Quercetin suppress microglial neuroinflammatory response and induce antidepressent-like effect in olfactory bulbectomized rats

Neuroscience

Volumn 255, Issue , 2013, Pages 86-98

  Rinwa, P ^a   Kumar, A ^a  

^a PANJAB UNIVERSITY   (India)

Author keywords

Bioflavonoid; Depression; Immobility time; Microglial inhibitor; Neuroinflammation; Olfactory bulbectomy

Indexed keywords

CASPASE 3; CORTICOSTERONE; INTERLEUKIN 6; MINOCYCLINE; QUERCETIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDEPRESSANT ACTIVITY; ARTICLE; BRAIN CORTEX; CORTICOSTERONE BLOOD LEVEL; DEPRESSION; DRUG INHIBITION; DRUG POTENTIATION; HIPPOCAMPUS; HISTOPATHOLOGY; HYPERACTIVITY; INFLAMMATION; MALE; MICROGLIA; NERVE CELL INHIBITION; NEUROPROTECTION; NONHUMAN; OLFACTORY BULBECTOMY; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANALYSIS OF VARIANCE; ANOVA; BIOFLAVONOID; CORT; CORTICOSTERONE; DEPRESSION; EDTA; ELISA; ENZYME-LINKED IMMUNOSORBENT ASSAY; ETHYLENE DIAMINE TETRA-ACETIC ACID; FORCED SWIM TEST; FST; GLUTATHIONE; GSH; H(2)O(2); HPA; HYDROGEN PEROXIDE; HYPOTHALAMIC-PITUITARY-ADRENOCORTICAL; IL-6; IMMOBILITY TIME; INTERLEUKIN-6; LIPID PEROXIDATION; LPO; MALONDIALDEHYDE; MDA; MICROGLIAL INHIBITOR; NEUROINFLAMMATION; OBX; OLFACTORY BULBECTOMY; P-NITROANILINE; P.O.; PBS; PER ORAL; PHOSPHATE-BUFFERED SOLUTION; PNA; SOD; SUPEROXIDE DISMUTASE; TNF-Α; TUMOR NECROSIS FACTOR-Α;

ANIMALS; ANTIDEPRESSIVE AGENTS; BRAIN; DEPRESSION; DISEASE MODELS, ANIMAL; INFLAMMATION; LIPID PEROXIDATION; MALE; MICROGLIA; MINOCYCLINE; OLFACTORY BULB; OXIDATIVE STRESS; QUERCETIN; RATS; RATS, WISTAR;

EID: 84887158953     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2013.09.044     Document Type: Article

References (54)

1. Bhutada P., Mundhada Y., Bansod K., Ubgade A., Quazi M., Umathe S., Mundhada D. Reversal by quercetin of corticotrophin releasing factor induced anxiety- and depression-like effect in mice. Prog Neuropsychopharmacol Biol Psychiatry 2010, 34(6):955-960.
2. Bilici M., Efe H., Koroglu M.A., Uydu H.A., Bekaroǧlu M., Deǧer O. Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments. J Affect Disord 2001, 64:43-51.
3. Borre Y., Sir V., de Kivit S., Westphal K.G., Olivier B., Oosting R.S. Minocycline restores spatial but not fear memory in olfactory bulbectomized rats. Eur J Pharmacol 2012, 697(1-3):59-64.
4. Bureau G., Longpré F., Martinoli M.G. Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation. J Neurosci Res 2008, 86(2):403-410.
5. Burke N.N., Geoghegan E., Kerr D.M., Moriarty O., Finn D.P., Roche M. Altered neuropathic pain behaviour in a rat model of depression is associated with changes in inflammatory gene expression in the amygdala. Genes Brain Behav 2013, [Epub ahead of print]. 10.1111/gbb.12080.
6. Cairncross K.D., Wren A., Cox B., Schnieden H. Effects of olfactory bulbectomy and domicile on stress-induced corticosterone release in the rat. Physiol Behav 1977, 19:485-487.
7. Cho J.Y., Kim I.S., Jang Y.H., Kim A.R., Lee S.R. Protective effect of quercetin, a natural flavonoid against neuronal damage after transient global cerebral ischemia. Neurosci Lett 2006, 404:330-335.
8. D'Sa C., Duman R.S. Antidepressants and neuroplasticity. Bipolar Disord 2002, 4:183-194.
9. Ellman G.L., Courtney V., Andres R.M. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 1961, 7:88-95.
10. Familian A., Boshuizen R.S., Eikelenboom P., Veerhuis R. Inhibitory effect of minocycline on amyloid beta fibril formation and human microglial activation. Glia 2006, 53:233-240.
11. Gladkevich A., Bosker F., Korf J., Yenkoyan K., Vahradyan H., Aghajanov M. Proline-rich polypeptides in Alzheimer's disease and neurodegenerative disorders therapeutic potential or a mirage?. Prog Neuropsychopharmacol Biol Psychiatry 2007, 31(7):1347-1355.
12. Gornall A.G., Bardawill C.T., David M.M. Determination of serum proteins by means of Biuret reaction. J Biol Chem 1949, 177:751-766.
13. Green L.C., Wagner D.A., Glagowski J., Skipper P.L., Wishnok J.S., Tannenbaum S.R. Analysis of nitrate, nitrite and (15N) nitrate in biological fluids. Annal Biochem 1982, 126:131-138.
14. Hall R.D., Macrides R. Olfactory bulbectomy impairs the rat's radial maze behaviour. Physiol Behav 1983, 30:797-803.
15. Harwood M., Danielewska-Nikiel B., Borzelleca J.F., Flamm G.W., Williams G.M., Lines T.C. A critical review of the data related to the safety of quercetin and lack of evidence of in vivo toxicity, including lack of genotoxic/carcinogenic properties. Food Chem Toxicol 2007, 45:2179-2205.
16. Hayley S., Poulter M.O., Merali Z., Anisman H. The pathogenesis of clinical depression: stressor- and cytokine-induced alterations of neuroplasticity. Neuroscience 2005, 135:659-678.
17. Homsi S., Federico F., Croci N., Palmier B., Plotkine M., Marchand-Leroux C., Jafarian-Tehrani M. Minocycline effects on cerebral edema: relations with inflammatory and oxidative stress markers following traumatic brain injury in mice. Brain Res 2009, 1291:122-132.
18. Jaako-Movits K., Zharkovsky T., Pedersen M., Zharkovsky A. Decreased hippocampal neurogenesis following olfactory bulbectomy is reversed by repeated citalopram administration. Cell Mol Neurobiol 2006, 26:1559-1570.
19. Kawabata K., Kawai Y., Terao J. Suppressive effect of quercetin on acute stress-induced hypothalamic-pituitary-adrenal axis response in Wistar rats. J Nutr Biochem 2010, 21:374-380.
20. Kelly J.P., Wrynn A.S., Leonard B.E. The olfactory bulbectomized rat as a model of depression: an update. Pharmacol Ther 1997, 74:299-316.
21. Kelly K.A., Miller D.B., Bowyer J.F., O'Callaghan J.P. Chronic exposure to corticosterone enhances the neuroinflammatory and neurotoxic responses to methamphetamine. J Neurochem 2012, 122(5):995-1009.
22. Kitayama M., Ueno M., Itakura T., Yamashita T. Activated microglia inhibit axonal growth through RGMa. PLoS One 2011, 6(9):e25234.
23. Kono Y. Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase. Arch Biochem Biophys 1978, 186:189-195.
24. Kraus R.L., Pasieczny R., Lariosa-Willingham K., Turner M.S., Jiang A., Trauger J.W. Antioxidant properties of minocycline: neuroprotection in an oxidative stress assay and direct radical-scavenging activity. J Neurochem 2005, 94:819-827.
25. Krogh J., Benros M.E., Jørgensen M.B., Vesterager L., Elfving B., Nordentoft M. The association between depressive symptoms, cognitive function, and inflammation in major depression. Brain Behav Immun 2013, [Epub ahead of print]. 10.1016/j.bbi.2013.08.014.
26. Kukongviriyapan U., Sompamit K., Pannangpetch P., Kukongviriyapan V., Donpunha W. Preventive and therapeutic effects of quercetin on lipopolysaccharide-induced oxidative stress and vascular dysfunction in mice. Can J Physiol Pharmacol 2012, 90(10):1345-1353.
27. Kumar A., Sehgal N., Kumar P., Padi S.S., Naidu P.S. Protective effect of quercetin against ICV colchicine-induced cognitive dysfunctions and oxidative damage in rats. Phytother Res 2008, 22:1563-1569.
28. Lindqvist D., Hall S., Surova Y., Nielsen H.M., Janelidze S., Brundin L., Hansson O. Cerebrospinal fluid inflammatory markers in Parkinson's disease - associations with depression, fatigue, and cognitive impairment. Brain Behav Immun 2013, 33:183-189.
29. Luck H. Catalase. Methods of enzymatic analysis 1971, 885-893. Academic Press, New York. H.U. Bergmeyer (Ed.).
30. Machado D.G., Cunha M.P., Neis V.B., Balen G.O., Colla A., Grando J., Brocardo P.S., Bettio L.E., Capra J.C., Rodrigues A.L. Fluoxetine reverses depressive-like behaviors and increases hippocampal acetylcholinesterase activity induced by olfactory bulbectomy. Pharmacol Biochem Behav 2012, 103(2):220-229.
31. Maes M. The cytokine hypothesis of depression: inflammation, oxidative & nitrosative stress (IO&NS) and leaky gut as new targets for adjunctive treatments in depression. Neuroendocrinol Lett 2008, 29:287-291.
32. Molina M.F., Sanchez-Reus I., Iglesias I., Benedi J. Quercetin, a flavonoid antioxidant, prevents and protects against ethanol-induced oxidative stress in mouse liver. Biol Pharm Bull 2003, 26:1398-1402.
33. Mucignat-Caretta C., Bondi' M., Caretta A. Animal models of depression: olfactory lesions affect amygdala, subventricular zone and aggression. Neurobiol Dis 2004, 16:386-395.
34. Myint A.M., Steinbusch H.W., Goeghegan L., Luchtman D., Kim Y.K., Leonard B.E. Effect of the COX-2 inhibitor celecoxib on behavioural and immune changes in an olfactory bulbectomized rat model of depression. Neuroimmunomodulation 2007, 14:65-71.
35. Nesterova I.V., Bobkova N.V., Medvinskaya N.I., Samokhin A.N., Aleksandrova I.Y. Morphofunctional state of neurons in the temporal cortex and hippocampus in relation to the level of spatial memory in rats after ablation of the olfactory bulbs. Neurosci Behav Physiol 2008, 38:349-353.
36. O'Connor J.C., Lawson M.A., Andre C., Moreau M., Lestage J., Castanon N., Kelley K.W., Dantzer R. Lipopolysaccharide induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice. Mol Psychiatry 2009, 14:511-522.
37. Pariante C.P., Lightman S.L. The HPA axis in major depression: classical theories and new developments. Trends Neurosci 2008, 31:464-468.
38. Patel H.C., Ross F.M., Heenan L.E., Davies R.E., Rothwell N.J., Allan S.M. Neurodegenerative actions of interleukin-1 in the rat brain are mediated through increases in seizure activity. J Neurosci Res 2006, 83:385-391.
39. Porsolt R.D., Le Pichon M., Jalfre M. Depression: a new animal model sensitive to antidepressant treatments. Nature 1977, 266:730-732.
40. Raghavendra V., Chopra K., Kulkarni S.K. Brain renin angiotensin system (RAS) in stress-induced analgesia and impaired retention. Peptides 1999, 20:335-342.
41. Rinwa P., Kumar A. Quercetin along with piperine prevents cognitive dysfunction, oxidative stress and neuro-inflammation associated with mouse model of chronic unpredictable stress. Arch Pharm Res 2013, [Epub ahead of print]. 10.1007/s12272-013-0205-4.
42. Seabrook T.J., Jiang L., Maier M., Lemere C.A. Minocycline affects microglia activation, Abeta deposition, and behavior in APP-tg mice. Glia 2006, 53:776-782.
43. Selvakumar K., Bavithra S., Ganesh L., Krishnamoorthy G., Venkataraman P., Arunakaran J. Polychlorinated biphenyls induced oxidative stress mediated neurodegeneration in hippocampus and behavioral changes of adult rats: anxiolytic-like effects of quercetin. Toxicol Lett 2013, 222(1):45-54.
44. Silber R.H., Busch R.D., Oslapas R. Practical procedure for estimation of corticosterone or hydrocortisone. Clin Chem 1958, 4:278-285.
45. Song C., Leonard B.E. The olfactory bulbectomized rat as a model of depression. Neurosci Biobehav Rev 2005, 29:627-647.
46. Song C., Zhang X., Manku M. Increased phospholipase A2 activity and inflammatory response but decreased nerve growth factor expression in the olfactory bulbectomized rat model of depression: effects of chronic ethyl-eicosapentaenoate treatment. J Neurosci 2009, 29:14-22.
47. Streit W.J., Mrak R.E., Griffin W.S. Microglia and neuroinflammation: a pathological perspective. J Neuroinflamm 2004, 1:14.
48. Suzuki E., Yagi G., Nakaki T., Kanba S., Asai M. Elevated plasma nitrate levels in depressive states. J Affect Disord 2001, 63:221-224.
49. Tasset I., Medina F.J., Peña J., Jimena I., Del Carmen Muñoz M., Salcedo M., Ruiz C., Feijóo M., Montilla P., Túnez I. Olfactory bulbectomy induced oxidative and cell damage in rat: protective effect of melatonin. Physiol Res 2010, 59:105-112.
50. Ustun T.B., Ayuso-Mateos J.L., Chatterji S., Mathers C., Murray C.J. Global burden of depressive disorders in the year 2000. Br J Psychiatry 2004, 184:386-392.
51. Van Reizen H., Leonard B.E. Effects of psychotropic drugs on the behaviour and neurochemistry of olfactory bulbectomised rats. Pharmacol Ther 1990, 47:21-34.
52. Willner P. Animal models of depression: an overview. Pharmacol Ther 1990, 45:425-455.
53. Wills E.D. Mechanism of lipid peroxide formation in animal tissues. Biochem J 1966, 99:667-676.
54. Wu C.H., Wu C.F., Huang H.W., Jao Y.C., Yen G.C. Naturally occurring flavonoids attenuate high glucose-induced expression of proinflammatory cytokines in human monocytic THP-1 cells. Mol Nutr Food Res 2009, 53(8):984-995.