Extracellular ATP enhances radiation-induced brain injury through microglial activation and paracrine signaling via P2X7 receptor

Brain, Behavior, and Immunity

Volumn 50, Issue , 2015, Pages 87-100

  Xu, Pengfei ^a   Xu, Yongteng ^a   Hu, Bin ^a   Wang, Jue ^a   Pan, Rui ^a   Murugan, Madhuvika ^b   Wu, Long Jun ^b   Tang, Yamei ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

BBG; COX 2; Extracellular ATP; IL 6; Inflammation; Microglia; P2X7R; Radiation induced brain injury; TNF

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PURINERGIC P2X7 RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN INJURY; BRAIN RADIATION; CANCER RADIOTHERAPY; CELL PROLIFERATION; CEREBROSPINAL FLUID; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; GLIA CELL; HIPPOCAMPUS; HUMAN; MALE; MICROGLIA; MOUSE; NASOPHARYNX CARCINOMA; NEWBORN; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; RADIATION INJURY; SPATIAL MEMORY; ADVERSE EFFECTS; ANIMAL; BRAIN; BRAIN INJURIES; CELL CULTURE; COMPLICATION; DRUG EFFECTS; FEMALE; INFLAMMATION; METABOLISM; RADIATION RESPONSE; RADIOTHERAPY; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATE; ANIMALS; BRAIN; BRAIN INJURIES; CELLS, CULTURED; FEMALE; HUMANS; INFLAMMATION; MALE; MICE; MICROGLIA; PARACRINE COMMUNICATION; RADIATION INJURIES; RADIOTHERAPY; RECEPTORS, PURINERGIC P2X7; SIGNAL TRANSDUCTION;

EID: 84935524352     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2015.06.020     Document Type: Article

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