Osteoblast-targeted suppression of PPARc increases osteogenesis through activation of mTOR signaling

Stem Cells

Volumn 31, Issue 10, 2013, Pages 2183-2192

  Sun, Hongli ^a   Kim, Jin Koo ^a   Mortensen, Richard ^b   Mutyaba, Lorraine P ^c   Hankenson, Kurt D ^c   Krebsbach, Paul H ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Bone; Fat; MTOR; Osteoblast; PPARc; RUNX2

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN KINASE B;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; CELL COUNT; CELL DIFFERENTIATION; IN VITRO STUDY; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; PHENOTYPE;

BONE; FAT; MTOR; OSTEOBLAST; PPARΓ; RUNX2;

ADIPOGENESIS; ANIMALS; BONE AND BONES; CALCIFICATION, PHYSIOLOGIC; CELLS, CULTURED; GENE KNOCKOUT TECHNIQUES; MESENCHYMAL STROMAL CELLS; MICE; MICE, INBRED C57BL; OSTEOBLASTS; OSTEOGENESIS; PPAR GAMMA; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84887985637     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1455     Document Type: Article

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