Regulation of IL-6-type cytokine responses by MAPKs

Biochemical Society Transactions

Volumn 42, Issue 1, 2014, Pages 59-62

  Costa Pereira, Ana P ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Cancer; Extracellular signal regulated kinase (ERK); Inflammation; Interleukin 6 type cytokine; Janus kinase (JAK); Signal transducer and activator of transcription (STAT)

Indexed keywords

GLYCOPROTEIN GP 130; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; STAT PROTEIN;

ARTICLE; PLEIOTROPY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR DOWN REGULATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; CYTOKINE RECEPTOR GP130; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-6; JANUS KINASES; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; STAT TRANSCRIPTION FACTORS;

EID: 84893316263     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20130267     Document Type: Article

References (29)

1. Costa-Pereira, A.P., Bonito, N.A. and Seckl, M.J. (2011) Dysregulation of Janus kinases and signal transducers and activators of transcription in cancer. Am. J. Cancer Res. 1, 806-816
2. Heinrich, P.C., Behrmann, I., Haan, S., Hermanns, H.M., Muller-Newen, G. and Schaper, F. (2003) Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem. J. 374, 1-20
3. Guschin, D., Rogers, N., Briscoe, J., Witthuhn, B., Watling, D., Horn, F., Pellegrini, S., Yasukawa, K., Heinrich, P., Stark, G.R. et al. (1995) A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6. EMBO J. 14, 1421-1429
4. Murakami, M., Narazaki, M., Hibi, M., Yawata, H., Yasukawa, K., Hamaguchi, M., Taga, T. and Kishimoto, T. (1991) Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family. Proc. Natl. Acad. Sci. U.S.A. 88, 11349-11353
5. Lutticken, C., Wegenka, U.M., Yuan, J., Buschmann, J., Schindler, C., Ziemiecki, A., Harpur, A.G., Wilks, A.F., Yasukawa, K., Taga, T. et al. (1994) Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130. Science 263, 89-92
6. Costa-Pereira, A.P., Tininini, S., Strobl, B., Alonzi, T., Schlaak, J.F., Is'harc, H., Gesualdo, I., Newman, S.J., Kerr, I.M. and Poli, V. (2002) Mutational switch of an IL-6 response to an interferon-γ-like response. Proc. Natl. Acad. Sci. U.S.A. 99, 8043-8047
7. Maritano, D., Sugrue, M.L., Tininini, S., Dewilde, S., Strobl, B., Fu, X., Murray-Tait, V., Chiarle, R. and Poli, V. (2004) The STAT3 isoforms α and β have unique and specific functions. Nat. Immunol. 5, 401-409
8. Bromberg, J.F., Wrzeszczynska, M.H., Devgan, G., Zhao, Y., Pestell, R.G., Albanese, C. and Darnell, Jr, J.E. (1999) Stat3 as an oncogene. Cell 98, 295-303
9. Kerr, I.M., Costa-Pereira, A.P., Lillemeier, B.F. and Strobl, B. (2003) Of JAKs, STATs, blind watchmakers, jeeps and trains. FEBS Lett. 546, 1-5
10. Qing, Y. and Stark, G.R. (2004) Alternative activation of STAT1 and STAT3 in response to interferon-γ. J. Biol. Chem. 279, 41679-41685
11. Zhao, W., Cha, E.N., Lee, C., Park, C.Y. and Schindler, C. (2007) Stat2-dependent regulation of MHC class II expression. J. Immunol. 179, 463-471
12. Fambrough, D., McClure, K., Kazlauskas, A. and Lander, E.S. (1999) Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes. Cell 97, 727-741
13. Tormo, A.J., Letellier, M.C., Sharma, M., Elson, G., Crabe, S. and Gauchat, J.F. (2012) IL-6 activates STAT5 in T cells. Cytokine 60, 575-582
14. Nishioka, C., Ikezoe, T., Yang, J. and Yokoyama, A. (2009) Multitargeted tyrosine kinase inhibitor stimulates expression of IL-6 and activates JAK2/STAT5 signaling in acute myelogenous leukemia cells. Leukemia 23, 2304-2308
15. Schaper, F., Gendo, C., Eck, M., Schmitz, J., Grimm, C., Anhuf, D., Kerr, I.M. and Heinrich, P.C. (1998) Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression. Biochem. J. 335, 557-565
16. Fuhrer, D.K., Feng, G.S. and Yang, Y.C. (1995) Syp associates with gp130 and Janus kinase 2 in response to interleukin-11 in 3T3-L1 mouse preadipocytes. J. Biol. Chem. 270, 24826-24830
17. Stahl, N., Farruggella, T.J., Boulton, T.G., Zhong, Z., Darnell, Jr, J.E. and Yancopoulos, G.D. (1995) Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science 267, 1349-1353
18. Jenkins, B.J., Grail, D., Nheu, T., Najdovska, M., Wang, B., Waring, P., Inglese, M., McLoughlin, R.M., Jones, S.A., Topley, N. et al. (2005) Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-β signaling. Nat. Med. 11, 845-852
19. Lang, R., Pauleau, A.L., Parganas, E., Takahashi, Y., Mages, J., Ihle, J.N., Rutschman, R. and Murray, P.J. (2003) SOCS3 regulates the plasticity of gp130 signaling. Nat. Immunol. 4, 546-550
20. Croker, B.A., Krebs, D.L., Zhang, J.G., Wormald, S., Willson, T.A., Stanley, E.G., Robb, L., Greenhalgh, C.J., Forster, I., Clausen, B.E. et al. (2003) SOCS3 negatively regulates IL-6 signaling in vivo. Nat. Immunol. 4, 540-545
21. Eulenfeld, R., Dittrich, A., Khouri, C., Muller, P.J., Mutze, B., Wolf, A. and Schaper, F. (2012) Interleukin-6 signalling: more than Jaks and STATs. Eur. J. Cell Biol. 91, 486-495
22. Ernst, M. and Jenkins, B.J. (2004) Acquiring signalling specificity from the cytokine receptor gp130. Trends Genet. 20, 23-32
23. Fukada, T., Hibi, M., Yamanaka, Y., Takahashi-Tezuka, M., Fujitani, Y., Yamaguchi, T., Nakajima, K. and Hirano, T. (1996) Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis. Immunity 5, 449-460
24. Eulenfeld, R. and Schaper, F. (2009) A new mechanism for the regulation of Gab1 recruitment to the plasma membrane. J. Cell Sci. 122, 55-64
25. Ragimbeau, J., Dondi, E., Alcover, A., Eid, P., Uze, G. and Pellegrini, S. (2003) The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression. EMBO J. 22, 537-547
26. Rodriguez, J. and Crespo, P. (2011) Working without kinase activity: phosphotransfer-independent functions of extracellular signal-regulated kinases. Sci. Signalling 4, re3
27. Bonito, N.A., Drechsler, J., Stoecker, S., Carmo, C.R., Seckl, M.J., Hermanns, H.M. and Costa-Pereira, A.P. (2013) Control of gp130 expression by the mitogen-activated protein kinase ERK2. Oncogene, doi:10.1038/onc.2013.159
28. Goke, J., Chan, Y.S., Yan, J., Vingron, M. and Ng, H.H. (2013) Genome-wide kinase-chromatin interactions reveal the regulatory network of ERK signaling in human embryonic stem cells. Mol. Cell 50, 844-855
29. Xu, S. and Neamati, N. (2013) gp130: a promising drug target for cancer therapy. Expert Opin. Ther. Targets 17, 1303-1328