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Volumn 127, Issue 4, 2017, Pages 1241-1253

FOXP1 controls mesenchymal stem cell commitment and senescence during skeletal aging

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CCAAT ENHANCER BINDING PROTEIN BETA; CCAAT ENHANCER BINDING PROTEIN DELTA; CYCLIN DEPENDENT KINASE INHIBITOR 2A; IMMUNOGLOBULIN KAPPA CHAIN; RECOMBINANT PROTEIN; TRANSCRIPTION FACTOR FOXP1; TRANSCRIPTION FACTOR FOXP2; UNCLASSIFIED DRUG; CEBPB PROTEIN, HUMAN; CEBPB PROTEIN, MOUSE; CEBPD PROTEIN, HUMAN; CEBPD PROTEIN, MOUSE; FORKHEAD TRANSCRIPTION FACTOR; FOXP1 PROTEIN, HUMAN; FOXP1 PROTEIN, MOUSE; REPRESSOR PROTEIN;

EID: 85018701648     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI89511     Document Type: Article
Times cited : (134)

References (73)
  • 1
    • 0036724870 scopus 로고    scopus 로고
    • Adipocytic proportion of bone marrow is inversely related to bone formation in osteoporosis
    • Verma S, Rajaratnam JH, Denton J, Hoyland JA, Byers RJ. Adipocytic proportion of bone marrow is inversely related to bone formation in osteoporosis. J Clin Pathol. 2002;55(9):693-698.
    • (2002) J Clin Pathol , vol.55 , Issue.9 , pp. 693-698
    • Verma, S.1    Rajaratnam, J.H.2    Denton, J.3    Hoyland, J.A.4    Byers, R.J.5
  • 2
  • 3
    • 0036184457 scopus 로고    scopus 로고
    • Age-related bone loss: Old bone, new facts
    • Chan GK, Duque G. Age-related bone loss: old bone, new facts. Gerontology. 2002;48(2):62-71.
    • (2002) Gerontology , vol.48 , Issue.2 , pp. 62-71
    • Chan, G.K.1    Duque, G.2
  • 4
    • 0347627149 scopus 로고    scopus 로고
    • Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells
    • Stenderup K, Justesen J, Clausen C, Kassem M. Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells. Bone. 2003;33(6):919-926.
    • (2003) Bone , vol.33 , Issue.6 , pp. 919-926
    • Stenderup, K.1    Justesen, J.2    Clausen, C.3    Kassem, M.4
  • 5
    • 77955646193 scopus 로고    scopus 로고
    • Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
    • Méndez-Ferrer S, et al. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature. 2010;466(7308):829-834.
    • (2010) Nature , vol.466 , Issue.7308 , pp. 829-834
    • Méndez-Ferrer, S.1
  • 6
    • 84875000886 scopus 로고    scopus 로고
    • Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches
    • Ding L, Morrison SJ. Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches. Nature. 2013;495(7440):231-235.
    • (2013) Nature , vol.495 , Issue.7440 , pp. 231-235
    • Ding, L.1    Morrison, S.J.2
  • 7
    • 84905861462 scopus 로고    scopus 로고
    • Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow
    • Zhou BO, Yue R, Murphy MM, Peyer JG, Morrison SJ. Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow. Cell Stem Cell. 2014;15(2):154-168.
    • (2014) Cell Stem Cell , vol.15 , Issue.2 , pp. 154-168
    • Zhou, B.O.1    Yue, R.2    Murphy, M.M.3    Peyer, J.G.4    Morrison, S.J.5
  • 8
    • 65949113378 scopus 로고    scopus 로고
    • Marrow fat and the bone microenvironment: Developmental, functional, and pathological implications
    • Rosen CJ, Ackert-Bicknell C, Rodriguez JP, Pino AM. Marrow fat and the bone microenvironment: developmental, functional, and pathological implications. Crit Rev Eukaryot Gene Expr. 2009;19(2):109-124.
    • (2009) Crit Rev Eukaryot Gene Expr , vol.19 , Issue.2 , pp. 109-124
    • Rosen, C.J.1    Ackert-Bicknell, C.2    Rodriguez, J.P.3    Pino, A.M.4
  • 9
    • 84957921954 scopus 로고    scopus 로고
    • Fate decision of mesenchymal stem cells: Adipocytes or osteoblasts?
    • Chen Q, et al. Fate decision of mesenchymal stem cells: adipocytes or osteoblasts? Cell Death Differ. 2016;23(7):1128-1139.
    • (2016) Cell Death Differ , vol.23 , Issue.7 , pp. 1128-1139
    • Chen, Q.1
  • 10
    • 33748942837 scopus 로고    scopus 로고
    • Transcriptional control of adipocyte formation
    • Farmer SR. Transcriptional control of adipocyte formation. Cell Metab. 2006;4(4):263-273.
    • (2006) Cell Metab , vol.4 , Issue.4 , pp. 263-273
    • Farmer, S.R.1
  • 11
    • 0030678549 scopus 로고    scopus 로고
    • Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation
    • Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell. 1997;89(5):747-754.
    • (1997) Cell , vol.89 , Issue.5 , pp. 747-754
    • Ducy, P.1    Zhang, R.2    Geoffroy, V.3    Ridall, A.L.4    Karsenty, G.5
  • 12
    • 0037059614 scopus 로고    scopus 로고
    • The novel zinc fingercontaining transcription factor osterix is required for osteoblast differentiation and bone formation
    • Nakashima K, et al. The novel zinc fingercontaining transcription factor osterix is required for osteoblast differentiation and bone formation. Cell. 2002;108(1):17-29.
    • (2002) Cell , vol.108 , Issue.1 , pp. 17-29
    • Nakashima, K.1
  • 13
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    • Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell. 1997;88(5):593-602.
    • (1997) Cell , vol.88 , Issue.5 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    McCurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 14
    • 34447543913 scopus 로고    scopus 로고
    • Cellular senescence in cancer and aging
    • Collado M, Blasco MA, Serrano M. Cellular senescence in cancer and aging. Cell. 2007;130(2):223-233.
    • (2007) Cell , vol.130 , Issue.2 , pp. 223-233
    • Collado, M.1    Blasco, M.A.2    Serrano, M.3
  • 15
    • 33749187810 scopus 로고    scopus 로고
    • P16INK4a induces an age-dependent decline in islet regenerative potential
    • Krishnamurthy J, et al. p16INK4a induces an age-dependent decline in islet regenerative potential. Nature. 2006;443(7110):453-457.
    • (2006) Nature , vol.443 , Issue.7110 , pp. 453-457
    • Krishnamurthy, J.1
  • 16
    • 33749171885 scopus 로고    scopus 로고
    • Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
    • Molofsky AV, et al. Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature. 2006;443(7110):448-452.
    • (2006) Nature , vol.443 , Issue.7110 , pp. 448-452
    • Molofsky, A.V.1
  • 17
    • 33749172559 scopus 로고    scopus 로고
    • Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a
    • Janzen V, et al. Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature. 2006;443(7110):421-426.
    • (2006) Nature , vol.443 , Issue.7110 , pp. 421-426
    • Janzen, V.1
  • 18
    • 84900969225 scopus 로고    scopus 로고
    • Ink4a/Arf expression is a biomarker of aging
    • Krishnamurthy J, et al. Ink4a/Arf expression is a biomarker of aging. J Clin Invest. 2004;114(9):1299-1307.
    • (2004) J Clin Invest , vol.114 , Issue.9 , pp. 1299-1307
    • Krishnamurthy, J.1
  • 19
    • 84865620125 scopus 로고    scopus 로고
    • Upregulation of p16INK4A promotes cellular senescence of bone marrow-derived mesenchymal stem cells from systemic lupus erythematosus patients
    • Gu Z, et al. Upregulation of p16INK4A promotes cellular senescence of bone marrow-derived mesenchymal stem cells from systemic lupus erythematosus patients. Cell Signal. 2012;24(12):2307-2314.
    • (2012) Cell Signal , vol.24 , Issue.12 , pp. 2307-2314
    • Gu, Z.1
  • 20
    • 0037011958 scopus 로고    scopus 로고
    • P53 mutant mice that display early ageing-associated phenotypes
    • Tyner SD, et al. p53 mutant mice that display early ageing-associated phenotypes. Nature. 2002;415(6867):45-53.
    • (2002) Nature , vol.415 , Issue.6867 , pp. 45-53
    • Tyner, S.D.1
  • 21
    • 0033552813 scopus 로고    scopus 로고
    • The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
    • Jacobs JJ, Kieboom K, Marino S, DePinho RA, van Lohuizen M. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature. 1999;397(6715):164-168.
    • (1999) Nature , vol.397 , Issue.6715 , pp. 164-168
    • Jacobs, J.J.1    Kieboom, K.2    Marino, S.3    DePinho, R.A.4    Van Lohuizen, M.5
  • 22
    • 0037439071 scopus 로고    scopus 로고
    • Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 fulllength isoform
    • Cao L, Li W, Kim S, Brodie SG, Deng CX. Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 fulllength isoform. Genes Dev. 2003;17(2):201-213.
    • (2003) Genes Dev , vol.17 , Issue.2 , pp. 201-213
    • Cao, L.1    Li, W.2    Kim, S.3    Brodie, S.G.4    Deng, C.X.5
  • 23
    • 25644440744 scopus 로고    scopus 로고
    • Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation
    • Varela I, et al. Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation. Nature. 2005;437(7058):564-568.
    • (2005) Nature , vol.437 , Issue.7058 , pp. 564-568
    • Varela, I.1
  • 24
    • 53749098061 scopus 로고    scopus 로고
    • Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression
    • Nishino J, Kim I, Chada K, Morrison SJ. Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression. Cell. 2008;135(2):227-239.
    • (2008) Cell , vol.135 , Issue.2 , pp. 227-239
    • Nishino, J.1    Kim, I.2    Chada, K.3    Morrison, S.J.4
  • 25
    • 80855138775 scopus 로고    scopus 로고
    • Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
    • Baker DJ, et al. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature. 2011;479(7372):232-236.
    • (2011) Nature , vol.479 , Issue.7372 , pp. 232-236
    • Baker, D.J.1
  • 26
    • 84923776535 scopus 로고    scopus 로고
    • RB maintains quiescence and prevents premature senescence through upregulation of DNMT1 in mesenchymal stromal cells
    • Lin SP, Chiu FY, Wang Y, Yen ML, Kao SY, Hung SC. RB maintains quiescence and prevents premature senescence through upregulation of DNMT1 in mesenchymal stromal cells. Stem Cell Reports. 2014;3(6):975-986.
    • (2014) Stem Cell Reports , vol.3 , Issue.6 , pp. 975-986
    • Lin, S.P.1    Chiu, F.Y.2    Wang, Y.3    Yen, M.L.4    Kao, S.Y.5    Hung, S.C.6
  • 28
    • 80052223272 scopus 로고    scopus 로고
    • An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming
    • Gabut M, et al. An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming. Cell. 2011;147(1):132-146.
    • (2011) Cell , vol.147 , Issue.1 , pp. 132-146
    • Gabut, M.1
  • 29
    • 33746150775 scopus 로고    scopus 로고
    • Foxp1 is an essential transcriptional regulator of B cell development
    • Hu H, et al. Foxp1 is an essential transcriptional regulator of B cell development. Nat Immunol. 2006;7(8):819-826.
    • (2006) Nat Immunol , vol.7 , Issue.8 , pp. 819-826
    • Hu, H.1
  • 30
    • 79956069829 scopus 로고    scopus 로고
    • Transcription factor Foxp1 exerts essential cell-intrinsic regulation of the quiescence of naive T cells
    • Feng X, Wang H, Takata H, Day TJ, Willen J, Hu H. Transcription factor Foxp1 exerts essential cell-intrinsic regulation of the quiescence of naive T cells. Nat Immunol. 2011;12(6):544-550.
    • (2011) Nat Immunol , vol.12 , Issue.6 , pp. 544-550
    • Feng, X.1    Wang, H.2    Takata, H.3    Day, T.J.4    Willen, J.5    Hu, H.6
  • 31
    • 77449127289 scopus 로고    scopus 로고
    • Foxp1 is an essential transcriptional regulator for the generation of quiescent naive T cells during thymocyte development
    • Feng X, et al. Foxp1 is an essential transcriptional regulator for the generation of quiescent naive T cells during thymocyte development. Blood. 2010;115(3):510-518.
    • (2010) Blood , vol.115 , Issue.3 , pp. 510-518
    • Feng, X.1
  • 32
    • 84863324107 scopus 로고    scopus 로고
    • Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2
    • Li S, et al. Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2. Development. 2012;139(14):2500-2509.
    • (2012) Development , vol.139 , Issue.14 , pp. 2500-2509
    • Li, S.1
  • 33
    • 6944232153 scopus 로고    scopus 로고
    • Foxp1 regulates cardiac outflow tract, endocardial cushion morphogenesis and myocyte proliferation and maturation
    • Wang B, et al. Foxp1 regulates cardiac outflow tract, endocardial cushion morphogenesis and myocyte proliferation and maturation. Development. 2004;131(18):4477-4487.
    • (2004) Development , vol.131 , Issue.18 , pp. 4477-4487
    • Wang, B.1
  • 34
    • 34250688302 scopus 로고    scopus 로고
    • Foxp2 and Foxp1 cooperatively regulate lung and esophagus development
    • Shu W, Lu MM, Zhang Y, Tucker PW, Zhou D, Morrisey EE. Foxp2 and Foxp1 cooperatively regulate lung and esophagus development. Development. 2007;134(10):1991-2000.
    • (2007) Development , vol.134 , Issue.10 , pp. 1991-2000
    • Shu, W.1    Lu, M.M.2    Zhang, Y.3    Tucker, P.W.4    Zhou, D.5    Morrisey, E.E.6
  • 35
    • 84988487544 scopus 로고    scopus 로고
    • Epithelium-generated neuropeptide y induces smooth muscle contraction to promote airway hyperresponsiveness
    • Li S, et al. Epithelium-generated neuropeptide Y induces smooth muscle contraction to promote airway hyperresponsiveness. J Clin Invest. 2016;126(5):1978-1982.
    • (2016) J Clin Invest , vol.126 , Issue.5 , pp. 1978-1982
    • Li, S.1
  • 36
    • 77955861743 scopus 로고    scopus 로고
    • Foxp1 coordinates cardiomyocyte proliferation through both cell-autonomous and nonautonomous mechanisms
    • Zhang Y, et al. Foxp1 coordinates cardiomyocyte proliferation through both cell-autonomous and nonautonomous mechanisms. Genes Dev. 2010;24(16):1746-1757.
    • (2010) Genes Dev , vol.24 , Issue.16 , pp. 1746-1757
    • Zhang, Y.1
  • 37
    • 84883243864 scopus 로고    scopus 로고
    • Foxp1 maintains hair follicle stem cell quiescence through regulation of Fgf18
    • Leishman E, et al. Foxp1 maintains hair follicle stem cell quiescence through regulation of Fgf18. Development. 2013;140(18):3809-3818.
    • (2013) Development , vol.140 , Issue.18 , pp. 3809-3818
    • Leishman, E.1
  • 38
    • 84944753604 scopus 로고    scopus 로고
    • FoxP1 orchestration of ASDrelevant signaling pathways in the striatum
    • Araujo DJ, et al. FoxP1 orchestration of ASDrelevant signaling pathways in the striatum. Genes Dev. 2015;29(20):2081-2096.
    • (2015) Genes Dev , vol.29 , Issue.20 , pp. 2081-2096
    • Araujo, D.J.1
  • 39
    • 84928105299 scopus 로고    scopus 로고
    • Foxp1-mediated programming of limbinnervating motor neurons from mouse and human embryonic stem cells
    • Adams KL, Rousso DL, Umbach JA, Novitch BG. Foxp1-mediated programming of limbinnervating motor neurons from mouse and human embryonic stem cells. Nat Commun. 2015;6:6778.
    • (2015) Nat Commun , vol.6 , pp. 6778
    • Adams, K.L.1    Rousso, D.L.2    Umbach, J.A.3    Novitch, B.G.4
  • 40
    • 84950349530 scopus 로고    scopus 로고
    • Forkhead box P1 (FOXP1) transcription factor regulates hepatic glucose homeostasis
    • Zou Y, et al. Forkhead box P1 (FOXP1) transcription factor regulates hepatic glucose homeostasis. J Biol Chem. 2015;290(51):30607-30615.
    • (2015) J Biol Chem , vol.290 , Issue.51 , pp. 30607-30615
    • Zou, Y.1
  • 41
    • 77958510976 scopus 로고    scopus 로고
    • Chiari i malformation, delayed gross motor skills, severe speech delay, and epileptiform discharges in a child with FOXP1 haploinsufficiency
    • Carr CW, et al. Chiari I malformation, delayed gross motor skills, severe speech delay, and epileptiform discharges in a child with FOXP1 haploinsufficiency. Eur J Hum Genet. 2010;18(11):1216-1220.
    • (2010) Eur J Hum Genet , vol.18 , Issue.11 , pp. 1216-1220
    • Carr, C.W.1
  • 42
    • 0042591396 scopus 로고    scopus 로고
    • Multiple domains define the expression and regulatory properties of Foxp1 forkhead transcriptional repressors
    • Wang B, Lin D, Li C, Tucker P. Multiple domains define the expression and regulatory properties of Foxp1 forkhead transcriptional repressors. J Biol Chem. 2003;278(27):24259-24268.
    • (2003) J Biol Chem , vol.278 , Issue.27 , pp. 24259-24268
    • Wang, B.1    Lin, D.2    Li, C.3    Tucker, P.4
  • 43
    • 84907386402 scopus 로고    scopus 로고
    • DNA methylation is developmentally regulated for genes essential for cardiogenesis
    • Chamberlain AA, et al. DNA methylation is developmentally regulated for genes essential for cardiogenesis. J Am Heart Assoc. 2014;3(3):e000976.
    • (2014) J Am Heart Assoc , vol.3 , Issue.3 , pp. e000976
    • Chamberlain, A.A.1
  • 44
    • 84874997081 scopus 로고    scopus 로고
    • CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance
    • Greenbaum A, et al. CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance. Nature. 2013;495(7440):227-230.
    • (2013) Nature , vol.495 , Issue.7440 , pp. 227-230
    • Greenbaum, A.1
  • 45
    • 44649137302 scopus 로고    scopus 로고
    • Identification of novel PPARgamma target genes by integrated analysis of ChIPon-chip and microarray expression data during adipocyte differentiation
    • Nakachi Y, et al. Identification of novel PPARgamma target genes by integrated analysis of ChIPon-chip and microarray expression data during adipocyte differentiation. Biochem Biophys Res Commun. 2008;372(2):362-366.
    • (2008) Biochem Biophys Res Commun , vol.372 , Issue.2 , pp. 362-366
    • Nakachi, Y.1
  • 46
    • 84942372197 scopus 로고    scopus 로고
    • Wntless spatially regulates bone development through ?-catenindependent and independent mechanisms
    • Zhong ZA, Zahatnansky J, Snider J, Van Wieren E, Diegel CR, Williams BO. Wntless spatially regulates bone development through ?-catenindependent and independent mechanisms. Dev Dyn. 2015;244(10):1347-1355.
    • (2015) Dev Dyn , vol.244 , Issue.10 , pp. 1347-1355
    • Zhong, Z.A.1    Zahatnansky, J.2    Snider, J.3    Van Wieren, E.4    Diegel, C.R.5    Williams, B.O.6
  • 48
    • 40449084522 scopus 로고    scopus 로고
    • Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation
    • Hilton MJ, et al. Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat Med. 2008;14(3):306-314.
    • (2008) Nat Med , vol.14 , Issue.3 , pp. 306-314
    • Hilton, M.J.1
  • 49
    • 77950679225 scopus 로고    scopus 로고
    • Alteration of Notch signaling in skeletal development and disease
    • Tao J, Chen S, Lee B. Alteration of Notch signaling in skeletal development and disease. Ann N Y Acad Sci. 2010;1192:257-268.
    • (2010) Ann N y Acad Sci , vol.1192 , pp. 257-268
    • Tao, J.1    Chen, S.2    Lee, B.3
  • 50
    • 84929435164 scopus 로고    scopus 로고
    • Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging
    • Zhang W, et al. Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. Science. 2015;348(6239):1160-1163.
    • (2015) Science , vol.348 , Issue.6239 , pp. 1160-1163
    • Zhang, W.1
  • 51
    • 33750030758 scopus 로고    scopus 로고
    • The regulation of INK4/ARF in cancer and aging
    • Kim WY, Sharpless NE. The regulation of INK4/ARF in cancer and aging. Cell. 2006;127(2):265-275.
    • (2006) Cell , vol.127 , Issue.2 , pp. 265-275
    • Kim, W.Y.1    Sharpless, N.E.2
  • 52
    • 84863222584 scopus 로고    scopus 로고
    • C-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression
    • Kua HY, et al. c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression. Nat Cell Biol. 2012;14(7):727-737.
    • (2012) Nat Cell Biol , vol.14 , Issue.7 , pp. 727-737
    • Kua, H.Y.1
  • 53
    • 61349196341 scopus 로고    scopus 로고
    • Identification of mesenchymal stem cell (MSC)-transcription factors by microarray and knockdown analyses, and signature molecule-marked MSC in bone marrow by immunohistochemistry
    • Kubo H, et al. Identification of mesenchymal stem cell (MSC)-transcription factors by microarray and knockdown analyses, and signature molecule-marked MSC in bone marrow by immunohistochemistry. Genes Cells. 2009;14(3):407-424.
    • (2009) Genes Cells , vol.14 , Issue.3 , pp. 407-424
    • Kubo, H.1
  • 54
    • 84866709603 scopus 로고    scopus 로고
    • The transcriptional profile of mesenchymal stem cell populations in primary osteoporosis is distinct and shows overexpression of osteogenic inhibitors
    • Benisch P, et al. The transcriptional profile of mesenchymal stem cell populations in primary osteoporosis is distinct and shows overexpression of osteogenic inhibitors. PLoS ONE. 2012;7(9):e45142.
    • (2012) PLoS ONE , vol.7 , Issue.9 , pp. e45142
    • Benisch, P.1
  • 55
    • 84954379553 scopus 로고    scopus 로고
    • DNA methylation and healthy human aging
    • Jones MJ, Goodman SJ, Kobor MS. DNA methylation and healthy human aging. Aging Cell. 2015;14(6):924-932.
    • (2015) Aging Cell , vol.14 , Issue.6 , pp. 924-932
    • Jones, M.J.1    Goodman, S.J.2    Kobor, M.S.3
  • 56
    • 13844257282 scopus 로고    scopus 로고
    • Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: The role of PPAR-gamma2 transcription factor and TGF-beta/BMP signaling pathways
    • Moerman EJ, Teng K, Lipschitz DA, Lecka-Czernik B. Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: the role of PPAR-gamma2 transcription factor and TGF-beta/BMP signaling pathways. Aging Cell. 2004;3(6):379-389.
    • (2004) Aging Cell , vol.3 , Issue.6 , pp. 379-389
    • Moerman, E.J.1    Teng, K.2    Lipschitz, D.A.3    Lecka-Czernik, B.4
  • 57
    • 2142652189 scopus 로고    scopus 로고
    • PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors
    • Akune T, et al. PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest. 2004;113(6):846-855.
    • (2004) J Clin Invest , vol.113 , Issue.6 , pp. 846-855
    • Akune, T.1
  • 58
    • 84949035197 scopus 로고    scopus 로고
    • Reciprocal control of osteogenic and adipogenic differentiation by ERK/MAP kinase phosphorylation of Runx2 and PPAR? transcription factors
    • Ge C, Cawthorn WP, Li Y, Zhao G, Macdougald OA, Franceschi RT. Reciprocal control of osteogenic and adipogenic differentiation by ERK/MAP kinase phosphorylation of Runx2 and PPAR? transcription factors. J Cell Physiol. 2016;231(3):587-596.
    • (2016) J Cell Physiol , vol.231 , Issue.3 , pp. 587-596
    • Ge, C.1    Cawthorn, W.P.2    Li, Y.3    Zhao, G.4    Macdougald, O.A.5    Franceschi, R.T.6
  • 59
    • 84887985637 scopus 로고    scopus 로고
    • Osteoblast-targeted suppression of PPAR? increases osteogenesis through activation of mTOR signaling
    • Sun H, Kim JK, Mortensen R, Mutyaba LP, Hankenson KD, Krebsbach PH. Osteoblast-targeted suppression of PPAR? increases osteogenesis through activation of mTOR signaling. Stem Cells. 2013;31(10):2183-2192.
    • (2013) Stem Cells , vol.31 , Issue.10 , pp. 2183-2192
    • Sun, H.1    Kim, J.K.2    Mortensen, R.3    Mutyaba, L.P.4    Hankenson, K.D.5    Krebsbach, P.H.6
  • 60
    • 84922711705 scopus 로고    scopus 로고
    • Foxp1/2/4 regulate endochondral ossification as a suppresser complex
    • Zhao H, et al. Foxp1/2/4 regulate endochondral ossification as a suppresser complex. Dev Biol. 2015;398(2):242-254.
    • (2015) Dev Biol , vol.398 , Issue.2 , pp. 242-254
    • Zhao, H.1
  • 61
    • 79959412176 scopus 로고    scopus 로고
    • Osteoblasts in osteoporosis: Past, emerging, and future anabolic targets
    • Marie PJ, Kassem M. Osteoblasts in osteoporosis: past, emerging, and future anabolic targets. Eur J Endocrinol. 2011;165(1):1-10.
    • (2011) Eur J Endocrinol , vol.165 , Issue.1 , pp. 1-10
    • Marie, P.J.1    Kassem, M.2
  • 62
    • 0035893741 scopus 로고    scopus 로고
    • The FOXP1 winged helix transcription factor is a novel candidate tumor suppressor gene on chromosome 3p
    • Banham AH, et al. The FOXP1 winged helix transcription factor is a novel candidate tumor suppressor gene on chromosome 3p. Cancer Res. 2001;61(24):8820-8829.
    • (2001) Cancer Res , vol.61 , Issue.24 , pp. 8820-8829
    • Banham, A.H.1
  • 63
    • 23744460273 scopus 로고    scopus 로고
    • FOXP1, a gene highly expressed in a subset of diffuse large B-cell lymphoma, is recurrently targeted by genomic aberrations
    • Wlodarska I, et al. FOXP1, a gene highly expressed in a subset of diffuse large B-cell lymphoma, is recurrently targeted by genomic aberrations. Leukemia. 2005;19(8):1299-1305.
    • (2005) Leukemia , vol.19 , Issue.8 , pp. 1299-1305
    • Wlodarska, I.1
  • 64
    • 31944445676 scopus 로고    scopus 로고
    • T(3;14)(p14;q32) results in aberrant expression of FOXP1 in a case of diffuse large B-cell lymphoma
    • Fenton JA, et al. t(3;14)(p14;q32) results in aberrant expression of FOXP1 in a case of diffuse large B-cell lymphoma. Genes Chromosomes Cancer. 2006;45(2):164-168.
    • (2006) Genes Chromosomes Cancer , vol.45 , Issue.2 , pp. 164-168
    • Fenton, J.A.1
  • 65
    • 26244456588 scopus 로고    scopus 로고
    • The FOXP1 transcription factor is expressed in the majority of follicular lymphomas but is rarely expressed in classical and lymphocyte predominant Hodgkin's lymphoma
    • Brown P, Marafioti T, Kusec R, Banham AH. The FOXP1 transcription factor is expressed in the majority of follicular lymphomas but is rarely expressed in classical and lymphocyte predominant Hodgkin's lymphoma. J Mol Histol. 2005;36(4):249-256.
    • (2005) J Mol Histol , vol.36 , Issue.4 , pp. 249-256
    • Brown, P.1    Marafioti, T.2    Kusec, R.3    Banham, A.H.4
  • 66
    • 84856386430 scopus 로고    scopus 로고
    • FOXP1 and PAX5 are rare but recurrent translocations partners in acute lymphoblastic leukemia
    • Put N, Deeren D, Michaux L, Vandenberghe P. FOXP1 and PAX5 are rare but recurrent translocations partners in acute lymphoblastic leukemia. Cancer Genet. 2011;204(8):462-464.
    • (2011) Cancer Genet , vol.204 , Issue.8 , pp. 462-464
    • Put, N.1    Deeren, D.2    Michaux, L.3    Vandenberghe, P.4
  • 67
    • 80054051092 scopus 로고    scopus 로고
    • FOXP1, an estrogen-inducible transcription factor, modulates cell proliferation in breast cancer cells and 5-year recurrence-free survival of patients with tamoxifen-treated breast cancer
    • Shigekawa T, et al. FOXP1, an estrogen-inducible transcription factor, modulates cell proliferation in breast cancer cells and 5-year recurrence-free survival of patients with tamoxifen-treated breast cancer. Horm Cancer. 2011;2(5):286-297.
    • (2011) Horm Cancer , vol.2 , Issue.5 , pp. 286-297
    • Shigekawa, T.1
  • 68
    • 79251520282 scopus 로고    scopus 로고
    • Expression of the Forkhead transcription factor FOXP1 is associated with tumor grade and Ki67 expression in clear cell renal cell carcinoma
    • Toma MI, et al. Expression of the Forkhead transcription factor FOXP1 is associated with tumor grade and Ki67 expression in clear cell renal cell carcinoma. Cancer Invest. 2011;29(2):123-129.
    • (2011) Cancer Invest , vol.29 , Issue.2 , pp. 123-129
    • Toma, M.I.1
  • 69
    • 84872394280 scopus 로고    scopus 로고
    • Both FOXP1 and p65 expression are adverse risk factors in diffuse large B-cell lymphoma: A retrospective study in China
    • Hu CR, Wang JH, Wang R, Sun Q, Chen LB. Both FOXP1 and p65 expression are adverse risk factors in diffuse large B-cell lymphoma: a retrospective study in China. Acta Histochem. 2013;115(2):137-143.
    • (2013) Acta Histochem , vol.115 , Issue.2 , pp. 137-143
    • Hu, C.R.1    Wang, J.H.2    Wang, R.3    Sun, Q.4    Chen, L.B.5
  • 71
    • 84956615779 scopus 로고    scopus 로고
    • Subtype-specific addiction of the activated B-cell subset of diffuse large B-cell lymphoma to FOXP1
    • Dekker JD, et al. Subtype-specific addiction of the activated B-cell subset of diffuse large B-cell lymphoma to FOXP1. Proc Natl Acad Sci USA. 2016;113(5):E577-E586.
    • (2016) Proc Natl Acad Sci USA , vol.113 , Issue.5 , pp. E577-E586
    • Dekker, J.D.1
  • 72
    • 0036076389 scopus 로고    scopus 로고
    • Expression of Cre Recombinase in the developing mouse limb bud driven by a Prxl enhancer
    • Logan M, Martin JF, Nagy A, Lobe C, Olson EN, Tabin CJ. Expression of Cre Recombinase in the developing mouse limb bud driven by a Prxl enhancer. Genesis. 2002;33(2):77-80.
    • (2002) Genesis , vol.33 , Issue.2 , pp. 77-80
    • Logan, M.1    Martin, J.F.2    Nagy, A.3    Lobe, C.4    Olson, E.N.5    Tabin, C.J.6
  • 73
    • 84893186610 scopus 로고    scopus 로고
    • Use of osmium tetroxide staining with microcomputerized tomography to visualize and quantify bone marrow adipose tissue in vivo
    • Scheller EL, et al. Use of osmium tetroxide staining with microcomputerized tomography to visualize and quantify bone marrow adipose tissue in vivo. Meth Enzymol. 2014;537:123-139.
    • (2014) Meth Enzymol , vol.537 , pp. 123-139
    • Scheller, E.L.1


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