Oxidative stress and depletion of hepatic long-chain polyunsaturated fatty acids may contribute to nonalcoholic fatty liver disease

Free Radical Biology and Medicine

Volumn 37, Issue 9, 2004, Pages 1499-1507

  Videla, Luis A ^a   Rodrigo, Ramón ^a   Araya, Julia ^b   Poniachik, Jaime ^c  

^a UNIVERSITY OF CHILE   (Chile)

^b Facultad de Medicina   (Chile)

^c HOSPITAL CLÍNICO UNIVERSIDAD DE CHILE   (Chile)

Author keywords

Free radicals; Long chain polyunsaturated fatty acids; Nonalcoholic fatty liver disease; Oxidative stress; Steatohepatitis; Steatosis

Indexed keywords

LIPID; LONG CHAIN FATTY ACID; POLYUNSATURATED FATTY ACID; TRIACYLGLYCEROL;

ADIPOSE TISSUE; DEPLETION; DIET; DISEASE COURSE; FATTY ACID OXIDATION; GENE EXPRESSION; HEPATITIS; HUMAN; LIPID PEROXIDATION; LIPID STORAGE; LIPOGENESIS; NONALCOHOLIC FATTY LIVER; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW;

EID: 5344239586     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2004.06.033     Document Type: Article

References (64)

1. S. Chitturi, and G.C. Farrell Etiopathogenesis of nonalcoholic steatohepatitis Semin. Liver Dis. 21 2001 27 41
2. P. Angulo Nonalcoholic fatty liver disease N. Engl. J. Med. 346 2002 1221 1231
3. C. Matteoni, Z.M. Younossi, and A. McCullough Nonalcoholic fatty liver disease: a spectrum of clinical pathological severity Gastroenterology 116 1999 1413 1419
4. M. Kuwajima, N. Kono, M. Horiuchi, Y. Imamura, A. Ono, T. Inui, S. Kawata, T. Koizymi, J. Hayakawa, and T. Saheki Animal model of systemic carnitine deficiency: analysis in C3H-2 strain of mouse associated with juvenile visceral steatosis Biochem. Biophys. Res. Commun. 174 1991 1090 1094
5. J. Bjorkegren, A. Beigneux, M.O. Bergo, J.J. Maher, and S.G. Young Blocking the secretion of hepatic very low density lipoproteins renders the liver more susceptible to toxin-induced injury J. Biol. Chem. 277 2002 5476 5483
6. A.M. Sessler, and J.M. Ntambi Polyunsaturated fatty acid regulation of gene expression J. Nutr. 128 1998 923 926
7. M.T. Nakamura, H.P. Cho, and S.D. Clarke Regulation of hepatic delta-6 desaturase expression and its role in the polyunsaturated fatty acid inhibition of fatty acid synthase gene expression in mice J. Nutr. 130 2000 1561 1565
8. S.D. Clarke Polyunsaturated fatty acid regulation of gene transcription: a molecular mechanism to improve the metabolic syndrome J. Nutr. 131 2001 1129 1132
9. J.K. Reddy Nonalcoholic steatosis and steatohepatitis. III. Peroxisomal β-oxidation, PPARα, and steatohepatitis Am. J. Physiol. 281 2001 G1333 G1339
10. M.M. Mahfouz, T.L. Smith, and F.A. Kummerow Effect of dietary fats on desaturase activities and the biosynthesis of fatty acids in rat-liver microsomes Lipids 19 1984 214 222
11. H. Sies Biochemistry of oxidative stress Angew. Chem. Int. Ed. Engl. 25 1986 1058 1071
12. A. Sevanian, and P. Hochstein Mechanisms and consequences of lipid peroxidation in biological systems Ann. Rev. Nutr. 5 1985 365 390
13. J. Araya, R. Rodrigo, L.A. Videla, L. Thielemann, M. Orellana, P. Pettinelli, and J. Poniachik Increase in long-chain polyunsaturated fatty acids n-6/n-3 ratio in relation to hepatic steatosis in nonalcoholic fatty liver disease patients Clin. Sci. 106 2004 635 643
14. T. Yoshikawa, H. Shimano, N. Yahagi, T. Ide, M. Amemiya-Kudo, T. Matsuzaka, M. Nakakuki, S. Tomita, H. Okasaki, Y. Tamura, Y. Iizuka, K. Ohashi, A. Takahashi, H. Sone, J. Osuga, T. Gotoda, S. Ishibashi, and N. Yamada Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements J. Biol. Chem. 277 2002 1705 1711
15. T. Matsuzaka, H. Shimano, N. Yahagi, M. Amemiya-Kudo, T. Yoshikawa, A.H. Hasty, Y. Tamura, J. Osuga, H. Okasaki, Y. Iizuka, A. Takahashi, H. Sone, T. Gotoda, S. Ishibashi, and N. Yamada Dual regulation of mouse delta(5)- and delta(6)-desaturase gene expression by SREBP-1 and PPARalpha J. Lipid Res. 43 2002 107 114
16. T.F. Osborne Sterol regulatory element-binding proteins (SREBPs): key regulators of nutritional homeostasis and insulin action J. Biol. Chem. 275 2000 32379 32382
17. S.D. Clarke, P. Thuillier, R.A. Baille, and X. Cha Peroxisome proliferator-activated receptors: a family of lipid-activated transcription factors Am. J. Clin. Nutr. 70 1999 566 571
18. S. Kersten Effects of fatty acids on gene expression: role of peroxisome proliferator-activated receptor alpha, liver X receptor alpha, and sterol regulatory-element binding protein-1c Proc. Nutr. Soc. 61 2002 371 374
19. D. Lindén, K. Lindberg, J. Oscarsson, C. Claesson, L. Asp, L. Li, M. Gustafsson, J. Borén, and S.O. Olofsson Influence of peroxisome proliferator-activated receptor α agonists on the intracellular turnover and secretion of apolipoprotein (Apo)B-100 and ApoB-48 J. Biol. Chem. 277 2002 23044 23053
20. M. Charlton, R. Sreekumar, D. Rasmussen, K. Lindor, and K.S. Nair Apolipoprotein synthesis in nonalcoholic steatohepatitis Hepatology 35 2002 898 904
21. C. Meunier-Durmort, H. Poirier, I. Niot, C. Forest, and P. Besnard Upregulation of the expression of the gene for liver fatty acid-binding protein by long-chain fatty acids Biochem. J. 319 1996 483 487
22. L. Carlsson, D. Lindén, J. Masoumeh, and J. Oscarsson Effects of fatty acids and growth hormone on liver fatty acid-binding protein and PPARα in rat liver Am. J. Physiol. 281 2001 E772 E781
23. S. Kersten, J. Seydoux, J.M. Peters, F.J. González, B. Desbvergne, and W. Wahli Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting J. Clin. Invest. 103 1999 1489 1498
24. A. Baylin, E.K. Kabagambe, X. Siles, and H. Campos Adipose tissue biomarkers of fatty acid intake Am. J. Clin. Nutr. 76 2002 750 757
25. E. Larqué, F. Pérez-Llamas, V. Puerta, M.D. Girón, M.D. Suárez, A. Zamora, and A. Gil Dietary trans fatty acids affect docosahexaenoic acid concentrations in plasma and liver but not brain of pregnant and fetal rats Pediatr. Res. 47 2000 278 283
26. P.A. Burke, P.R. Ling, R.A. Forse, and B.R. Bistrian Conditionally essential fatty acid deficiencies in end-stage liver disease Nutrition 15 1999 302 304
27. M. Okita, T. Sasagawa, K. Tomioka, K. Hasuda, Y. Ota, K. Sizuki, and A. Watanabe Habitual food intake and polyunsaturated fatty acid deficiency in liver cirrhosis Nutrition 18 2002 304 308
28. L.A. Videla, V. Fernández, Y. Carrión, L.A. Azzalis, A.C.D. Bainy, and V.B.C. Junqueira Biochemical mechanisms in hepatotoxicity: oxidative stress induced by xenobiotics and hormonal changes J. Braz. Assoc. Adv. Sci. 47 1995 385 394
29. H. Jaeschke, G.J. Gores, A.I. Cederbaum, J.A. Hinson, D. Pessayre, and J.J. Lemasters Mechanisms of hepatotoxicity Toxicol. Sci. 65 2002 166 176
30. H. Tsukamoto Redox regulation of cytokine expression in Kupffer cells Antioxid. Redox Signaling 4 2002 741 748
31. J.L. Martindale, and N.J. Holbrook Cellular responses to oxidative stress: signaling for suicide and survival J. Cell. Physiol. 192 2002 1 15
32. P. Klatt, and S. Lamas Regulation of protein function by S-glutathiolation in response to oxidative and nitrosative stress Eur. J. Biochem. 267 2000 4928 4944
33. L.A. Videla, R. Rodrigo, M. Orellana, V. Fernández, G. Tapia, L. Quiñones, N. Varela, J. Contreras, R. Lazarte, A. Csendes, J. Rojas, F. Maluenda, P. Burdiles, J.C. Díaz, G. Smok, L. Thielemann, and J. Poniachik Oxidative stress-related parameters in the liver of non-alcoholic fatty liver disease patients Clin. Sci. 106 2004 261 268
34. H. Cortez-Pinto, P. Filipe, M.E. Camilo, A. Baptista, A. Fernándes, and M.C. de Moura A peroxidação dos lípidos na esteatohepatite não alcoólica: Relação com a esteatose J. Português Gastroenterol. 6 1999 234 240
35. C. Loguercio, V. De Girolamo, I. de Sio, C. Tuccillo, A. Ascione, F. Baldi, G. Budillon, L. Cimino, A. Di Carlo, M.P. Di Marino, F. Morisco, F. Picciotto, L. Terracciano, R. Vecchione, V. Verde, and C. Del Vecchio Blanco Non-alcoholic fatty liver disease in an area of southern Italy: main clinical, histological, and pathophysiological aspects J. Hepatol. 35 2001 568 574
36. A.J. Sanyal, C. Campbell-Sargent, F. Mirshani, W.B. Rizzo, M.J. Contos, R.K. Sterling, V.A. Luketic, M.L. Shiffman, and J.N. Clore Nonalcoholic steatohepatitis: association with insulin resistance and mitochondrial abnormalities Gastroenterology 120 2001 1183 1192
37. C. García-Monzón, E. Martín-Pérez, O. Lo Iacono, M. Fernández-Bermejo, P.L. Majano, A. Apolinario, E. Larrañaga, and R. Moreno-Otero Characterization of pathogenic and prognostic factors of nonalcoholic steatohepatitis associated with obesity J. Hepatol. 33 2000 716 724
38. S. Seki, T. Kitada, T. Yamada, H. Sakaguchi, K. Nakatani, and K. Wakasa In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases J. Hepatol. 37 2002 56 62
39. R.E. Stadtman Metal ion-catalyzed oxidation of proteins: biochemical mechanism and biological consequences Free Radic. Biol. Med. 9 1990 315 325
40. N. Chalasani, J.C. Gorski, M.S. Asghar, A. Asghar, B. Foresman, S.D. Hall, and D.W. Crabb Hepatic cytochrome P450 2E1 activity in nondiabetic patients with nonalcoholic steatohepatitis Hepatology 37 2003 544 550
41. M.D. Weltman, G.C. Farrel, P. Hall, M. Ongelman-Sundberg, and C. Liddle Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis Hepatology 27 1998 128 133
42. D. Lucas, C. Farez, L.G. Bardou, J. Caisse, J.R. Attali, and P. Valensi Cytochrome P450 2E1 activity in diabetic and obese patients as assessed by chlorzoxazone hydroxylation Fundam. Clin. Pharmacol. 12 1998 553 558
43. M.P. de la Maza, S. Hirsch, M. Petermann, M. Suazo, G. Ugarte, and D. Binout Changes in microsomal activity in alcoholism and obesity Alcohol. Clin. Exp. Res. 24 2000 605 610
44. C.S. Lieber Cytochrome P-4502E1: its physiological and pathological role Physiol. Rev. 77 1997 517 544
45. R.C. Zangar, and R.F. Novak Effects of fatty acids and ketone bodies on cytochromes P450 2B, 4A, and 2E1 expression in primary cultured rat hepatocytes Arch. Biochem. Biophys. 337 1997 217 224
46. B.J. Song, R.I. Veech, S.S. Park, H.V. Gelboin, and F.J. Gonzalez Induction of rat hepatic N-nitrosodimethylamine demethylase by acetone is due to protein stabilization J. Biol. Chem. 264 1989 3568 3572
47. G. Robertson, I. Leclercq, and G.C. Farrell Nonalcoholic steatosis and steatohepatitis. II. Cytochrome P-450 enzymes and oxidative stress Am. J. Physiol. Gastrointest. Liver Physiol. 281 2001 G1135 G1139
48. A. Koteish, and A.M. Diehl Animal models of steatosis Semin. Liver Dis. 21 2001 89 104
49. L.M. Kaplan Leptin, obesity, and liver disease Gastroenterology 115 1998 997 1001
50. B.A. Neuschwander-Tetri, and S.H. Caldwell Nonalcoholic steatohepatitis: summary of an AASLD single topic conference Hepatology 37 2003 1202 1219
51. J. Crespo, A. Cayon, P. Fernández-Gil, M. Hernández-Guerra, M. Mayorga, A. Domínguez-Diez, J.C. Fernández-Escalante, and F. Pons-Romero Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients Hepatology 34 2001 1158 1163
52. A.J. Wigg, I.C. Roberts-Thomson, R.B. Dymock, P.J. McCarthy, R.H. Grose, and A.G. Cummins The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxemia, and tumor necrosis factor α in the pathogenesis of non-alcoholic steatohepatitis Gut 48 2001 206 211
53. M. Kugelmas, D.B. Hill, B. Vivian, L. Marsano, and C.J. McClain Cytokines and NASH: a pilot study of the effects of lifestyle modification and vitamin E Hepatology 38 2003 413 419
54. K. Schulze-Osthoff, A.C. Bakker, B. Vanhaesebroeck, R. Beyaert, W.A. Jacob, and W. Fiers Cytotoxic activity of tumor necrosis factor is mediated by early damage to mitochondrial functions J. Biol. Chem. 267 1992 5317 5323
55. S.H. Caldwell, R.H. Swerdlow, E.M. Khan, J.C. Iezzoni, E.E. Hespenheide, J.K. Parks, and W.D. Parker Jr. Mitochondrial abnormalities in non-alcoholic steatohepatitis J. Hepatol. 31 1999 430 434
56. H. Cortéz-Pinto, J. Chatham, V.P. Chacko, C. Arnold, A. Rashid, and A.M. Diehl Alterations in liver ATP homeostasis in human nonalcoholic steatohepatitis: a pilot study JAMA 282 1999 1659 1664
57. P. Delerive, J.-C. Fruchart, and B. Staels Peroxisome proliferator-activated receptors in inflammation control J. Endocrinol. 169 2001 453 459
58. J.E. Lavine Vitamin E treatment of nonalcoholic steatohepatitis in children: a pilot study J. Pediatr. 136 2000 734 738
59. T. Hasegawa, M. Yoneda, K. Nakamura, I. Makino, and A. Terano Plasma transforming growth factor-β1 level and efficacy of α-tocopherol in patients with non-alcoholic steatohepatitis: a pilot study Aliment. Pharmacol. Ther. 15 2001 1667 1672
60. M. Sekiya, N. Yahagi, T. Matsuzaka, Y. Najima, M. Nakakuki, R. Nagai, S. Ishibashi, J. Osuga, N. Yamada, and H. Shimano Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression Hepatology 38 2003 1529 1539
61. A. Ip, G.C. Farrell, G.R. Robertson, D. Hall, R. Kirsch, and I. Leclercq Central role of PPAR-α-dependent hepatic lipid turnover in dietary steatohepatitis in mice Hepatology 38 2003 123 132
62. T. Uesugi, M. Froh, G.E. Arteel, B.U. Bradford, E. Gäbele, M.D. Wheeler, and R.G. Thurman Delivery of IκB superrepressor gene with adenovirus reduces early alcohol-induced liver injury in rats Hepatology 34 2001 1149 1157
63. S.I. Aleynik, M.A. Leo, U. Takeshige, M.K. Aleynik, and C.S. Lieber Dilinoleoylphosphatidylcholine is the active antioxidant of polyenylphosphatidylcholine J. Invest. Med. 47 1999 507 512
64. S.I. Aleynik, and C.S. Lieber Polyenylphosphatidylcholine corrects the alcohol-induced hepatic oxidative stress by restoring S-adenosylmethionine Alcohol Alcohol. 38 2003 208 212