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Volumn 8, Issue 4, 2017, Pages 1526-1537

Molecular adaptations underlying the beneficial effects of hydroxytyrosol in the pathogenic alterations induced by a high-fat diet in mouse liver: PPAR-α and Nrf2 activation, and NF-κB down-regulation

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL ACTIVATION; CHEMICAL COMPOUNDS; FATTY ACIDS; OLIVE OIL; POLYUNSATURATED FATTY ACIDS; TRANSCRIPTION; TRANSCRIPTION FACTORS;

EID: 85018365029     PISSN: 20426496     EISSN: 2042650X     Source Type: Journal    
DOI: 10.1039/c7fo00090a     Document Type: Article
Times cited : (106)

References (60)
  • 1
    • 84994131204 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease in 2016
    • S. A. Townsend P. N. Newsome Non-alcoholic fatty liver disease in 2016 Br. Med. Bull. 2016 119 143 156
    • (2016) Br. Med. Bull. , vol.119 , pp. 143-156
    • Townsend, S.A.1    Newsome, P.N.2
  • 2
    • 84976479130 scopus 로고    scopus 로고
    • Global Epidemiology of Non-Alcoholic Fatty Liver Disease-Meta-Analytic Assessment of Prevalence, Incidence and Outcomes
    • Z. M. Younossi A. B. Koening D. Abdelatif Y. Fazel L. Henry M. Wymer Global Epidemiology of Non-Alcoholic Fatty Liver Disease-Meta-Analytic Assessment of Prevalence, Incidence and Outcomes Hepatology 2016 64 73 84
    • (2016) Hepatology , vol.64 , pp. 73-84
    • Younossi, Z.M.1    Koening, A.B.2    Abdelatif, D.3    Fazel, Y.4    Henry, L.5    Wymer, M.6
  • 3
    • 84945311254 scopus 로고    scopus 로고
    • Relevant aspects of nutritional and dietary interventions in non-alcoholic fatty liver disease
    • M. C. Hernandez-Rodas R. Valenzuela L. A. Videla Relevant aspects of nutritional and dietary interventions in non-alcoholic fatty liver disease Int. J. Mol. Sci. 2015 16 25168 25198
    • (2015) Int. J. Mol. Sci. , vol.16 , pp. 25168-25198
    • Hernandez-Rodas, M.C.1    Valenzuela, R.2    Videla, L.A.3
  • 4
    • 78049522194 scopus 로고    scopus 로고
    • Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis
    • H. Tilg A. R. Moschen Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis Hepatology 2010 52 1836 1846
    • (2010) Hepatology , vol.52 , pp. 1836-1846
    • Tilg, H.1    Moschen, A.R.2
  • 5
    • 84856650278 scopus 로고    scopus 로고
    • The importance of the long-chain polyunsaturated fatty acid n-6/n-3 ratio in development of non-alcoholic fatty liver associated with obesity
    • R. Valenzuela L. A. Videla The importance of the long-chain polyunsaturated fatty acid n-6/n-3 ratio in development of non-alcoholic fatty liver associated with obesity Food Funct. 2011 2 644 648
    • (2011) Food Funct. , vol.2 , pp. 644-648
    • Valenzuela, R.1    Videla, L.A.2
  • 6
    • 2942706241 scopus 로고    scopus 로고
    • Increase in long-chain polyunsaturated fatty acid n-6/n-3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease
    • J. Araya R. Valenzuela L. A. Videla L. Thielemann M. Orellana P. Pettinelli J. Poniachik Increase in long-chain polyunsaturated fatty acid n-6/n-3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease Clin. Sci. 2004 106 635 643
    • (2004) Clin. Sci. , vol.106 , pp. 635-643
    • Araya, J.1    Valenzuela, R.2    Videla, L.A.3    Thielemann, L.4    Orellana, M.5    Pettinelli, P.6    Poniachik, J.7
  • 7
    • 28844485678 scopus 로고    scopus 로고
    • Effects of dietary polyunsaturated n-3 fatty acids on dyslipidemia and insulin resistance in rodents and humans. A review
    • Y. B. Lombardo A. G. Chicco Effects of dietary polyunsaturated n-3 fatty acids on dyslipidemia and insulin resistance in rodents and humans. A review J. Nutr. Biochem. 2006 17 1 13
    • (2006) J. Nutr. Biochem. , vol.17 , pp. 1-13
    • Lombardo, Y.B.1    Chicco, A.G.2
  • 8
    • 84952874326 scopus 로고    scopus 로고
    • The Riddle of Nonalcoholic Fatty Liver Disease: Progression from Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis
    • M. Sharma S. Mitnala R. K. Vishnubhotla R. Mukherjee D. N. Reddy P. N. Rao The Riddle of Nonalcoholic Fatty Liver Disease: Progression from Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis J. Clin. Exp. Hepatol. 2015 5 147 158
    • (2015) J. Clin. Exp. Hepatol. , vol.5 , pp. 147-158
    • Sharma, M.1    Mitnala, S.2    Vishnubhotla, R.K.3    Mukherjee, R.4    Reddy, D.N.5    Rao, P.N.6
  • 9
    • 84894234845 scopus 로고    scopus 로고
    • Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease
    • X. Q. Zhang C. F. Xu C. H. Yu W. X. Chen Y. M. Li Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease World J. Gastroenterol. 2014 20 1768 1776
    • (2014) World J. Gastroenterol. , vol.20 , pp. 1768-1776
    • Zhang, X.Q.1    Xu, C.F.2    Yu, C.H.3    Chen, W.X.4    Li, Y.M.5
  • 10
    • 85006753982 scopus 로고    scopus 로고
    • Supplementation with antioxidant-rich extra virgin olive oil prevents hepatic oxidative stress and reduction of desaturation capacity in mice fed a high-fat diet: Effects on fatty acid composition in liver and extrahepatic tissues
    • M. A. Rincón-Cervera R. Valenzuela M. C. Hernandez-Rodas M. Marambio A. Espinosa S. Mayer N. Romero C. Barrera L. A. Videla Supplementation with antioxidant-rich extra virgin olive oil prevents hepatic oxidative stress and reduction of desaturation capacity in mice fed a high-fat diet: Effects on fatty acid composition in liver and extrahepatic tissues Nutrition 2016 32 1254 1267
    • (2016) Nutrition , vol.32 , pp. 1254-1267
    • Rincón-Cervera, M.A.1    Valenzuela, R.2    Hernandez-Rodas, M.C.3    Marambio, M.4    Espinosa, A.5    Mayer, S.6    Romero, N.7    Barrera, C.8    Videla, L.A.9
  • 11
    • 84929707927 scopus 로고    scopus 로고
    • Reduction in the desaturation capacity of the liver in mice subjected to high fat diet: Relation to LCPUFA depletion in liver and extrahepatic tissues
    • R. Valenzuela C. Barrera A. Espinosa P. Llanos P. Orellana L. A. Videla Reduction in the desaturation capacity of the liver in mice subjected to high fat diet: Relation to LCPUFA depletion in liver and extrahepatic tissues Prostaglandins, Leukotrienes Essent. Fatty Acids 2015 98 7 14
    • (2015) Prostaglandins, Leukotrienes Essent. Fatty Acids , vol.98 , pp. 7-14
    • Valenzuela, R.1    Barrera, C.2    Espinosa, A.3    Llanos, P.4    Orellana, P.5    Videla, L.A.6
  • 12
    • 77957362125 scopus 로고    scopus 로고
    • Liver NF-κB and AP-1 activation and PPAR-α expression are negatively correlated in obese patients: Pro-inflammatory implications
    • L. A. Videla Liver NF-κB and AP-1 activation and PPAR-α expression are negatively correlated in obese patients: pro-inflammatory implications Clin. Nutr. 2010 29 687 688
    • (2010) Clin. Nutr. , vol.29 , pp. 687-688
    • Videla, L.A.1
  • 13
    • 84883746590 scopus 로고    scopus 로고
    • The innate immune response during liver inflammation and metabolic disease
    • V. Bieghs C. Trautwein The innate immune response during liver inflammation and metabolic disease Trends Immunol. 2013 34 446 452
    • (2013) Trends Immunol. , vol.34 , pp. 446-452
    • Bieghs, V.1    Trautwein, C.2
  • 14
    • 84937044346 scopus 로고    scopus 로고
    • The role of olive oil in disease prevention: A focus on the recent epidemiological evidence from cohort studies and dietary intervention trials
    • G. Buckland C. A. Gonzalez The role of olive oil in disease prevention: a focus on the recent epidemiological evidence from cohort studies and dietary intervention trials Br. J. Nutr. 2015 113 94 101
    • (2015) Br. J. Nutr. , vol.113 , pp. 94-101
    • Buckland, G.1    Gonzalez, C.A.2
  • 15
    • 84925677832 scopus 로고    scopus 로고
    • Modulation of hepatic lipid metabolism by olive oil and its phenols in nonalcoholic fatty liver disease
    • P. Priore A. Cavallo A. Gnoni F. Damiano G. V. Gnoni L. Siculella Modulation of hepatic lipid metabolism by olive oil and its phenols in nonalcoholic fatty liver disease IUBMB Life 2015 67 9 17
    • (2015) IUBMB Life , vol.67 , pp. 9-17
    • Priore, P.1    Cavallo, A.2    Gnoni, A.3    Damiano, F.4    Gnoni, G.V.5    Siculella, L.6
  • 16
    • 84962122628 scopus 로고    scopus 로고
    • Hydroxytyrosol prevents metabolic impairment reducing hepatic inflammation and restoring duodenal integrity in a rat model of NAFLD
    • C. Pirozzi Hydroxytyrosol prevents metabolic impairment reducing hepatic inflammation and restoring duodenal integrity in a rat model of NAFLD J. Nutr. Biochem. 2016 30 108 115
    • (2016) J. Nutr. Biochem. , vol.30 , pp. 108-115
    • Pirozzi, C.1
  • 17
    • 84907813831 scopus 로고    scopus 로고
    • Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: Focus on protection against cardiovascular and metabolic diseases
    • S. Bulotta M. Celano S. M. Lepore T. Montalcini A. Pujia D. Russo Beneficial effects of the olive oil phenolic components oleuropein and hydroxytyrosol: focus on protection against cardiovascular and metabolic diseases J. Transl. Med. 2014 12 1 9
    • (2014) J. Transl. Med. , vol.12 , pp. 1-9
    • Bulotta, S.1    Celano, M.2    Lepore, S.M.3    Montalcini, T.4    Pujia, A.5    Russo, D.6
  • 18
    • 85006266086 scopus 로고    scopus 로고
    • Hydroxytyrosol ameliorates metabolic, cardiovascular and liver changes in a rat model of diet-induced metabolic syndrome: Pharmacological and metabolism-based investigation
    • H. Poudyal N. Lemonakis P. Efentakis E. Gikas M. Halabalaki L. Skaltsounis L. Brown Hydroxytyrosol ameliorates metabolic, cardiovascular and liver changes in a rat model of diet-induced metabolic syndrome: pharmacological and metabolism-based investigation Pharmacol. Res. 2017 117 32 45
    • (2017) Pharmacol. Res. , vol.117 , pp. 32-45
    • Poudyal, H.1    Lemonakis, N.2    Efentakis, P.3    Gikas, E.4    Halabalaki, M.5    Skaltsounis, L.6    Brown, L.7
  • 20
    • 77951486280 scopus 로고    scopus 로고
    • Olive Leaf Extract Attenuates Cardiac, Hepatic and Metabolic Changes in High Carbohydrate -High Fat Fed Rats
    • H. Poudyal F. Campbell L. Brown Olive Leaf Extract Attenuates Cardiac, Hepatic and Metabolic Changes in High Carbohydrate -High Fat Fed Rats J. Nutr. 2010 140 946 953
    • (2010) J. Nutr. , vol.140 , pp. 946-953
    • Poudyal, H.1    Campbell, F.2    Brown, L.3
  • 21
    • 85018344720 scopus 로고    scopus 로고
    • Hydroxytyrosol prevents reduction in liver activity of Δ-5 and Δ-6 desaturases, oxidative stress, and depletion in long chain polyunsaturated fatty acid content in different tissues of high-fat diet fed mice
    • 10.1186/s12944-017-0450-5
    • R. Valenzuela F. Echeverria M. Ortiz M. A. Rincón-Cervera A. Espinosa M. C. Hernandez-Rodas P. Illesca A. Valenzuela L. A. Videla Hydroxytyrosol prevents reduction in liver activity of Δ-5 and Δ-6 desaturases, oxidative stress, and depletion in long chain polyunsaturated fatty acid content in different tissues of high-fat diet fed mice Lipids Health Dis. 2017 10.1186/s12944-017-0450-5
    • (2017) Lipids Health Dis.
    • Valenzuela, R.1    Echeverria, F.2    Ortiz, M.3    Rincón-Cervera, M.A.4    Espinosa, A.5    Hernandez-Rodas, M.C.6    Illesca, P.7    Valenzuela, A.8    Videla, L.A.9
  • 23
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • E. G. Bligh W. J. Dyer A rapid method of total lipid extraction and purification Can. J. Biochem. Physiol. 1959 37 911 917
    • (1959) Can. J. Biochem. Physiol. , vol.37 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2
  • 24
    • 4243190715 scopus 로고
    • Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride - Methanol
    • W. R. Morrison L. M. Smith Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride - methanol J. Lipid Res. 1964 5 600 608
    • (1964) J. Lipid Res. , vol.5 , pp. 600-608
    • Morrison, W.R.1    Smith, L.M.2
  • 25
    • 0000964637 scopus 로고
    • Soluble diaphorase in animal tissues
    • L. Ernster F. Navazio Soluble diaphorase in animal tissues Acta Chem. Scand. 1958 12 595 602
    • (1958) Acta Chem. Scand. , vol.12 , pp. 595-602
    • Ernster, L.1    Navazio, F.2
  • 26
    • 0016275313 scopus 로고
    • Glutathione S-transferases. the first enzymatic step in mercapturic acid formation
    • W. H. Habig M. J. Pabst W. B. Jakoby Glutathione S-transferases. The first enzymatic step in mercapturic acid formation J. Biol. Chem. 1974 249 7130 7139
    • (1974) J. Biol. Chem. , vol.249 , pp. 7130-7139
    • Habig, W.H.1    Pabst, M.J.2    Jakoby, W.B.3
  • 27
    • 0022192447 scopus 로고
    • Kinetic assay of gamma-glutamyltransferase with use of bilirubin oxidase as a coupled enzyme
    • S. Satomura Y. Miki T. Hamanaka Y. Sakata Kinetic assay of gamma-glutamyltransferase with use of bilirubin oxidase as a coupled enzyme Clin. Chem. 1985 31 1380 1383
    • (1985) Clin. Chem. , vol.31 , pp. 1380-1383
    • Satomura, S.1    Miki, Y.2    Hamanaka, T.3    Sakata, Y.4
  • 28
    • 0344667491 scopus 로고    scopus 로고
    • Decreased fatty acid esterification compensates for the reduced lipolytic activity in hormone-sensitive lipase-deficient white adipose tissue
    • R. Zimmermann G. Haemmerle E. M. Wagner J. G. Strauss D. Kratky R. Zechner Decreased fatty acid esterification compensates for the reduced lipolytic activity in hormone-sensitive lipase-deficient white adipose tissue J. Lipid Res. 2003 44 2089 2099
    • (2003) J. Lipid Res. , vol.44 , pp. 2089-2099
    • Zimmermann, R.1    Haemmerle, G.2    Wagner, E.M.3    Strauss, J.G.4    Kratky, D.5    Zechner, R.6
  • 29
    • 0015594233 scopus 로고
    • Insulin and the regulation of adipose tissue acetyl-coenzyme A carboxylase
    • A. P. Halestrap R. M. Denton Insulin and the regulation of adipose tissue acetyl-coenzyme A carboxylase Biochem. J. 1973 132 509 517
    • (1973) Biochem. J. , vol.132 , pp. 509-517
    • Halestrap, A.P.1    Denton, R.M.2
  • 30
    • 0036146821 scopus 로고    scopus 로고
    • Dietary l-carnitine stimulates carnitine acyltransferases in the liver of aged rats
    • H. Karlic S. Lohninger T. Koeck A. Lohninger Dietary l-carnitine stimulates carnitine acyltransferases in the liver of aged rats J. Histochem. Cytochem. 2002 50 205 212
    • (2002) J. Histochem. Cytochem. , vol.50 , pp. 205-212
    • Karlic, H.1    Lohninger, S.2    Koeck, T.3    Lohninger, A.4
  • 33
    • 77954143472 scopus 로고    scopus 로고
    • Decreased liver fatty acid delta-6 and delta-5 desaturase activity in obese patients
    • J. Araya R. Rodrigo P. Pettinelli A. V. Araya J. Poniachik L. A. Videla Decreased liver fatty acid delta-6 and delta-5 desaturase activity in obese patients Obesity 2010 18 1460 1463
    • (2010) Obesity , vol.18 , pp. 1460-1463
    • Araya, J.1    Rodrigo, R.2    Pettinelli, P.3    Araya, A.V.4    Poniachik, J.5    Videla, L.A.6
  • 34
    • 5344239586 scopus 로고    scopus 로고
    • Oxidative stress and depletion of hepatic long-chain polyunsaturated fatty acids may contribute to nonalcoholic fatty liver disease
    • L. A. Videla R. Rodrigo J. Araya J. Poniachik Oxidative stress and depletion of hepatic long-chain polyunsaturated fatty acids may contribute to nonalcoholic fatty liver disease Free Radicals Biol. Med. 2004 9 1499 1507
    • (2004) Free Radicals Biol. Med. , vol.9 , pp. 1499-1507
    • Videla, L.A.1    Rodrigo, R.2    Araya, J.3    Poniachik, J.4
  • 35
    • 84893405239 scopus 로고    scopus 로고
    • Enhanced endoplasmic reticulum SERCA activity by overexpression of hepatic stimulator substance gene prevents hepatic cells from ER stress-induced apoptosis
    • J. Zhang Y. Li S. Jiang H. Yu W. An Enhanced endoplasmic reticulum SERCA activity by overexpression of hepatic stimulator substance gene prevents hepatic cells from ER stress-induced apoptosis Am. J. Physiol.: Cell Physiol. 2014 3 279 290
    • (2014) Am. J. Physiol.: Cell Physiol. , vol.3 , pp. 279-290
    • Zhang, J.1    Li, Y.2    Jiang, S.3    Yu, H.4    An, W.5
  • 36
    • 84867637301 scopus 로고    scopus 로고
    • N-3 long-chain polyunsaturated fatty acid supplementation significantly reduces liver oxidative stress in high fat induced steatosis
    • R. Valenzuela A. Espinosa D. González-Mañán A. D'Espessailles V. Fernández L. A. Videla G. Tapia N-3 long-chain polyunsaturated fatty acid supplementation significantly reduces liver oxidative stress in high fat induced steatosis PLoS One 2012 10 1 8
    • (2012) PLoS One , vol.10 , pp. 1-8
    • Valenzuela, R.1    Espinosa, A.2    González-Mañán, D.3    D'Espessailles, A.4    Fernández, V.5    Videla, L.A.6    Tapia, G.7
  • 38
    • 84872450820 scopus 로고    scopus 로고
    • Mitochondrial DNA damage and dysfunction, and oxidative stress are associated with endoplasmic reticulum stress, protein degradation and apoptosis in high fat diet-induced insulin resistance mice
    • L. V. Yuzefovych S. I. Musiyenko G. L. Wilson L. I. Rachek Mitochondrial DNA damage and dysfunction, and oxidative stress are associated with endoplasmic reticulum stress, protein degradation and apoptosis in high fat diet-induced insulin resistance mice PLoS One 2013 8 1 8
    • (2013) PLoS One , vol.8 , pp. 1-8
    • Yuzefovych, L.V.1    Musiyenko, S.I.2    Wilson, G.L.3    Rachek, L.I.4
  • 39
    • 84904382730 scopus 로고    scopus 로고
    • High fat diet feeding results in gender specific steatohepatitis and inflammasome activation
    • M. Ganz T. Csak G. Szabo High fat diet feeding results in gender specific steatohepatitis and inflammasome activation World J. Gastroenterol. 2014 20 8525 8534
    • (2014) World J. Gastroenterol. , vol.20 , pp. 8525-8534
    • Ganz, M.1    Csak, T.2    Szabo, G.3
  • 41
    • 82955188750 scopus 로고    scopus 로고
    • N-3 PUFA supplementation triggers PPAR-α activation and PPAR-α/NF-κB interaction: Anti-inflammatory implications in liver ischemia-reperfusion injury
    • J. Zúñiga M. Cancino F. Medina P. Varela R. Vargas G. Tapia L. A. Videla V. Fernández N-3 PUFA supplementation triggers PPAR-α activation and PPAR-α/NF-κB interaction: anti-inflammatory implications in liver ischemia-reperfusion injury PLoS One 2011 6 1 9
    • (2011) PLoS One , vol.6 , pp. 1-9
    • Zúñiga, J.1    Cancino, M.2    Medina, F.3    Varela, P.4    Vargas, R.5    Tapia, G.6    Videla, L.A.7    Fernández, V.8
  • 42
    • 84908551652 scopus 로고    scopus 로고
    • Chronic hydroxytyrosol feeding modulates glutathione-mediated oxido-reduction pathways in adipose tissue: A nutrigenomic study
    • E. Giordano A. Dávalos F. Visioli Chronic hydroxytyrosol feeding modulates glutathione-mediated oxido-reduction pathways in adipose tissue: A nutrigenomic study Nutr., Metab. Cardiovasc. Dis. 2014 24 1144 1150
    • (2014) Nutr., Metab. Cardiovasc. Dis. , vol.24 , pp. 1144-1150
    • Giordano, E.1    Dávalos, A.2    Visioli, F.3
  • 44
    • 84930927332 scopus 로고    scopus 로고
    • Hydroxytyrosol improves mitochondrial function and reduces oxidative stress in the brain of db/db mice: Role of AMP-activated protein kinase activation
    • A. Zheng H. Li K. Cao H. Li W. Pu Z. Yang Y. Peng J. Long J. Liu Z. Feng Hydroxytyrosol improves mitochondrial function and reduces oxidative stress in the brain of db/db mice: role of AMP-activated protein kinase activation Br. J. Nutr. 2015 113 1667 1676
    • (2015) Br. J. Nutr. , vol.113 , pp. 1667-1676
    • Zheng, A.1    Li, H.2    Cao, K.3    Li, H.4    Pu, W.5    Yang, Z.6    Peng, Y.7    Long, J.8    Liu, J.9    Feng, Z.10
  • 45
    • 84949447913 scopus 로고    scopus 로고
    • Olive oil and its phenolic compounds (hydroxytyrosol and tyrosol) ameliorated TCDD-induced heptotoxicity in rats via inhibition of oxidative stress and apoptosis
    • I. Kalaiselvan M. Samuthirapandi A. Govindaraju D. Sheeja Malar P. D. Kasi Olive oil and its phenolic compounds (hydroxytyrosol and tyrosol) ameliorated TCDD-induced heptotoxicity in rats via inhibition of oxidative stress and apoptosis Pharm. Biol. 2016 54 338 346
    • (2016) Pharm. Biol. , vol.54 , pp. 338-346
    • Kalaiselvan, I.1    Samuthirapandi, M.2    Govindaraju, A.3    Sheeja Malar, D.4    Kasi, P.D.5
  • 46
    • 37549003700 scopus 로고    scopus 로고
    • Active components and clinical applications of olive oil
    • E. Waterman B. Lockwood Active components and clinical applications of olive oil Altern. Med. Rev. 2007 12 331 342
    • (2007) Altern. Med. Rev. , vol.12 , pp. 331-342
    • Waterman, E.1    Lockwood, B.2
  • 51
    • 77954626997 scopus 로고    scopus 로고
    • Hydroxytyrosol induces antioxidant/detoxificant enzymes and Nrf2 translocation via extracellular regulated kinases and phosphatidylinositol-3-kinase/protein kinase B pathways in HepG2 cells
    • M. A. Martín S. Ramos A. B. Granado-Serrano I. Rodríguez-Ramiro M. Trujillo L. Bravo L. Goya Hydroxytyrosol induces antioxidant/detoxificant enzymes and Nrf2 translocation via extracellular regulated kinases and phosphatidylinositol-3-kinase/protein kinase B pathways in HepG2 cells Mol. Nutr. Food Res. 2010 54 956 966
    • (2010) Mol. Nutr. Food Res. , vol.54 , pp. 956-966
    • Martín, M.A.1    Ramos, S.2    Granado-Serrano, A.B.3    Rodríguez-Ramiro, I.4    Trujillo, M.5    Bravo, L.6    Goya, L.7
  • 52
    • 84897059494 scopus 로고    scopus 로고
    • Hydroxytyrosol, a natural molecule from olive oil, suppresses the growth of human hepatocellular carcinoma cells via inactivating AKT and nuclear factor-kappa B pathways
    • B. Zhao Y. Ma Z. Xu J. Wang F. Wang D. Wang S. Pan Y. Wu H. Pan D. Xu L. Liu H. Jiang Hydroxytyrosol, a natural molecule from olive oil, suppresses the growth of human hepatocellular carcinoma cells via inactivating AKT and nuclear factor-kappa B pathways Cancer Lett. 2014 347 79 87
    • (2014) Cancer Lett. , vol.347 , pp. 79-87
    • Zhao, B.1    Ma, Y.2    Xu, Z.3    Wang, J.4    Wang, F.5    Wang, D.6    Pan, S.7    Wu, Y.8    Pan, H.9    Xu, D.10    Liu, L.11    Jiang, H.12
  • 53
    • 84898959061 scopus 로고    scopus 로고
    • Hydroxytyrosol attenuates tunicamycin-induced endoplasmic reticulum stress in human hepatocarcinoma cells
    • E. Giordano A. Davalos N. Nicod F. Visioli Hydroxytyrosol attenuates tunicamycin-induced endoplasmic reticulum stress in human hepatocarcinoma cells Mol. Nutr. Food Res 2014 58 954 962
    • (2014) Mol. Nutr. Food Res , vol.58 , pp. 954-962
    • Giordano, E.1    Davalos, A.2    Nicod, N.3    Visioli, F.4
  • 54
    • 84901940803 scopus 로고    scopus 로고
    • N-3 long-chain PUFA supplementation prevents high fat diet induced mouse liver steatosis and inflammation in relation to PPAR-α upregulation and NF-κB DNA binding abrogation
    • G. Tapia R. Valenzuela A. Espinosa P. Romanque C. Dossi D. González-Mañán L. A. Videla A. D'Espessailles N-3 long-chain PUFA supplementation prevents high fat diet induced mouse liver steatosis and inflammation in relation to PPAR-α upregulation and NF-κB DNA binding abrogation Mol. Nutr. Food Res 2014 58 1333 1341
    • (2014) Mol. Nutr. Food Res , vol.58 , pp. 1333-1341
    • Tapia, G.1    Valenzuela, R.2    Espinosa, A.3    Romanque, P.4    Dossi, C.5    González-Mañán, D.6    Videla, L.A.7    D'Espessailles, A.8
  • 56
    • 67649402187 scopus 로고    scopus 로고
    • The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress
    • T. Nguyen P. Nioi C. B. Pickett The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress J. Biol. Chem. 2009 284 13291 13295
    • (2009) J. Biol. Chem. , vol.284 , pp. 13291-13295
    • Nguyen, T.1    Nioi, P.2    Pickett, C.B.3
  • 58
    • 84953635674 scopus 로고    scopus 로고
    • Cell type-specific modulation of lipid mediator's formation in murine adipose tissue by omega-3 fatty acids
    • O. Kuda M. Rombaldova P. Janovska P. Flachs J. Kopecky Cell type-specific modulation of lipid mediator's formation in murine adipose tissue by omega-3 fatty acids Biochem. Biophys. Res. Commun. 2016 469 731 736
    • (2016) Biochem. Biophys. Res. Commun. , vol.469 , pp. 731-736
    • Kuda, O.1    Rombaldova, M.2    Janovska, P.3    Flachs, P.4    Kopecky, J.5
  • 59
    • 0016805102 scopus 로고
    • Metabolic turnover rate: A physiological meaning of the metabolic rate per unit body weight
    • M. Kleiber Metabolic turnover rate: A physiological meaning of the metabolic rate per unit body weight J. Theor. Biol. 1975 53 199 204
    • (1975) J. Theor. Biol. , vol.53 , pp. 199-204
    • Kleiber, M.1


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