Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: The role of PPAR-γ2 transcription factor and TGF-β/BMP signaling pathways

Aging Cell

Volumn 3, Issue 6, 2004, Pages 379-389

  Moerman, Elena J ^a   Teng, Kui ^a   Lipschitz, David A ^a   Lecka Czernik, Beata ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Adipocyte; Aging; Marrow stem cells; Osteoblast; PPAR ; TGF BMP

Indexed keywords

BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; COLLAGEN; CYTOKINE; FATTY ACID BINDING PROTEIN; OSTEOCALCIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR DLX5; TRANSCRIPTION FACTOR RUNX2; TRANSFORMING GROWTH FACTOR BETA;

ADIPOCYTE; ADOLESCENT; AGED; AGING; ANIMAL CELL; ARTICLE; AUTOCRINE EFFECT; CELL COUNT; CELL DIFFERENTIATION; CELL MATURATION; CELL SPECIFICITY; CONTROLLED STUDY; GENE EXPRESSION; HEMATOPOIETIC STEM CELL; HOMEOSTASIS; MARKER GENE; MESENCHYMAL STEM CELL; MICROENVIRONMENT; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSSIFICATION; OSTEOBLAST; PARACRINE SIGNALING; PHENOTYPE; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STROMA CELL;

ADIPOCYTES; ANIMALS; BONE MORPHOGENETIC PROTEINS; CELL AGING; CELL DIFFERENTIATION; MESENCHYMAL STEM CELLS; MICE; MICE, INBRED C57BL; OSTEOGENESIS; PPAR GAMMA; RNA, MESSENGER; SIGNAL TRANSDUCTION; STROMAL CELLS; TRANSFORMING GROWTH FACTOR BETA;

EID: 13844257282     PISSN: 14749718     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1474-9728.2004.00127.x     Document Type: Article

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