A review of the relationship between proinflammatory cytokines and major depressive disorder

Journal of Affective Disorders

Volumn 169, Issue , 2014, Pages 15-20

  Young, Juan Joseph ^a   Bruno, Davide ^b   Pomara, Nunzio ^a,c  

^a NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^b LIVERPOOL HOPE UNIVERSITY   (United Kingdom)

^c NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Immune activation; Inflammatory hypothesis; Major depressive disorder; Neuroimaging; Proinflammatory cytokines

Indexed keywords

ANTIDEPRESSANT AGENT; ANTIINFLAMMATORY AGENT; C REACTIVE PROTEIN; CYTOKINE; INTERLEUKIN 1; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA; CHEMOKINE; AUTACOID;

ADJUVANT THERAPY; ARTICLE; CYTOKINE PRODUCTION; DISEASE COURSE; DISEASE SEVERITY; HUMAN; MAJOR DEPRESSION; NEAR INFRARED SPECTROSCOPY; NEUROIMAGING; NEUROPATHOLOGY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN CEREBROSPINAL FLUID LEVEL; RANDOMIZED CONTROLLED TRIAL (TOPIC); CEREBROSPINAL FLUID; DEPRESSION; DRUG EFFECT; REVIEW; STRESS; ADULT; BLOOD; BRAIN; DEPRESSIVE DISORDER, MAJOR; PATHOPHYSIOLOGY;

ADULT; ANTI-INFLAMMATORY AGENTS; BRAIN; CYTOKINES; DEPRESSIVE DISORDER, MAJOR; DISEASE PROGRESSION; HUMANS; INFLAMMATION MEDIATORS; NEUROIMAGING;

EID: 84906331370     PISSN: 01650327     EISSN: 15732517     Source Type: Journal    
DOI: 10.1016/j.jad.2014.07.032     Document Type: Review

References (60)

1. F. Amico, E. Meisenzahl, N. Koutsouleris, M. Reiser, H.J. Möller, and T. Frodl Structural MRI correlates for vulnerability and resilience to major depressive disorder J. Psychiatry Neurosci. 36 1 2011 15 22
2. R. Azar, and D. Mercer Mild depressive symptoms are associated with elevated C-reactive protein and proinflammatory cytokine levels during early to midgestation: a prospective pilot study J. Womens Health 22 4 2013 385 389
3. S. Akhondzadeh, S. Jafari, F. Raisi, A.A. Nasehi, A. Ghoreishi, B. Salehi, S. Mohebbi-Rasa, M. Raznahan, and A. Kamalipour Clinical trial of adjunctive Celecoxib treatment in patients with major depression: a double blind and placebo controlled trial Depress. Anxiety 26 2009 607 611
4. G. Banisadr, W. Rostène, P. Kitabgi, and S.M. Parsadaniantz Chemokines and brain functions Curr. Drug Targets Inflamm. Allergy 4 2005 387 399 (Pubitemid 40879603)
5. W.A. Banks Blood-brain barrier transport of cytokines: a mechanism for neuropathology Curr. Pharm. Des. 11 2005 973 984 (Pubitemid 40331299)
6. G.M. Barton, and J.C. Kagan A cell biological view of toll-like receptor function: regulation through compartmentalization Nat. Rev. Immunol. 9 2009 535 542
7. L.L. Carpenter, G.R. Heninger, R.T. Malison, A.R. Tyrka, and L.H. Price Cerebrospinal fluid interleukin (IL)-6 in unipolar major depression J. Affect. Disord. 79 2004 285 289 (Pubitemid 38340558)
8. D. Christmas, J.D. Steele, S. Tolomeo, M.S. Eljamel, and K. Matthews Vagus nerve stimulation for chronic major depressive disorder: 12-month outcomes in highly tretment-refractory patients J. Affect. Disord. 150 2013 1221 1225
9. R. Dantzer Cytokine, sickness behavior, and depression Neurol. Clin. 24 3 2006 441 460 (Pubitemid 44108539)
10. C. Fields, L. Drye, and V. Vaidya Celecoxib or Naproxen treatment does not benefit depressive symptoms in persons age 70 and older: findings from a randomized controlled trial Am. J. Geriatr. Psychiatry 20 6 2012 505 513
11. L.R. Frick, K. Williams, and C. Pittenger Microglial dysregulation in Ppsychiatric diseases Clin. Dev. Immunol. 2013 2013 608654
12. A. Friebe, C. Brünahl, K. Karimi, M. Schäfer, G. Juckel, B. Sakic, and P. Arck Effects of complete vagotomy and blockage of cell adhesion molecules on interferon-α induced behavioral changes in mice Behav. Brain Res. 240 2013 1 10
13. T. Frodl, and F. Amico Is there an association between peripheral immune markers and structural/functional neuroimaging findings? Prog. Neuropsychopharmacol. Biol. Psychiatry 48 2014 295 303
14. I. Goshen, T. Kreisel, O. Ben-Menachem-Zidon, T. Licht, J. Weidenfeld, T. Ben-Hur, and R. Yirmiya Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression Mol. Psychiatry 13 7 2008 717 728 (Pubitemid 351861529)
15. I. Goshen, and R. Yirmiya Interleukin-1 (IL-1) a central regulator of stress responses Front. Neuroendocrinol. 30 1 2009 30 45
16. I.H. Gotlib, and J.P. Hamilton Neuroimaging and Depression Curr. Dir. Psychol. Sci. 17 2 2008 159 163
17. A. Harada, N. Sekido, T. Akahoshi, T. Wada, N. Mukaida, and K. Matsushima Essential involvement of interleukin-8 (IL-8) in acute inflammation J. Leukoc. Biol. 56 5 1994 559 564 (Pubitemid 24348812)
18. N.A. Harrison, L. Brydon, C. Walker, M.A. Gray, A. Steptoe, and H.D. Critchley Inflammation causes mood changes through alterations in subgenual cingulate activity and mesolimbic connectivity Biol. Psychiatry 66 2009 407 414
19. S. Hayley, M.O. Poulter, Z. Merali, and H. Anisman The pathogenesis of clinical depression: stressor- and cytokine-induced alterations of neuroplasticity Neuroscience 135 2005 659 678 (Pubitemid 41407732)
20. A. Karson, T. Demirtas, D. Bayramgürler, F. Balc, and T. Utkan Chronic administration of Infliximab (TNF-α Inhibitor) decreases depression and anxiety-like behaviour in rat model of chronic mild stress Basic Clin. Pharmacol. Toxicol. 112 2013 335 340
21. S. Kern, I. Skoog, A. Börjesson-Hanson, K. Blennow, H. Zetterberg, S. Östling, J. Kern, P. Gudmundsson, T. Marlow, L. Rosengren, and M. Waern Lower CSF interleukin-6 predicts future depression in a population-based sample of older women followed for 17 years Brain Behav. Immun. 32 2013 153 158
22. R.C. Kessler, P. Berglund, O. Demler, R. Jin, D. Koretz, K.R. Merikangas, and A.J. Rush The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R) JAMA 289 23 2003 3095 3105 (Pubitemid 37432885)
23. J.P. Konsman, G.N. Luheshi, R.M. Bluthé, and R. Dantzer The vagus nerve mediates behavioural depression, but not fever, in response to peripheral immune signals; a functional anatomical analysis Eur. J. Neurosci. 12 2000 4434 4446 (Pubitemid 32037852)
24. S.G. Kornstein, and R.K. Schneider Clinical features of treatment-resistant depression J. Clin. Psychiatry 62 Suppl 16 2001 S18 S25
25. M.A. Lawson, R.H. McCusker, and K.W. Kelly Interleukin-1 beta converting enzyme is necessary for development of depression-like behavior following intracerebroventricular administration of lipoplysccharide to mice J. Neuroinflamm. 10 2013 54
26. S. Layé, R.M. Bluthé, S. Kent, C. Combe, C. Médina, P. Parnet, K. Kelley, and R. Dantzer Subdiaphragmatic vagotomy blocks induction of IL-1 beta mRNA in mice brain in response to peripheral LPS Am. J. Physiol. 268 5 Pt 2 1995 R1327 R1331
27. S.M. Lehto, L. Niskanen, K.H. Herzig, T. Tolmunen, A. Huotari, H. Viinamäki, H. Koivumaa-Honkanen, K. Honkalampi, H. Ruotsalainen, and J. Hintikka Serum chemokine levels in major depressive disorder Psychoneuroendocrinology 35 2010 226 232
28. J. Levine, Y. Barak, K.N.R. Chengappa, A. Rapoport, and M. Rebey Cerebrospinal cytokine levels in patients with acute depression Neuropsychobiology 40 1999 171 176 (Pubitemid 29515729)
29. D. Lindqvist, S. Janelidze, P. Hagell, S. Erhardt, M. Samuelsson, L. Minthon, O. Hansson, M. Björkqvist, L. Träskman-Bendz, and L. Brundin Interleukin-6 is elevated in the cerebrospinal fluid of suicide attempters and related to symptom severity Biol. Psychiatry 66 3 2009 287 292
30. D. Lindqvist, S. Janelidze, S. Erhardt, L. Träskman-Bendz, G. Engström, and L. Brundin CSF biomarkers in suicide attempters - a principle component analysis Acta Psychiatr. Scand. 124 1 2011 52 61
31. S.F. Maier, and L.R. Watkins Cytokines for psychologists: implications of bidirectional immune-to brain communication for understanding behavior, mood, and cognition Psychol. Rev. 105 1 1998 83 107 (Pubitemid 128459559)
32. K.M. Malone Suicidal ideation is associated with elevated inflammation in patients with major depressive disorder Depress. Anxiety 30 2013 307 314
33. R.K. McNamara, and F.E. Lotrich Elevated immune-inflammatory signaling in mood disorders: a new therapeutic target? Expert Rev. Neurother. 12 9 2012 1143 1161
34. J.E. Merrill, and G.M. Jonakait Interactions of the nervous and immune systems in development, normal brain homeostasis, and disease FASEB J. 9 8 1995 611 618
35. A.H. Miller, and C.L. Raison Cytokines, p38 MAP kinase and the pathophysiology of depression Neuropsychopharmacology 31 2006 2089 2090 (Pubitemid 44413187)
36. A.H. Miller, V. Maletic, and C.L. Raison Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression Biol. Psychiatry 65 9 2009 732 741
37. S.S. Morimoto, and G.S. Alexopoulos Immunity, aging, and geriatric depression Psychiatr. Clin. North Am. 34 2 2011 437 449 10.1016/j.psc.2011.02. 006
38. N. Müller, and M.J. Schwarz The immune-mediated alteration of serotonin and glutamate: towards an integrated view of depression Mol. Psychiatry 12 2007 988 1000 (Pubitemid 350006207)
39. N. Müller The role of anti-inflammatory treatment in psychiatric disorders Psychiatr. Danub. 25 3 2013 292 298
40. A. Munzer, U. Sack, R. Mergl, J. Schönherr, C. Petersein, S. Bartsch, K.C. Kirkby, K. Bauer, and H. Himmerich Impact of antidepressants on cytokine production of depressed patients in Vitro Toxins (Basel) 5 11 2013 2227 2240
41. S.M. O'Brien, P. Scully, P. Fitzgerald, L.V. Scott, and T.G. Dinan Plasma cytokine profiles in depressed patients who fail to respond to selective serotonin reuptake inhibitor therapy J. Psychiatr. Res. 41 3-4 2007 326 331 (Pubitemid 44854992)
42. A. O'Donavan, G. Rush, G. Hoatam, B.M. Hughes, A. McCrohan, C. Kelleher, C. O'Farrelly, A.H. Miller, E. Haroon, C.L. Raison, and J.C. Felger Cytokine targets in the brain: Impact on neurotransmitters and neurocircuits Depress. Anxiety 30 2013 297 306
43. C.L. Raison, L. Capuron, and A.H. Miller Cytokines sing the blues: inflammation and the pathogenesis of depression Trends Immunol. 27 1 2006 24 31 (Pubitemid 43083561)
44. C.L. Raison, A.S. Borisov, M. Majer, D.F. Drake, G. Pagnoni, B.J. Woolwine, G.J Vogt, B. Massung, and A.H. Miller Activation of central nervous system inflammatory pathways by interferon-alpha: relationship to monoamines and depression Biol. Psychiatry 65 2009 296 303
45. C.L. Raison, R. Dantzer, K.W. Kelly, M.A. Lawson, B.J. Woolwine, G. Vogt, J.R. Spivey, K. Saito, and A.H. Miller CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-α: relationships to CNS immune responses and depression Mol. Psychiatry 15 2010 393 403
46. C.L. Raison, R.E. Rutherford, B.J. Woolwine, C. Shuo, P. Schettler, D.F. Drake, E. Haroon, and A.H. Miller A randomized controlled trial of the tumor necrosis factor antagonist Infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers JAMA Psychiatry 70 1 2013 31 41
47. R.M. Sapolsky, L.C. Krey, and B.S. McEwen The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis Endocr. Rev. 7 3 1986 284 301
48. S.C. Saris, S.A. Rosenberg, R.B. Friedman, J.T. Rubin, D. Barba, and E.H. Oldfield Penetration of recombinant interleukin-2 across the blood-cerebrospinal fluid barrier J. Neurosurg. 69 1 1988 29 34
49. H.D. Schmidt, R.C. Shelton, and R.S. Duman Function biomarkers of depression: diagnosis, treatment, and pathophysiology Neuropsychopharmacology 36 2011 2375 2394
50. N.M. Simon, K. McNamara, C.W. Chow, R.S. Maser, G.I. Papakostas, M.H. Pollack, A.A. Nierenberg, and M. Fava A detailed examination of cytokine abnormalities in Major Depressive Disorder Eur. Neuropsychopharmacol. 18 3 2008 230 233
51. G.M. Slavich, B.M. Way, N.I. Eisenberger, and S.E. Taylor Neural sensitivity to social rejection is associated with inflammatory responses to social stress Proc. Natl. Acad. Sci. U. S. A. 107 33 2010 14817 14822
52. G.M. Slavich, and M.R. Irwin From stress to inflammation and major depressive disorder: a social signal transduction theory of depression Psychol. Bull. 140 3 2014 774 815
53. S. Stübner, T. Schön, F. Padberg, S.J. Teipel, M.J. Schwarz, A. Haslinger, K. Buch, R. Dukoff, R. Lasser, N. Müller, T. Sunderland, S.I. Rapoport, H.J. Möller, and H. Hampel Interleukin-6 and the soluble IL-6 receptor are decreased in cerebrospinal fluid of geriatric patients with major depression: no alteration of soluble gp130 Neurosci. Lett. 259 1999 145 148 (Pubitemid 29059605)
54. E.C. Suarez, R.R. Krishnan, and J.G. Lewis The relation of severity of depressive symptoms to monocyte-associated proinflammatory cytokines and chemokines in apparently healthy men Pscyhosom Med. 65 2003 362 368 (Pubitemid 36628888)
55. E.C. Suarez, J.G. Lewis, R.R. Krishnan, and K.H. Young Enhanced expression of cytokines and chemokines by blood monocytes to in vitro lipopolysaccharide stimulation are associated with hostility and severity of depressive symptoms in healthy women Psychoneuroendocrinology 29 2004 1119 1128 (Pubitemid 38829173)
56. M.E. Sublette, H.C. Galfalvy, D. Fuchs, M. Lapidus, M.F. Grunebaum, M.A. Oquendo, J.J. Mann, and T.T. Postolache Plasma kynurenine levels are elevated in suicide attempters with major depressive disorder Brain Behav. Immun. 25 2011 1272 1278
57. R. Takizawa, M. Fukuda, S. Kawasaki, K. Kasai, M. Mimura, S. Pu, T. Noda, S. Niwa, and Y. Okazaki Neuroimaging-aided differential diagnosis of the depressive state NeuroImage 85 Pt 1 2014 498 507
58. A.J. Thomas, S. Davis, C. Morris, E. Jackson, R. Harrison, and J.T. O'Brien Increase in interleukin-1β in late-life depression Am. J. Psychiatry 162 2005 175 177
59. A.K. Walker, A. Kavelaars, C.J. Heijen, and R. Dantzer Neuroinflammation and comorbidity of pain and depression Pharmacol. Rev. 66 2014 80 101
60. M.N. Woodroofe Cytokine production in the central nervous system Neurology 45 6 1995 S6 S10