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Volumn 117, Issue , 2017, Pages 32-45

Hydroxytyrosol ameliorates metabolic, cardiovascular and liver changes in a rat model of diet-induced metabolic syndrome: Pharmacological and metabolism-based investigation

Author keywords

Cardiovascular; Hydroxytyrosol; Metabolic syndrome; Obesity; Olive oil; Olives

Indexed keywords

BIOLOGICAL MARKER; DRUG METABOLITE; FRUCTOSE; HYDROXYTYROSOL; OLIVE OIL; STARCH; 3,4-DIHYDROXYPHENYLETHANOL; PHENETHYL ALCOHOL;

EID: 85006266086     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2016.12.002     Document Type: Article
Times cited : (44)

References (51)
  • 1
    • 75549088102 scopus 로고    scopus 로고
    • Mediterranean diet and metabolic syndrome: the evidence
    • [1] Babio, N., Bullo, M., Salas-Salvado, J., Mediterranean diet and metabolic syndrome: the evidence. Public Health Nutr. 12:9A (2009), 1607–1617.
    • (2009) Public Health Nutr. , vol.12 , Issue.9A , pp. 1607-1617
    • Babio, N.1    Bullo, M.2    Salas-Salvado, J.3
  • 2
    • 79955942633 scopus 로고    scopus 로고
    • Dietary monounsaturated fatty acids are protective against metabolic syndrome and cardiovascular disease risk factors
    • [2] Gillingham, L.G., Harris-Janz, S., Jones, P.J., Dietary monounsaturated fatty acids are protective against metabolic syndrome and cardiovascular disease risk factors. Lipids 46:3 (2011), 209–228.
    • (2011) Lipids , vol.46 , Issue.3 , pp. 209-228
    • Gillingham, L.G.1    Harris-Janz, S.2    Jones, P.J.3
  • 4
    • 4444367778 scopus 로고    scopus 로고
    • Can a Mediterranean diet moderate the development and clinical progression of coronary heart disease? A systematic review
    • [4] Panagiotakos, D.B., Pitsavos, C., Polychronopoulos, E., Chrysohoou, C., Zampelas, A., Trichopoulou, A., Can a Mediterranean diet moderate the development and clinical progression of coronary heart disease? A systematic review. Med. Sci. Monit. 10:8 (2004), RA193–8.
    • (2004) Med. Sci. Monit. , vol.10 , Issue.8 , pp. RA193-8
    • Panagiotakos, D.B.1    Pitsavos, C.2    Polychronopoulos, E.3    Chrysohoou, C.4    Zampelas, A.5    Trichopoulou, A.6
  • 5
    • 77951486280 scopus 로고    scopus 로고
    • Olive leaf extract attenuates cardiac, hepatic, and metabolic changes in high carbohydrate-, high fat-fed rats
    • [5] Poudyal, H., Campbell, F., Brown, L., Olive leaf extract attenuates cardiac, hepatic, and metabolic changes in high carbohydrate-, high fat-fed rats. J. Nutr. 140:5 (2010), 946–953.
    • (2010) J. Nutr. , vol.140 , Issue.5 , pp. 946-953
    • Poudyal, H.1    Campbell, F.2    Brown, L.3
  • 6
    • 84886741489 scopus 로고    scopus 로고
    • Intake of fatty acids in general populations worldwide does not meet dietary recommendations to prevent coronary heart disease: a systematic review of data from 40 countries
    • [6] Harika, R.K., Eilander, A., Alssema, M., Osendarp, S.J., Zock, P.L., Intake of fatty acids in general populations worldwide does not meet dietary recommendations to prevent coronary heart disease: a systematic review of data from 40 countries. Ann. Nutr. Metab. 63:3 (2013), 229–238.
    • (2013) Ann. Nutr. Metab. , vol.63 , Issue.3 , pp. 229-238
    • Harika, R.K.1    Eilander, A.2    Alssema, M.3    Osendarp, S.J.4    Zock, P.L.5
  • 7
    • 79958214551 scopus 로고    scopus 로고
    • Extra virgin olive oil's polyphenols: biological activities
    • [7] Visioli, F., Bernardini, E., Extra virgin olive oil's polyphenols: biological activities. Curr. Pharm. Des. 17:8 (2011), 786–804.
    • (2011) Curr. Pharm. Des. , vol.17 , Issue.8 , pp. 786-804
    • Visioli, F.1    Bernardini, E.2
  • 10
    • 85006292896 scopus 로고    scopus 로고
    • EFSA Panel on Dietetic Products, Allergies, Scientific Opinion on the substantiation of health claims related to polyphenols in olive and protection of LDL particles from oxidative damage (ID 1333, 1638, 1639, 1696, 2865), maintenance of normal blood HDL cholesterol concentrations (ID 1639), maintenance of normal blood pressure (ID 3781), anti-inflammatory properties (ID 1882), contributes to the upper respiratory tract health (ID 3468), can help to maintain a normal function of gastrointestinal tract (3779), and contributes to body defences against external agents (ID 3467) pursuant to Article 13(1) of Regulation (EC) No 1924/2006, EFSA Journal 9(4) (2011) n/a-n/a.
    • [10] EFSA Panel on Dietetic Products, Allergies, Scientific Opinion on the substantiation of health claims related to polyphenols in olive and protection of LDL particles from oxidative damage (ID 1333, 1638, 1639, 1696, 2865), maintenance of normal blood HDL cholesterol concentrations (ID 1639), maintenance of normal blood pressure (ID 3781), anti-inflammatory properties (ID 1882), contributes to the upper respiratory tract health (ID 3468), can help to maintain a normal function of gastrointestinal tract (3779), and contributes to body defences against external agents (ID 3467) pursuant to Article 13(1) of Regulation (EC) No 1924/2006, EFSA Journal 9(4) (2011) n/a-n/a.
  • 11
    • 79955680290 scopus 로고    scopus 로고
    • Hydroxytyrosol induces proliferation and cytoprotection against oxidative injury in vascular endothelial cells: role of Nrf2 activation and HO-1 induction
    • [11] Zrelli, H., Matsuoka, M., Kitasaki, S., Araki, M., Kusunoki, M., Zarrouk, M., Miyazaki, H., Hydroxytyrosol induces proliferation and cytoprotection against oxidative injury in vascular endothelial cells: role of Nrf2 activation and HO-1 induction. J. Agric. Food Chem. 59:9 (2011), 4473–4482.
    • (2011) J. Agric. Food Chem. , vol.59 , Issue.9 , pp. 4473-4482
    • Zrelli, H.1    Matsuoka, M.2    Kitasaki, S.3    Araki, M.4    Kusunoki, M.5    Zarrouk, M.6    Miyazaki, H.7
  • 12
    • 33744794936 scopus 로고    scopus 로고
    • The fate of olive oil polyphenols in the gastrointestinal tract: implications of gastric and colonic microflora-dependent biotransformation
    • [12] Corona, G., Tzounis, X., Assunta Dessi, M., Deiana, M., Debnam, E.S., Visioli, F., Spencer, J.P., The fate of olive oil polyphenols in the gastrointestinal tract: implications of gastric and colonic microflora-dependent biotransformation. Free Radic. Res. 40:6 (2006), 647–658.
    • (2006) Free Radic. Res. , vol.40 , Issue.6 , pp. 647-658
    • Corona, G.1    Tzounis, X.2    Assunta Dessi, M.3    Deiana, M.4    Debnam, E.S.5    Visioli, F.6    Spencer, J.P.7
  • 17
    • 84930927332 scopus 로고    scopus 로고
    • Hydroxytyrosol improves mitochondrial function and reduces oxidative stress in the brain of db/db mice: role of AMP-activated protein kinase activation
    • [17] Zheng, A., Li, H., Xu, J., Cao, K., Li, H., Pu, W., Yang, Z., Peng, Y., Long, J., Liu, J., Feng, Z., Hydroxytyrosol improves mitochondrial function and reduces oxidative stress in the brain of db/db mice: role of AMP-activated protein kinase activation. Br. J. Nutr. 113:11 (2015), 1667–1676.
    • (2015) Br. J. Nutr. , vol.113 , Issue.11 , pp. 1667-1676
    • Zheng, A.1    Li, H.2    Xu, J.3    Cao, K.4    Li, H.5    Pu, W.6    Yang, Z.7    Peng, Y.8    Long, J.9    Liu, J.10    Feng, Z.11
  • 19
    • 84860280468 scopus 로고    scopus 로고
    • Protection of LDL from oxidation by olive oil polyphenols is associated with a downregulation of CD40-ligand expression and its downstream products in vivo in humans
    • [19] Castaner, O., Covas, M.I., Khymenets, O., Nyyssonen, K., Konstantinidou, V., Zunft, H.F., de la Torre, R., Munoz-Aguayo, D., Vila, J., Fito, M., Protection of LDL from oxidation by olive oil polyphenols is associated with a downregulation of CD40-ligand expression and its downstream products in vivo in humans. Am. J. Clin. Nutr. 95:5 (2012), 1238–1244.
    • (2012) Am. J. Clin. Nutr. , vol.95 , Issue.5 , pp. 1238-1244
    • Castaner, O.1    Covas, M.I.2    Khymenets, O.3    Nyyssonen, K.4    Konstantinidou, V.5    Zunft, H.F.6    de la Torre, R.7    Munoz-Aguayo, D.8    Vila, J.9    Fito, M.10
  • 21
    • 84949809889 scopus 로고    scopus 로고
    • Development of a sustainable procedure for the recovery of hydroxytyrosol from table olive processing wastewater using adsorption resin technology and centrifugal partition chromatography
    • [21] Xynos, N., Abatis, D., Argyropoulou, A., Polychronopoulos, P., Aligiannis, N., Skaltsounis, A.L., Development of a sustainable procedure for the recovery of hydroxytyrosol from table olive processing wastewater using adsorption resin technology and centrifugal partition chromatography. Planta Med. 81:17 (2015), 1621–1627.
    • (2015) Planta Med. , vol.81 , Issue.17 , pp. 1621-1627
    • Xynos, N.1    Abatis, D.2    Argyropoulou, A.3    Polychronopoulos, P.4    Aligiannis, N.5    Skaltsounis, A.L.6
  • 22
    • 84855483237 scopus 로고    scopus 로고
    • Lipid redistribution by alpha-linolenic acid-rich chia seed inhibits stearoyl-CoA desaturase-1 and induces cardiac and hepatic protection in diet-induced obese rats
    • [22] Poudyal, H., Panchal, S.K., Waanders, J., Ward, L., Brown, L., Lipid redistribution by alpha-linolenic acid-rich chia seed inhibits stearoyl-CoA desaturase-1 and induces cardiac and hepatic protection in diet-induced obese rats. J. Nutr. Biochem. 23:2 (2012), 153–162.
    • (2012) J. Nutr. Biochem. , vol.23 , Issue.2 , pp. 153-162
    • Poudyal, H.1    Panchal, S.K.2    Waanders, J.3    Ward, L.4    Brown, L.5
  • 26
    • 65549099260 scopus 로고    scopus 로고
    • Diets for cardiovascular disease prevention: what is the evidence?
    • [26] Walker, C., Reamy, B.V., Diets for cardiovascular disease prevention: what is the evidence?. Am. Fam. Physician 79:7 (2009), 571–578.
    • (2009) Am. Fam. Physician , vol.79 , Issue.7 , pp. 571-578
    • Walker, C.1    Reamy, B.V.2
  • 29
    • 0035985099 scopus 로고    scopus 로고
    • Biological properties of olive oil phytochemicals
    • [29] Visioli, F., Galli, C., Biological properties of olive oil phytochemicals. Crit. Rev. Food Sci. Nutr. 42:3 (2002), 209–221.
    • (2002) Crit. Rev. Food Sci. Nutr. , vol.42 , Issue.3 , pp. 209-221
    • Visioli, F.1    Galli, C.2
  • 30
    • 34047207720 scopus 로고    scopus 로고
    • Olive oil and the cardiovascular system
    • [30] Covas, M.I., Olive oil and the cardiovascular system. Pharmacol. Res. 55:3 (2007), 175–186.
    • (2007) Pharmacol. Res. , vol.55 , Issue.3 , pp. 175-186
    • Covas, M.I.1
  • 31
    • 49749137827 scopus 로고    scopus 로고
    • Olive oil, the mediterranean diet, and cardiovascular health
    • [31] Huang, C.L., Sumpio, B.E., Olive oil, the mediterranean diet, and cardiovascular health. J. Am. Coll. Surg. 207:3 (2008), 407–416.
    • (2008) J. Am. Coll. Surg. , vol.207 , Issue.3 , pp. 407-416
    • Huang, C.L.1    Sumpio, B.E.2
  • 33
    • 0141742647 scopus 로고    scopus 로고
    • Main polyphenols in the bitter taste of virgin olive oil. Structural confirmation by on-line high-performance liquid chromatography electrospray ionization mass spectrometry
    • [33] Gutierrez-Rosales, F., Rios, J.J., Gomez-Rey, M.L., Main polyphenols in the bitter taste of virgin olive oil. Structural confirmation by on-line high-performance liquid chromatography electrospray ionization mass spectrometry. J. Agric. Food Chem. 51:20 (2003), 6021–6025.
    • (2003) J. Agric. Food Chem. , vol.51 , Issue.20 , pp. 6021-6025
    • Gutierrez-Rosales, F.1    Rios, J.J.2    Gomez-Rey, M.L.3
  • 34
    • 0042521013 scopus 로고    scopus 로고
    • Fast separation and determination of tyrosol, hydroxytyrosol and other phenolic compounds in extra-virgin olive oil by capillary zone electrophoresis with ultraviolet-diode array detection
    • [34] Bonoli, M., Montanucci, M., Gallina Toschi, T., Lercker, G., Fast separation and determination of tyrosol, hydroxytyrosol and other phenolic compounds in extra-virgin olive oil by capillary zone electrophoresis with ultraviolet-diode array detection. J. Chromatogr. A 1011:1-2 (2003), 163–172.
    • (2003) J. Chromatogr. A , vol.1011 , Issue.1-2 , pp. 163-172
    • Bonoli, M.1    Montanucci, M.2    Gallina Toschi, T.3    Lercker, G.4
  • 37
  • 39
    • 84867101055 scopus 로고    scopus 로고
    • Mediterranean diet polyphenols reduce inflammatory angiogenesis through MMP-9 and COX-2 inhibition in human vascular endothelial cells: a potentially protective mechanism in atherosclerotic vascular disease and cancer
    • [39] Scoditti, E., Calabriso, N., Massaro, M., Pellegrino, M., Storelli, C., Martines, G., De Caterina, R., Carluccio, M.A., Mediterranean diet polyphenols reduce inflammatory angiogenesis through MMP-9 and COX-2 inhibition in human vascular endothelial cells: a potentially protective mechanism in atherosclerotic vascular disease and cancer. Arch. Biochem. Biophys. 527:2 (2012), 81–89.
    • (2012) Arch. Biochem. Biophys. , vol.527 , Issue.2 , pp. 81-89
    • Scoditti, E.1    Calabriso, N.2    Massaro, M.3    Pellegrino, M.4    Storelli, C.5    Martines, G.6    De Caterina, R.7    Carluccio, M.A.8
  • 41
    • 84879304964 scopus 로고    scopus 로고
    • Responses to oleic, linoleic and alpha-linolenic acids in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats
    • [41] Poudyal, H., Kumar, S.A., Iyer, A., Waanders, J., Ward, L.C., Brown, L., Responses to oleic, linoleic and alpha-linolenic acids in high-carbohydrate, high-fat diet-induced metabolic syndrome in rats. J. Nutr. Biochem. 24:7 (2013), 1381–1392.
    • (2013) J. Nutr. Biochem. , vol.24 , Issue.7 , pp. 1381-1392
    • Poudyal, H.1    Kumar, S.A.2    Iyer, A.3    Waanders, J.4    Ward, L.C.5    Brown, L.6
  • 42
    • 0036136289 scopus 로고    scopus 로고
    • Antioxidant and other biological activities of phenols from olives and olive oil
    • [42] Visioli, F., Poli, A., Gall, C., Antioxidant and other biological activities of phenols from olives and olive oil. Med. Res. Rev. 22:1 (2002), 65–75.
    • (2002) Med. Res. Rev. , vol.22 , Issue.1 , pp. 65-75
    • Visioli, F.1    Poli, A.2    Gall, C.3
  • 43
    • 84874419837 scopus 로고    scopus 로고
    • Toxicological evaluation of pure hydroxytyrosol
    • [43] Aunon-Calles, D., Canut, L., Visioli, F., Toxicological evaluation of pure hydroxytyrosol. Food Chem. Toxicol. 55 (2013), 498–504.
    • (2013) Food Chem. Toxicol. , vol.55 , pp. 498-504
    • Aunon-Calles, D.1    Canut, L.2    Visioli, F.3
  • 44
    • 40449086665 scopus 로고    scopus 로고
    • Dose translation from animal to human studies revisited
    • [44] Reagan-Shaw, S., Nihal, M., Ahmad, N., Dose translation from animal to human studies revisited. FASEB J. 22:3 (2008), 659–661.
    • (2008) FASEB J. , vol.22 , Issue.3 , pp. 659-661
    • Reagan-Shaw, S.1    Nihal, M.2    Ahmad, N.3
  • 47
    • 79955611314 scopus 로고    scopus 로고
    • Resveratrol exerts anti-obesity effects via mechanisms involving down-regulation of adipogenic and inflammatory processes in mice
    • [47] Kim, S., Jin, Y., Choi, Y., Park, T., Resveratrol exerts anti-obesity effects via mechanisms involving down-regulation of adipogenic and inflammatory processes in mice. Biochem. Pharmacol. 81:11 (2011), 1343–1351.
    • (2011) Biochem. Pharmacol. , vol.81 , Issue.11 , pp. 1343-1351
    • Kim, S.1    Jin, Y.2    Choi, Y.3    Park, T.4
  • 50
    • 30544436539 scopus 로고    scopus 로고
    • Metabolism of the olive oil phenols hydroxytyrosol, tyrosol, and hydroxytyrosyl acetate by human hepatoma HepG2 cells
    • [50] Mateos, R., Goya, L., Bravo, L., Metabolism of the olive oil phenols hydroxytyrosol, tyrosol, and hydroxytyrosyl acetate by human hepatoma HepG2 cells. J. Agric. Food Chem. 53:26 (2005), 9897–9905.
    • (2005) J. Agric. Food Chem. , vol.53 , Issue.26 , pp. 9897-9905
    • Mateos, R.1    Goya, L.2    Bravo, L.3
  • 51
    • 0042710935 scopus 로고    scopus 로고
    • Hydroxytyrosol excretion differs between rats and humans and depends on the vehicle of administration
    • [51] Visioli, F., Galli, C., Grande, S., Colonnelli, K., Patelli, C., Galli, G., Caruso, D., Hydroxytyrosol excretion differs between rats and humans and depends on the vehicle of administration. J. Nutr. 133:8 (2003), 2612–2615.
    • (2003) J. Nutr. , vol.133 , Issue.8 , pp. 2612-2615
    • Visioli, F.1    Galli, C.2    Grande, S.3    Colonnelli, K.4    Patelli, C.5    Galli, G.6    Caruso, D.7


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