Hydroxytyrosol improves mitochondrial function and reduces oxidative stress in the brain of db/db mice: Role of AMP-activated protein kinase activation

British Journal of Nutrition

Volumn 113, Issue 11, 2015, Pages 1667-1676

  Zheng, Adi ^a   Li, Hao ^a   Xu, Jie ^a   Cao, Ke ^a   Li, Hua ^a   Pu, Wenjun ^a   Yang, Ziqi ^a   Peng, Yunhua ^a   Long, Jiangang ^a   Liu, Jiankang ^a   Feng, Zhihui ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

AMP activated protein kinase pathway; db db Mice; Hydroxytyrosol; Mitochondrial function; Oxidative stress; Reactive oxygen species

Indexed keywords

ACTIVITY REGULATED CYTOSKELETON ASSOCIATED PROTEIN; COPPER ZINC SUPEROXIDE DISMUTASE; CYTOCHROME C OXIDASE; GLUCOSE; HEME OXYGENASE 1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYTYROSOL; MANGANESE SUPEROXIDE DISMUTASE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NERVE GROWTH FACTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN P62; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SIRTUIN 1; SUCCINATE DEHYDROGENASE (UBIQUINONE); TRANSCRIPTION FACTOR NRF2; 3,4-DIHYDROXYPHENYLETHANOL; HEAT SHOCK PROTEIN; HMOX1 PROTEIN, MOUSE; MEMBRANE PROTEIN; NFE2L2 PROTEIN, MOUSE; OLIVE OIL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHENETHYL ALCOHOL; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SIRT1 PROTEIN, MOUSE; SQSTM1 PROTEIN, MOUSE; SUPEROXIDE DISMUTASE; VEGETABLE OIL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN LEVEL; BRAIN MITOCHONDRION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; LOW DRUG DOSE; MALE; MOUSE; NERVE CELL LESION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; TREATMENT DURATION; ANALOGS AND DERIVATIVES; ANIMAL; BRAIN; C57BL MOUSE; CHEMISTRY; DRUG EFFECTS; GENETICS; METABOLISM; MITOCHONDRION; NEUROBLASTOMA; TUMOR CELL LINE;

MUS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BRAIN; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HEAT-SHOCK PROTEINS; HEME OXYGENASE-1; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MITOCHONDRIA; NEUROBLASTOMA; NF-E2-RELATED FACTOR 2; OLIVE OIL; OXIDATIVE STRESS; PHENYLETHYL ALCOHOL; PLANT OILS; PPAR GAMMA; REACTIVE OXYGEN SPECIES; SIRTUIN 1; SUPEROXIDE DISMUTASE;

EID: 84930927332     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114515000884     Document Type: Article

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