Production of pro-inflammatory cytokines correlates with the symptoms of acute sickness behaviour in humans

Psychological Medicine

Volumn 34, Issue 7, 2004, Pages 1289-1297

  Vollmer Conna, Ute ́ ^a,b,c   Fazou, C ^a,b,c   Cameron, B ^a,b,c   Li, H ^a,b,c   Brennan, C ^a,b,c   Luck, L ^a,b,c   Davenport, T ^a,b,c   Wakefield, D ^a,b,c   Hickie, I ^a,b,c   Lloyd, A ^a,b,c  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c National Depression Initiative   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 6;

ACUTE DISEASE; ADOLESCENT; ADULT; ANHEDONIA; ANOREXIA; ARTHRALGIA; ARTICLE; BIOLOGICAL MONITORING; BLOOD SAMPLING; CELL CULTURE; CONCENTRATION LOSS; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DEPRESSION; DIAGNOSTIC VALUE; DIFFERENTIAL DIAGNOSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; EPSTEIN BARR VIRUS; FATIGUE; FEMALE; FEVER; HEADACHE; HUMAN; HUMAN CELL; ILLNESS BEHAVIOR; IMMUNE RESPONSE; IMMUNE SYSTEM; MAJOR CLINICAL STUDY; MALAISE; MALE; MENTAL DISEASE; MOOD DISORDER; MYALGIA; PAIN; PERIPHERAL BLOOD MONONUCLEAR CELL; PSYCHOSOMATIC DISORDER; Q FEVER; ROSS RIVER ALPHA VIRUS; SELF REPORT; VIRUS INFECTION;

EID: 8744242039     PISSN: 00332917     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0033291704001953     Document Type: Article

References (31)

1. Anisman, H. & Merali, Z. (2003). Cytokines, stress and depressive illness: brain immune interaction. Annals of Medicine 35, 2-11.
2. Capo, C., Zaffran, Y., Zugun, F., Houpikian, P., Raoult, D. & Mege, J. L. (1996). Production of Interleukin-10 and Transforming Growth Factor β by peripheral blood mononuclear cells in Q fever endocarditis. Infection and Immunity 64, 4143-4147.
3. Capuron, L., Hauser, P., Hinze-Selch, D., Miller, A. & Neveu, P. J. (2002). Treatment of cytokine-induced depression. Brain, Behavior and Immunity 16, 575-580.
4. Capuron, L., Lamarque, D., Dantzer, R. & Goodall, G. (1999). Attentional and mnemonic deficits associated with infectious diseases in humans. Psychological Medicine 29, 291-297.
5. Charlton, B. G. (2000). The malaise theory of depression: major depressive disorder is sickness behaviour and antidepressants are analgesics. Medical Hypotheses 54, 126-130.
6. Dantzer, R., Bluthe, R.-M., Aubert, A., Goodall, G., Bret-Dibat, J.-L., Kent, S., Goujon, E., Laye, S., Parnet, P. & Kelley, K. W. (1996). Cytokine actions on behavior. In Cytokines in the Nervous System (ed. N. J. Rothwell), pp. 117-144. R. G. Landes Co.: Austin, USA.
7. Dinarello, C. A. (1997). Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shock. Chest 112, 312S-329S.
8. Eysenck, H. J. (1994). Neuroticism and the illusion of mental health. American Psychologist 49, 971-972.
9. Eysenck, H. J. & Eysenck, S. B. G. (1975). Manual of the Eysenck Personality Questionnaire. Hodder & Stoughton: London.
10. Goehler, L. E., Gaykema, R. P., Nguyen, K. T. et al. (1999). Interleukin-1β in immune cells of the abdominal vagus nerve: a link between the immune and nervous system? Journal of Neuroscience 19, 2799-2806.
11. Goldberg, D. & Williams, P. (1988). A User's Guide to the General Health Questionnaire. NFER-NELSON: Windsor, Berks., UK.
12. Hart, B. L. (1988). Biological basis of the behavior of sick animals. Neuroscience and Biobehavioral Reviews 12, 123-137.
13. Hickie, I. & Lloyd, A. (1995). Are cytokines associated with neuropsychiatric syndromes in humans? International Journal of Immunopharmacology 17, 677-683.
14. Hickie, I. B., Davenport, T. A., Hadzi-Pavlovic, D., Koschera, A., Naismith, S. L., Scott, E. M. & Wilhelm, K. A. (2001). Development of a simple screening tool for common mental disorders in general practice. Medical Journal of Australia 175, S2-S9.
15. Imboden, J. B., Canter, A. & Cluff, L. E. (1961). Convalescence from influenza. Archives of Internal Medicine 108 115-121.
16. Irwin, I. (2002). Effects of sleep and sleep loss on immunity and cytokines. Brain, Behavior & Immunity 16, 503-512.
17. Konsman, J. P., Parnet, P. & Dantzer, R. (2002). Cytokine-induced sickness behaviour: mechanisms and implications. Trends in Neurosciences 25, 154-159.
18. Lutgendorf, S. K., Garand, L., Buckwalter, K. C., Reimer, T. T., Hong, S.-Y. & Lubaroff, D. M. (1999). Life stress, mood disturbance, and elevated interleukin-6 in healthy older women. Journal of Gerontology: Medical Sciences 54, M434-M439.
19. Maes, M. (1999). Psychological stress, cytokines and the inflammatory response system. Current Opinion in Psychiatry 12, 695-700.
20. Maier, S. F. & Watkins, L. R. (1999). Bidirectional communication between the brain and the immune system: implications for behaviour. Animal Behaviour 57, 741-751.
21. Papanicolaou, D. A., Wilde, R. L., Manolagas, S. C. & Chrousos, G. P. (1999). The pathophysiologic roles of interleukin-6 in human disease. Annals of Internal Medicine 128, 127-137.
22. Pollmacher, T., Haak, M., Schuld, A., Reichenberg, A. & Yirmiya, R. (2002). Low levels of inflammatory circulating cytokines - Do they affect brain function? Brain, Behavior & Immunity 16, 525-532.
23. Rothwell, N. J. & Hopkins, S. J. (1995). Cytokines and the nervous system: actions and mechanisms of action. Trends in Neuroscience 18, 130-136.
24. Renault, P. F. & Hoofnagel, J. H. (1989). Side effects of alpha interferon. Seminars in Liver Disease 9, 273-277.
25. Saper, C. B. & Breder, C. D. (1994). The neurologic basis of fever. New England Journal of Medicine 330, 1880-1886.
26. Smith, A., Thomas, M. & Whitney, H. (2000). Effects of upper respiratory tract illness on mood and performance over the working day. Ergonomics 43, 752-763.
27. Smith, A. P., Tyrrell, D. A. J., Al-Nakib, W., Coyle, K. B., Donovan, C. B., Higgins, P. G. & Willman, J. S. (1987). Effects of experimentally induced respiratory virus infections and illness on psychomotor performance. Neuropsychology 18, 144-148.
28. Vollmer-Conna, U. (2001). Acute sickness behaviour: an immune system-to-brain communication? Psychological Medicine 31 761-767.
29. Vollmer-Conna, U., Lloyd, A., Hickie, I. & Wakefield, D. (1998). Chronic fatigue syndrome: an immunological perspective. Australian and New Zealand Journal of Psychiatry 32, 523-527.
30. Vollmer-Conna, U., Wakefield, D., Lloyd, A., Hickie, I., Lemon, J., Bird, K. D. & Westbrook, R. F. (1997). Cognitive deficits in patients suffering from chronic fatigue syndrome, acute infective illness or depression. British Journal of Psychiatry 171, 377-391.
31. Westley-Wise, V. J., Beard, J. R., Sladden, T. J., Dunn, T. M. & Simpson, J. (1996). Ross River virus infection on the North Coast of New South Wales. Australian and New Zealand Journal of Public Health 20, 87-92.