 로고    scopus 로고
    • Increased IL 23p19 expression in multiple sclerosis lesions and its induction in microglia
    • Li Y, et al. Increased IL 23p19 expression in multiple sclerosis lesions and its induction in microglia. Brain 130, 490-501 (2007).
    • (2007) Brai , vol.130 , pp. 490-501
    • Li, Y.1
  • 55
    • 0031852288 scopus 로고    scopus 로고
    • IL 6 deficient mice resist myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis
    • Eugster H. P, Frei K, Kopf M, Lassmann H, & Fontana A. IL 6 deficient mice resist myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis. Eur. J. Immunol. 28, 2178-2187 (1998).
    • (1998) Eur. J. Immunol , vol.28 , pp. 2178-2187
    • Eugster, H.P.1    Frei, K.2    Kopf, M.3    Lassmann, H.4    Fontana, A.5
  • 56
    • 53349143503 scopus 로고    scopus 로고
    • GM CSF mediates autoimmunity by enhancing IL 6 dependent Th17 cell development and survival
    • Sonderegger I, et al. GM CSF mediates autoimmunity by enhancing IL 6 dependent Th17 cell development and survival. J. Exp. Med. 205, 2281-2294 (2008).
    • (2008) J. Exp. Med , vol.205 , pp. 2281-2294
    • Sonderegger, I.1
  • 57
    • 64049089798 scopus 로고    scopus 로고
    • Critical regulation of early Th17 cell differentiation by interleukin 1 signaling
    • Chung Y, et al. Critical regulation of early Th17 cell differentiation by interleukin 1 signaling. Immunity 30, 576-587 (2009).
    • (2009) Immunit , vol.30 , pp. 576-587
    • Chung, Y.1
  • 58
    • 84879198756 scopus 로고    scopus 로고
    • Transcription factors and CD4 T cells seeking identity: Masters, minions, setters and spikers
    • Vahedi G, Kanno Y, Sartorelli V, & O?Shea J. J. Transcription factors and CD4 T cells seeking identity: masters, minions, setters and spikers. Immunology 139, 294-298 (2013).
    • (2013) Immunolog , vol.139 , pp. 294-298
    • Vahedi, G.1    Kanno, Y.2    Sartorelli, V.3    O'Shea, J.J.4
  • 59
    • 79951677394 scopus 로고    scopus 로고
    • Fate mapping of IL 17 producing T cells in inflammatory responses
    • Hirota K, et al. Fate mapping of IL 17 producing T cells in inflammatory responses. Nat. Immunol. 12, 255-263 (2011).
    • (2011) Nat. Immunol , vol.12 , pp. 255-263
    • Hirota, K.1
  • 60
    • 74049131014 scopus 로고    scopus 로고
    • Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells
    • Pepper M, et al. Different routes of bacterial infection induce long-lived TH1 memory cells and short-lived TH17 cells. Nat. Immunol. 11, 83-89 (2010).
    • (2010) Nat. Immunol , vol.11 , pp. 83-89
    • Pepper, M.1
  • 61
    • 84929955331 scopus 로고    scopus 로고
    • Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation
    • Gagliani N, et al. Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation. Nature 523, 221-225 (2015).
    • (2015) Natur , vol.523 , pp. 221-225
    • Gagliani, N.1
  • 62
    • 13244283212 scopus 로고    scopus 로고
    • IL 23 drives a pathogenic T cell population that induces autoimmune inflammation
    • Langrish C. L, et al. IL 23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201, 233-240 (2005).
    • (2005) J. Exp. Med , vol.201 , pp. 233-240
    • Langrish, C.L.1
  • 63
    • 40049103352 scopus 로고    scopus 로고
    • IL 22 is expressed by Th17 cells in an IL 23 dependent fashion, but not required for the development of autoimmune encephalomyelitis
    • Kreymborg K, et al. IL 22 is expressed by Th17 cells in an IL 23 dependent fashion, but not required for the development of autoimmune encephalomyelitis. J. Immunol. 179, 8098-8104 (2007).
    • (2007) J. Immunol , vol.179 , pp. 8098-8104
    • Kreymborg, K.1
  • 64
    • 79956116032 scopus 로고    scopus 로고
    • RORγt drives production of the cytokine GM CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation
    • Codarri L, et al. RORγt drives production of the cytokine GM CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation. Nat. Immunol. 12, 560-567 (2011).
    • (2011) Nat. Immunol , vol.12 , pp. 560-567
    • Codarri, L.1
  • 65
    • 84891702406 scopus 로고    scopus 로고
    • Therapeutic opportunities of the IL 22 IL 22R1 system
    • Sabat R, Ouyang W, & Wolk K. Therapeutic opportunities of the IL 22 IL 22R1 system. Nat. Rev. Drug Discov. 13, 21-38 (2014).
    • (2014) Nat. Rev. Drug Discov , vol.13 , pp. 21-38
    • Sabat, R.1    Ouyang, W.2    Wolk, K.3
  • 66
    • 84866934694 scopus 로고    scopus 로고
    • Targeting IL 17 and TH17 cells in chronic inflammation
    • Miossec P, & Kolls J. K. Targeting IL 17 and TH17 cells in chronic inflammation. Nat. Rev. Drug Discov. 11, 763-776 (2012).
    • (2012) Nat. Rev. Drug Discov , vol.11 , pp. 763-776
    • Miossec, P.1    Kolls, J.K.2
  • 67
    • 84933045525 scopus 로고    scopus 로고
    • Interleukin 22 is increased in multiple sclerosis patients and targets astrocytes
    • Perriard G, et al. Interleukin 22 is increased in multiple sclerosis patients and targets astrocytes. J. Neuroinflamm. 12, 119 (2015).
    • (2015) J. Neuroinflamm , vol.12 , pp. 119
    • Perriard, G.1
  • 68
    • 67449155295 scopus 로고    scopus 로고
    • Functional interleukin 17 receptor A is expressed in central nervous system glia and upregulated in experimental autoimmune encephalomyelitis
    • Das Sarma J, et al. Functional interleukin 17 receptor A is expressed in central nervous system glia and upregulated in experimental autoimmune encephalomyelitis. J. Neuroinflamm. 6, 14 (2009).
    • (2009) J. Neuroinflamm , vol.6 , pp. 14
    • Das Sarma, J.1
  • 69
    • 82955228112 scopus 로고    scopus 로고
    • TH17 cytokines in autoimmune neuro-inflammation
    • Becher B, & Segal B. M. TH17 cytokines in autoimmune neuro-inflammation. Curr. Opin. Immunol. 23, 707-712 (2011).
    • (2011) Curr. Opin. Immunol , vol.23 , pp. 707-712
    • Becher, B.1    Segal, B.M.2
  • 71
    • 61749093508 scopus 로고    scopus 로고
    • IL 17A and IL 17F do not contribute vitally to autoimmune neuro-inflammation in mice
    • Haak S, et al. IL 17A and IL 17F do not contribute vitally to autoimmune neuro-inflammation in mice. J. Clin. Invest. 119, 61-69 (2009).
    • (2009) J. Clin. Invest , vol.119 , pp. 61-69
    • Haak, S.1
  • 72
    • 33745321276 scopus 로고    scopus 로고
    • IL 17 plays an important role in the development of experimental autoimmune encephalomyelitis
    • Komiyama Y, et al. IL 17 plays an important role in the development of experimental autoimmune encephalomyelitis. J. Immunol. 177, 566-573 (2006).
    • (2006) J. Immunol , vol.177 , pp. 566-573
    • Komiyama, Y.1
  • 73
    • 34948909646 scopus 로고    scopus 로고
    • Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation
    • Kebir H, et al. Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nat. Med. 13, 1173-1175 (2007).
    • (2007) Nat. Med , vol.13 , pp. 1173-1175
    • Kebir, H.1
  • 74
    • 77951636292 scopus 로고    scopus 로고
    • Cellular mechanisms of IL 17 induced blood-brain barrier disruption
    • Huppert J, et al. Cellular mechanisms of IL 17 induced blood-brain barrier disruption. FASEB J. 24, 1023-1034 (2010).
    • (2010) FASEB J , vol.24 , pp. 1023-1034
    • Huppert, J.1
  • 75
    • 84904246348 scopus 로고    scopus 로고
    • Cytokine-regulated neutrophil recruitment is required for brain but not spinal cord inflammation during experimental autoimmune encephalomyelitis
    • Simmons S. B, Liggitt D, & Goverman J. M. Cytokine-regulated neutrophil recruitment is required for brain but not spinal cord inflammation during experimental autoimmune encephalomyelitis. J. Immunol. 193, 555-563 (2014).
    • (2014) J. Immunol , vol.193 , pp. 555-563
    • Simmons, S.B.1    Liggitt, D.2    Goverman, J.M.3
  • 76
    • 77949973725 scopus 로고    scopus 로고
    • Astrocyte-restricted ablation of interleukin 17 induced Act1 mediated signaling ameliorates autoimmune encephalomyelitis
    • Kang Z, et al. Astrocyte-restricted ablation of interleukin 17 induced Act1 mediated signaling ameliorates autoimmune encephalomyelitis. Immunity 32, 414-425 (2010).
    • (2010) Immunit , vol.32 , pp. 414-425
    • Kang, Z.1
  • 77
    • 0141720769 scopus 로고    scopus 로고
    • Class II cytokine receptors and their ligands: Key antiviral and inflammatory modulators
    • Renauld J. C. Class II cytokine receptors and their ligands: key antiviral and inflammatory modulators. Nat. Rev. Immunol. 3, 667-676 (2003).
    • (2003) Nat. Rev. Immunol , vol.3 , pp. 667-676
    • Renauld, J.C.1
  • 78
    • 42649106556 scopus 로고    scopus 로고
    • The aryl hydrocarbon receptor links TH17 cell-mediated autoimmunity to environmental toxins
    • Veldhoen M, et al. The aryl hydrocarbon receptor links TH17 cell-mediated autoimmunity to environmental toxins. Nature 453, 106-109 (2008).
    • (2008) Natur , vol.453 , pp. 106-109
    • Veldhoen, M.1
  • 79
    • 84893938271 scopus 로고    scopus 로고
    • Differential influences of the aryl hydrocarbon receptor on Th17 mediated responses in vitro and in vivo
    • Duarte J. H, Di Meglio P, Hirota K, Ahlfors H, & Stockinger B. Differential influences of the aryl hydrocarbon receptor on Th17 mediated responses in vitro and in vivo. PLoS ONE 8, e79819 (2013).
    • (2013) PLoS on , vol.8 , pp. e79819
    • Duarte, J.H.1    Di Meglio, P.2    Hirota, K.3    Ahlfors, H.4    Stockinger, B.5
  • 80
    • 0023221133 scopus 로고
    • Treatment of multiple sclerosis with γ interferon: Exacerbations associated with activation of the immune system
    • Panitch H. S, Hirsch R. L, Schindler J, & Johnson K. P. Treatment of multiple sclerosis with γ interferon: exacerbations associated with activation of the immune system. Neurology 37, 1097-1102 (1987).
    • (1987) Neurolog , vol.37 , pp. 1097-1102
    • Panitch, H.S.1    Hirsch, R.L.2    Schindler, J.3    Johnson, K.P.4
  • 81
    • 84946569137 scopus 로고    scopus 로고
    • Opposing roles of interferon-γ on cells of the central nervous system in autoimmune neuroinflammation
    • Ottum P. A, Arellano G, Reyes L. I, Iruretagoyena M, & Naves R. Opposing roles of interferon-γ on cells of the central nervous system in autoimmune neuroinflammation. Front. Immunol. 6, 539 (2015).
    • (2015) Front. Immunol , vol.6 , pp. 539
    • Ottum, P.A.1    Arellano, G.2    Reyes, L.I.3    Iruretagoyena, M.4    Naves, R.5
  • 82
    • 0025607948 scopus 로고
    • Direct injection of cytokines into the spinal-cord causes autoimmune encephalomyelitis-like inflammation
    • Simmons R. D, & Willenborg D. O. Direct injection of cytokines into the spinal-cord causes autoimmune encephalomyelitis-like inflammation. J. Neurol. Sci. 100, 37-42 (1990).
    • (1990) J. Neurol. Sci , vol.100 , pp. 37-42
    • Simmons, R.D.1    Willenborg, D.O.2
  • 83
    • 0025991518 scopus 로고
    • Immune modulation within the brain - Recruitment of inflammatory cells and increased major histocompatibility antigen expression following intracerebral injection of interferon-γ
    • Sethna M. P, & Lampson L. A. Immune modulation within the brain - recruitment of inflammatory cells and increased major histocompatibility antigen expression following intracerebral injection of interferon-γ. J. Neuroimmunol. 34, 121-132 (1991).
    • (1991) J. Neuroimmunol , vol.34 , pp. 121-132
    • Sethna, M.P.1    Lampson, L.A.2
  • 84
    • 0023879766 scopus 로고
    • Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-γ
    • Billiau A, et al. Enhancement of experimental allergic encephalomyelitis in mice by antibodies against IFN-γ. J. Immunol. 140, 1506-1510 (1988).
    • (1988) J. Immunol , vol.140 , pp. 1506-1510
    • Billiau, A.1
  • 85
    • 33846966636 scopus 로고    scopus 로고
    • A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage
    • Steinman L. A brief history of T(H)17 the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage. Nat. Med. 13, 139-145 (2007).
    • (2007) Nat. Med , vol.13 , pp. 139-145
    • Steinman, L.1
  • 86
    • 84884239709 scopus 로고    scopus 로고
    • The interdependent, overlapping, and differential roles of type i and II IFNs in the pathogenesis of experimental autoimmune encephalomyelitis
    • Naves R, et al. The interdependent, overlapping, and differential roles of type I and II IFNs in the pathogenesis of experimental autoimmune encephalomyelitis. J. Immunol. 191, 2967-2977 (2013).
    • (2013) J. Immunol , vol.191 , pp. 2967-2977
    • Naves, R.1
  • 87
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17 producinqg CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington L. E, et al. Interleukin 17 producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 6, 1123-1132 (2005).
    • (2005) Nat. Immunol , vol.6 , pp. 1123-1132
    • Harrington, L.E.1
  • 88
    • 27544465354 scopus 로고    scopus 로고
    • A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    • Park H, et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat. Immunol. 6, 1133-1141 (2005).
    • (2005) Nat. Immunol , vol.6 , pp. 1133-1141
    • Park, H.1
  • 89
    • 33748294322 scopus 로고    scopus 로고
    • Role of IFN-γ in induction of Foxp3 and conversion of CD4+ CD25-T cells to CD4+ Tregs
    • Wang Z, et al. Role of IFN-γ in induction of Foxp3 and conversion of CD4+ CD25-T cells to CD4+ Tregs. J. Clin. Invest. 116, 2434-2441 (2006).
    • (2006) J. Clin. Invest , vol.116 , pp. 2434-2441
    • Wang, Z.1
  • 90
    • 0030788405 scopus 로고    scopus 로고
    • Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis
    • Chin Y. E, Kitagawa M, Kuida K, Flavell R. A, & Fu X. Y. Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis. Mol. Cell. Biol. 17, 5328-5337 (1997).
    • (1997) Mol. Cell. Biol , vol.17 , pp. 5328-5337
    • Chin, Y.E.1    Kitagawa, M.2    Kuida, K.3    Flavell, R.A.4    Fu, X.Y.5
  • 91
    • 23444449846 scopus 로고    scopus 로고
    • Indolamine 2,3 dioxygenase is expressed in the CNS and down-regulates autoimmune inflammation
    • Kwidzinski E, et al. Indolamine 2,3 dioxygenase is expressed in the CNS and down-regulates autoimmune inflammation. FASEB J. 19, 1347-1349 (2005).
    • (2005) FASEB J , vol.19 , pp. 1347-1349
    • Kwidzinski, E.1
  • 92
    • 33846811702 scopus 로고    scopus 로고
    • The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage
    • Lin W, et al. The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage. J. Clin. Invest. 117, 448-456 (2007).
    • (2007) J. Clin. Invest , vol.117 , pp. 448-456
    • Lin, W.1
  • 93
    • 84928473638 scopus 로고    scopus 로고
    • Silencing IFN-γ binding/signaling in astrocytes versus microglia leads to opposite effects on central nervous system autoimmunity
    • Ding X, et al. Silencing IFN-γ binding/signaling in astrocytes versus microglia leads to opposite effects on central nervous system autoimmunity. J. Immunol. 194, 4251-4264 (2015).
    • (2015) J. Immunol , vol.194 , pp. 4251-4264
    • Ding, X.1
  • 94
    • 84864414689 scopus 로고    scopus 로고
    • IFN-γ signaling to astrocytes protects from autoimmune mediated neurological disability
    • Hindinger C, et al. IFN-γ signaling to astrocytes protects from autoimmune mediated neurological disability. PLoS ONE 7, e42088 (2012).
    • (2012) PLoS on , vol.7 , pp. e42088
    • Hindinger, C.1
  • 95
    • 84913573590 scopus 로고    scopus 로고
    • Interferon-γ safeguards blood-brain barrier during experimental autoimmune encephalomyelitis
    • Ni C, et al. Interferon-γ safeguards blood-brain barrier during experimental autoimmune encephalomyelitis. Am. J. Pathol. 184, 3308-3320 (2014).
    • (2014) Am. J. Pathol , vol.184 , pp. 3308-3320
    • Ni, C.1
  • 96
    • 84941242991 scopus 로고    scopus 로고
    • IFN-γ ameliorates autoimmune encephalomyelitis by limiting myelin lipid peroxidation
    • Sosa R. A, Murphey C, Robinson R. R, & Forsthuber T. G. IFN-γ ameliorates autoimmune encephalomyelitis by limiting myelin lipid peroxidation. Proc. Natl Acad. Sci. USA 112, E5038-E5047 (2015).
    • (2015) Proc. Natl Acad. Sci. US , vol.112 , pp. E5038-E5047
    • Sosa, R.A.1    Murphey, C.2    Robinson, R.R.3    Forsthuber, T.G.4
  • 97
    • 12444329705 scopus 로고    scopus 로고
    • IFN-γ determines distinct clinical outcomes in autoimmune encephalomyelitis
    • Wensky A. K, et al. IFN-γ determines distinct clinical outcomes in autoimmune encephalomyelitis. J. Immunol. 174, 1416-1423 (2005).
    • (2005) J. Immunol , vol.174 , pp. 1416-1423
    • Wensky, A.K.1
  • 98
    • 58149159798 scopus 로고    scopus 로고
    • Regional CNS responses to IFN-γ determine lesion localization patterns during EAE pathogenesis
    • Lees J. R, Golumbek P. T, Sim J, Dorsey D, & Russell J. H. Regional CNS responses to IFN-γ determine lesion localization patterns during EAE pathogenesis. J. Exp. Med. 205, 2633-2642 (2008).
    • (2008) J. Exp. Med , vol.205 , pp. 2633-2642
    • Lees, J.R.1    Golumbek, P.T.2    Sim, J.3    Dorsey, D.4    Russell, J.H.5
  • 99
    • 77956103058 scopus 로고    scopus 로고
    • EAE mediated by a non-IFN-γ/non IL 17 pathway
    • Kroenke M. A, Chensue S. W, & Segal B. M. EAE mediated by a non-IFN-γ/non IL 17 pathway. Eur. J. Immunol. 40, 2340-2348 (2010).
    • (2010) Eur. J. Immunol , vol.40 , pp. 2340-2348
    • Kroenke, M.A.1    Chensue, S.W.2    Segal, B.M.3
  • 100
    • 84957431867 scopus 로고    scopus 로고
    • PD 1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer?s disease
    • Baruch K, et al. PD 1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer?s disease. Nat. Med. 22, 135-137 (2016).
    • (2016) Nat. Med , vol.22 , pp. 135-137
    • Baruch, K.1
  • 101
    • 84874225589 scopus 로고    scopus 로고
    • IFN-γ production by amyloid β-specific Th1 cells promotes microglial activation and increases plaque burden in a mouse model of Alzheimer?s disease
    • Browne T. C, et al. IFN-γ production by amyloid β-specific Th1 cells promotes microglial activation and increases plaque burden in a mouse model of Alzheimer?s disease. J. Immunol. 190, 2241-2251 (2013).
    • (2013) J. Immunol , vol.190 , pp. 2241-2251
    • Browne, T.C.1
  • 102
    • 0023794099 scopus 로고
    • Increased production of interferon γ and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: Do cytokines trigger off exacerbations?
    • Beck J, et al. Increased production of interferon γ and tumor necrosis factor precedes clinical manifestation in multiple sclerosis: do cytokines trigger off exacerbations?. Acta Neurol. Scand. 78, 318-323 (1988).
    • (1988) Acta Neurol. Scand , vol.78 , pp. 318-323
    • Beck, J.1
  • 103
    • 0028985320 scopus 로고
    • Tumor necrosis factor-α messenger RNA expression in patients with relapsing-remitting multiple sclerosis is associated with disease activity
    • Rieckmann P, et al. Tumor necrosis factor-α messenger RNA expression in patients with relapsing-remitting multiple sclerosis is associated with disease activity. Ann. Neurol. 37, 82-88 (1995).
    • (1995) Ann. Neurol , vol.37 , pp. 82-88
    • Rieckmann, P.1
  • 104
    • 27144460509 scopus 로고    scopus 로고
    • Apoptosis of oligodendrocytes via Fas and TNF R1 is a key event in the induction of experimental autoimmune encephalomyelitis
    • Hovelmeyer N, et al. Apoptosis of oligodendrocytes via Fas and TNF R1 is a key event in the induction of experimental autoimmune encephalomyelitis. J. Immunol. 175, 5875-5884 (2005).
    • (2005) J. Immunol , vol.175 , pp. 5875-5884
    • Hovelmeyer, N.1
  • 105
    • 27744437016 scopus 로고    scopus 로고
    • Autoantigen specific T cells inhibit glutamate uptake in astrocytes by decreasing expression of astrocytic glutamate transporter GLAST: A mechanism mediated by tumor necrosis factor-α
    • Korn T, Magnus T, & Jung S. Autoantigen specific T cells inhibit glutamate uptake in astrocytes by decreasing expression of astrocytic glutamate transporter GLAST: a mechanism mediated by tumor necrosis factor-α. FASEB J. 19, 1878-1880 (2005).
    • (2005) FASEB J , vol.19 , pp. 1878-1880
    • Korn, T.1    Magnus, T.2    Jung, S.3
  • 106
    • 0028796804 scopus 로고
    • Cytokine-induced expression of vascular cell adhesion molecule 1 (VCAM 1) by astrocytes and astrocytoma cell lines
    • Rosenman S. J, Shrikant P, Dubb L, Benveniste E. N, & Ransohoff R. M. Cytokine-induced expression of vascular cell adhesion molecule 1 (VCAM 1) by astrocytes and astrocytoma cell lines. J. Immunol. 154, 1888-1899 (1995).
    • (1995) J. Immunol , vol.154 , pp. 1888-1899
    • Rosenman, S.J.1    Shrikant, P.2    Dubb, L.3    Benveniste, E.N.4    Ransohoff, R.M.5
  • 107
    • 0024420184 scopus 로고
    • Tumor necrosis factor-Alpha enhances interferon-γ-mediated class II antigen expression on astrocytes
    • Benveniste E. N, Sparacio S. M, & Bethea J. R. Tumor necrosis factor-Alpha enhances interferon-γ-mediated class II antigen expression on astrocytes. J. Neuroimmunol. 25, 209-219 (1989).
    • (1989) J. Neuroimmunol , vol.25 , pp. 209-219
    • Benveniste, E.N.1    Sparacio, S.M.2    Bethea, J.R.3
  • 108
    • 0032457436 scopus 로고    scopus 로고
    • Synergistic stimulation of MHC class i and IRF 1 gene expression by IFN-γ and TNF-α in oligodendrocytes
    • Agresti C, et al. Synergistic stimulation of MHC class I and IRF 1 gene expression by IFN-γ and TNF-α in oligodendrocytes. Eur. J. Neurosci. 10, 2975-2983 (1998).
    • (1998) Eur. J. Neurosci , vol.10 , pp. 2975-2983
    • Agresti, C.1
  • 109
    • 0033546665 scopus 로고    scopus 로고
    • TNF neutralization in MS: Results of a randomized, placebo-controlled multicenter study
    • The Lenercept Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis Groupq
    • The Lenercept Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis Group. TNF neutralization in MS: results of a randomized, placebo-controlled multicenter study. Neurology 53, 457-465 (1999).
    • (1999) Neurolog , vol.53 , pp. 457-465
  • 110
    • 0035674613 scopus 로고    scopus 로고
    • Demyelination occurring during anti-Tumor necrosis factor α therapy for inflammatory arthritides
    • Mohan N, et al. Demyelination occurring during anti-Tumor necrosis factor α therapy for inflammatory arthritides. Arthritis Rheum. 44, 2862-2869 (2001).
    • (2001) Arthritis Rheum , vol.44 , pp. 2862-2869
    • Mohan, N.1
  • 111
    • 0033032129 scopus 로고    scopus 로고
    • Severity of symptoms and demyelination in MOG-induced EAE depends on TNFR1
    • Eugster H. P, et al. Severity of symptoms and demyelination in MOG-induced EAE depends on TNFR1. Eur. J. Immunol. 29, 626-632 (1999).
    • (1999) Eur. J. Immunol , vol.29 , pp. 626-632
    • Eugster, H.P.1
  • 112
    • 0034633542 scopus 로고    scopus 로고
    • Divergent roles for p55 and p75 tumor necrosis factor receptors in the pathogenesis of MOG(35-55)-induced experimental autoimmune encephalomyelitis
    • Suvannavejh G. C, et al. Divergent roles for p55 and p75 tumor necrosis factor receptors in the pathogenesis of MOG(35-55)-induced experimental autoimmune encephalomyelitis. Cell. Immunol. 205, 24-33 (2000).
    • (2000) Cell. Immunol , vol.205 , pp. 24-33
    • Suvannavejh, G.C.1
  • 113
    • 84876931396 scopus 로고    scopus 로고
    • Beyond oxidative stress: An immunologist?s guide to reactive oxygen species
    • Nathan C, & Cunningham-Bussel A. Beyond oxidative stress: an immunologist?s guide to reactive oxygen species. Nat. Rev. Immunol. 13, 349-361 (2013).
    • (2013) Nat. Rev. Immunol , vol.13 , pp. 349-361
    • Nathan, C.1    Cunningham-Bussel, A.2
  • 114
    • 84856804751 scopus 로고    scopus 로고
    • Neutrophils in multiple sclerosis are characterized by a primed phenotype
    • Naegele M, et al. Neutrophils in multiple sclerosis are characterized by a primed phenotype. J. Neuroimmunol. 242, 60-71 (2012).
    • (2012) J. Neuroimmunol , vol.242 , pp. 60-71
    • Naegele, M.1
  • 115
    • 84921342055 scopus 로고    scopus 로고
    • Neutrophil-related factors as biomarkers in EAE and MS
    • Rumble J. M, et al. Neutrophil-related factors as biomarkers in EAE and MS. J. Exp. Med. 212, 23-35 (2015).
    • (2015) J. Exp. Med , vol.212 , pp. 23-35
    • Rumble, J.M.1
  • 116
    • 85002892488 scopus 로고    scopus 로고
    • The contribution of neutrophils to CNS autoimmunity
    • Pierson E. R, Wagner C. A, & Goverman J. M. The contribution of neutrophils to CNS autoimmunity. Clin. Immunol. doi: 10.1016/j.clim.2016.06.017 (2016).
    • Clin. Immunol
    • Pierson, E.R.1    Wagner, C.A.2    Goverman, J.M.3
  • 117
    • 0035476518 scopus 로고    scopus 로고
    • Granulocyte macrophage colony-stimulating factor: A new putative therapeutic target in multiple sclerosis
    • McQualter J. L, et al. Granulocyte macrophage colony-stimulating factor: a new putative therapeutic target in multiple sclerosis. J. Exp. Med. 194, 873-882 (2001).
    • (2001) J. Exp. Med , vol.194 , pp. 873-882
    • McQualter, J.L.1
  • 118
    • 79956152607 scopus 로고    scopus 로고
    • The encephalitogenicity of T(H)17 cells is dependent on IL 1-And IL 23 induced production of the cytokine GM CSF
    • El Behi M, et al. The encephalitogenicity of T(H)17 cells is dependent on IL 1-And IL 23 induced production of the cytokine GM CSF. Nat. Immunol. 12, 568-575 (2011).
    • (2011) Nat. Immunol , vol.12 , pp. 568-575
    • El Behi, M.1
  • 119
    • 84942516683 scopus 로고    scopus 로고
    • GM CSF in neuroinflammation: Licensing myeloid cells for tissue damage
    • Croxford A. L, Spath S, & Becher B. GM CSF in neuroinflammation: licensing myeloid cells for tissue damage. Trends Immunol. 36, 651-662 (2015).
    • (2015) Trends Immunol , vol.36 , pp. 651-662
    • Croxford, A.L.1    Spath, S.2    Becher, B.3
  • 120
    • 84916918681 scopus 로고    scopus 로고
    • Exposure to inflammatory cytokines selectively limits GM CSF production by induced T regulatory cells
    • Reynolds B. C, et al. Exposure to inflammatory cytokines selectively limits GM CSF production by induced T regulatory cells. Eur. J. Immunol. 44, 3342-3352 (2014).
    • (2014) Eur. J. Immunol , vol.44 , pp. 3342-3352
    • Reynolds, B.C.1
  • 121
    • 84941735780 scopus 로고    scopus 로고
    • The cytokine GM CSF drives the inflammatory signature of CCR2(+) monocytes and licenses autoimmunity
    • Croxford A. L, et al. The cytokine GM CSF drives the inflammatory signature of CCR2(+) monocytes and licenses autoimmunity. Immunity 43, 502-514 (2015).
    • (2015) Immunit , vol.43 , pp. 502-514
    • Croxford, A.L.1
  • 122
    • 0035911254 scopus 로고    scopus 로고
    • Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis
    • Huang D. R, Wang J, Kivisakk P, Rollins B. J, & Ransohoff R. M. Absence of monocyte chemoattractant protein 1 in mice leads to decreased local macrophage recruitment and antigen-specific T helper cell type 1 immune response in experimental autoimmune encephalomyelitis. J. Exp. Med. 193, 713-726 (2001).
    • (2001) J. Exp. Med , vol.193 , pp. 713-726
    • Huang, D.R.1    Wang, J.2    Kivisakk, P.3    Rollins, B.J.4    Ransohoff, R.M.5
  • 123
    • 71549167047 scopus 로고    scopus 로고
    • CCR2+Ly 6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system
    • Mildner A, et al. CCR2+Ly 6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system. Brain 132, 2487-2500 (2009).
    • (2009) Brai , vol.132 , pp. 2487-2500
    • Mildner, A.1
  • 124
    • 0034596949 scopus 로고    scopus 로고
    • Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2
    • Izikson L, Klein R. S, Charo I. F, Weiner H. L, & Luster A. D. Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2. J. Exp. Med. 192, 1075-1080 (2000).
    • (2000) J. Exp. Med , vol.192 , pp. 1075-1080
    • Izikson, L.1    Klein, R.S.2    Charo, I.F.3    Weiner, H.L.4    Luster, A.D.5
  • 125
    • 0033807680 scopus 로고    scopus 로고
    • CC chemokine receptor 2 is critical for induction of experimental autoimmune encephalomyelitis
    • Fife B. T, Huffnagle G. B, Kuziel W. A, & Karpus W. J. CC chemokine receptor 2 is critical for induction of experimental autoimmune encephalomyelitis. J. Exp. Med. 192, 899-905 (2000).
    • (2000) J. Exp. Med , vol.192 , pp. 899-905
    • Fife, B.T.1    Huffnagle, G.B.2    Kuziel, W.A.3    Karpus, W.J.4
  • 126
    • 0037221976 scopus 로고    scopus 로고
    • Experimental autoimmune encephalomyelitis (EAE) in CCR2(-/-) mice: Susceptibility in multiple strains
    • Gaupp S, Pitt D, Kuziel W. A, Cannella B, & Raine C. S. Experimental autoimmune encephalomyelitis (EAE) in CCR2(-/-) mice: susceptibility in multiple strains. Am. J. Pathol. 162, 139-150 (2003).
    • (2003) Am. J. Pathol , vol.162 , pp. 139-150
    • Gaupp, S.1    Pitt, D.2    Kuziel, W.A.3    Cannella, B.4    Raine, C.S.5
  • 127
    • 84905116959 scopus 로고    scopus 로고
    • Differential roles of microglia and monocytes in the inflamed central nervous system
    • Yamasaki R, et al. Differential roles of microglia and monocytes in the inflamed central nervous system. J. Exp. Med. 211, 1533-1549 (2014).
    • (2014) J. Exp. Med , vol.211 , pp. 1533-1549
    • Yamasaki, R.1
  • 128
    • 84874446407 scopus 로고    scopus 로고
    • Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status
    • Vogel D. Y, et al. Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status. J. Neuroinflamm. 10, 35 (2013).
    • (2013) J. Neuroinflamm , vol.10 , pp. 35
    • Vogel, D.Y.1
  • 129
    • 84926370173 scopus 로고    scopus 로고
    • Neuroinflammation in Alzheimer?s disease
    • Heneka M. T, et al. Neuroinflammation in Alzheimer?s disease. Lancet Neurol. 14, 388-405 (2015).
    • (2015) Lancet Neurol , vol.14 , pp. 388-405
    • Heneka, M.T.1
  • 130
    • 33845727067 scopus 로고    scopus 로고
    • What is the blood-brain barrier (not)?
    • Bechmann I, Galea I, & Perry V. H. What is the blood-brain barrier (not)?. Trends Immunol. 28, 5-11 (2007).
    • (2007) Trends Immunol , vol.28 , pp. 5-11
    • Bechmann, I.1    Galea, I.2    Perry, V.H.3
  • 132
  • 134
    • 84945453289 scopus 로고    scopus 로고
    • Control of autoimmune CNS inflammation by astrocytes
    • Rothhammer V, & Quintana F. J. Control of autoimmune CNS inflammation by astrocytes. Semin. Immunopathol. 37, 625-638 (2015).
    • (2015) Semin. Immunopathol , vol.37 , pp. 625-638
    • Rothhammer, V.1    Quintana, F.J.2
  • 135
    • 84940795878 scopus 로고    scopus 로고
    • Astrocyte depletion impairs redox homeostasis and triggers neuronal loss in the adult CNS
    • Schreiner B, et al. Astrocyte depletion impairs redox homeostasis and triggers neuronal loss in the adult CNS. Cell Rep. 12, 1377-1384 (2015).
    • (2015) Cell Rep , vol.12 , pp. 1377-1384
    • Schreiner, B.1
  • 137
    • 84963841577 scopus 로고    scopus 로고
    • Origin, fate and dynamics of macrophages at central nervous system interfaces
    • Goldmann T, et al. Origin, fate and dynamics of macrophages at central nervous system interfaces. Nat. Immunol. 17, 797-805 (2016).
    • (2016) Nat. Immunol , vol.17 , pp. 797-805
    • Goldmann, T.1
  • 138
    • 65649096159 scopus 로고    scopus 로고
    • Localizing central nervous system immune surveillance: Meningeal antigen-presenting cells activate T cells during experimental autoimmune encephalomyelitis
    • Kivisakk P, et al. Localizing central nervous system immune surveillance: meningeal antigen-presenting cells activate T cells during experimental autoimmune encephalomyelitis. Ann. Neurol. 65, 457-469 (2009).
    • (2009) Ann. Neurol , vol.65 , pp. 457-469
    • Kivisakk, P.1
  • 139
    • 16244380177 scopus 로고    scopus 로고
    • Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis
    • Greter M, et al. Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis. Nat. Med. 11, 328-334 (2005).
    • (2005) Nat. Med , vol.11 , pp. 328-334
    • Greter, M.1
  • 140
    • 84905107360 scopus 로고    scopus 로고
    • Dendritic cells, monocytes and macrophages: A unified nomenclature based on ontogeny
    • Guilliams M, et al. Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny. Nat. Rev. Immunol. 14, 571-578 (2014).
    • (2014) Nat. Rev. Immunol , vol.14 , pp. 571-578
    • Guilliams, M.1
  • 141
    • 77349089236 scopus 로고    scopus 로고
    • Differentiation and function of mouse monocyte-derived dendritic cells in steady state and inflammation
    • Dominguez P. M, & Ardavin C. Differentiation and function of mouse monocyte-derived dendritic cells in steady state and inflammation. Immunol. Rev. 234, 90-104 (2010).
    • (2010) Immunol. Rev , vol.234 , pp. 90-104
    • Dominguez, P.M.1    Ardavin, C.2
  • 142
    • 84876668586 scopus 로고    scopus 로고
    • How does the brain limit the severity of inflammation and tissue injury during bacterial meningitis?
    • Neal J. W, & Gasque P. How does the brain limit the severity of inflammation and tissue injury during bacterial meningitis?. J. Neuropathol. Exp. Neurol. 72, 370-385 (2013).
    • (2013) J. Neuropathol. Exp. Neurol , vol.72 , pp. 370-385
    • Neal, J.W.1    Gasque, P.2


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