Retinal neurodegeneration may precede microvascular changes characteristic of diabetic retinopathy in diabetes mellitus

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 19, 2016, Pages E2655-E2664

  Sohn, Elliott H ^a   Van Dijk, Hille W ^b   Jiao, Chunhua ^a   Kok, Pauline H B ^b   Jeong, Woojin ^a   Demirkaya, Nazli ^b   Garmager, Allison ^a   Wit, Ferdinand ^b   Kucukevcilioglu, Murat ^a   Van Velthoven, Mirjam E J ^c   DeVries, J Hans ^b   Mullins, Robert F ^a   Kuehn, Markus H ^a   Schlingemann, Reinier Otto ^b   Sonka, Milan ^d,e   Verbraak, Frank D ^b   Abràmoff, Michael David ^a,d,e,f  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c Oogziekenhuis   (Netherlands)

^d UNIVERSITY OF IOWA   (United States)

^e IA United States   (United States)

^f VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Diabetes; Diabetic retinopathy; Neurodegeneration; Optical coherence tomography; Retina

Indexed keywords

GLYCOSYLATED HEMOGLOBIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DENSITY; DIABETES MELLITUS; DIABETIC RETINOPATHY; FEMALE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INSULIN DEPENDENT DIABETES MELLITUS; MALE; MOUSE; NERVE CELL; NERVE FIBER; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OPTICAL COHERENCE TOMOGRAPHY; PRIORITY JOURNAL; RETINA DEGENERATION; RETINAL INNER PLEXIFORM LAYER; RETINAL THICKNESS; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; ADULT; ANIMAL; C57BL MOUSE; DISEASE COURSE; LONGITUDINAL STUDY; MICROVASCULATURE; NEURODEGENERATIVE DISEASES; PATHOLOGY; PATHOPHYSIOLOGY; RETINAL DEGENERATION; SPECIES DIFFERENCE;

ADULT; ANIMALS; DIABETIC RETINOPATHY; DISEASE PROGRESSION; FEMALE; HUMANS; LONGITUDINAL STUDIES; MALE; MICE; MICE, INBRED C57BL; MICROVESSELS; NEURODEGENERATIVE DISEASES; RETINAL DEGENERATION; SPECIES SPECIFICITY;

EID: 84966359120     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1522014113     Document Type: Article

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