Upregulation of p16 INK4A promotes cellular senescence of bone marrow-derived mesenchymal stem cells from systemic lupus erythematosus patients

Cellular Signalling

Volumn 24, Issue 12, 2012, Pages 2307-2314

  Gu, Zhifeng ^a   Cao, Xiaolei ^b   Jiang, Jinxia ^a   Li, Liren ^a   Da, Zhanyun ^a   Liu, Hong ^a   Cheng, Chun ^b  

^a NANTONG UNIVERSITY   (China)

^b NANTONG MEDICAL COLLEGE   (China)

Author keywords

Immune regulation; Mesenchymal stem cells; P16 INK4A; Senescence; Systemic lupus erythematosus

Indexed keywords

CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLOPHOSPHAMIDE; HYDROXYCHLOROQUINE; LEFLUNOMIDE; PREDNISOLONE; RETINOBLASTOMA PROTEIN; TRANSFORMING GROWTH FACTOR BETA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SMALL INTERFERING RNA;

ADOLESCENT; ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CELL CYCLE REGULATION; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOREGULATION; MESENCHYMAL STEM CELL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SENESCENCE; SYSTEMIC LUPUS ERYTHEMATOSUS; UPREGULATION; BONE MARROW CELL; CELL AGING; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; GENETICS; IMMUNOLOGY; MESENCHYMAL STROMA CELL; METABOLISM; PATHOLOGY; RNA INTERFERENCE;

ADOLESCENT; ADULT; BONE MARROW CELLS; CELL AGING; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE 6; CYCLIN-DEPENDENT KINASE INHIBITOR P16; FEMALE; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MESENCHYMAL STROMAL CELLS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; RNA INTERFERENCE; RNA, SMALL INTERFERING; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION; YOUNG ADULT;

EID: 84865620125     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2012.07.012     Document Type: Article

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