Transcriptional control of adipocyte formation

Cell Metabolism

Volumn 4, Issue 4, 2006, Pages 263-273

  Farmer, Stephen R ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOBESITY AGENT; CCAAT ENHANCER BINDING PROTEIN ALPHA; CCAAT ENHANCER BINDING PROTEIN BETA; CCAAT ENHANCER BINDING PROTEIN DELTA; CELL CYCLE PROTEIN; HISTONE ACETYLTRANSFERASE PCAF; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 3; LIGAND; MESSENGER RNA; NUCLEAR RECEPTOR COREPRESSOR; NUCLEAR RESPIRATORY FACTOR 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; PROTEIN BMAL1; RETINOBLASTOMA PROTEIN; SILENT INFORMATION REGULATOR PROTEIN 2; SIRTUIN; STAT5A PROTEIN; STAT5B PROTEIN; STEROID RECEPTOR COACTIVATOR 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TATA BINDING PROTEIN RELATED FACTOR; THYROID HORMONE RECEPTOR; TRANSCRIPTION FACTOR E2F1; TRANSCRIPTION FACTOR E2F2; TRANSCRIPTION FACTOR E2F3; TRANSCRIPTION FACTOR E2F4; TRANSCRIPTION FACTOR FKHR;

ADIPOCYTE; ADIPOGENESIS; ADIPOSE TISSUE; CARDIOVASCULAR DISEASE; CELL CYCLE REGULATION; CELL DIFFERENTIATION; CELL FUNCTION; CELL MATURATION; DIABETES MELLITUS; EPIDEMIC; HUMAN; MESENCHYMAL STEM CELL; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW;

ADIPOCYTES; ANIMALS; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MODELS, BIOLOGICAL; TRANSCRIPTION FACTORS;

EID: 33748942837     PISSN: 15504131     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cmet.2006.07.001     Document Type: Review

References (102)

1. Arango N.A., Szotek P.P., Manganaro T.F., Oliva E., Donahoe P.K., and Teixeira J. Conditional deletion of beta-catenin in the mesenchyme of the developing mouse uterus results in a switch to adipogenesis in the myometrium. Dev. Biol. 288 (2005) 276-283
2. Banerjee S.S., Feinberg M.W., Watanabe M., Gray S., Haspel R.L., Denkinger D.J., Kawahara R., Hauner H., and Jain M.K. The Kruppel-like factor KLF2 inhibits peroxisome proliferator-activated receptor-gamma expression and adipogenesis. J. Biol. Chem. 278 (2003) 2581-2584
3. Barak Y., Nelson M.C., Ong E.S., Jones Y.Z., Ruiz-Lozano P., Chien K.R., Koder A., and Evans R.M. PPAR gamma is required for placental, cardiac, and adipose tissue development. Mol. Cell 4 (1999) 585-595
4. Batchnarova N., Wang X.-Z., and Ron D. Inhibition of adipogenesis by the stress-induced protein CHOP (Gadd153). EMBO J. 14 (1995) 4654-4661
5. Bennett C.N., Longo K.A., Wright W.S., Suva L.J., Lane T.F., Hankenson K.D., and MacDougald O.A. Regulation of osteoblastogenesis and bone mass by Wnt10b. Proc. Natl. Acad. Sci. USA 102 (2005) 3324-3329
6. Bezy O., Elabd C., Cochet O., Petersen R.K., Kristiansen K., Dani C., Ailhaud G., and Amri E.Z. Delta-interacting protein A, a new inhibitory partner of CCAAT/enhancer-binding protein beta, implicated in adipocyte differentiation. J. Biol. Chem. 280 (2005) 11432-11438
7. Blumberg J.M., Tzameli I., Astapova I., Lam F.S., Flier J.S., and Hollenberg A.N. Complex role of the vitamin D receptor and its ligand in adipogenesis in 3T3-L1 cells. J. Biol. Chem. 281 (2006) 11205-11213
8. Boudjelal M., Taneja R., Matsubara S., Bouillet P., Dolle P., and Chambon P. Overexpression of Stra13, a novel retinoic acid-inducible gene of the basic helix-loop-helix family, inhibits mesodermal and promotes neuronal differentiation of P19 cells. Genes Dev. 11 (1997) 2052-2065
9. Cao Z., Umek R.M., and McKnight S.L. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev. 5 (1991) 1538-1552
10. Chen P.L., Riley D.J., Chen Y., and Lee W.H. Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs. Genes Dev. 10 (1996) 2794-2804
11. Chen Z., Torrens J.I., Anand A., Spiegelman B.M., and Friedman J.M. Krox20 stimulates adipogenesis via C/EBPbeta-dependent and -independent mechanisms. Cell Metab. 1 (2005) 93-106
12. Christian M., Kiskinis E., Debevec D., Leonardsson G., White R., and Parker M.G. RIP140-targeted repression of gene expression in adipocytes. Mol. Cell. Biol. 25 (2005) 9383-9391
13. Christy R.J., Kaestner K.H., Geiman D.E., and Lane M.D. CCAAT/enhancer binding protein gene promoter: binding of nuclear factors during differentiation of 3T3-L1 preadipocytes. Proc. Natl. Acad. Sci. USA 88 (1991) 2593-2597
14. Clarke S.L., Robinson C.E., and Gimble J.M. CAAT/enhancer binding proteins directly modulate transcription from the peroxisome proliferator-activated receptor gamma2 promoter. Biochem. Biophys. Res. Commun. 240 (1997) 99-103
15. Classon M., Kennedy B.K., Mulloy R., and Harlow E. Opposing roles of pRB and p107 in adipocyte differentiation. Proc. Natl. Acad. Sci. USA 97 (2000) 10826-10831
16. Davis K.E., Moldes M., and Farmer S.R. The forkhead transcription factor FoxC2 inhibits white adipocyte differentiation. J. Biol. Chem. 279 (2004) 42453-42461
17. El-Jack A.K., Hamm J.K., Pilch P.F., and Farmer S.R. Reconstitution of insulin-sensitive glucose transport in fibroblasts requires expression of both PPARγ and C/EBPα. J. Biol. Chem. 274 (1999) 7946-7951
18. Erickson R.L., Hemati N., Ross S.E., and MacDougald O.A. p300 coactivates the adipogenic transcription factor CCAAT/enhancer-binding protein alpha. J. Biol. Chem. 276 (2001) 16348-16355
19. Fajas L., Auboeuf D., Raspe E., Schoonjans K., Lefebvre A.M., Saladin R., Najib J., Laville M., Fruchart J.C., Deeb S., et al. The organization, promoter analysis, and expression of the human PPARgamma gene. J. Biol. Chem. 272 (1997) 18779-18789
20. Fajas L., Schoonjans K., Gelman L., Kim J.B., Najib J., Martin G., Fruchart J.C., Briggs M., Spiegelman B.M., and Auwerx J. Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism. Mol. Cell. Biol. 19 (1999) 5495-5503
21. Fajas L., Egler V., Reiter R., Hansen J., Kristiansen K., Debril M.B., Miard S., and Auwerx J. The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation. Dev. Cell 3 (2002) 903-910
22. Fajas L., Landsberg R.L., Huss-Garcia Y., Sardet C., Lees J.A., and Auwerx J. E2Fs regulate adipocyte differentiation. Dev. Cell 3 (2002) 39-49
23. Floyd Z.E., and Stephens J.M. STAT5A promotes adipogenesis in nonprecursor cells and associates with the glucocorticoid receptor during adipocyte differentiation. Diabetes 52 (2003) 308-314
24. Fontaine C., Dubois G., Duguay Y., Helledie T., Vu-Dac N., Gervois P., Soncin F., Mandrup S., Fruchart J.C., Fruchart-Najib J., and Staels B. The orphan nuclear receptor Rev-Erbalpha is a peroxisome proliferator-activated receptor (PPAR) gamma target gene and promotes PPARgamma-induced adipocyte differentiation. J. Biol. Chem. 278 (2003) 37672-37680
25. Freytag S.O., Paielli D.L., and Gilbert J.D. Ectopic expression of the CCAAT/enhancer-binding protein alpha promotes the adipogenic program in a variety of mouse fibroblastic cells. Genes Dev. 8 (1994) 1654-1663
26. Fu M., Rao M., Bouras T., Wang C., Wu K., Zhang X., Li Z., Yao T.P., and Pestell R.G. Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment. J. Biol. Chem. 280 (2005) 16934-16941
27. Fu M., Sun T., Bookout A.L., Downes M., Yu R.T., Evans R.M., and Mangelsdorf D.J. A Nuclear Receptor Atlas: 3T3-L1 adipogenesis. Mol. Endocrinol. 19 (2005) 2437-2450
28. Ge K., Guermah M., Yuan C.X., Ito M., Wallberg A.E., Spiegelman B.M., and Roeder R.G. Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Nature 417 (2002) 563-567
29. Gelman L., Zhou G., Fajas L., Raspe E., Fruchart J.C., and Auwerx J. p300 interacts with the N- and C-terminal part of PPARgamma2 in a ligand-independent and -dependent manner, respectively. J. Biol. Chem. 274 (1999) 7681-7688
30. Green H., and Kehinde O. An established preadipose cell line and its differentiation in culture. II. Factors affecting the adipose conversion. Cell 5 (1975) 19-27
31. Green H., and Kehinde O. Spontaneous heritable changes leading to increased adipose conversion in 3T3 cells. Cell 7 (1976) 105-113
32. Guermah M., Ge K., Chiang C.M., and Roeder R.G. The TBN protein, which is essential for early embryonic mouse development, is an inducible TAFII implicated in adipogenesis. Mol. Cell 12 (2003) 991-1001
33. Hamm J.K., Park B.H., and Farmer S.R. A role for C/EBPbeta in regulating peroxisome proliferator-activated receptor gamma activity during adipogenesis in 3T3-L1 preadipocytes. J. Biol. Chem. 276 (2001) 18464-18471
34. Hansen J.B., Jorgensen C., Petersen R.K., Hallenborg P., De Matteis R., Boye H.A., Petrovic N., Enerback S., Nedergaard J., Cinti S., et al. Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation. Proc. Natl. Acad. Sci. USA 101 (2004) 4112-4117
35. Hansen J.B., te Riele H., and Kristiansen K. Novel function of the retinoblastoma protein in fat: regulation of white versus brown adipocyte differentiation. Cell Cycle 3 (2004) 774-778
36. Imai S., Armstrong C.M., Kaeberlein M., and Guarente L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403 (2000) 795-800
37. Kim J.B., and Spiegelman B.M. ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism. Genes Dev. 10 (1996) 1096-1107
38. Kim J.B., Sarraf P., Wright M., Yao K.M., Mueller E., Solanes G., Lowell B.B., and Spiegelman B.M. Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1. J. Clin. Invest. 101 (1998) 1-9
39. Kim J.B., Wright H.M., Wright M., and Spiegelman B.M. ADD1/SREBP1 activates PPAR gamma through the production of endogenous ligand. Proc. Natl. Acad. Sci. USA 95 (1998) 4333-4337
40. Koutnikova H., Cock T.A., Watanabe M., Houten S.M., Champy M.F., Dierich A., and Auwerx J. Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPAR gamma hypomorphic mice. Proc. Natl. Acad. Sci. USA 100 (2003) 14457-14462
41. Leonardsson G., Steel J.H., Christian M., Pocock V., Milligan S., Bell J., So P.W., Medina-Gomez G., Vidal-Puig A., White R., and Parker M.G. Nuclear receptor corepressor RIP140 regulates fat accumulation. Proc. Natl. Acad. Sci. USA 101 (2004) 8437-8442
42. Li D., Yea S., Li S., Chen Z., Narla G., Banck M., Laborda J., Tan S., Friedman J.M., Friedman S.L., and Walsh M.J. Kruppel-like factor-6 promotes preadipocyte differentiation through histone deacetylase 3-dependent repression of DLK1. J. Biol. Chem. 280 (2005) 26941-26952
43. Lin J., Handschin C., and Spiegelman B.M. Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab. 1 (2005) 361-370
44. Linhart H.G., Ishimura-Oka K., DeMayo F., Kibe T., Repka D., Poindexter B., Bick R.J., and Darlington G.J. C/EBPalpha is required for differentiation of white, but not brown, adipose tissue. Proc. Natl. Acad. Sci. USA 98 (2001) 12532-12537
45. Liu J., and Farmer S.R. Regulating the balance between peroxisome proliferator-activated receptor gamma and beta-catenin signaling during adipogenesis. A glycogen synthase kinase 3beta phosphorylation-defective mutant of beta-catenin inhibits expression of a subset of adipogenic genes. J. Biol. Chem. 279 (2004) 45020-45027
46. Liu J., Wang H., Zuo Y., and Farmer S.R. A functional interaction between PPARgamma and beta-catenin. Mol. Cell. Biol. 26 (2006) 5827-5837
47. Meirhaeghe A., Fajas L., Gouilleux F., Cottel D., Helbecque N., Auwerx J., and Amouyel P. A functional polymorphism in a STAT5B site of the human PPAR gamma 3 gene promoter affects height and lipid metabolism in a French population. Arterioscler. Thromb. Vasc. Biol. 23 (2003) 289-294
48. Moldes M., Zuo Y., Morrison R.F., Silva D., Park B.H., Liu J., and Farmer S.R. Peroxisome-proliferator-activated receptor gamma suppresses Wnt/beta-catenin signalling during adipogenesis. Biochem. J. 376 (2003) 607-613
49. Mori T., Sakaue H., Iguchi H., Gomi H., Okada Y., Takashima Y., Nakamura K., Nakamura T., Yamauchi T., Kubota N., et al. Role of Kruppel-like factor 15 (KLF15) in transcriptional regulation of adipogenesis. J. Biol. Chem. 280 (2005) 12867-12875
50. Morrison R.F., and Farmer S.R. Role of PPARgamma in regulating a cascade expression of cyclin-dependent kinase inhibitors, p18(INK4c) and p21(Waf1/Cip1), during adipogenesis. J. Biol. Chem. 274 (1999) 17088-17097
51. Mueller E., Drori S., Aiyer A., Yie J., Sarraf P., Chen H., Hauser S., Rosen E.D., Ge K., Roeder R.G., and Spiegelman B.M. Genetic analysis of adipogenesis through peroxisome proliferator-activated receptor gamma isoforms. J. Biol. Chem. 277 (2002) 41925-41930
52. Nakae J., Kitamura T., Kitamura Y., Biggs III W.H., Arden K.C., and Accili D. The forkhead transcription factor Foxo1 regulates adipocyte differentiation. Dev. Cell 4 (2003) 119-129
53. Oishi Y., Manabe I., Tobe K., Tsushima K., Shindo T., Fujiu K., Nishimura G., Maemura K., Yamauchi T., Kubota N., et al. Kruppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation. Cell Metab. 1 (2005) 27-39
54. Park B.-H., Qiang L., and Farmer S.R. Phosphorylation of C/EBPbeta at a consensus ERK/GSK3 site is required for the induction of adiponectin gene expression during the differentiation of mouse fibroblasts into adipocytes. Mol. Cell. Biol. 24 (2004) 8671-8680
55. Patel Y.M., and Lane M.D. Mitotic clonal expansion during preadipocyte differentiation: calpain-mediated turnover of p27. J. Biol. Chem. 275 (2000) 17653-17660
56. Pedersen T.A., Kowenz-Leutz E., Leutz A., and Nerlov C. Cooperation between C/EBPalpha TBP/TFIIB and SWI/SNF recruiting domains is required for adipocyte differentiation. Genes Dev. 15 (2001) 3208-3216
57. Picard F., Gehin M., Annicotte J., Rocchi S., Champy M.F., O'Malley B.W., Chambon P., and Auwerx J. SRC-1 and TIF2 control energy balance between white and brown adipose tissues. Cell 111 (2002) 931-941
58. Picard F., Kurtev M., Chung N., Topark-Ngarm A., Senawong T., Machado De Oliveira R., Leid M., McBurney M.W., and Guarente L. Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 429 (2004) 771-776
59. Powelka A.M., Seth A., Virbasius J.V., Kiskinis E., Nicoloro S.M., Guilherme A., Tang X., Straubhaar J., Cherniack A.D., Parker M.G., and Czech M.P. Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes. J. Clin. Invest. 116 (2006) 125-136
60. Qi C., Surapureddi S., Zhu Y.J., Yu S., Kashireddy P., Rao M.S., and Reddy J.K. Transcriptional coactivator PRIP, the peroxisome proliferator-activated receptor gamma (PPARgamma)-interacting protein, is required for PPARgamma-mediated adipogenesis. J. Biol. Chem. 278 (2003) 25281-25284
61. Rochford J.J., Semple R.K., Laudes M., Boyle K.B., Christodoulides C., Mulligan C., Lelliott C.J., Schinner S., Hadaschik D., Mahadevan M., et al. ETO/MTG8 is an inhibitor of C/EBPbeta activity and a regulator of early adipogenesis. Mol. Cell. Biol. 24 (2004) 9863-9872
62. Rodgers J.T., Lerin C., Haas W., Gygi S.P., Spiegelman B.M., and Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 434 (2005) 113-118
63. Rosen E.D., Sarraf P., Troy A.E., Bradwin G., Moore K., Milstone D.S., Spiegelman B.M., and Mortensen R.M. PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol. Cell 4 (1999) 611-617
64. Rosen E.D., Hsu C.H., Wang X., Sakai S., Freeman M.W., Gonzalez F.J., and Spiegelman B.M. C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway. Genes Dev. 16 (2002) 22-26
65. Ross D.A., Rao P.K., and Kadesch T. Dual roles for the Notch target gene Hes-1 in the differentiation of 3T3-L1 preadipocytes. Mol. Cell. Biol. 24 (2004) 3505-3513
66. Ross D.A., Hannenhalli S., Tobias J.W., Cooch N., Shiekhattar R., and Kadesch T. Functional analysis of Hes-1 in preadipocytes. Mol. Endocrinol. 20 (2006) 698-705
67. Ross S.E., Hemati N., Longo K.A., Bennett C.N., Lucas P.C., Erickson R.L., and MacDougald O.A. Inhibition of adipogenesis by Wnt signaling. Science 289 (2000) 950-953
68. Salma N., Xiao H., Mueller E., and Imbalzano A.N. Temporal recruitment of transcription factors and SWI/SNF chromatin-remodeling enzymes during adipogenic induction of the peroxisome proliferator-activated receptor gamma nuclear hormone receptor. Mol. Cell. Biol. 24 (2004) 4651-4663
69. Salma N., Xiao H., and Imbalzano A.N. Temporal recruitment of CCAAT/enhancer-binding proteins to early and late adipogenic promoters in vivo. J. Mol. Endocrinol. 36 (2006) 139-151
70. Schwarz E.J., Reginato M.J., Shao D., Krakow S.L., and Lazar M.A. Retinoic acid blocks adipogenesis by inhibiting C/EBPbeta-mediated transcription. Mol. Cell. Biol. 17 (1997) 1552-1561
71. Shi X., Shi W., Li Q., Song B., Wan M., Bai S., and Cao X. A glucocorticoid-induced leucine-zipper protein, GILZ, inhibits adipogenesis of mesenchymal cells. EMBO Rep. 4 (2003) 374-380
72. Shimba S., Ishii N., Ohta Y., Ohno T., Watabe Y., Hayashi M., Wada T., Aoyagi T., and Tezuka M. Brain and muscle Arnt-like protein-1 (BMAL1), a component of the molecular clock, regulates adipogenesis. Proc. Natl. Acad. Sci. USA 102 (2005) 12071-12076
73. Soukas A., Socci N.D., Saatkamp B.D., Novelli S., and Friedman J.M. Distinct transcriptional profiles of adipogenesis in vivo and in vitro. J. Biol. Chem. 276 (2001) 34167-34174
74. Suh J.M., Gao X., McKay J., McKay R., Salo Z., and Graff J.M. Hedgehog signaling plays a conserved role in inhibiting fat formation. Cell Metab. 3 (2006) 25-34
75. Swiersz L.M., Giaccia A.J., and Yun Z. Oxygen-dependent regulation of adipogenesis. Methods Enzymol. 381 (2004) 387-395
76. Tanaka T., Yoshida N., Kishimoto T., and Akira S. Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene. EMBO J. 16 (1997) 7432-7443
77. Tang Q.Q., and Lane M.D. Activation and centromeric localization of CCAAT/enhancer-binding proteins during the mitotic clonal expansion of adipocyte differentiation. Genes Dev. 13 (1999) 2231-2241
78. Tang Q.Q., Otto T.C., and Lane M.D. Mitotic clonal expansion: a synchronous process required for adipogenesis. Proc. Natl. Acad. Sci. USA 100 (2003) 44-49
79. Tang Q.Q., Gronborg M., Huang H., Kim J.W., Otto T.C., Pandey A., and Lane M.D. Sequential phosphorylation of CCAAT enhancer-binding protein beta by MAPK and glycogen synthase kinase 3beta is required for adipogenesis. Proc. Natl. Acad. Sci. USA 102 (2005) 9766-9771
80. Teglund S., McKay C., Schuetz E., van Deursen J.M., Stravopodis D., Wang D., Brown M., Bodner S., Grosveld G., and Ihle J.N. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell 93 (1998) 841-850
81. Tong Q., Dalgin G., Xu H., Ting C.N., Leiden J.M., and Hotamisligil G.S. Function of GATA transcription factors in preadipocyte-adipocyte transition. Science 290 (2000) 134-138
82. Tong Q., Tsai J., Tan G., Dalgin G., and Hotamisligil G.S. Interaction between GATA and the C/EBP family of transcription factors is critical in GATA-mediated suppression of adipocyte differentiation. Mol. Cell. Biol. 25 (2005) 706-715
83. Tontonoz P., Graves R.A., Budavari A.I., Erdjument-Bromage H., Lui M., Hu E., Tempst P., and Spiegelman B.M. Adipocyte-specific transcription factor ARF6 is a heterodimeric complex of two nuclear hormone receptors, PPAR gamma and RXR alpha. Nucleic Acids Res. 22 (1994) 5628-5634
84. Tontonoz P., Hu E., Graves R.A., Budavari A.I., and Spiegelman B.M. mPPARγ2: tissue-specific regulator of an adipocyte enhancer. Genes Dev. 8 (1994) 1224-1234
85. Tontonoz P., Hu E., and Spiegelman B.M. Stimulation of adipogenesis in fibroblasts by PPARγ, a lipid-activated transcription factor. Cell 79 (1994) 1147-1156
86. Uldry M., Yang W., St-Pierre J., Lin J., Seale P., and Spiegelman B. Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation. Cell Metab. 3 (2006) 333-341
87. Wang C., Pattabiraman N., Zhou J.N., Fu M., Sakamaki T., Albanese C., Li Z., Wu K., Hulit J., Neumeister P., et al. Cyclin D1 repression of peroxisome proliferator-activated receptor gamma expression and transactivation. Mol. Cell. Biol. 23 (2003) 6159-6173
88. Wang N.D., Finegold M.J., Bradley A., Ou C.N., Abdelsayed S.V., Wilde M.D., Taylor L.R., Wilson D.R., and Darlington G.J. Impaired energy homeostasis in C/EBP alpha knockout mice. Science 269 (1995) 1108-1112
89. Wiper-Bergeron N., Wu D., Pope L., Schild-Poulter C., and Hache R.J. Stimulation of preadipocyte differentiation by steroid through targeting of an HDAC1 complex. EMBO J. 22 (2003) 2135-2145
90. Wolfrum C., Shih D.Q., Kuwajima S., Norris A.W., Kahn C.R., and Stoffel M. Role of Foxa-2 in adipocyte metabolism and differentiation. J. Clin. Invest. 112 (2003) 345-356
91. Wu J., Srinivasan S.V., Neumann J.C., and Lingrel J.B. The KLF2 transcription factor does not affect the formation of preadipocytes but inhibits their differentiation into adipocytes. Biochemistry 44 (2005) 11098-11105
92. Wu Z., Xie Y., Bucher N.L.R., and Farmer S.R. Conditional ectopic expression of C/EBPβ in NIH-3T3 cells induces PPARγ and stimulates adipogenesis. Genes Dev. 9 (1995) 2350-2363
93. Wu Z., Bucher N.L.R., and Farmer S.R. Induction of peroxisome proliferator-activated receptor gamma during conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBPβ, C/EBPδ and glucocorticoids. Mol. Cell. Biol. 16 (1996) 4128-4136
94. Wu Z., Rosen E.D., Brun R., Hauser S., Adelmont G., Troy A.E., McKeon C., Darlington G.J., and Spiegelman B.M. Cross-regulation of C/EBPα and PPARγ controls the transcriptional pathway of adipogenesis and insulin sensitivity. Mol. Cell 3 (1999) 151-158
95. Yamauchi T., Oike Y., Kamon J., Waki H., Komeda K., Tsuchida A., Date Y., Li M.X., Miki H., Akanuma Y., et al. Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice. Nat. Genet. 30 (2002) 221-226
96. Yeh W.C., Cao Z., Classon M., and McKnight S.L. Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. Genes Dev. 9 (1995) 168-181
97. Yoo E.J., Chung J.J., Choe S.S., Kim K.H., and Kim J.B. Down-regulation of histone deacetylases stimulates adipocyte differentiation. J. Biol. Chem. 281 (2006) 6608-6615
98. Yu C., Markan K., Temple K.A., Deplewski D., Brady M.J., and Cohen R.N. The nuclear receptor corepressors NCoR and SMRT decrease peroxisome proliferator-activated receptor gamma transcriptional activity and repress 3T3-L1 adipogenesis. J. Biol. Chem. 280 (2005) 13600-13605
99. Yun Z., Maecker H.L., Johnson R.S., and Giaccia A.J. Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia. Dev. Cell 2 (2002) 331-341
100. Zhang J., Fu M., Cui T., Xiong C., Xu K., Zhong W., Xiao Y., Floyd D., Liang J., Li E., et al. Selective disruption of PPARgamma 2 impairs the development of adipose tissue and insulin sensitivity. Proc. Natl. Acad. Sci. USA 101 (2004) 10703-10708
101. Zhang J.W., Klemm D.J., Vinson C., and Lane M.D. Role of CREB in transcriptional regulation of CCAAT/enhancer-binding protein beta gene during adipogenesis. J. Biol. Chem. 279 (2004) 4471-4478
102. Zuo Y., Qiang L., and Farmer S.R. Activation of C/EBPalpha expression by C/EBPbeta during adipogenesis requires a PPARgamma-associated repression of HDAC1 at the C/EBPalpha gene promoter. J. Biol. Chem. 281 (2006) 7960-7967