-
1
-
-
0022499547
-
Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin
-
Hirano T, Yasukawa K, Harada H, Taga T, Watanabe Y, Matsuda T, et al. Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature (1986) 324:73-6. doi: 10.1038/324073a0
-
(1986)
Nature
, vol.324
, pp. 73-76
-
-
Hirano, T.1
Yasukawa, K.2
Harada, H.3
Taga, T.4
Watanabe, Y.5
Matsuda, T.6
-
2
-
-
0031913593
-
Interleukin 6 and its receptor: ten years later
-
Hirano T. Interleukin 6 and its receptor: ten years later. Int Rev Immunol (1998) 16:249-84. doi:10.3109/08830189809042997
-
(1998)
Int Rev Immunol
, vol.16
, pp. 249-284
-
-
Hirano, T.1
-
3
-
-
0041677606
-
Principles of interleukin (IL)-6-type cytokine signalling and its regulation
-
Heinrich PC, Behrmann I, Haan S, Hermanns HM, Muller-Newen G, Schaper F. Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J (2003) 374:1-20. doi:10.1042/BJ20030407
-
(2003)
Biochem J
, vol.374
, pp. 1-20
-
-
Heinrich, P.C.1
Behrmann, I.2
Haan, S.3
Hermanns, H.M.4
Muller-Newen, G.5
Schaper, F.6
-
4
-
-
33747245173
-
Updating interleukin-6 classic-and trans-signaling
-
Scheller J, Grötzinger J, Rose-John S. Updating interleukin-6 classic-and trans-signaling. Signal Transduct (2006) 6:240-59. doi:10.1002/sita.200600086
-
(2006)
Signal Transduct
, vol.6
, pp. 240-259
-
-
Scheller, J.1
Grötzinger, J.2
Rose-John, S.3
-
5
-
-
84893316263
-
Regulation of IL-6-type cytokine responses by MAPKs
-
Costa-Pereira AP. Regulation of IL-6-type cytokine responses by MAPKs. Biochem Soc Trans (2014) 42:59-62. doi:10.1042/BST20130267
-
(2014)
Biochem Soc Trans
, vol.42
, pp. 59-62
-
-
Costa-Pereira, A.P.1
-
6
-
-
84861697180
-
Plasticity and cross-talk of interleukin 6-type cytokines
-
Garbers C, Hermanns HM, Schaper F, Muller-Newen G, Grotzinger J, Rose-John S, et al. Plasticity and cross-talk of interleukin 6-type cytokines. Cytokine Growth Factor Rev (2012) 23:85-97. doi:10.1016/j.cytogfr.2012.04.001
-
(2012)
Cytokine Growth Factor Rev
, vol.23
, pp. 85-97
-
-
Garbers, C.1
Hermanns, H.M.2
Schaper, F.3
Muller-Newen, G.4
Grotzinger, J.5
Rose-John, S.6
-
8
-
-
0031201133
-
Soluble IL-6 receptor leads to a paracrine modulation of the IL-6-induced hepatic acute phase response in double transgenic mice
-
Peters M, Odenthal M, Schirmacher P, Blessing M, Fattori E, Ciliberto G, et al. Soluble IL-6 receptor leads to a paracrine modulation of the IL-6-induced hepatic acute phase response in double transgenic mice. J Immunol (1997) 159:1474-81
-
(1997)
J Immunol
, vol.159
, pp. 1474-1481
-
-
Peters, M.1
Odenthal, M.2
Schirmacher, P.3
Blessing, M.4
Fattori, E.5
Ciliberto, G.6
-
10
-
-
0027136189
-
Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6
-
Tamura T, Udagawa N, Takahashi N, Miyaura C, Tanaka S, Yamada Y, et al. Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6. Proc Natl Acad Sci U S A (1993) 90:11924-8. doi:10.1073/pnas.90.24.11924
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, pp. 11924-11928
-
-
Tamura, T.1
Udagawa, N.2
Takahashi, N.3
Miyaura, C.4
Tanaka, S.5
Yamada, Y.6
-
11
-
-
0033923617
-
Stimulation of osteoclast differentiation in vitro by mouse oncostatin M, leukaemia inhibitory factor, cardiotrophin-1 and interleukin 6: synergy with dexamethasone
-
Richards CD, Langdon C, Deschamps P, Pennica D, Shaughnessy SG. Stimulation of osteoclast differentiation in vitro by mouse oncostatin M, leukaemia inhibitory factor, cardiotrophin-1 and interleukin 6: synergy with dexamethasone. Cytokine (2000) 12:613-21. doi:10.1006/cyto.1999.0635
-
(2000)
Cytokine
, vol.12
, pp. 613-621
-
-
Richards, C.D.1
Langdon, C.2
Deschamps, P.3
Pennica, D.4
Shaughnessy, S.G.5
-
12
-
-
0030292721
-
Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis
-
Fukada T, Hibi M, Yamanaka Y, Takahashi-Tezuka M, Fujitani Y, Yamaguchi T, et al. Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis. Immunity (1996) 5:449-60. doi:10.1016/S1074-7613(00)80501-4
-
(1996)
Immunity
, vol.5
, pp. 449-460
-
-
Fukada, T.1
Hibi, M.2
Yamanaka, Y.3
Takahashi-Tezuka, M.4
Fujitani, Y.5
Yamaguchi, T.6
-
13
-
-
0001903105
-
Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3-and SHP2-mediated signals in immune responses
-
Ohtani T, Ishihara K, Atsumi T, Nishida K, Kaneko Y, Miyata T, et al. Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3-and SHP2-mediated signals in immune responses. Immunity (2000) 12:95-105. doi:10.1016/S1074-7613(00)80162-4
-
(2000)
Immunity
, vol.12
, pp. 95-105
-
-
Ohtani, T.1
Ishihara, K.2
Atsumi, T.3
Nishida, K.4
Kaneko, Y.5
Miyata, T.6
-
14
-
-
1542297244
-
IL-6 signal transduction and its physiological roles: the signal orchestration model
-
Kamimura D, Ishihara K, Hirano T. IL-6 signal transduction and its physiological roles: the signal orchestration model. Rev Physiol Biochem Pharmacol (2003) 149:1-38. doi:10.1007/s10254-003-0012-2
-
(2003)
Rev Physiol Biochem Pharmacol
, vol.149
, pp. 1-38
-
-
Kamimura, D.1
Ishihara, K.2
Hirano, T.3
-
15
-
-
0028167853
-
Interleukin-6 and interleukin-6 receptor are expressed by cultured glomerular epithelial cells
-
Moutabarrik A, Nakanishi I, Ishibashi M. Interleukin-6 and interleukin-6 receptor are expressed by cultured glomerular epithelial cells. Scand J Immunol (1994) 40:181-6. doi:10.1111/j.1365-3083.1994.tb03448.x
-
(1994)
Scand J Immunol
, vol.40
, pp. 181-186
-
-
Moutabarrik, A.1
Nakanishi, I.2
Ishibashi, M.3
-
16
-
-
33645233489
-
Differential expression of CD126 and CD130 mediates different STAT-3 phosphorylation in CD4+CD25-and CD25high regulatory T cells
-
Oberg HH, Wesch D, Grussel S, Rose-John S, Kabelitz D. Differential expression of CD126 and CD130 mediates different STAT-3 phosphorylation in CD4+CD25-and CD25high regulatory T cells. Int Immunol (2006) 18:555-63. doi:10.1093/intimm/dxh396
-
(2006)
Int Immunol
, vol.18
, pp. 555-563
-
-
Oberg, H.H.1
Wesch, D.2
Grussel, S.3
Rose-John, S.4
Kabelitz, D.5
-
17
-
-
0031454425
-
Role of metalloproteases in the release of the IL-1 type II decoy receptor
-
Orlando S, Sironi M, Bianchi G, Drummond AH, Boraschi D, Yabes D, et al. Role of metalloproteases in the release of the IL-1 type II decoy receptor. J Biol Chem (1997) 272:31764-9. doi:10.1074/jbc.272.50.31764
-
(1997)
J Biol Chem
, vol.272
, pp. 31764-31769
-
-
Orlando, S.1
Sironi, M.2
Bianchi, G.3
Drummond, A.H.4
Boraschi, D.5
Yabes, D.6
-
18
-
-
0032515018
-
An essential role for ectodomain shedding in mammalian development
-
Peschon JJ, Slack JL, Reddy P, Stocking KL, Sunnarborg SW, Lee DC, et al. An essential role for ectodomain shedding in mammalian development. Science (1998) 282:1281-4. doi:10.1126/science.282.5392.1281
-
(1998)
Science
, vol.282
, pp. 1281-1284
-
-
Peschon, J.J.1
Slack, J.L.2
Reddy, P.3
Stocking, K.L.4
Sunnarborg, S.W.5
Lee, D.C.6
-
19
-
-
0034640286
-
Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzyme
-
Reddy P, Slack JL, Davis R, Cerretti DP, Kozlosky CJ, Blanton RA, et al. Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzyme. J Biol Chem (2000) 275:14608-14. doi:10.1074/jbc.275.19.14608
-
(2000)
J Biol Chem
, vol.275
, pp. 14608-14614
-
-
Reddy, P.1
Slack, J.L.2
Davis, R.3
Cerretti, D.P.4
Kozlosky, C.J.5
Blanton, R.A.6
-
20
-
-
0024458160
-
Soluble cytokine receptors are present in normal human urine
-
Novick D, Engelmann H, Wallach D, Rubinstein M. Soluble cytokine receptors are present in normal human urine. J Exp Med (1989) 170:1409-14. doi:10.1084/jem.170.4.1409
-
(1989)
J Exp Med
, vol.170
, pp. 1409-1414
-
-
Novick, D.1
Engelmann, H.2
Wallach, D.3
Rubinstein, M.4
-
21
-
-
0037037586
-
A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis
-
Atsumi T, Ishihara K, Kamimura D, Ikushima H, Ohtani T, Hirota S, et al. A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis. J Exp Med (2002) 196:979-90. doi:10.1084/jem.20020619
-
(2002)
J Exp Med
, vol.196
, pp. 979-990
-
-
Atsumi, T.1
Ishihara, K.2
Kamimura, D.3
Ikushima, H.4
Ohtani, T.5
Hirota, S.6
-
22
-
-
33750166463
-
Interleukin-6 and its receptor: from bench to bedside
-
Scheller J, Rose-John S. Interleukin-6 and its receptor: from bench to bedside. Med Microbiol Immunol (2006) 195:173-83. doi:10.1007/s00430-006-0019-9
-
(2006)
Med Microbiol Immunol
, vol.195
, pp. 173-183
-
-
Scheller, J.1
Rose-John, S.2
-
23
-
-
34248341267
-
The IL-6/sIL-6R complex as a novel target for therapeutic approaches
-
Rose-John S, Waetzig GH, Scheller J, Grotzinger J, Seegert D. The IL-6/sIL-6R complex as a novel target for therapeutic approaches. Expert Opin Ther Targets (2007) 11:613-24. doi:10.1517/14728222.11.5.613
-
(2007)
Expert Opin Ther Targets
, vol.11
, pp. 613-624
-
-
Rose-John, S.1
Waetzig, G.H.2
Scheller, J.3
Grotzinger, J.4
Seegert, D.5
-
24
-
-
84931076559
-
Soluble IL6R represents a miR-34a target: potential implications for the recently identified IL-6R/STAT3/miR-34a feed-back loop
-
Li H, Rokavec M, Hermeking H. Soluble IL6R represents a miR-34a target: potential implications for the recently identified IL-6R/STAT3/miR-34a feed-back loop. Oncotarget (2015) 6:14026-32. doi:10.18632/oncotarget.4334
-
(2015)
Oncotarget
, vol.6
, pp. 14026-14032
-
-
Li, H.1
Rokavec, M.2
Hermeking, H.3
-
25
-
-
84945928726
-
Higher proliferation of peritumoral endothelial cells to IL-6/sIL-6R than tumoral endothelial cells in hepatocellular carcinoma
-
Zhuang PY, Wang JD, Tang ZH, Zhou XP, Quan ZW, Liu YB, et al. Higher proliferation of peritumoral endothelial cells to IL-6/sIL-6R than tumoral endothelial cells in hepatocellular carcinoma. BMC Cancer (2015) 15:830. doi:10.1186/s12885-015-1763-2
-
(2015)
BMC Cancer
, vol.15
, pp. 830
-
-
Zhuang, P.Y.1
Wang, J.D.2
Tang, Z.H.3
Zhou, X.P.4
Quan, Z.W.5
Liu, Y.B.6
-
26
-
-
0028226196
-
Soluble receptors for cytokines and growth factors: generation and biological function
-
Rose-John S, Heinrich PC. Soluble receptors for cytokines and growth factors: generation and biological function. Biochem J (1994) 300(Pt 2):281-90. doi:10.1042/bj3000281
-
(1994)
Biochem J
, vol.300
, pp. 281-290
-
-
Rose-John, S.1
Heinrich, P.C.2
-
27
-
-
80055113800
-
Role of the IL-6 classic-and trans-signaling pathways in corneal sterile inflammation and wound healing
-
Ebihara N, Matsuda A, Nakamura S, Matsuda H, Murakami A. Role of the IL-6 classic-and trans-signaling pathways in corneal sterile inflammation and wound healing. Invest Ophthalmol Vis Sci (2011) 52:8549-57. doi:10.1167/iovs.11-7956
-
(2011)
Invest Ophthalmol Vis Sci
, vol.52
, pp. 8549-8557
-
-
Ebihara, N.1
Matsuda, A.2
Nakamura, S.3
Matsuda, H.4
Murakami, A.5
-
28
-
-
78650588695
-
Essential role of neutrophil mobilization in concanavalin A-induced hepatitis is based on classic IL-6 signaling but not on IL-6 trans-signaling
-
Malchow S, Thaiss W, Janner N, Waetzig GH, Gewiese-Rabsch J, Garbers C, et al. Essential role of neutrophil mobilization in concanavalin A-induced hepatitis is based on classic IL-6 signaling but not on IL-6 trans-signaling. Biochim Biophys Acta (2011) 1812:290-301. doi:10.1016/j.bbadis.2010.11.009
-
(2011)
Biochim Biophys Acta
, vol.1812
, pp. 290-301
-
-
Malchow, S.1
Thaiss, W.2
Janner, N.3
Waetzig, G.H.4
Gewiese-Rabsch, J.5
Garbers, C.6
-
29
-
-
84962016526
-
The role of interleukin-6 signaling in nervous tissue
-
Rothaug M, Becker-Pauly C, Rose-John S. The role of interleukin-6 signaling in nervous tissue. Biochim Biophys Acta (2016) 1863:1218-27. doi:10.1016/j.bbamcr.2016.03.018
-
(2016)
Biochim Biophys Acta
, vol.1863
, pp. 1218-1227
-
-
Rothaug, M.1
Becker-Pauly, C.2
Rose-John, S.3
-
30
-
-
0026828552
-
Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor
-
Lust JA, Donovan KA, Kline MP, Greipp PR, Kyle RA, Maihle NJ. Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor. Cytokine (1992) 4:96-100. doi:10.1016/1043-4666(92)90043-Q
-
(1992)
Cytokine
, vol.4
, pp. 96-100
-
-
Lust, J.A.1
Donovan, K.A.2
Kline, M.P.3
Greipp, P.R.4
Kyle, R.A.5
Maihle, N.J.6
-
31
-
-
0027398766
-
The soluble interleukin-6 receptor is generated by shedding
-
Mullberg J, Schooltink H, Stoyan T, Gunther M, Graeve L, Buse G, et al. The soluble interleukin-6 receptor is generated by shedding. Eur J Immunol (1993) 23:473-80. doi:10.1002/eji.1830230226
-
(1993)
Eur J Immunol
, vol.23
, pp. 473-480
-
-
Mullberg, J.1
Schooltink, H.2
Stoyan, T.3
Gunther, M.4
Graeve, L.5
Buse, G.6
-
32
-
-
84875381278
-
Alternative splicing and proteolytic rupture contribute to the generation of soluble IL-6 receptors (sIL-6R) in rheumatoid arthritis
-
Lamas JR, Rodriguez-Rodriguez L, Tornero-Esteban P, Villafuertes E, Hoyas J, Abasolo L, et al. Alternative splicing and proteolytic rupture contribute to the generation of soluble IL-6 receptors (sIL-6R) in rheumatoid arthritis. Cytokine (2013) 61:720-3. doi:10.1016/j.cyto.2012.12.025
-
(2013)
Cytokine
, vol.61
, pp. 720-723
-
-
Lamas, J.R.1
Rodriguez-Rodriguez, L.2
Tornero-Esteban, P.3
Villafuertes, E.4
Hoyas, J.5
Abasolo, L.6
-
33
-
-
33845668702
-
Sleep enhances IL-6 trans-signaling in humans
-
Dimitrov S, Lange T, Benedict C, Nowell MA, Jones SA, Scheller J, et al. Sleep enhances IL-6 trans-signaling in humans. FASEB J (2006) 20:2174-6. doi:10.1096/fj.06-5754fje
-
(2006)
FASEB J
, vol.20
, pp. 2174-2176
-
-
Dimitrov, S.1
Lange, T.2
Benedict, C.3
Nowell, M.A.4
Jones, S.A.5
Scheller, J.6
-
34
-
-
34548856204
-
Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils
-
Chalaris A, Rabe B, Paliga K, Lange H, Laskay T, Fielding CA, et al. Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils. Blood (2007) 110:1748-55. doi:10.1182/blood-2007-01-067918
-
(2007)
Blood
, vol.110
, pp. 1748-1755
-
-
Chalaris, A.1
Rabe, B.2
Paliga, K.3
Lange, H.4
Laskay, T.5
Fielding, C.A.6
-
35
-
-
77649271394
-
ADAM17-mediated shedding of the IL6R induces cleavage of the membrane stub by gamma-secretase
-
Chalaris A, Gewiese J, Paliga K, Fleig L, Schneede A, Krieger K, et al. ADAM17-mediated shedding of the IL6R induces cleavage of the membrane stub by gamma-secretase. Biochim Biophys Acta (2010) 1803:234-45. doi:10.1016/j.bbamcr.2009.12.001
-
(2010)
Biochim Biophys Acta
, vol.1803
, pp. 234-245
-
-
Chalaris, A.1
Gewiese, J.2
Paliga, K.3
Fleig, L.4
Schneede, A.5
Krieger, K.6
-
36
-
-
0141866756
-
Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE)
-
Matthews V, Schuster B, Schutze S, Bussmeyer I, Ludwig A, Hundhausen C, et al. Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE). J Biol Chem (2003) 278:38829-39. doi:10.1074/jbc.M210584200
-
(2003)
J Biol Chem
, vol.278
, pp. 38829-38839
-
-
Matthews, V.1
Schuster, B.2
Schutze, S.3
Bussmeyer, I.4
Ludwig, A.5
Hundhausen, C.6
-
37
-
-
0029795014
-
Pore-forming toxins trigger shedding of receptors for interleukin 6 and lipopolysaccharide
-
Walev I, Vollmer P, Palmer M, Bhakdi S, Rose-John S. Pore-forming toxins trigger shedding of receptors for interleukin 6 and lipopolysaccharide. Proc Natl Acad Sci U S A (1996) 93:7882-7. doi:10.1073/pnas.93.15.7882
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 7882-7887
-
-
Walev, I.1
Vollmer, P.2
Palmer, M.3
Bhakdi, S.4
Rose-John, S.5
-
38
-
-
19944430946
-
Interleukin-6 receptor shedding is enhanced by interleukin-1beta and tumor necrosis factor alpha and is partially mediated by tumor necrosis factor alpha-converting enzyme in osteoblast-like cells
-
Franchimont N, Lambert C, Huynen P, Ribbens C, Relic B, Chariot A, et al. Interleukin-6 receptor shedding is enhanced by interleukin-1beta and tumor necrosis factor alpha and is partially mediated by tumor necrosis factor alpha-converting enzyme in osteoblast-like cells. Arthritis Rheum (2005) 52:84-93. doi:10.1002/art.20727
-
(2005)
Arthritis Rheum
, vol.52
, pp. 84-93
-
-
Franchimont, N.1
Lambert, C.2
Huynen, P.3
Ribbens, C.4
Relic, B.5
Chariot, A.6
-
39
-
-
74249090820
-
TNF-alpha-converting enzyme (TACE/ADAM17)-dependent loss of CD30 induced by proteasome inhibition through reactive oxygen species
-
Vahdat AM, Reiners KS, Simhadri VL, Eichenauer DA, Boll B, Chalaris A, et al. TNF-alpha-converting enzyme (TACE/ADAM17)-dependent loss of CD30 induced by proteasome inhibition through reactive oxygen species. Leukemia (2010) 24:51-7. doi:10.1038/leu.2009.230
-
(2010)
Leukemia
, vol.24
, pp. 51-57
-
-
Vahdat, A.M.1
Reiners, K.S.2
Simhadri, V.L.3
Eichenauer, D.A.4
Boll, B.5
Chalaris, A.6
-
40
-
-
84944909402
-
Shedding of endogenous interleukin-6 receptor (IL-6R) is governed by a disintegrin and metalloproteinase (ADAM) proteases while a full-length IL-6R isoform localizes to circulating microvesicles
-
Schumacher N, Meyer D, Mauermann A, Von Der Heyde J, Wolf J, Schwarz J, et al. Shedding of endogenous interleukin-6 receptor (IL-6R) is governed by a disintegrin and metalloproteinase (ADAM) proteases while a full-length IL-6R isoform localizes to circulating microvesicles. J Biol Chem (2015) 290:26059-71. doi:10.1074/jbc.M115.649509
-
(2015)
J Biol Chem
, vol.290
, pp. 26059-26071
-
-
Schumacher, N.1
Meyer, D.2
Mauermann, A.3
Von Der Heyde, J.4
Wolf, J.5
Schwarz, J.6
-
41
-
-
0027293104
-
Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130
-
Narazaki M, Yasukawa K, Saito T, Ohsugi Y, Fukui H, Koishihara Y, et al. Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130. Blood (1993) 82:1120-6
-
(1993)
Blood
, vol.82
, pp. 1120-1126
-
-
Narazaki, M.1
Yasukawa, K.2
Saito, T.3
Ohsugi, Y.4
Fukui, H.5
Koishihara, Y.6
-
42
-
-
0032562601
-
Identification and characterization of two distinct truncated forms of gp130 and a soluble form of leukemia inhibitory factor receptor alpha-chain in normal human urine and plasma
-
Zhang JG, Zhang Y, Owczarek CM, Ward LD, Moritz RL, Simpson RJ, et al. Identification and characterization of two distinct truncated forms of gp130 and a soluble form of leukemia inhibitory factor receptor alpha-chain in normal human urine and plasma. J Biol Chem (1998) 273:10798-805. doi:10.1074/jbc.273.17.10798
-
(1998)
J Biol Chem
, vol.273
, pp. 10798-10805
-
-
Zhang, J.G.1
Zhang, Y.2
Owczarek, C.M.3
Ward, L.D.4
Moritz, R.L.5
Simpson, R.J.6
-
43
-
-
0033916898
-
Cloning of novel soluble gp130 and detection of its neutralizing autoantibodies in rheumatoid arthritis
-
Tanaka M, Kishimura M, Ozaki S, Osakada F, Hashimoto H, Okubo M, et al. Cloning of novel soluble gp130 and detection of its neutralizing autoantibodies in rheumatoid arthritis. J Clin Invest (2000) 106:137-44. doi:10.1172/JCI7479
-
(2000)
J Clin Invest
, vol.106
, pp. 137-144
-
-
Tanaka, M.1
Kishimura, M.2
Ozaki, S.3
Osakada, F.4
Hashimoto, H.5
Okubo, M.6
-
44
-
-
34648832277
-
Regulation of a lymphocyte-endothelial-IL-6 trans-signaling axis by fever-range thermal stress: hot spot of immune surveillance
-
Vardam TD, Zhou L, Appenheimer MM, Chen Q, Wang WC, Baumann H, et al. Regulation of a lymphocyte-endothelial-IL-6 trans-signaling axis by fever-range thermal stress: hot spot of immune surveillance. Cytokine (2007) 39:84-96. doi:10.1016/j.cyto.2007.07.184
-
(2007)
Cytokine
, vol.39
, pp. 84-96
-
-
Vardam, T.D.1
Zhou, L.2
Appenheimer, M.M.3
Chen, Q.4
Wang, W.C.5
Baumann, H.6
-
45
-
-
0027428924
-
Differential shedding of the two subunits of the interleukin-6 receptor
-
Mullberg J, Dittrich E, Graeve L, Gerhartz C, Yasukawa K, Taga T, et al. Differential shedding of the two subunits of the interleukin-6 receptor. FEBS Lett (1993) 332:174-8. doi:10.1016/0014-5793(93)80507-Q
-
(1993)
FEBS Lett
, vol.332
, pp. 174-178
-
-
Mullberg, J.1
Dittrich, E.2
Graeve, L.3
Gerhartz, C.4
Yasukawa, K.5
Taga, T.6
-
46
-
-
0035160256
-
Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses
-
Jostock T, Mullberg J, Ozbek S, Atreya R, Blinn G, Voltz N, et al. Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses. Eur J Biochem (2001) 268:160-7. doi:10.1046/j.1432-1327.2001.01867.x
-
(2001)
Eur J Biochem
, vol.268
, pp. 160-167
-
-
Jostock, T.1
Mullberg, J.2
Ozbek, S.3
Atreya, R.4
Blinn, G.5
Voltz, N.6
-
47
-
-
84928667962
-
Circulating levels of interleukin 6 soluble receptor and its natural antagonist, sgp130, and the risk of myocardial infarction
-
Moreno Velasquez I, Golabkesh Z, Kallberg H, Leander K, De Faire U, Gigante B. Circulating levels of interleukin 6 soluble receptor and its natural antagonist, sgp130, and the risk of myocardial infarction. Atherosclerosis (2015) 240:477-81. doi:10.1016/j.atherosclerosis.2015.04.014
-
(2015)
Atherosclerosis
, vol.240
, pp. 477-481
-
-
Moreno Velasquez, I.1
Golabkesh, Z.2
Kallberg, H.3
Leander, K.4
De Faire, U.5
Gigante, B.6
-
48
-
-
0033621731
-
Soluble glycoprotein 130 (gp130) attenuates OSM-and LIF-induced cartilage proteoglycan catabolism
-
Hui W, Bell M, Carroll G. Soluble glycoprotein 130 (gp130) attenuates OSM-and LIF-induced cartilage proteoglycan catabolism. Cytokine (2000) 12:151-5. doi:10.1006/cyto.1999.0550
-
(2000)
Cytokine
, vol.12
, pp. 151-155
-
-
Hui, W.1
Bell, M.2
Carroll, G.3
-
49
-
-
10644250867
-
No inhibition of IL-27 signaling by soluble gp130
-
Scheller J, Schuster B, Holscher C, Yoshimoto T, Rose-John S. No inhibition of IL-27 signaling by soluble gp130. Biochem Biophys Res Commun (2005) 326:724-8. doi:10.1016/j.bbrc.2004.11.098
-
(2005)
Biochem Biophys Res Commun
, vol.326
, pp. 724-728
-
-
Scheller, J.1
Schuster, B.2
Holscher, C.3
Yoshimoto, T.4
Rose-John, S.5
-
50
-
-
84857411475
-
Hitting a complex target: an update on interleukin-6 trans-signalling
-
Waetzig GH, Rose-John S. Hitting a complex target: an update on interleukin-6 trans-signalling. Expert Opin Ther Targets (2012) 16:225-36. doi:10.1517/14728222.2012.660307
-
(2012)
Expert Opin Ther Targets
, vol.16
, pp. 225-236
-
-
Waetzig, G.H.1
Rose-John, S.2
-
51
-
-
79955650634
-
The pro-and anti-inflammatory properties of the cytokine interleukin-6
-
Scheller J, Chalaris A, Schmidt-Arras D, Rose-John S. The pro-and anti-inflammatory properties of the cytokine interleukin-6. Biochim Biophys Acta (2011) 1813:878-88. doi:10.1016/j.bbamcr.2011.01.034
-
(2011)
Biochim Biophys Acta
, vol.1813
, pp. 878-888
-
-
Scheller, J.1
Chalaris, A.2
Schmidt-Arras, D.3
Rose-John, S.4
-
52
-
-
0030823183
-
IL-6 and APPs: anti-inflammatory and immunosuppressive mediators
-
Tilg H, Dinarello CA, Mier JW. IL-6 and APPs: anti-inflammatory and immunosuppressive mediators. Immunol Today (1997) 18:428-32. doi:10.1016/S0167-5699(97)01103-1
-
(1997)
Immunol Today
, vol.18
, pp. 428-432
-
-
Tilg, H.1
Dinarello, C.A.2
Mier, J.W.3
-
53
-
-
18344410191
-
Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in Crohn disease and experimental colitis in vivo
-
Atreya R, Mudter J, Finotto S, Mullberg J, Jostock T, Wirtz S, et al. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in Crohn disease and experimental colitis in vivo. Nat Med (2000) 6:583-8. doi:10.1038/75068
-
(2000)
Nat Med
, vol.6
, pp. 583-588
-
-
Atreya, R.1
Mudter, J.2
Finotto, S.3
Mullberg, J.4
Jostock, T.5
Wirtz, S.6
-
54
-
-
33747774200
-
STAT3 activation via interleukin 6 trans-signalling contributes to ileitis in SAMP1/Yit mice
-
Mitsuyama K, Matsumoto S, Rose-John S, Suzuki A, Hara T, Tomiyasu N, et al. STAT3 activation via interleukin 6 trans-signalling contributes to ileitis in SAMP1/Yit mice. Gut (2006) 55:1263-9. doi:10.1136/gut.2005.079343
-
(2006)
Gut
, vol.55
, pp. 1263-1269
-
-
Mitsuyama, K.1
Matsumoto, S.2
Rose-John, S.3
Suzuki, A.4
Hara, T.5
Tomiyasu, N.6
-
55
-
-
34447572925
-
Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells
-
Finotto S, Eigenbrod T, Karwot R, Boross I, Doganci A, Ito H, et al. Local blockade of IL-6R signaling induces lung CD4+ T cell apoptosis in a murine model of asthma via regulatory T cells. Int Immunol (2007) 19:685-93. doi:10.1093/intimm/dxm037
-
(2007)
Int Immunol
, vol.19
, pp. 685-693
-
-
Finotto, S.1
Eigenbrod, T.2
Karwot, R.3
Boross, I.4
Doganci, A.5
Ito, H.6
-
56
-
-
38949164424
-
Transgenic blockade of interleukin 6 transsignaling abrogates inflammation
-
Rabe B, Chalaris A, May U, Waetzig GH, Seegert D, Williams AS, et al. Transgenic blockade of interleukin 6 transsignaling abrogates inflammation. Blood (2008) 111:1021-8. doi:10.1182/blood-2007-07-102137
-
(2008)
Blood
, vol.111
, pp. 1021-1028
-
-
Rabe, B.1
Chalaris, A.2
May, U.3
Waetzig, G.H.4
Seegert, D.5
Williams, A.S.6
-
57
-
-
77949326158
-
Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model
-
Matsumoto S, Hara T, Mitsuyama K, Yamamoto M, Tsuruta O, Sata M, et al. Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model. J Immunol (2010) 184:1543-51. doi:10.4049/jimmunol.0801217
-
(2010)
J Immunol
, vol.184
, pp. 1543-1551
-
-
Matsumoto, S.1
Hara, T.2
Mitsuyama, K.3
Yamamoto, M.4
Tsuruta, O.5
Sata, M.6
-
58
-
-
79251578016
-
IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3
-
Greenhill CJ, Rose-John S, Lissilaa R, Ferlin W, Ernst M, Hertzog PJ, et al. IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3. J Immunol (2011) 186:1199-208. doi:10.4049/jimmunol.1002971
-
(2011)
J Immunol
, vol.186
, pp. 1199-1208
-
-
Greenhill, C.J.1
Rose-John, S.2
Lissilaa, R.3
Ferlin, W.4
Ernst, M.5
Hertzog, P.J.6
-
59
-
-
79953756112
-
Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer
-
Lesina M, Kurkowski MU, Ludes K, Rose-John S, Treiber M, Kloppel G, et al. Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer. Cancer Cell (2011) 19:456-69. doi:10.1016/j.ccr.2011.03.009
-
(2011)
Cancer Cell
, vol.19
, pp. 456-469
-
-
Lesina, M.1
Kurkowski, M.U.2
Ludes, K.3
Rose-John, S.4
Treiber, M.5
Kloppel, G.6
-
60
-
-
78751549236
-
IL-6 trans-signaling in formation and progression of malignant ascites in ovarian cancer
-
Lo CW, Chen MW, Hsiao M, Wang S, Chen CA, Hsiao SM, et al. IL-6 trans-signaling in formation and progression of malignant ascites in ovarian cancer. Cancer Res (2011) 71:424-34. doi:10.1158/0008-5472
-
(2011)
Cancer Res
, vol.71
, pp. 424-434
-
-
Lo, C.W.1
Chen, M.W.2
Hsiao, M.3
Wang, S.4
Chen, C.A.5
Hsiao, S.M.6
-
61
-
-
84943659478
-
Enhanced IL-6 trans-signaling in pulmonary arterial hypertension and its potential role in disease-related systemic damage
-
Jasiewicz M, Knapp M, Waszkiewicz E, Ptaszynska-Kopczynska K, Szpakowicz A, Sobkowicz B, et al. Enhanced IL-6 trans-signaling in pulmonary arterial hypertension and its potential role in disease-related systemic damage. Cytokine (2015) 76:187-92. doi:10.1016/j.cyto.2015.06.018
-
(2015)
Cytokine
, vol.76
, pp. 187-192
-
-
Jasiewicz, M.1
Knapp, M.2
Waszkiewicz, E.3
Ptaszynska-Kopczynska, K.4
Szpakowicz, A.5
Sobkowicz, B.6
-
62
-
-
0037213682
-
IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammation
-
Kaplanski G, Marin V, Montero-Julian F, Mantovani A, Farnarier C. IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammation. Trends Immunol (2003) 24:25-9. doi:10.1016/S1471-4906(02)00013-3
-
(2003)
Trends Immunol
, vol.24
, pp. 25-29
-
-
Kaplanski, G.1
Marin, V.2
Montero-Julian, F.3
Mantovani, A.4
Farnarier, C.5
-
63
-
-
33646577466
-
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
-
Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature (2006) 441:235-8. doi:10.1038/nature04753
-
(2006)
Nature
, vol.441
, pp. 235-238
-
-
Bettelli, E.1
Carrier, Y.2
Gao, W.3
Korn, T.4
Strom, T.B.5
Oukka, M.6
-
64
-
-
33646560950
-
Transforming growth factor-beta induces development of the T(H)17 lineage
-
Mangan PR, Harrington LE, O'Quinn DB, Helms WS, Bullard DC, Elson CO, et al. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature (2006) 441:231-4. doi:10.1038/nature04754
-
(2006)
Nature
, vol.441
, pp. 231-234
-
-
Mangan, P.R.1
Harrington, L.E.2
O'Quinn, D.B.3
Helms, W.S.4
Bullard, D.C.5
Elson, C.O.6
-
65
-
-
32244442562
-
TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
-
Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity (2006) 24:179-89. doi:10.1016/j.immuni.2006.01.001
-
(2006)
Immunity
, vol.24
, pp. 179-189
-
-
Veldhoen, M.1
Hocking, R.J.2
Atkins, C.J.3
Locksley, R.M.4
Stockinger, B.5
-
66
-
-
79952101377
-
Th17 cells in inflammation
-
Kimura A, Kishimoto T. Th17 cells in inflammation. Int Immunopharmacol (2011) 11:319-22. doi:10.1016/j.intimp.2010.10.004
-
(2011)
Int Immunopharmacol
, vol.11
, pp. 319-322
-
-
Kimura, A.1
Kishimoto, T.2
-
67
-
-
0348223787
-
Conversion of peripheral CD4+CD25-naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
-
Chen W, Jin W, Hardegen N, Lei KJ, Li L, Marinos N, et al. Conversion of peripheral CD4+CD25-naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med (2003) 198:1875-86. doi:10.1084/jem.20030152
-
(2003)
J Exp Med
, vol.198
, pp. 1875-1886
-
-
Chen, W.1
Jin, W.2
Hardegen, N.3
Lei, K.J.4
Li, L.5
Marinos, N.6
-
68
-
-
2142645808
-
Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25-T cells through Foxp3 induction and down-regulation of Smad7
-
Fantini MC, Becker C, Monteleone G, Pallone F, Galle PR, Neurath MF. Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25-T cells through Foxp3 induction and down-regulation of Smad7. J Immunol (2004) 172:5149-53. doi:10.4049/jimmunol.172.9.5149
-
(2004)
J Immunol
, vol.172
, pp. 5149-5153
-
-
Fantini, M.C.1
Becker, C.2
Monteleone, G.3
Pallone, F.4
Galle, P.R.5
Neurath, M.F.6
-
69
-
-
34848876937
-
Cutting edge: trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cells
-
Dominitzki S, Fantini MC, Neufert C, Nikolaev A, Galle PR, Scheller J, et al. Cutting edge: trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cells. J Immunol (2007) 179:2041-5. doi:10.4049/jimmunol.179.4.2041
-
(2007)
J Immunol
, vol.179
, pp. 2041-2045
-
-
Dominitzki, S.1
Fantini, M.C.2
Neufert, C.3
Nikolaev, A.4
Galle, P.R.5
Scheller, J.6
-
70
-
-
79251543298
-
The influence of excessive IL-6 production in vivo on the development and function of Foxp3+ regulatory T cells
-
Fujimoto M, Nakano M, Terabe F, Kawahata H, Ohkawara T, Han Y, et al. The influence of excessive IL-6 production in vivo on the development and function of Foxp3+ regulatory T cells. J Immunol (2011) 186:32-40. doi:10.4049/jimmunol.0903314
-
(2011)
J Immunol
, vol.186
, pp. 32-40
-
-
Fujimoto, M.1
Nakano, M.2
Terabe, F.3
Kawahata, H.4
Ohkawara, T.5
Han, Y.6
-
72
-
-
77951192680
-
Anti-IL-6 receptor antibody suppressed T cell activation by inhibiting IL-2 production and inducing regulatory T cells
-
Yoshida H, Hashizume M, Suzuki M, Mihara M. Anti-IL-6 receptor antibody suppressed T cell activation by inhibiting IL-2 production and inducing regulatory T cells. Eur J Pharmacol (2010) 634:178-83. doi:10.1016/j.ejphar.2010.02.026
-
(2010)
Eur J Pharmacol
, vol.634
, pp. 178-183
-
-
Yoshida, H.1
Hashizume, M.2
Suzuki, M.3
Mihara, M.4
-
73
-
-
0031058726
-
Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells
-
Rincon M, Anguita J, Nakamura T, Fikrig E, Flavell RA. Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells. J Exp Med (1997) 185:461-9. doi:10.1084/jem.185.3.461
-
(1997)
J Exp Med
, vol.185
, pp. 461-469
-
-
Rincon, M.1
Anguita, J.2
Nakamura, T.3
Fikrig, E.4
Flavell, R.A.5
-
74
-
-
77955487468
-
Signals that influence T follicular helper cell differentiation and function
-
Linterman MA, Vinuesa CG. Signals that influence T follicular helper cell differentiation and function. Semin Immunopathol (2010) 32:183-96. doi:10.1007/s00281-009-0194-z
-
(2010)
Semin Immunopathol
, vol.32
, pp. 183-196
-
-
Linterman, M.A.1
Vinuesa, C.G.2
-
75
-
-
0033781454
-
Modulation of protein kinase activity and gene expression by reactive oxygen species and their role in vascular physiology and pathophysiology
-
Griendling KK, Sorescu D, Lassegue B, Ushio-Fukai M. Modulation of protein kinase activity and gene expression by reactive oxygen species and their role in vascular physiology and pathophysiology. Arterioscler Thromb Vasc Biol (2000) 20:2175-83. doi:10.1161/01.ATV.20.10.2175
-
(2000)
Arterioscler Thromb Vasc Biol
, vol.20
, pp. 2175-2183
-
-
Griendling, K.K.1
Sorescu, D.2
Lassegue, B.3
Ushio-Fukai, M.4
-
76
-
-
0037421492
-
Role of oxidative stress in atherosclerosis
-
Harrison D, Griendling KK, Landmesser U, Hornig B, Drexler H. Role of oxidative stress in atherosclerosis. Am J Cardiol (2003) 91:7A-11A. doi:10.1016/S0002-9149(02)03144-2
-
(2003)
Am J Cardiol
, vol.91
, pp. 7A-11A
-
-
Harrison, D.1
Griendling, K.K.2
Landmesser, U.3
Hornig, B.4
Drexler, H.5
-
77
-
-
0034038677
-
Activity of interleukin 6 in the differentiation of monocytes to macrophages and dendritic cells
-
Mitani H, Katayama N, Araki H, Ohishi K, Kobayashi K, Suzuki H, et al. Activity of interleukin 6 in the differentiation of monocytes to macrophages and dendritic cells. Br J Haematol (2000) 109:288-95. doi:10.1046/j.1365-2141.2000.02020.x
-
(2000)
Br J Haematol
, vol.109
, pp. 288-295
-
-
Mitani, H.1
Katayama, N.2
Araki, H.3
Ohishi, K.4
Kobayashi, K.5
Suzuki, H.6
-
78
-
-
0032530257
-
The zinc finger transcription factor Egr-1 activates macrophage differentiation in M1 myeloblastic leukemia cells
-
Krishnaraju K, Hoffman B, Liebermann DA. The zinc finger transcription factor Egr-1 activates macrophage differentiation in M1 myeloblastic leukemia cells. Blood (1998) 92:1957-66
-
(1998)
Blood
, vol.92
, pp. 1957-1966
-
-
Krishnaraju, K.1
Hoffman, B.2
Liebermann, D.A.3
-
79
-
-
0034577943
-
IL-6 switches the differentiation of monocytes from dendritic cells to macrophages
-
Chomarat P, Banchereau J, Davoust J, Palucka AK. IL-6 switches the differentiation of monocytes from dendritic cells to macrophages. Nat Immunol (2000) 1:510-4. doi:10.1038/82763
-
(2000)
Nat Immunol
, vol.1
, pp. 510-514
-
-
Chomarat, P.1
Banchereau, J.2
Davoust, J.3
Palucka, A.K.4
-
80
-
-
0034651544
-
GATA-1 blocks IL-6-induced macrophage differentiation and apoptosis through the sustained expression of cyclin D1 and bcl-2 in a murine myeloid cell line M1
-
Tanaka H, Matsumura I, Nakajima K, Daino H, Sonoyama J, Yoshida H, et al. GATA-1 blocks IL-6-induced macrophage differentiation and apoptosis through the sustained expression of cyclin D1 and bcl-2 in a murine myeloid cell line M1. Blood (2000) 95:1264-73
-
(2000)
Blood
, vol.95
, pp. 1264-1273
-
-
Tanaka, H.1
Matsumura, I.2
Nakajima, K.3
Daino, H.4
Sonoyama, J.5
Yoshida, H.6
-
81
-
-
0031975143
-
Interleukin-6 induces monocyte chemotactic protein-1 in peripheral blood mononuclear cells and in the U937 cell line
-
Biswas P, Delfanti F, Bernasconi S, Mengozzi M, Cota M, Polentarutti N, et al. Interleukin-6 induces monocyte chemotactic protein-1 in peripheral blood mononuclear cells and in the U937 cell line. Blood (1998) 91:258-65
-
(1998)
Blood
, vol.91
, pp. 258-265
-
-
Biswas, P.1
Delfanti, F.2
Bernasconi, S.3
Mengozzi, M.4
Cota, M.5
Polentarutti, N.6
-
82
-
-
8944251628
-
A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells
-
Nakajima K, Yamanaka Y, Nakae K, Kojima H, Ichiba M, Kiuchi N, et al. A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells. EMBO J (1996) 15:3651-8
-
(1996)
EMBO J
, vol.15
, pp. 3651-3658
-
-
Nakajima, K.1
Yamanaka, Y.2
Nakae, K.3
Kojima, H.4
Ichiba, M.5
Kiuchi, N.6
-
83
-
-
0029968757
-
Differentiation and growth arrest signals are generated through the cytoplasmic region of gp130 that is essential for Stat3 activation
-
Yamanaka Y, Nakajima K, Fukada T, Hibi M, Hirano T. Differentiation and growth arrest signals are generated through the cytoplasmic region of gp130 that is essential for Stat3 activation. EMBO J (1996) 15:1557-65
-
(1996)
EMBO J
, vol.15
, pp. 1557-1565
-
-
Yamanaka, Y.1
Nakajima, K.2
Fukada, T.3
Hibi, M.4
Hirano, T.5
-
84
-
-
0028328436
-
Impaired immune and acute-phase responses in interleukin-6-deficient mice
-
Kopf M, Baumann H, Freer G, Freudenberg M, Lamers M, Kishimoto T, et al. Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature (1994) 368:339-42. doi:10.1038/368339a0
-
(1994)
Nature
, vol.368
, pp. 339-342
-
-
Kopf, M.1
Baumann, H.2
Freer, G.3
Freudenberg, M.4
Lamers, M.5
Kishimoto, T.6
-
85
-
-
0028853334
-
Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages
-
Tanaka T, Akira S, Yoshida K, Umemoto M, Yoneda Y, Shirafuji N, et al. Targeted disruption of the NF-IL6 gene discloses its essential role in bacteria killing and tumor cytotoxicity by macrophages. Cell (1995) 80:353-61. doi:10.1016/0092-8674(95)90418-2
-
(1995)
Cell
, vol.80
, pp. 353-361
-
-
Tanaka, T.1
Akira, S.2
Yoshida, K.3
Umemoto, M.4
Yoneda, Y.5
Shirafuji, N.6
-
86
-
-
0029893140
-
Role of interleukin-6 in macrophage function
-
Akira S, Kishimoto T. Role of interleukin-6 in macrophage function. Curr Opin Hematol (1996) 3:87-93. doi:10.1097/00062752-199603010-00013
-
(1996)
Curr Opin Hematol
, vol.3
, pp. 87-93
-
-
Akira, S.1
Kishimoto, T.2
-
87
-
-
0033972346
-
Selective induction of MCP-1 in human mesangial cells by the IL-6/sIL-6R complex
-
Coletta I, Soldo L, Polentarutti N, Mancini F, Guglielmotti A, Pinza M, et al. Selective induction of MCP-1 in human mesangial cells by the IL-6/sIL-6R complex. Exp Nephrol (2000) 8:37-43. doi:10.1159/000059327
-
(2000)
Exp Nephrol
, vol.8
, pp. 37-43
-
-
Coletta, I.1
Soldo, L.2
Polentarutti, N.3
Mancini, F.4
Guglielmotti, A.5
Pinza, M.6
-
88
-
-
48049096638
-
IL-6/IL-6R axis plays a critical role in acute kidney injury
-
Nechemia-Arbely Y, Barkan D, Pizov G, Shriki A, Rose-John S, Galun E, et al. IL-6/IL-6R axis plays a critical role in acute kidney injury. J Am Soc Nephrol (2008) 19:1106-15. doi:10.1681/ASN.2007070744
-
(2008)
J Am Soc Nephrol
, vol.19
, pp. 1106-1115
-
-
Nechemia-Arbely, Y.1
Barkan, D.2
Pizov, G.3
Shriki, A.4
Rose-John, S.5
Galun, E.6
-
89
-
-
70349912143
-
Reduction of Stat3 activity attenuates HIV-induced kidney injury
-
Feng X, Lu TC, Chuang PY, Fang W, Ratnam K, Xiong H, et al. Reduction of Stat3 activity attenuates HIV-induced kidney injury. J Am Soc Nephrol (2009) 20:2138-46. doi:10.1681/ASN.2008080879
-
(2009)
J Am Soc Nephrol
, vol.20
, pp. 2138-2146
-
-
Feng, X.1
Lu, T.C.2
Chuang, P.Y.3
Fang, W.4
Ratnam, K.5
Xiong, H.6
-
90
-
-
67449161568
-
Knockdown of Stat3 activity in vivo prevents diabetic glomerulopathy
-
Lu TC, Wang ZH, Feng X, Chuang PY, Fang W, Shen Y, et al. Knockdown of Stat3 activity in vivo prevents diabetic glomerulopathy. Kidney Int (2009) 76:63-71. doi:10.1038/ki.2009.98
-
(2009)
Kidney Int
, vol.76
, pp. 63-71
-
-
Lu, T.C.1
Wang, Z.H.2
Feng, X.3
Chuang, P.Y.4
Fang, W.5
Shen, Y.6
-
91
-
-
84888370428
-
Podocyte-specific deletion of signal transducer and activator of transcription 3 attenuates nephrotoxic serum-induced glomerulonephritis
-
Dai Y, Gu L, Yuan W, Yu Q, Ni Z, Ross MJ, et al. Podocyte-specific deletion of signal transducer and activator of transcription 3 attenuates nephrotoxic serum-induced glomerulonephritis. Kidney Int (2013) 84:950-61. doi:10.1038/ki.2013.197
-
(2013)
Kidney Int
, vol.84
, pp. 950-961
-
-
Dai, Y.1
Gu, L.2
Yuan, W.3
Yu, Q.4
Ni, Z.5
Ross, M.J.6
-
92
-
-
0035137811
-
Dilazep hydrochloride, an antiplatelet drug, inhibits lipopolysaccharide-induced mouse mesangial cell IL-6 secretion and proliferation
-
Gohda T, Makita Y, Shike T, Funabiki K, Shirato I, Tomino Y. Dilazep hydrochloride, an antiplatelet drug, inhibits lipopolysaccharide-induced mouse mesangial cell IL-6 secretion and proliferation. Kidney Blood Press Res (2001) 24:33-8. doi:10.1159/000054203
-
(2001)
Kidney Blood Press Res
, vol.24
, pp. 33-38
-
-
Gohda, T.1
Makita, Y.2
Shike, T.3
Funabiki, K.4
Shirato, I.5
Tomino, Y.6
-
93
-
-
45749101288
-
HBV X gene transfection upregulates IL-1beta and IL-6 gene expression and induces rat glomerular mesangial cell proliferation
-
Lu H, Zhou J. HBV X gene transfection upregulates IL-1beta and IL-6 gene expression and induces rat glomerular mesangial cell proliferation. J Huazhong Univ Sci Technolog Med Sci (2008) 28:247-50. doi:10.1007/s11596-008-0304-5
-
(2008)
J Huazhong Univ Sci Technolog Med Sci
, vol.28
, pp. 247-250
-
-
Lu, H.1
Zhou, J.2
-
94
-
-
1542313876
-
Interleukin-6 induces oxidative stress and endothelial dysfunction by overexpression of the angiotensin II type 1 receptor
-
Wassmann S, Stumpf M, Strehlow K, Schmid A, Schieffer B, Bohm M, et al. Interleukin-6 induces oxidative stress and endothelial dysfunction by overexpression of the angiotensin II type 1 receptor. Circ Res (2004) 94:534-41. doi:10.1161/01.RES.0000115557.25127.8D
-
(2004)
Circ Res
, vol.94
, pp. 534-541
-
-
Wassmann, S.1
Stumpf, M.2
Strehlow, K.3
Schmid, A.4
Schieffer, B.5
Bohm, M.6
-
95
-
-
36349024339
-
IL-6 deficiency protects against angiotensin II induced endothelial dysfunction and hypertrophy
-
Schrader LI, Kinzenbaw DA, Johnson AW, Faraci FM, Didion SP. IL-6 deficiency protects against angiotensin II induced endothelial dysfunction and hypertrophy. Arterioscler Thromb Vasc Biol (2007) 27:2576-81. doi:10.1161/ATVBAHA.107.153080
-
(2007)
Arterioscler Thromb Vasc Biol
, vol.27
, pp. 2576-2581
-
-
Schrader, L.I.1
Kinzenbaw, D.A.2
Johnson, A.W.3
Faraci, F.M.4
Didion, S.P.5
-
96
-
-
84878658824
-
Proximal tubule-specific overexpression of netrin-1 suppresses acute kidney injury-induced interstitial fibrosis and glomerulosclerosis through suppression of IL-6/STAT3 signaling
-
Ranganathan P, Jayakumar C, Ramesh G. Proximal tubule-specific overexpression of netrin-1 suppresses acute kidney injury-induced interstitial fibrosis and glomerulosclerosis through suppression of IL-6/STAT3 signaling. Am J Physiol Renal Physiol (2013) 304:F1054-65. doi:10.1152/ajprenal.00650.2012
-
(2013)
Am J Physiol Renal Physiol
, vol.304
, pp. F1054-F1065
-
-
Ranganathan, P.1
Jayakumar, C.2
Ramesh, G.3
-
97
-
-
33644874979
-
Maladaptive role of IL-6 in ischemic acute renal failure
-
Kielar ML, John R, Bennett M, Richardson JA, Shelton JM, Chen L, et al. Maladaptive role of IL-6 in ischemic acute renal failure. J Am Soc Nephrol (2005) 16:3315-25. doi:10.1681/ASN.2003090757
-
(2005)
J Am Soc Nephrol
, vol.16
, pp. 3315-3325
-
-
Kielar, M.L.1
John, R.2
Bennett, M.3
Richardson, J.A.4
Shelton, J.M.5
Chen, L.6
-
98
-
-
84857615919
-
Obesity-induced renal impairment is exacerbated in interleukin-6-knockout mice
-
Harcourt BE, Forbes JM, Matthews VB. Obesity-induced renal impairment is exacerbated in interleukin-6-knockout mice. Nephrology (Carlton) (2012) 17:257-62. doi:10.1111/j.1440-1797.2011.01547.x
-
(2012)
Nephrology (Carlton)
, vol.17
, pp. 257-262
-
-
Harcourt, B.E.1
Forbes, J.M.2
Matthews, V.B.3
-
99
-
-
84870766660
-
Podocytes express IL-6 and lipocalin 2/neutrophil gelatinase-associated lipocalin in lipopolysaccharide-induced acute glomerular injury
-
Lee SJ, Borsting E, Decleves AE, Singh P, Cunard R. Podocytes express IL-6 and lipocalin 2/neutrophil gelatinase-associated lipocalin in lipopolysaccharide-induced acute glomerular injury. Nephron Exp Nephrol (2012) 121:e86-96. doi:10.1159/000345151
-
(2012)
Nephron Exp Nephrol
, vol.121
, pp. e86-e96
-
-
Lee, S.J.1
Borsting, E.2
Decleves, A.E.3
Singh, P.4
Cunard, R.5
-
100
-
-
84878981482
-
Sequential signaling cascade of IL-6 and PGC-1alpha is involved in high glucose-induced podocyte loss and growth arrest
-
Kim DI, Park SH. Sequential signaling cascade of IL-6 and PGC-1alpha is involved in high glucose-induced podocyte loss and growth arrest. Biochem Biophys Res Commun (2013) 435:702-7. doi:10.1016/j.bbrc.2013.05.046
-
(2013)
Biochem Biophys Res Commun
, vol.435
, pp. 702-707
-
-
Kim, D.I.1
Park, S.H.2
-
101
-
-
84874934810
-
LPS and PAN-induced podocyte injury in an in vitro model of minimal change disease: changes in TLR profile
-
Srivastava T, Sharma M, Yew KH, Sharma R, Duncan RS, Saleem MA, et al. LPS and PAN-induced podocyte injury in an in vitro model of minimal change disease: changes in TLR profile. J Cell Commun Signal (2013) 7:49-60. doi:10.1007/s12079-012-0184-0
-
(2013)
J Cell Commun Signal
, vol.7
, pp. 49-60
-
-
Srivastava, T.1
Sharma, M.2
Yew, K.H.3
Sharma, R.4
Duncan, R.S.5
Saleem, M.A.6
-
102
-
-
84903593069
-
Angiotensin II and canonical transient receptor potential-6 activation stimulate release of a signal transducer and activator of transcription 3-activating factor from mouse podocytes
-
Abkhezr M, Dryer SE. Angiotensin II and canonical transient receptor potential-6 activation stimulate release of a signal transducer and activator of transcription 3-activating factor from mouse podocytes. Mol Pharmacol (2014) 86:150-8. doi:10.1124/mol.114.092536
-
(2014)
Mol Pharmacol
, vol.86
, pp. 150-158
-
-
Abkhezr, M.1
Dryer, S.E.2
-
103
-
-
33748430642
-
Direct effects of dexamethasone on human podocytes
-
Xing CY, Saleem MA, Coward RJ, Ni L, Witherden IR, Mathieson PW. Direct effects of dexamethasone on human podocytes. Kidney Int (2006) 70:1038-45. doi:10.1038/sj.ki.5001655
-
(2006)
Kidney Int
, vol.70
, pp. 1038-1045
-
-
Xing, C.Y.1
Saleem, M.A.2
Coward, R.J.3
Ni, L.4
Witherden, I.R.5
Mathieson, P.W.6
-
104
-
-
77957981927
-
Proteomic analysis identifies insulin-like growth factor-binding protein-related protein-1 as a podocyte product
-
Matsumoto T, Hess S, Kajiyama H, Sakairi T, Saleem MA, Mathieson PW, et al. Proteomic analysis identifies insulin-like growth factor-binding protein-related protein-1 as a podocyte product. Am J Physiol Renal Physiol (2010) 299:F776-84. doi:10.1152/ajprenal.00597.2009
-
(2010)
Am J Physiol Renal Physiol
, vol.299
, pp. F776-F784
-
-
Matsumoto, T.1
Hess, S.2
Kajiyama, H.3
Sakairi, T.4
Saleem, M.A.5
Mathieson, P.W.6
-
105
-
-
84858234310
-
Beyond proteinuria: VDR activation reduces renal inflammation in experimental diabetic nephropathy
-
Sanchez-Nino MD, Bozic M, Cordoba-Lanus E, Valcheva P, Gracia O, Ibarz M, et al. Beyond proteinuria: VDR activation reduces renal inflammation in experimental diabetic nephropathy. Am J Physiol Renal Physiol (2012) 302:F647-57. doi:10.1152/ajprenal.00090.2011
-
(2012)
Am J Physiol Renal Physiol
, vol.302
, pp. F647-F657
-
-
Sanchez-Nino, M.D.1
Bozic, M.2
Cordoba-Lanus, E.3
Valcheva, P.4
Gracia, O.5
Ibarz, M.6
-
106
-
-
84890473534
-
Angiotensin II activation of TRPC6 channels in rat podocytes requires generation of reactive oxygen species
-
Anderson M, Roshanravan H, Khine J, Dryer SE. Angiotensin II activation of TRPC6 channels in rat podocytes requires generation of reactive oxygen species. J Cell Physiol (2014) 229:434-42. doi:10.1002/jcp.24461
-
(2014)
J Cell Physiol
, vol.229
, pp. 434-442
-
-
Anderson, M.1
Roshanravan, H.2
Khine, J.3
Dryer, S.E.4
-
107
-
-
54149110149
-
Activation of signal transducer and activator of transcription 3 correlates with cell proliferation and renal injury in human glomerulonephritis
-
Arakawa T, Masaki T, Hirai T, Doi S, Kuratsune M, Arihiro K, et al. Activation of signal transducer and activator of transcription 3 correlates with cell proliferation and renal injury in human glomerulonephritis. Nephrol Dial Transplant (2008) 23:3418-26. doi:10.1093/ndt/gfn314
-
(2008)
Nephrol Dial Transplant
, vol.23
, pp. 3418-3426
-
-
Arakawa, T.1
Masaki, T.2
Hirai, T.3
Doi, S.4
Kuratsune, M.5
Arihiro, K.6
-
108
-
-
84903618700
-
Podocytes regulate neutrophil recruitment by glomerular endothelial cells via IL-6-mediated crosstalk
-
Kuravi SJ, Mcgettrick HM, Satchell SC, Saleem MA, Harper L, Williams JM, et al. Podocytes regulate neutrophil recruitment by glomerular endothelial cells via IL-6-mediated crosstalk. J Immunol (2014) 193:234-43. doi:10.4049/jimmunol.1300229
-
(2014)
J Immunol
, vol.193
, pp. 234-243
-
-
Kuravi, S.J.1
Mcgettrick, H.M.2
Satchell, S.C.3
Saleem, M.A.4
Harper, L.5
Williams, J.M.6
-
109
-
-
5444254462
-
IL-6 and the acute phase response in murine atherosclerosis
-
Song L, Schindler C. IL-6 and the acute phase response in murine atherosclerosis. Atherosclerosis (2004) 177:43-51. doi:10.1016/j.atherosclerosis.2004.06.018
-
(2004)
Atherosclerosis
, vol.177
, pp. 43-51
-
-
Song, L.1
Schindler, C.2
-
110
-
-
33845654846
-
Increased glucose uptake and metabolism in mesangial cells overexpressing glucose transporter 1 increases interleukin-6 and vascular endothelial growth factor production: role of AP-1 and HIF-1alpha
-
Pfafflin A, Brodbeck K, Heilig CW, Haring HU, Schleicher ED, Weigert C. Increased glucose uptake and metabolism in mesangial cells overexpressing glucose transporter 1 increases interleukin-6 and vascular endothelial growth factor production: role of AP-1 and HIF-1alpha. Cell Physiol Biochem (2006) 18:199-210. doi:10.1159/000097667
-
(2006)
Cell Physiol Biochem
, vol.18
, pp. 199-210
-
-
Pfafflin, A.1
Brodbeck, K.2
Heilig, C.W.3
Haring, H.U.4
Schleicher, E.D.5
Weigert, C.6
-
111
-
-
84903575263
-
The combined role of galactose-deficient IgA1 and streptococcal IgA-binding M protein in inducing IL-6 and C3 secretion from human mesangial cells: implications for IgA nephropathy
-
Schmitt R, Stahl AL, Olin AI, Kristoffersson AC, Rebetz J, Novak J, et al. The combined role of galactose-deficient IgA1 and streptococcal IgA-binding M protein in inducing IL-6 and C3 secretion from human mesangial cells: implications for IgA nephropathy. J Immunol (2014) 193:317-26. doi:10.4049/jimmunol.1302249
-
(2014)
J Immunol
, vol.193
, pp. 317-326
-
-
Schmitt, R.1
Stahl, A.L.2
Olin, A.I.3
Kristoffersson, A.C.4
Rebetz, J.5
Novak, J.6
-
112
-
-
84990935160
-
C5a induces the synthesis of IL-6 and TNF-alpha in rat glomerular mesangial cells through MAPK signaling pathways
-
Ji M, Lu Y, Zhao C, Gao W, He F, Zhang J, et al. C5a induces the synthesis of IL-6 and TNF-alpha in rat glomerular mesangial cells through MAPK signaling pathways. PLoS One (2016) 11:e0161867. doi:10.1371/journal.pone.0161867
-
(2016)
PLoS One
, vol.11
-
-
Ji, M.1
Lu, Y.2
Zhao, C.3
Gao, W.4
He, F.5
Zhang, J.6
-
113
-
-
0024559125
-
IL-1 stimulates IL-6 production in endothelial cells
-
Sironi M, Breviario F, Proserpio P, Biondi A, Vecchi A, Van Damme J, et al. IL-1 stimulates IL-6 production in endothelial cells. J Immunol (1989) 142:549-53
-
(1989)
J Immunol
, vol.142
, pp. 549-553
-
-
Sironi, M.1
Breviario, F.2
Proserpio, P.3
Biondi, A.4
Vecchi, A.5
Van Damme, J.6
-
114
-
-
0030891228
-
Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment
-
Romano M, Sironi M, Toniatti C, Polentarutti N, Fruscella P, Ghezzi P, et al. Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment. Immunity (1997) 6:315-25. doi:10.1016/S1074-7613(00)80334-9
-
(1997)
Immunity
, vol.6
, pp. 315-325
-
-
Romano, M.1
Sironi, M.2
Toniatti, C.3
Polentarutti, N.4
Fruscella, P.5
Ghezzi, P.6
-
115
-
-
33644878084
-
Effect of human anti-DNA antibodies on proximal renal tubular epithelial cell cytokine expression: implications on tubulointerstitial inflammation in lupus nephritis
-
Yung S, Tsang RC, Sun Y, Leung JK, Chan TM. Effect of human anti-DNA antibodies on proximal renal tubular epithelial cell cytokine expression: implications on tubulointerstitial inflammation in lupus nephritis. J Am Soc Nephrol (2005) 16:3281-94. doi:10.1681/ASN.2004110917
-
(2005)
J Am Soc Nephrol
, vol.16
, pp. 3281-3294
-
-
Yung, S.1
Tsang, R.C.2
Sun, Y.3
Leung, J.K.4
Chan, T.M.5
-
116
-
-
0028172011
-
Soluble IgA and IgG aggregates are catabolized by cultured rat mesangial cells and induce production of TNF-alpha and IL-6, and proliferation
-
Gomez-Guerrero C, Lopez-Armada MJ, Gonzalez E, Egido J. Soluble IgA and IgG aggregates are catabolized by cultured rat mesangial cells and induce production of TNF-alpha and IL-6, and proliferation. J Immunol (1994) 153:5247-55
-
(1994)
J Immunol
, vol.153
, pp. 5247-5255
-
-
Gomez-Guerrero, C.1
Lopez-Armada, M.J.2
Gonzalez, E.3
Egido, J.4
-
117
-
-
33644789446
-
Engagement of transferrin receptor by polymeric IgA1: evidence for a positive feedback loop involving increased receptor expression and mesangial cell proliferation in IgA nephropathy
-
Moura IC, Arcos-Fajardo M, Gdoura A, Leroy V, Sadaka C, Mahlaoui N, et al. Engagement of transferrin receptor by polymeric IgA1: evidence for a positive feedback loop involving increased receptor expression and mesangial cell proliferation in IgA nephropathy. J Am Soc Nephrol (2005) 16:2667-76. doi:10.1681/ASN.2004111006
-
(2005)
J Am Soc Nephrol
, vol.16
, pp. 2667-2676
-
-
Moura, I.C.1
Arcos-Fajardo, M.2
Gdoura, A.3
Leroy, V.4
Sadaka, C.5
Mahlaoui, N.6
-
118
-
-
84870582926
-
The IgA1 immune complex-mediated activation of the MAPK/ERK kinase pathway in mesangial cells is associated with glomerular damage in IgA nephropathy
-
Tamouza H, Chemouny JM, Raskova Kafkova L, Berthelot L, Flamant M, Demion M, et al. The IgA1 immune complex-mediated activation of the MAPK/ERK kinase pathway in mesangial cells is associated with glomerular damage in IgA nephropathy. Kidney Int (2012) 82:1284-96. doi:10.1038/ki.2012.192
-
(2012)
Kidney Int
, vol.82
, pp. 1284-1296
-
-
Tamouza, H.1
Chemouny, J.M.2
Raskova Kafkova, L.3
Berthelot, L.4
Flamant, M.5
Demion, M.6
-
119
-
-
84899524958
-
Sublytic C5b-9 induces IL-6 and TGF-beta1 production by glomerular mesangial cells in rat Thy-1 nephritis through p300-mediated C/EBPbeta acetylation
-
Zhang J, Li Y, Shan K, Wang L, Qiu W, Lu Y, et al. Sublytic C5b-9 induces IL-6 and TGF-beta1 production by glomerular mesangial cells in rat Thy-1 nephritis through p300-mediated C/EBPbeta acetylation. FASEB J (2014) 28:1511-25. doi:10.1096/fj.13-242693
-
(2014)
FASEB J
, vol.28
, pp. 1511-1525
-
-
Zhang, J.1
Li, Y.2
Shan, K.3
Wang, L.4
Qiu, W.5
Lu, Y.6
-
120
-
-
0025990288
-
Elevated levels of endogenous IL-6 in systemic lupus erythematosus. A putative role in pathogenesis
-
Linker-Israeli M, Deans RJ, Wallace DJ, Prehn J, Ozeri-Chen T, Klinenberg JR. Elevated levels of endogenous IL-6 in systemic lupus erythematosus. A putative role in pathogenesis. J Immunol (1991) 147:117-23
-
(1991)
J Immunol
, vol.147
, pp. 117-123
-
-
Linker-Israeli, M.1
Deans, R.J.2
Wallace, D.J.3
Prehn, J.4
Ozeri-Chen, T.5
Klinenberg, J.R.6
-
121
-
-
0030457978
-
Serum and urinary interleukin-6 in systemic lupus erythematosus
-
Peterson E, Robertson AD, Emlen W. Serum and urinary interleukin-6 in systemic lupus erythematosus. Lupus (1996) 5:571-5. doi:10.1177/096120339600500603
-
(1996)
Lupus
, vol.5
, pp. 571-575
-
-
Peterson, E.1
Robertson, A.D.2
Emlen, W.3
-
122
-
-
73649123508
-
Interleukin 6 (IL-6) deficiency delays lupus nephritis in MRL-Faslpr mice: the IL-6 pathway as a new therapeutic target in treatment of autoimmune kidney disease in systemic lupus erythematosus
-
Cash H, Relle M, Menke J, Brochhausen C, Jones SA, Topley N, et al. Interleukin 6 (IL-6) deficiency delays lupus nephritis in MRL-Faslpr mice: the IL-6 pathway as a new therapeutic target in treatment of autoimmune kidney disease in systemic lupus erythematosus. J Rheumatol (2010) 37:60-70. doi:10.3899/jrheum.090194
-
(2010)
J Rheumatol
, vol.37
, pp. 60-70
-
-
Cash, H.1
Relle, M.2
Menke, J.3
Brochhausen, C.4
Jones, S.A.5
Topley, N.6
-
123
-
-
84890508411
-
Plasma IL-6 levels correlate with clinical and ultrasound measures of arthritis in patients with systemic lupus erythematosus
-
Ball EM, Gibson DS, Bell AL, Rooney MR. Plasma IL-6 levels correlate with clinical and ultrasound measures of arthritis in patients with systemic lupus erythematosus. Lupus (2014) 23:46-56. doi:10.1177/0961203313512882
-
(2014)
Lupus
, vol.23
, pp. 46-56
-
-
Ball, E.M.1
Gibson, D.S.2
Bell, A.L.3
Rooney, M.R.4
-
124
-
-
84943819103
-
The role of serum IL-17 and IL-6 as biomarkers of disease activity and predictors of remission in patients with lupus nephritis
-
Abdel Galil SM, Ezzeldin N, El-Boshy ME. The role of serum IL-17 and IL-6 as biomarkers of disease activity and predictors of remission in patients with lupus nephritis. Cytokine (2015) 76:280-7. doi:10.1007/BF02253829
-
(2015)
Cytokine
, vol.76
, pp. 280-287
-
-
Abdel Galil, S.M.1
Ezzeldin, N.2
El-Boshy, M.E.3
-
125
-
-
84938748830
-
Genetics of serum concentration of IL-6 and TNFalpha in systemic lupus erythematosus and rheumatoid arthritis: a candidate gene analysis
-
Solus JF, Chung CP, Oeser A, Li C, Rho YH, Bradley KM, et al. Genetics of serum concentration of IL-6 and TNFalpha in systemic lupus erythematosus and rheumatoid arthritis: a candidate gene analysis. Clin Rheumatol (2015) 34:1375-82. doi:10.1007/s10067-015-2881-6
-
(2015)
Clin Rheumatol
, vol.34
, pp. 1375-1382
-
-
Solus, J.F.1
Chung, C.P.2
Oeser, A.3
Li, C.4
Rho, Y.H.5
Bradley, K.M.6
-
126
-
-
84946570716
-
Role of IL-1beta, IL-6, IL-8 and IFN-gamma in pathogenesis of central nervous system neuropsychiatric systemic lupus erythematous
-
Wang JB, Li H, Wang LL, Liang HD, Zhao L, Dong J. Role of IL-1beta, IL-6, IL-8 and IFN-gamma in pathogenesis of central nervous system neuropsychiatric systemic lupus erythematous. Int J Clin Exp Med (2015) 8:16658-63
-
(2015)
Int J Clin Exp Med
, vol.8
, pp. 16658-16663
-
-
Wang, J.B.1
Li, H.2
Wang, L.L.3
Liang, H.D.4
Zhao, L.5
Dong, J.6
-
127
-
-
66949176660
-
IL-6 modulates CD5 expression in B cells from patients with lupus by regulating DNA methylation
-
Garaud S, Le Dantec C, Jousse-Joulin S, Hanrotel-Saliou C, Saraux A, Mageed RA, et al. IL-6 modulates CD5 expression in B cells from patients with lupus by regulating DNA methylation. J Immunol (2009) 182:5623-32. doi:10.4049/jimmunol.0802412
-
(2009)
J Immunol
, vol.182
, pp. 5623-5632
-
-
Garaud, S.1
Le Dantec, C.2
Jousse-Joulin, S.3
Hanrotel-Saliou, C.4
Saraux, A.5
Mageed, R.A.6
-
128
-
-
33845273119
-
Lack of association of interleukin-6 and interleukin-8 gene polymorphisms in Chinese patients with systemic lupus erythematosus
-
Huang CM, Huo AP, Tsai CH, Chen CL, Tsai FJ. Lack of association of interleukin-6 and interleukin-8 gene polymorphisms in Chinese patients with systemic lupus erythematosus. J Clin Lab Anal (2006) 20:255-9. doi:10.1002/jcla.20151
-
(2006)
J Clin Lab Anal
, vol.20
, pp. 255-259
-
-
Huang, C.M.1
Huo, A.P.2
Tsai, C.H.3
Chen, C.L.4
Tsai, F.J.5
-
129
-
-
79954593760
-
Interleukin-6 promoter polymorphism-174 G/C is associated with nephritis in Portuguese Caucasian systemic lupus erythematosus patients
-
Santos MJ, Fernandes D, Capela S, Da Silva JC, Fonseca JE. Interleukin-6 promoter polymorphism-174 G/C is associated with nephritis in Portuguese Caucasian systemic lupus erythematosus patients. Clin Rheumatol (2011) 30:409-13. doi:10.1007/s10067-010-1640-y
-
(2011)
Clin Rheumatol
, vol.30
, pp. 409-413
-
-
Santos, M.J.1
Fernandes, D.2
Capela, S.3
Da Silva, J.C.4
Fonseca, J.E.5
-
130
-
-
83655164152
-
The association between interleukin-6 polymorphisms and systemic lupus erythematosus: a meta-analysis
-
Lee YH, Lee HS, Choi SJ, Ji JD, Song GG. The association between interleukin-6 polymorphisms and systemic lupus erythematosus: a meta-analysis. Lupus (2012) 21:60-7. doi:10.1177/0961203311422711
-
(2012)
Lupus
, vol.21
, pp. 60-67
-
-
Lee, Y.H.1
Lee, H.S.2
Choi, S.J.3
Ji, J.D.4
Song, G.G.5
-
131
-
-
0027237857
-
Urinary levels of IL-6 in patients with active lupus nephritis
-
Iwano M, Dohi K, Hirata E, Kurumatani N, Horii Y, Shiiki H, et al. Urinary levels of IL-6 in patients with active lupus nephritis. Clin Nephrol (1993) 40:16-21
-
(1993)
Clin Nephrol
, vol.40
, pp. 16-21
-
-
Iwano, M.1
Dohi, K.2
Hirata, E.3
Kurumatani, N.4
Horii, Y.5
Shiiki, H.6
-
132
-
-
0033623775
-
Increased excretions of beta2-microglobulin, IL-6, and IL-8 and decreased excretion of Tamm-Horsfall glycoprotein in urine of patients with active lupus nephritis
-
Tsai CY, Wu TH, Yu CL, Lu JY, Tsai YY. Increased excretions of beta2-microglobulin, IL-6, and IL-8 and decreased excretion of Tamm-Horsfall glycoprotein in urine of patients with active lupus nephritis. Nephron (2000) 85:207-14. doi:10.1159/000045663
-
(2000)
Nephron
, vol.85
, pp. 207-214
-
-
Tsai, C.Y.1
Wu, T.H.2
Yu, C.L.3
Lu, J.Y.4
Tsai, Y.Y.5
-
134
-
-
84885126530
-
Interleukin-6 trans-signaling exacerbates inflammation and renal pathology in lupus-prone mice
-
Tsantikos E, Maxwell MJ, Putoczki T, Ernst M, Rose-John S, Tarlinton DM, et al. Interleukin-6 trans-signaling exacerbates inflammation and renal pathology in lupus-prone mice. Arthritis Rheum (2013) 65:2691-702. doi:10.1002/art.38061
-
(2013)
Arthritis Rheum
, vol.65
, pp. 2691-2702
-
-
Tsantikos, E.1
Maxwell, M.J.2
Putoczki, T.3
Ernst, M.4
Rose-John, S.5
Tarlinton, D.M.6
-
135
-
-
0036067631
-
A Reg family protein is overexpressed in islets from a patient with new-onset type 1 diabetes and acts as T-cell autoantigen in NOD mice
-
Gurr W, Yavari R, Wen L, Shaw M, Mora C, Christa L, et al. A Reg family protein is overexpressed in islets from a patient with new-onset type 1 diabetes and acts as T-cell autoantigen in NOD mice. Diabetes (2002) 51:339-46. doi:10.2337/diabetes.51.2.339
-
(2002)
Diabetes
, vol.51
, pp. 339-346
-
-
Gurr, W.1
Yavari, R.2
Wen, L.3
Shaw, M.4
Mora, C.5
Christa, L.6
-
136
-
-
59649087714
-
Levels of serum interleukin (IL)-6 and gingival crevicular fluid of IL-1beta and prostaglandin E(2) among non-smoking subjects with gingivitis and type 2 diabetes
-
Andriankaja OM, Barros SP, Moss K, Panagakos FS, Devizio W, Beck J, et al. Levels of serum interleukin (IL)-6 and gingival crevicular fluid of IL-1beta and prostaglandin E(2) among non-smoking subjects with gingivitis and type 2 diabetes. J Periodontol (2009) 80:307-16. doi:10.1902/jop.2009.080385
-
(2009)
J Periodontol
, vol.80
, pp. 307-316
-
-
Andriankaja, O.M.1
Barros, S.P.2
Moss, K.3
Panagakos, F.S.4
Devizio, W.5
Beck, J.6
-
137
-
-
0242299763
-
Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone
-
Lagathu C, Bastard JP, Auclair M, Maachi M, Capeau J, Caron M. Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone. Biochem Biophys Res Commun (2003) 311:372-9. doi:10.1016/j.bbrc.2003.10.013
-
(2003)
Biochem Biophys Res Commun
, vol.311
, pp. 372-379
-
-
Lagathu, C.1
Bastard, J.P.2
Auclair, M.3
Maachi, M.4
Capeau, J.5
Caron, M.6
-
138
-
-
0242580711
-
Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects
-
Rotter V, Nagaev I, Smith U. Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects. J Biol Chem (2003) 278:45777-84. doi:10.1074/jbc.M301977200
-
(2003)
J Biol Chem
, vol.278
, pp. 45777-45784
-
-
Rotter, V.1
Nagaev, I.2
Smith, U.3
-
139
-
-
20844458389
-
Acute-phase markers of inflammation and glomerular structure in patients with type 2 diabetes
-
Dalla Vestra M, Mussap M, Gallina P, Bruseghin M, Cernigoi AM, Saller A, et al. Acute-phase markers of inflammation and glomerular structure in patients with type 2 diabetes. J Am Soc Nephrol (2005) 16(Suppl 1):S78-82. doi:10.1681/ASN.2004110961
-
(2005)
J Am Soc Nephrol
, vol.16
, pp. S78-S82
-
-
Dalla Vestra, M.1
Mussap, M.2
Gallina, P.3
Bruseghin, M.4
Cernigoi, A.M.5
Saller, A.6
-
140
-
-
33846419118
-
Renal pro-inflammatory cytokine gene expression in diabetic nephropathy: effect of angiotensin-converting enzyme inhibition and pentoxifylline administration
-
Navarro JF, Milena FJ, Mora C, Leon C, Garcia J. Renal pro-inflammatory cytokine gene expression in diabetic nephropathy: effect of angiotensin-converting enzyme inhibition and pentoxifylline administration. Am J Nephrol (2006) 26:562-70. doi:10.1159/000098004
-
(2006)
Am J Nephrol
, vol.26
, pp. 562-570
-
-
Navarro, J.F.1
Milena, F.J.2
Mora, C.3
Leon, C.4
Garcia, J.5
-
141
-
-
84867708435
-
Hyperglycemia induces toll like receptor 4 expression and activity in mouse mesangial cells: relevance to diabetic nephropathy
-
Kaur H, Chien A, Jialal I. Hyperglycemia induces toll like receptor 4 expression and activity in mouse mesangial cells: relevance to diabetic nephropathy. Am J Physiol Renal Physiol (2012) 303:F1145-50. doi:10.1152/ajprenal.00319.2012
-
(2012)
Am J Physiol Renal Physiol
, vol.303
, pp. F1145-F1150
-
-
Kaur, H.1
Chien, A.2
Jialal, I.3
-
142
-
-
84863061473
-
Association between IL6-174G/C and cancer: a meta-analysis of 105,482 individuals
-
Liu RY, Song X, Chen P, Lei Z, Miao J, Yi N, et al. Association between IL6-174G/C and cancer: a meta-analysis of 105,482 individuals. Exp Ther Med (2012) 3:655-64. doi:10.3892/etm.2012.454
-
(2012)
Exp Ther Med
, vol.3
, pp. 655-664
-
-
Liu, R.Y.1
Song, X.2
Chen, P.3
Lei, Z.4
Miao, J.5
Yi, N.6
-
143
-
-
60949088752
-
Cytokine and cytokine receptor gene polymorphisms and their functionality
-
Smith AJ, Humphries SE. Cytokine and cytokine receptor gene polymorphisms and their functionality. Cytokine Growth Factor Rev (2009) 20:43-59. doi:10.1016/j.cytogfr.2008.11.006
-
(2009)
Cytokine Growth Factor Rev
, vol.20
, pp. 43-59
-
-
Smith, A.J.1
Humphries, S.E.2
-
144
-
-
84887054209
-
The association of the 174G>C polymorphism of interleukin 6 gene with diabetic nephropathy in patients with type 2 diabetes mellitus
-
Papaoikonomou S, Tentolouris N, Tousoulis D, Papadodiannis D, Miliou A, Papageorgiou N, et al. The association of the 174G>C polymorphism of interleukin 6 gene with diabetic nephropathy in patients with type 2 diabetes mellitus. J Diabetes Complications (2013) 27:576-9. doi:10.1016/j.jdiacomp.2013.06.006
-
(2013)
J Diabetes Complications
, vol.27
, pp. 576-579
-
-
Papaoikonomou, S.1
Tentolouris, N.2
Tousoulis, D.3
Papadodiannis, D.4
Miliou, A.5
Papageorgiou, N.6
-
145
-
-
84891863355
-
Association of interleukin-6-174 G>C promoter polymorphism with increased risk of type 2 diabetes mellitus patients with diabetic nephropathy in Turkey
-
Karadeniz M, Erdogan M, Berdeli A, Yilmaz C. Association of interleukin-6-174 G>C promoter polymorphism with increased risk of type 2 diabetes mellitus patients with diabetic nephropathy in Turkey. Genet Test Mol Biomarkers (2014) 18:62-5. doi:10.1089/gtmb.2013.0357
-
(2014)
Genet Test Mol Biomarkers
, vol.18
, pp. 62-65
-
-
Karadeniz, M.1
Erdogan, M.2
Berdeli, A.3
Yilmaz, C.4
-
146
-
-
40449094520
-
The local and systemic inflammatory transcriptome after acute kidney injury
-
Grigoryev DN, Liu M, Hassoun HT, Cheadle C, Barnes KC, Rabb H. The local and systemic inflammatory transcriptome after acute kidney injury. J Am Soc Nephrol (2008) 19:547-58. doi:10.1681/ASN.2007040469
-
(2008)
J Am Soc Nephrol
, vol.19
, pp. 547-558
-
-
Grigoryev, D.N.1
Liu, M.2
Hassoun, H.T.3
Cheadle, C.4
Barnes, K.C.5
Rabb, H.6
-
147
-
-
0034653592
-
Prominent and sustained up-regulation of gp130-signaling cytokines and the chemokine MIP-2 in murine renal ischemia-reperfusion injury
-
Lemay S, Rabb H, Postler G, Singh AK. Prominent and sustained up-regulation of gp130-signaling cytokines and the chemokine MIP-2 in murine renal ischemia-reperfusion injury. Transplantation (2000) 69:959-63. doi:10.1097/00007890-200003150-00049
-
(2000)
Transplantation
, vol.69
, pp. 959-963
-
-
Lemay, S.1
Rabb, H.2
Postler, G.3
Singh, A.K.4
-
148
-
-
0344236404
-
Leukemia inhibitory factor is involved in tubular regeneration after experimental acute renal failure
-
Yoshino J, Monkawa T, Tsuji M, Hayashi M, Saruta T. Leukemia inhibitory factor is involved in tubular regeneration after experimental acute renal failure. J Am Soc Nephrol (2003) 14:3090-101. doi:10.1097/01.ASN.0000101180.96787.02
-
(2003)
J Am Soc Nephrol
, vol.14
, pp. 3090-3101
-
-
Yoshino, J.1
Monkawa, T.2
Tsuji, M.3
Hayashi, M.4
Saruta, T.5
-
149
-
-
0038100467
-
Associations between circulating inflammatory markers and residual renal function in CRF patients
-
Pecoits-Filho R, Heimburger O, Barany P, Suliman M, Fehrman-Ekholm I, Lindholm B, et al. Associations between circulating inflammatory markers and residual renal function in CRF patients. Am J Kidney Dis (2003) 41:1212-8. doi:10.1016/S0272-6386(03)00353-6
-
(2003)
Am J Kidney Dis
, vol.41
, pp. 1212-1218
-
-
Pecoits-Filho, R.1
Heimburger, O.2
Barany, P.3
Suliman, M.4
Fehrman-Ekholm, I.5
Lindholm, B.6
-
150
-
-
0034037999
-
Interleukin-6 gene expression in peripheral blood mononuclear cells from patients undergoing hemodialysis or continuous ambulatory peritoneal dialysis
-
Takahashi T, Kubota M, Nakamura T, Ebihara I, Koide H. Interleukin-6 gene expression in peripheral blood mononuclear cells from patients undergoing hemodialysis or continuous ambulatory peritoneal dialysis. Ren Fail (2000) 22:345-54. doi:10.1081/JDI-100100878
-
(2000)
Ren Fail
, vol.22
, pp. 345-354
-
-
Takahashi, T.1
Kubota, M.2
Nakamura, T.3
Ebihara, I.4
Koide, H.5
-
151
-
-
0036380965
-
Inflammatory signals associated with hemodialysis
-
Caglar K, Peng Y, Pupim LB, Flakoll PJ, Levenhagen D, Hakim RM, et al. Inflammatory signals associated with hemodialysis. Kidney Int (2002) 62:1408-16. doi:10.1111/j.1523-1755.2002.kid556.x
-
(2002)
Kidney Int
, vol.62
, pp. 1408-1416
-
-
Caglar, K.1
Peng, Y.2
Pupim, L.B.3
Flakoll, P.J.4
Levenhagen, D.5
Hakim, R.M.6
-
152
-
-
0042466384
-
Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans
-
Bruun JM, Lihn AS, Verdich C, Pedersen SB, Toubro S, Astrup A, et al. Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans. Am J Physiol Endocrinol Metab (2003) 285:E527-33. doi:10.1152/ajpendo.00110.2003
-
(2003)
Am J Physiol Endocrinol Metab
, vol.285
, pp. E527-E533
-
-
Bruun, J.M.1
Lihn, A.S.2
Verdich, C.3
Pedersen, S.B.4
Toubro, S.5
Astrup, A.6
-
153
-
-
0032856199
-
Interleukin-6 exacerbates early atherosclerosis in mice
-
Huber SA, Sakkinen P, Conze D, Hardin N, Tracy R. Interleukin-6 exacerbates early atherosclerosis in mice. Arterioscler Thromb Vasc Biol (1999) 19:2364-7. doi:10.1161/01.ATV.19.10.2364
-
(1999)
Arterioscler Thromb Vasc Biol
, vol.19
, pp. 2364-2367
-
-
Huber, S.A.1
Sakkinen, P.2
Conze, D.3
Hardin, N.4
Tracy, R.5
-
154
-
-
77949875590
-
Interleukin-6 as a therapeutic target in candidate inflammatory diseases
-
Nishimoto N. Interleukin-6 as a therapeutic target in candidate inflammatory diseases. Clin Pharmacol Ther (2010) 87:483-7. doi:10.1038/clpt.2009.313
-
(2010)
Clin Pharmacol Ther
, vol.87
, pp. 483-487
-
-
Nishimoto, N.1
-
155
-
-
78149297155
-
Circulating permeability factors in idiopathic nephrotic syndrome and focal segmental glomerulosclerosis
-
Mccarthy ET, Sharma M, Savin VJ. Circulating permeability factors in idiopathic nephrotic syndrome and focal segmental glomerulosclerosis. Clin J Am Soc Nephrol (2010) 5:2115-21. doi:10.2215/CJN.03800609
-
(2010)
Clin J Am Soc Nephrol
, vol.5
, pp. 2115-2121
-
-
Mccarthy, E.T.1
Sharma, M.2
Savin, V.J.3
|