The role of brain-derived neurotrophic factor genotype, parental depression, and relationship discord in predicting early-emerging negative emotionality

Psychological Science

Volumn 21, Issue 11, 2010, Pages 1678-1685

  Hayden, Elizabeth P ^a   Klein, Daniel N ^b   Dougherty, Lea R ^b   Olino, Thomas M ^b   Dyson, Margaret W ^b   Durbin, C ^c   Sheikh, Haroon I ^a   Singh, Shiva M ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b STONY BROOK UNIVERSITY   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

depression; emotional development; genetics; personality

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR;

AFFECT; ALLELE; ARTICLE; DEPRESSION; FAMILY CONFLICT; FEMALE; FRUSTRATION; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; HOMOZYGOTE; HUMAN; INHIBITION (PSYCHOLOGY); MALE; PRESCHOOL CHILD; PSYCHOLOGIC TEST; PSYCHOLOGICAL ASPECT; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; SOCIAL ENVIRONMENT;

AFFECT; ALLELES; BRAIN-DERIVED NEUROTROPHIC FACTOR; CHILD, PRESCHOOL; DEPRESSIVE DISORDER; FAMILY CONFLICT; FEMALE; FRUSTRATION; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HOMOZYGOTE; HUMANS; INHIBITION (PSYCHOLOGY); INTERVIEW, PSYCHOLOGICAL; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; SOCIAL ENVIRONMENT;

EID: 78649538841     PISSN: 09567976     EISSN: 14679280     Source Type: Journal    
DOI: 10.1177/0956797610385357     Document Type: Article

References (40)

1. Aguilera, M., Arias, B., Wichers, M., Barrantes-Vidal, N., Moya, J., Villa, H.,et al.(2009). Early adversity and 5-HTT/BDNF genes: New evidence of gene-environment interactions on depressive symptoms in a general population. Psychological Medicine, 39, 1425-1432.
2. Anthony, J.L., Lonigan, C.J., Hooe, E.S., & Phillips, B.M. (2002). An affect-based, hierarchical model of temperament and its relations with internalizing symptomatology. Journal of Clinical Child and Adolescent Psychology, 31, 480-490.
3. Belsky, J., & Pluess, M. (2009). Beyond diathesis-stress: Differential susceptibility to environmental influences. Psychological Bulletin, 135, 885-908.
4. Brown, T.A., Chorpita, B.F., & Barlow, D.H. (1998). Structural relationships among dimensions of the DSM-IV anxiety and mood disorders and dimensions of negative affect, positive affect, and autonomic arousal. Journal of Abnormal Psychology, 107, 179-192.
5. Bueller, J.A., Aftab, M., Sen, S., Gomez-Hassan, D., Burmeister, M., & Zubieta, J.-K. (2006). BDNF val66met allele is associated with reduced hippocampal volume in healthy subjects. Biological Psychiatry, 59, 812-815.
6. Chen, Z.-Y., Patel, P.D., Sant, G., Meng, C.-X., Teng, K.K., Hempstead, B.L., & Lee, F.S. (2004). Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. Journal of Neuroscience, 24, 4401-4411.
7. de Los Reyes, A., & Kazdin, A.E. (2005). Informant discrepancies in the assessment of childhood psychopathology: A critical review, theoretical framework, and recommendations for further study. Psychological Bulletin, 131, 483-509.
8. Duman, R.S., & Monteggia, L.M. (2006). A neurotrophic model for stress-related mood disorders. Biological Psychiatry, 59, 1116-1127.
9. Dunn, L.M., & Dunn, L.M. (1997). Peabody Picture Vocabulary Test (3rd ed.). Circle Pines, MN: American Guidance Service.
10. Durbin, C.E., Hayden, E.P., Klein, D.N., & Olino, T.M. (2007). Stability of laboratory-assessed temperamental emotionality traits from ages 3 to 7. Emotion, 7, 388-399.
11. Eddy, J.M., Heyman, R.E., & Weiss, R.L. (1991). An empirical evaluation of the Dyadic Adjustment Scale: Exploring the differences between marital satisfaction and adjustment. Behavioral Assessment, 13, 199-220.
12. Egan, M.F., Kojima, M., Callicott, J.H., Goldberg, T.E., Kolachana, B.S., & Bertolino, A. (2003). The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell, 112, 257-269.
13. Ellis, B.J., & Boyce, W.T. (2008). Biological sensitivity to context. Current Directions in Psychological Science, 17, 183-187.
14. First, M.B., Spitzer, R.L., Gibbon, M., & Williams, J.B.W. (1996). The Structured Clinical Interview for DSM-IV Axis I Disorders- Non-patient edition. New York, NY: New York State Psychiatric Institute, Biometrics Research Department.
15. Fox, N.A., Nichols, K.E., Henderson, H.A., Rubin, K., Schmidt, L., & Hamer, D. (2005). Evidence for a gene-environment interaction in predicting behavioral inhibition in middle childhood. Psychological Science, 16, 921-926.
16. Gagne, J.R., Vendlinski, M.K., & Goldsmith, H.H. (2009). The genetics of childhood temperament. In Y.-K. Kim (Ed.), Handbook of behavior genetics (pp. 251-267). New York, NY: Springer.
17. Glenn, N.D. (1998). The course of marital success and failure in five American 10-year marriage cohorts. Journal of Marriage and Family, 60, 569-576.
18. Goldsmith, H.H., Buss, K.A., & Lemery, K.S. (1997). Toddler and childhood temperament: Expanded content, stronger genetic evidence, new evidence for the importance of environment. Developmental Psychology, 33, 891-905.
19. Goldsmith, H.H., Reilly, J., Lemery, K.S., Longley, S., & Prescott, A. (1995). Laboratory Temperament Assessment Battery: Preschool version. Unpublished manuscript, University of Wisconsin-Madison.
20. Gonul, A.S., Akdeniz, F., Taneli, F., Donat, O., Eker, C., & Vahip, S. (2005). Effect of treatment on serum brain-derived neurotrophic factor levels in depressed patients. European Archives of Psychiatry and Clinical Neuroscience, 255, 381-386.
21. Goodman, S.H., & Gotlib, I.H. (1999). Children of depressed parents: Mechanisms of risk and implications for treatment. Washington, DC: American Psychological Association.
22. Gottesman, I.I., & Gould, T.D. (2003). The endophenotype concept in psychiatry: Etymology and strategic intentions. American Journal of Psychiatry, 160, 636-645.
23. Hasler, G., Drevets, W.C., Manji, H.K., & Charney, D.S. (2004). Discovering endophenotypes for major depression. Neuropsychopharmacology, 29, 1765-1781.
24. Hollingshead, A.B. (1975). Four factor index of social status. Unpublished manuscript, Yale University.
25. Kaufman, J., Yang, B.-Z., Douglas-Palumberi, H., Grasso, D., Lipschitz, D., Houshyar, S.,et al.(2006). Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children. Biological Psychiatry, 59, 673-680.
26. Kendler, K.S., Gatz, M., Gardner, C.O., & Pederson, N.L. (2006). Personality and major depression. Archives of General Psychiatry, 63, 1113-1120.
27. Kessler, R.C., Berglund, P., Demler, O., Jin, R., Merikangas, K.R., & Walters, E.E. (2005). Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey replication. Archives of General Psychiatry, 62, 593-602.
28. Lauer, C.J., Bronisch, T., Kainz, M., Schreiber, W., Holsboer, F., & Krieg, J.C. (1997). Pre-morbid psychometric profile of subjects at high familial risk for affective disorder. Psychological Medicine, 27, 355-362.
29. Moffitt, T.E., Caspi, A., & Rutter, M. (2006). Strategy for investigating interactions between measured genes and measured environments. Archives of General Psychiatry, 66, 488-497.
30. O'Brien, M., Margolin, G., John, R.S., & Krueger, L. (1991). Mothers' and sons' cognitive and emotional reactions to simulated marital and family conflict. Journal of Consulting and Clinical Psychology, 59, 692-703.
31. Pezawas, L., Verchinski, B.A., Mattay, V.S., Callicott, J.H., Kolachana, B.S., Straub, R.E.,et al.(2004). The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology. Journal of Neuroscience, 24, 10099-10102.
32. Repetti, R.L., Taylor, S.E., & Seeman, T.E. (2002). Risky families: Family social environments and the mental and physical health of offspring. Psychological Bulletin, 128, 330-366.
33. Schüle, C., Zill, P., Baghai, T.C., Eser, D., Zwanzger, P., Wenig, N.,et al.(2006). Brain-derived neurotrophic factor Val66Met polymorphism and dexamethasone/CRH test results in depressed patients. Psychoneuroendocrinology, 31, 1019-1025.
34. Shimizu, E., Hashimoto, K., Okamura, N., Koibe, K., Komatsu, N., Kumakiri, C.,et al.(2003). Alternations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biological Psychiatry, 54, 70-75.
35. Smith, M.A., Makino, S., Kvetnansky, R., & Post, R.M. (1995). Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus. Journal of Neuroscience, 15, 1768-1777.
36. Spanier, G.B. (1976). Measuring dyadic adjustment: New scales for assessing the quality of marriage and similar dyads. Journal of Marriage and Family, 38, 15-28.
37. Surtees, P.G., Wainwright, N.W., Willis-Owen, S.A., Luben, R., Day, N.E., & Flint, J. (2006). Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder. Biological Psychiatry, 59, 224-229.
38. Uher, R., & McGuffin, P. (2008). The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: Review and methodological analysis. Molecular Psychiatry, 13, 131-146.
39. Warner-Schmidt, J.L., & Duman, R.S. (2006). Hippocampal neuro-genesis: Opposing effects of stress and antidepressant treatment. Hippocampus, 16, 239-249.
40. Willis-Owen, S.A.G., Fullerton, J., Surtees, P.G., Wainwright, N.W.J., Miller, S., & Flint, J. (2005). The val66met coding variant of the brain-derived neurotrophic factor (BDNF) gene does not contribute toward variation in the personality trait neuroticism. Biological Psychiatry, 58, 738-742.