Activation of P2X7 receptor and NLRP3 inflammasome assembly in hippocampal glial cells mediates chronic stress-induced depressive-like behaviors

Journal of Neuroinflammation

Volumn 14, Issue 1, 2017, Pages

  Yue, Na ^a   Huang, Huijie ^a   Zhu, Xiaocang ^a   Han, Qiuqin ^a   Wang, Yalin ^a   Li, Bing ^a   Liu, Qiong ^a,b   Wu, Gencheng ^a   Zhang, Yuqiu ^a   Yu, Jin ^a  

^a FUDAN UNIVERSITY   (China)

^b Key Laboratory of Medical Imaging Computing Computer Assisted Intervention of Shanghai   (China)

Author keywords

Depression; EATP; Glia; NLRP3 inflammasome; P2X7 receptor

Indexed keywords

3-(5-(2,3-DICHLOROPHENYL)-1H-TETRAZOL-1-YL)METHYLPYRIDINE; ADENOSINE TRIPHOSPHATE; NALP1 PROTEIN, RAT; NERVE PROTEIN; PURINERGIC P2X RECEPTOR ANTAGONIST; PURINERGIC P2X7 RECEPTOR; PYRIDINE DERIVATIVE; TETRAZOLE DERIVATIVE;

ANIMAL; COMPLICATION; DEPRESSION; DISEASE MODEL; DRUG EFFECTS; EXPLORATORY BEHAVIOR; FOOD DEPRIVATION; GENETICS; GLIA; HEAT; HIPPOCAMPUS; MALE; MENTAL STRESS; METABOLISM; PATHOLOGY; PHYSIOLOGY; PSYCHOLOGY; RAT; SPRAGUE DAWLEY RAT; SWIMMING; TRANSGENIC RAT; WATER DEPRIVATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; DEPRESSION; DISEASE MODELS, ANIMAL; EXPLORATORY BEHAVIOR; FOOD DEPRIVATION; HIPPOCAMPUS; HOT TEMPERATURE; MALE; NERVE TISSUE PROTEINS; NEUROGLIA; PURINERGIC P2X RECEPTOR ANTAGONISTS; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RATS, TRANSGENIC; RECEPTORS, PURINERGIC P2X7; STRESS, PSYCHOLOGICAL; SWIMMING; TETRAZOLES; WATER DEPRIVATION;

EID: 85019092078     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/s12974-017-0865-y     Document Type: Article

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