Expression of the forkhead transcription factor FOXP1 is associated with tumor grade and Ki67 expression in clear cell renal cell carcinoma

Cancer Investigation

Volumn 29, Issue 2, 2011, Pages 123-129

  Toma, Marieta I ^a   Weber, Thomas ^b   Meinhardt, Matthias ^a   Zastrow, Stefan ^b   Grimm, Marc Oliver ^b   Füssel, Susanne ^b   Wirth, Manfred P ^b   Baretton, Gustavo B ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Clear cell renal cell carcinoma; FOXP1; Ki67; Survival; Tumor grading

Indexed keywords

FORKHEAD TRANSCRIPTION FACTOR; FORKHEAD TRANSCRIPTION FACTOR FOXP1; KI 67 ANTIGEN; UNCLASSIFIED DRUG;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CANCER DIAGNOSIS; CANCER GRADING; CANCER SURVIVAL; CLEAR CELL CARCINOMA; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY CARCINOMA; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, RENAL CELL; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; KIDNEY NEOPLASMS; MIDDLE AGED; NEOPLASM STAGING; REPRESSOR PROTEINS;

EID: 79251520282     PISSN: 07357907     EISSN: 15324192     Source Type: Journal    
DOI: 10.3109/07357907.2010.535059     Document Type: Article

References (23)

1. Leibovich BC, Blute MC, Cheville JC, et al. Prediction of progression after radical nephrectomy for patients with clear cell renal cell carcinoma. Cancer 2002;97:1663-1671.
2. Frank I, Blute ML, Cheville JC, et al. An outcome prediction model for patients with clear cell renal cell carcinoma treated with radical nephrectomy based on tumor stage, size, grade and necrosis: the SSIGN score. J Urol 2002;168:2395-2400.
3. Cheville JC, Zincke H, Lohse CM, et al. pT1 clear cell renal cell carcinoma: a study of association between MIB-1 proliferative activity and pathologic features and cancer specific survival. Cancer 2002;94:2180-2184.
4. Tollefson MK, Thompson RH, Sheinin Y, et al. Ki-67 and coagulative tumor necrosis are independent predictors of poor outcome for patients with clear cell renal cell carcinoma and not surrogates for each other. Cancer 2007;110:783-790.
5. Van den Berg A, Buys CH. Involvement of multiple loci on chromosome 3 in renal cancer development. Genes Chromosomes Cancer 1997;19:59-76.
6. Sükösd F, Kuroda N, Beothe T, et al. Deletion of chromosome 3p14.2-p25 involving the VHL and FHIT genes in conventional renal cell carcinoma. Cancer Res 2003;63:455-457.
7. Toma MI, Grosser M, Herr A, et al. Loss of heterozygosity and copy number abnormality in clear cell renal cell carcinoma discovered by high-density affymetrix 10K single nucleotide polymorphism mapping array. Neoplasia 2008;10:634-642.
8. Huebner K, Garrison PN, Barnes LD, Croce CM. The role of FHIT/FRA3B locus in cancer. Annu Rev Genet 1998;32:7-31.
9. Tamura S, Morikawa Y, Iwanishi H, et al. Expression pattern of the winged-helix/forkhead transcription factor Foxp1 in the developing central nervous system. Gene Expr Patterns 2003;3:193-197.
10. Rousso DL, Gaber ZB, Wellik D, Morrisey EE, Novitch BG. Coordinated actions of the forkhead protein Foxp1 and Hox proteins in the columnar organization of spinal motor neurons. Neuron 2008;59:226-240.
11. Hu H, Wang B, Borde M, et al. Foxp1 is an essential transcriptional regulator of B cell development. Nat Immunol 2006;7:819-826.
12. Shi C, Sakuma M, Mooroka T, et al. Down-regulation of the forkhead transcription factor Foxp1 is required for monocyte differentiation and macrophage function. Blood 2008;112:4699-4711.
13. Banham AH, Beasley N, Campo E, et al. The FOXP1 winged helix transcription factor is a novel candidate tumor suppressor gene on chromosome 3p. Cancer Res 2001;61:8820-8829.
14. Banham AH, Connors JM, Brown PJ, et al. Expression of FOXP1 transcription factor is strongly associated with inferior survival in patients with diffuse large B-cell lymphoma. Clin Cancer Res 2005;11:1065-1072.
15. Korac P, Dominis M. Prognostic markers and gene abnormalities in subgroups of diffuse large B-cell lymphomas: single center experience. Croat Med J 2008;49:618-624.
16. Jais JP, Haioun C, Molina TJ; et al., for the Groupe d'Etude des Lymphomes de l'Adulte. The expression of 16 genes related to the cell of origin and immune response predicts survival in elderly patients with diffuse large B-cell lymphoma treated with CHOP and rituximab. Leukemia 2008;22:1917-1924.
17. Fox SB, Brown P, Han C, et al. Expression of the forkhead transcription factor FOXP1 is associated with estrogen receptor α and improved survival in primary human breast carcinomas. Clin Cancer Res 2004;10:3521-3527.
18. Bates GJ, Fox SB, Han C, et al. Expression of the forkhead transcription factor FOXP1 is associated with that of estrogen receptor β in primary invasive breast carcinomas. Breast Cancer Res Treat 2008;111:453-459.
19. Fu L, Girling JE, Rogers PA. Expression of Fox head protein 1 in human eutopic endometrium and endometriosis. Reprod Sci 2008;15:243-252.
20. Giatromanolaki A, Koukourakis MI, Sivridis E, Gatter KC, Harris AL, Banham AH. Loss of expression and nuclear/cytoplasmic localization of the FOXP1 forkhead transcription factor are common events in early endometrial cancer: relationship with estrogen receptors and HIF-1α expression. Modern Pathol 2006;19:9-16.
21. Banham AH, Boddy J, Launchbury R, et al. Expression of the forkhead transcription factor FOXP1 is associated both with hypoxia inducible factors (HIFs) and the androgen receptor in prostate cancer but is not directly regulated by androgens or hypoxia. Prostate 2007;67:1091-1098.
22. Thoenes W, Storkel S, Rumpelt J. Histopathology and classification of renal cell tumors (adenomas, oncocytomas and carcinomas). The basic cytological and histopathological elements and their use for diagnostics. Pathol Res Pract 1986;181:125-143.
23. Kim HL, Selingson D, Liu X, et al. Using tumor markers to predict the survival of patients with metastastic renal cell carcinoma. J Urol 2005;173:1496-1501.