IL-1β is upregulated in the diabetic retina and retinal vessels: Cell-specific effect of high glucose and IL-1β autostimulation

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Liu, Yang ^a   Costa, Montserrat ^a   Gerhardinger, Chiara ^a  

^a SCHEPENS EYE RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 MACROGLOBULIN; CALPHOSTIN C; CERULOPLASMIN; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUCOSE; INTERLEUKIN 1 RECEPTOR TYPE I; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; PROTEIN KINASE C; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; AUTOCRINE EFFECT; CELL ACTIVATION; CELL SPECIFICITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOKINE PRODUCTION; DIABETIC RETINOPATHY; DISEASE COURSE; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; HYPERGLYCEMIA; IMMUNOBLOTTING; IN VITRO STUDY; MALE; MICROGLIA; MICROVASCULAR ENDOTHELIAL CELL; MOLECULAR DYNAMICS; MUELLER CELL; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PARACRINE SIGNALING; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RETINAL VASCULAR ENDOTHELIAL CELL; SELF STIMULATION; STREPTOZOCIN DIABETES; UPREGULATION;

ALPHA-MACROGLOBULINS; ANIMALS; ASTROCYTES; CERULOPLASMIN; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC RETINOPATHY; ENDOTHELIAL CELLS; ENDOTHELIUM; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUCOSE; HYPERGLYCEMIA; INTERLEUKIN-1BETA; MALE; MICROGLIA; NEUROGLIA; PROTEIN KINASE C; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RETINA; RETINAL VESSELS; UP-REGULATION;

RATTUS;

EID: 84861212022     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0036949     Document Type: Article

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