P2X7R/cryopyrin inflammasome axis inhibition reduces neuroinflammation after SAH

Neurobiology of Disease

Volumn 58, Issue , 2013, Pages 296-307

  Chen, Sheng ^a,b   Ma, Qingyi ^b   Krafft, Paul R ^b   Hu, Qin ^b   Rolland, William ^b   Sherchan, Prativa ^b   Zhang, Jianmin ^a   Tang, Jiping ^b   Zhang, John H ^b  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cryopyrin; Early brain injury; Edema; Inflammation; P2X purinoceptor 7; Subarachnoid hemorrhage

Indexed keywords

CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LIPOPOLYSACCHARIDE; PURINERGIC P2X7 RECEPTOR; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN WATER; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISEASE SEVERITY; ENZYME ACTIVATION; ENZYME INHIBITION; IMMUNOFLUORESCENCE; IN VIVO STUDY; MALE; NERVOUS SYSTEM INFLAMMATION; NEUROBEHAVIORAL TEST; NONHUMAN; PRIORITY JOURNAL; RAT; SUBARACHNOID HEMORRHAGE; WESTERN BLOTTING;

ADENOSINE TRIPHOSPHATE; ANALYSIS OF VARIANCE; ANOVA; APOPTOSIS-ASSOCIATED SPECK-LIKE PROTEIN CONTAINING A CAED; ASC; ATP; BBG; BENZOYLBENZOYL-ATP; BRILLIANT BLUE G; BZATP; CENTRAL NERVOUS SYSTEM; CNS; CRYOPYRIN; EARLY BRAIN INJURY; EBI; EDEMA; IACUC; IL-1Β; INFLAMMATION; INSTITUTIONAL ANIMAL CARE AND USE COMMITTEE; INTERLEUKIN-1Β; LIPOPOLYSACCHARIDE; LPS; MPO; MYELOPEROXIDASE; NF-ΚB; NLR; NUCLEAR FACTOR-KAPPA B; NUCLEOTIDE-BINDING DOMAIN, LEUCINE-RICH REPEAT CONTAINING; P2X PURINOCEPTOR 7; P2X7R; SAH; SD; SIRNA; SMALL INTERFERING RNA; SPRAGUE-DAWLEY; SUBARACHNOID HEMORRHAGE; TLR4; TOLL-LIKE RECEPTOR 4;

ADENOSINE TRIPHOSPHATE; ANIMALS; BRAIN EDEMA; CYTOKINES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENCEPHALITIS; INJECTIONS, INTRAVENTRICULAR; LIPOPOLYSACCHARIDES; MALE; PLATELET AGGREGATION INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, PURINERGIC P2X7; RNA, SMALL INTERFERING; ROSANILINE DYES; SIGNAL TRANSDUCTION; SUBARACHNOID HEMORRHAGE;

EID: 84880601342     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2013.06.011     Document Type: Article

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