Shedding of endogenous interleukin-6 receptor (IL-6R) is governed by a disintegrin and metalloproteinase (ADAM) proteases while a full-length IL-6R isoform localizes to circulating microvesicles

Journal of Biological Chemistry

Volumn 290, Issue 43, 2015, Pages 26059-26071

  Schumacher, Neele ^a   Meyer, Dörte ^a   Mauermann, Andre ^a   Von Der Heyde, Jan ^a   Wolf, Janina ^a   Schwarz, Jeanette ^a   Knittler, Katharina ^a   Murphy, Gillian ^b   Michalek, Matthias ^a   Garbers, Christoph ^a   Bartsch, Jörg W ^c   Guo, Songbo ^c   Schacher, Beate ^d   Eickholz, Peter ^d   Chalaris, Athena ^a   Rose John, Stefan ^a   Rabe, Björn ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c PHILIPPS UNIVERSITY MARBURG   (Germany)

^d GOETHE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD VESSELS; BODY FLUIDS; ENZYME ACTIVITY; MAMMALS;

ALTERNATIVE SPLICING; HUMAN PATIENTS; METALLOPROTEINASES; MICROVESICLES; PHARMACOLOGICAL INHIBITORS; POTENTIAL SOURCES; PRIMARY CELLS; SIGNALING PATHWAYS;

IMMUNOLOGY;

A DISINTEGRIN AND METALLOPROTEINASE 17 PROTEASE; ADAM PROTEIN; ADAM10 ENDOPEPTIDASE; CATHEPSIN G; CD11B ANTIGEN; CD14 ANTIGEN; CD3 ANTIGEN; INTERLEUKIN 6 RECEPTOR; LEUKOCYTE ELASTASE; MESSENGER RNA; MYELOBLASTIN; UNCLASSIFIED DRUG; ADAM10 PROTEIN, HUMAN; ADAM17 PROTEIN, HUMAN; ADAM17 PROTEIN, MOUSE; ISOPROTEIN; LIPOPOLYSACCHARIDE; MEMBRANE PROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE; SECRETASE; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME;

5' UNTRANSLATED REGION; ALTERNATIVE RNA SPLICING; ANIMAL CELL; ARTICLE; BONE MARROW DERIVED MONONUCLEAR CELL; CANCER CELL LINE; CIRCULATING MICROVESICLE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; EXON; HUMAN; HUMAN CELL; IN VITRO STUDY; MACROPHAGE; MEMBRANE MICROPARTICLE; MOLECULAR DYNAMICS; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION, SYNTHESIS AND MODIFICATION; PROTEIN LOCALIZATION; PROTEIN SECRETION; PROTEIN SHEDDING; SIGNAL TRANSDUCTION; THP 1 CELL LINE; U937 CELL LINE; ANIMAL; CELL LINE; DRUG EFFECTS; GENETICS; METABOLISM; RNA SPLICING;

ADAM PROTEINS; ADAM10 PROTEIN; ADAM17 PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELL LINE; HUMANS; LIPOPOLYSACCHARIDES; MEMBRANE PROTEINS; MICE; MONOCYTES; PROTEIN ISOFORMS; PROTEOLYSIS; RECEPTORS, INTERLEUKIN-6; RNA SPLICING; TETRADECANOYLPHORBOL ACETATE;

EID: 84944909402     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.649509     Document Type: Article

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