Chronic glucocorticoids exposure enhances neurodegeneration in the frontal cortex and hippocampus via NLRP-1 inflammasome activation in male mice

Brain, Behavior, and Immunity

Volumn 52, Issue , 2016, Pages 58-70

  Hu, Wen ^a   Zhang, Yaodong ^a   Wu, Wenning ^a   Yin, Yanyan ^a   Huang, Dake ^a   Wang, Yuchan ^a   Li, Weiping ^a   Li, Weizu ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Alzheimer's disease; Glucocorticoids; Locomotor behavior; Neurodegenerative diseases; Neuroinflammation; NLRP1 inflammasome

Indexed keywords

APOPTOSIS ASSOCIATED SPECK LIKE PROTEIN; APOPTOSIS REGULATORY PROTEIN; CASPASE 5; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; MESSENGER RNA; MICROTUBULE ASSOCIATED PROTEIN 2; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR PYRIN DOMAIN CONTAINING 1; UNCLASSIFIED DRUG; CYTOSKELETON PROTEIN; DEXAMETHASONE; INTERLEUKIN DERIVATIVE; NALP1 PROTEIN, MOUSE; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; EXPLORATORY BEHAVIOR; FRONTAL CORTEX; GENE EXPRESSION; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; HIPPOCAMPUS; LONG TERM EXPOSURE; MALE; MOTOR ACTIVITY; MOUSE; NERVE CELL LESION; NERVE DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; WEIGHT REDUCTION; ANIMAL; DRUG EFFECTS; FRONTAL LOBE; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; PATHOLOGY; RANDOMIZATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; APOPTOSIS REGULATORY PROTEINS; CASPASE 1; CYTOSKELETAL PROTEINS; DEXAMETHASONE; FRONTAL LOBE; HIPPOCAMPUS; INFLAMMASOMES; INTERLEUKINS; MALE; MICE; MICE, INBRED ICR; NF-KAPPA B; RANDOM ALLOCATION; RECEPTORS, GLUCOCORTICOID;

EID: 84953360204     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2015.09.019     Document Type: Article

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