메뉴 건너뛰기




Volumn 114, Issue , 2016, Pages 28-34

Long-chain polyunsaturated fatty acids regulation of PPARs, signaling: Relationship to tissue development and aging

Author keywords

Aging; Long chain polyunsaturated fatty acids; n 3 long chain polyunsaturated fatty acids; Peroxisome proliferator activated receptors; Tissue development

Indexed keywords

FATTY ACID DERIVATIVE; LONG CHAIN FATTY ACID; OMEGA 3 FATTY ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; POLYUNSATURATED FATTY ACID; PROTEIN BINDING; UNSATURATED FATTY ACID;

EID: 84991687061     PISSN: 09523278     EISSN: 15322823     Source Type: Journal    
DOI: 10.1016/j.plefa.2016.10.001     Document Type: Review
Times cited : (161)

References (105)
  • 1
    • 77956835278 scopus 로고    scopus 로고
    • Coactivators in PPAR-Regulated Gene Expression
    • [1] Viswakarma, N., Jia, Y., Bai, L., et al. Coactivators in PPAR-Regulated Gene Expression. PPAR Res. 2010 (2015), 1–22.
    • (2015) PPAR Res. , vol.2010 , pp. 1-22
    • Viswakarma, N.1    Jia, Y.2    Bai, L.3
  • 2
    • 33751533892 scopus 로고    scopus 로고
    • International union of pharmacology. LXI. Peroxisome proliferator-activated receptors
    • (726–4)
    • [2] Michalik, L., Auwerx, J., Berger, J.P., et al. International union of pharmacology. LXI. Peroxisome proliferator-activated receptors. Pharm. Rev., 58, 2006 (726–4).
    • (2006) Pharm. Rev. , vol.58
    • Michalik, L.1    Auwerx, J.2    Berger, J.P.3
  • 4
    • 38649119729 scopus 로고    scopus 로고
    • The roles of PPARs in the fetal origins of metabolic health and disease
    • [4] Rees, W.D., McNeil, C.J., Maloney, C.A., The roles of PPARs in the fetal origins of metabolic health and disease. PPAR Res 2008 (2008), 1–8.
    • (2008) PPAR Res , vol.2008 , pp. 1-8
    • Rees, W.D.1    McNeil, C.J.2    Maloney, C.A.3
  • 5
    • 37649030647 scopus 로고    scopus 로고
    • Genetic manipulations of PPARs: effects on obesity and metabolic disease
    • [5] Barak, Y., Kim, S., Genetic manipulations of PPARs: effects on obesity and metabolic disease. PPAR Res. 2007 (2007), 1–32.
    • (2007) PPAR Res. , vol.2007 , pp. 1-32
    • Barak, Y.1    Kim, S.2
  • 6
    • 42749099527 scopus 로고    scopus 로고
    • Striking the right balance in targeting PPARgamma in the metabolic syndrome: novel insights from human genetic studies
    • [6] Gurnell, M., Striking the right balance in targeting PPARgamma in the metabolic syndrome: novel insights from human genetic studies. PPAR Res. 2007 (2007), 1–14.
    • (2007) PPAR Res. , vol.2007 , pp. 1-14
    • Gurnell, M.1
  • 7
    • 84893794489 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications
    • [7] Grygiel-Górniak, B., Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications. Nutr. J. 13 (2014), 1–10.
    • (2014) Nutr. J. , vol.13 , pp. 1-10
    • Grygiel-Górniak, B.1
  • 8
    • 0030985318 scopus 로고    scopus 로고
    • Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay
    • [8] Krey, G., Braissant, O., L'Horset, F., et al. Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay. Mol. Endocrinol. 11 (1997), 779–791.
    • (1997) Mol. Endocrinol. , vol.11 , pp. 779-791
    • Krey, G.1    Braissant, O.2    L'Horset, F.3
  • 9
    • 34047166373 scopus 로고    scopus 로고
    • n-3 fatty acids preserve insulin sensitivity in vivo in a peroxisome proliferator – activated receptor- α – dependent manner
    • [9] Neschen, S., Morino, K., Dong, J., et al. n-3 fatty acids preserve insulin sensitivity in vivo in a peroxisome proliferator – activated receptor- α – dependent manner. Diabetes 56 (2007), 1034–1041.
    • (2007) Diabetes , vol.56 , pp. 1034-1041
    • Neschen, S.1    Morino, K.2    Dong, J.3
  • 11
    • 0038220757 scopus 로고    scopus 로고
    • Rosiglitazone improves insulin sensitivity and lowers blood pressure in hipertensive patients
    • [11] Raji, A.S., Seely, E., Bekins, S., Williams, G., Simonson, D., Rosiglitazone improves insulin sensitivity and lowers blood pressure in hipertensive patients. Diabetes Care 26 (2003), 172–178.
    • (2003) Diabetes Care , vol.26 , pp. 172-178
    • Raji, A.S.1    Seely, E.2    Bekins, S.3    Williams, G.4    Simonson, D.5
  • 12
    • 0033305213 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: nuclear control of metabolism
    • [12] Desvergne, B., Wahli, W., Peroxisome proliferator-activated receptors: nuclear control of metabolism. J. Clin. Endocrinol. Metab. 20 (1999), 649–688.
    • (1999) J. Clin. Endocrinol. Metab. , vol.20 , pp. 649-688
    • Desvergne, B.1    Wahli, W.2
  • 13
    • 0034713444 scopus 로고    scopus 로고
    • Roles of PPARs in health and disease
    • [13] Kersten, S., Desvergne, B., Wahli, W., Roles of PPARs in health and disease. Nature 405 (2000), 421–424.
    • (2000) Nature , vol.405 , pp. 421-424
    • Kersten, S.1    Desvergne, B.2    Wahli, W.3
  • 14
    • 84903483525 scopus 로고    scopus 로고
    • Lipid metabolites as metabolic messengers in inter-organ communication
    • [14] Liu, S., Alexander, R.K., Lee, C.H., Lipid metabolites as metabolic messengers in inter-organ communication. Trends Endocrinol. Metab. 25 (2014), 356–363.
    • (2014) Trends Endocrinol. Metab. , vol.25 , pp. 356-363
    • Liu, S.1    Alexander, R.K.2    Lee, C.H.3
  • 15
    • 84885434165 scopus 로고    scopus 로고
    • New insights into the molecular mechanism of intestinal fatty acid absorption
    • [15] Wang, T.Y., Liu, M., Portincasa, P., Wang, D.Q., New insights into the molecular mechanism of intestinal fatty acid absorption. Eur. J. Clin. Investig. 43 (2013), 1203–1223.
    • (2013) Eur. J. Clin. Investig. , vol.43 , pp. 1203-1223
    • Wang, T.Y.1    Liu, M.2    Portincasa, P.3    Wang, D.Q.4
  • 16
    • 84921289631 scopus 로고    scopus 로고
    • Type of fatty acids in maternal diets during pregnancy and/or lactation and metabolic consequences of the offspring
    • [16] Mennitti, L.V., Oliveira, J.L., Morais, C.A., et al. Type of fatty acids in maternal diets during pregnancy and/or lactation and metabolic consequences of the offspring. J. Nutr. Biochem. 26 (2015), 99–111.
    • (2015) J. Nutr. Biochem. , vol.26 , pp. 99-111
    • Mennitti, L.V.1    Oliveira, J.L.2    Morais, C.A.3
  • 18
    • 84866271175 scopus 로고    scopus 로고
    • Mechanisms of gene regulation by fatty acids
    • [18] Georgiadi, A., Kersten, S., Mechanisms of gene regulation by fatty acids. Adv. Nutr. 3 (2012), 127–134.
    • (2012) Adv. Nutr. , vol.3 , pp. 127-134
    • Georgiadi, A.1    Kersten, S.2
  • 19
    • 84956620224 scopus 로고    scopus 로고
    • Free-fatty acid receptor 4 (GPR120): cellular and molecular function and its role in metabolic disorders
    • [19] Moniri, N.H., Free-fatty acid receptor 4 (GPR120): cellular and molecular function and its role in metabolic disorders. Biochem. Pharmcol. 110-111 (2016), 1–15.
    • (2016) Biochem. Pharmcol. , vol.110-111 , pp. 1-15
    • Moniri, N.H.1
  • 20
    • 0029977518 scopus 로고    scopus 로고
    • A human peroxisome-proliferator-activated receptor-gamma is activated by inducers of adipogenesis, including thiazolidinedione drugs
    • [20] Lambe, K.G., Tugwood, J.D., A human peroxisome-proliferator-activated receptor-gamma is activated by inducers of adipogenesis, including thiazolidinedione drugs. Eur. J. Biochem. 239 (1996), 1–7.
    • (1996) Eur. J. Biochem. , vol.239 , pp. 1-7
    • Lambe, K.G.1    Tugwood, J.D.2
  • 22
    • 84883824317 scopus 로고    scopus 로고
    • Expression and function of PPARs in placenta
    • [22] Matsuda, S., Kobayashi, M., Kitagishi, Y., Expression and function of PPARs in placenta. PPAR Res 2013 (2013), 1–7.
    • (2013) PPAR Res , vol.2013 , pp. 1-7
    • Matsuda, S.1    Kobayashi, M.2    Kitagishi, Y.3
  • 23
    • 0036839504 scopus 로고    scopus 로고
    • Aging-induced decrease in the PPAR-alpha level in hearts is improved by exercise training
    • [23] Iemitsu, M., Miyauchi, T., Maeda, S., et al. Aging-induced decrease in the PPAR-alpha level in hearts is improved by exercise training. Am. J. Physiol. 283 (2002), 1750–1760.
    • (2002) Am. J. Physiol. , vol.283 , pp. 1750-1760
    • Iemitsu, M.1    Miyauchi, T.2    Maeda, S.3
  • 25
    • 0032484123 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha activation modulates cellular redox status, represses nuclear factor-kappaB signaling, and reduces inflammatory cytokine production in aging
    • [25] Poynter, M.E., Daynes, R.A., Peroxisome proliferator-activated receptor alpha activation modulates cellular redox status, represses nuclear factor-kappaB signaling, and reduces inflammatory cytokine production in aging. J. Biol. Chem. 273 (1998), 32833–32841.
    • (1998) J. Biol. Chem. , vol.273 , pp. 32833-32841
    • Poynter, M.E.1    Daynes, R.A.2
  • 26
    • 0038720453 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-alpha activation as a mechanism of preventive neuroprotection induced by chronic fenofibrate treatment
    • [26] Deplanque, D., Gelé, P., Pétrault, O., et al. Peroxisome proliferator-activated receptor-alpha activation as a mechanism of preventive neuroprotection induced by chronic fenofibrate treatment. J. Neurosci. 23 (2003), 6264–6271.
    • (2003) J. Neurosci. , vol.23 , pp. 6264-6271
    • Deplanque, D.1    Gelé, P.2    Pétrault, O.3
  • 27
    • 0033574663 scopus 로고    scopus 로고
    • A unified nomenclature system for the nuclear receptor superfamily
    • [27] Laudet, V., Auwerx, J., Gustafsson, J.A., Wahli, W., A unified nomenclature system for the nuclear receptor superfamily. Cell 97 (1999), 161–163.
    • (1999) Cell , vol.97 , pp. 161-163
    • Laudet, V.1    Auwerx, J.2    Gustafsson, J.A.3    Wahli, W.4
  • 28
    • 80051579737 scopus 로고    scopus 로고
    • Role of peroxisome proliferator-activated receptor (PPAR) δ in embryonic stem cell proliferation
    • [28] Lee, M.Y., Lee, Y.J., Kim, Y.H., et al. Role of peroxisome proliferator-activated receptor (PPAR) δ in embryonic stem cell proliferation. Int J. Stem Cells 2 (2009), 28–34.
    • (2009) Int J. Stem Cells , vol.2 , pp. 28-34
    • Lee, M.Y.1    Lee, Y.J.2    Kim, Y.H.3
  • 29
    • 84960467663 scopus 로고    scopus 로고
    • Role of docosahexaec acid in the modulation of glial cells in Alzheimer's disease
    • [29] Heras-Sandoval, D., Pedraza-Chaverri, J., Pérez-Rojas, J.M., Role of docosahexaec acid in the modulation of glial cells in Alzheimer's disease. J. Neuroinflamm. 13 (2016), 1–13.
    • (2016) J. Neuroinflamm. , vol.13 , pp. 1-13
    • Heras-Sandoval, D.1    Pedraza-Chaverri, J.2    Pérez-Rojas, J.M.3
  • 30
    • 23944435868 scopus 로고    scopus 로고
    • Polyunsaturated fatty acid regulation of genes of lipid metabolism
    • [30] Sampath, H., Ntambi, J.M., Polyunsaturated fatty acid regulation of genes of lipid metabolism. Annu. Rev. Nutr. 25 (2005), 317–340.
    • (2005) Annu. Rev. Nutr. , vol.25 , pp. 317-340
    • Sampath, H.1    Ntambi, J.M.2
  • 32
    • 0034666132 scopus 로고    scopus 로고
    • Defect in peroxisome proliferator-activated receptor alpha -inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting
    • [32] Hashimoto, T., Cook, W.S., Qi, C., Yeldandi, A.V., Reddy, J.K., Rao, M.S., Defect in peroxisome proliferator-activated receptor alpha -inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting. J. Biol. Chem. 275 (2000), 28918–28928.
    • (2000) J. Biol. Chem. , vol.275 , pp. 28918-28928
    • Hashimoto, T.1    Cook, W.S.2    Qi, C.3    Yeldandi, A.V.4    Reddy, J.K.5    Rao, M.S.6
  • 33
    • 84891702448 scopus 로고    scopus 로고
    • PPAR-α as a key nutritional and environmental sensor for metabolic adaptation
    • [33] Contreras, A.V., Torres, N., Tovar, A.R., PPAR-α as a key nutritional and environmental sensor for metabolic adaptation. Adv. Nutr. 4 (2013), 439–452.
    • (2013) Adv. Nutr. , vol.4 , pp. 439-452
    • Contreras, A.V.1    Torres, N.2    Tovar, A.R.3
  • 34
    • 77955057772 scopus 로고    scopus 로고
    • PPAR α: an emerging therapeutic target in diabetic microvascular damage
    • [34] Hiukka, A., Maranghi, M., Matikainen, N., Taskinen, M., PPAR α: an emerging therapeutic target in diabetic microvascular damage. Nat. Rev. Endocrinol. 6 (2010), 454–463.
    • (2010) Nat. Rev. Endocrinol. , vol.6 , pp. 454-463
    • Hiukka, A.1    Maranghi, M.2    Matikainen, N.3    Taskinen, M.4
  • 35
    • 77954987061 scopus 로고    scopus 로고
    • PPARα: energy combustion, hypolipidemia, inflammation and cancer
    • [35] Pyper, S.R., Viswakarma, N., Yu, S., Reddy, J.K., PPARα: energy combustion, hypolipidemia, inflammation and cancer. Nucl. Recept Signal 8 (2010), 1–21.
    • (2010) Nucl. Recept Signal , vol.8 , pp. 1-21
    • Pyper, S.R.1    Viswakarma, N.2    Yu, S.3    Reddy, J.K.4
  • 36
    • 78349283454 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha target genes
    • [36] Rakhshandehroo, M., Knoch, B., Müller, M., Kersten, S., Peroxisome proliferator-activated receptor alpha target genes. PPAR Res. 2010 (2010), 1–20.
    • (2010) PPAR Res. , vol.2010 , pp. 1-20
    • Rakhshandehroo, M.1    Knoch, B.2    Müller, M.3    Kersten, S.4
  • 37
    • 0033527569 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor α negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF- κB and AP-1
    • [37] Delerive, P., De Bosscher, K., Besnard, S., et al. Peroxisome proliferator-activated receptor α negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF- κB and AP-1. J. Biol. Chem. 274 (1999), 32048–32054.
    • (1999) J. Biol. Chem. , vol.274 , pp. 32048-32054
    • Delerive, P.1    De Bosscher, K.2    Besnard, S.3
  • 38
    • 56349166510 scopus 로고    scopus 로고
    • PPARα ligands inhibit radiation-induced microglial inflammatory responses by negatively regulating NF-κB and AP-1 pathways
    • [38] Ramanan, S., Kooshki, M., Zhao, W., Hsu, F.C., Robbins, M.E., PPARα ligands inhibit radiation-induced microglial inflammatory responses by negatively regulating NF-κB and AP-1 pathways. Free Radic. Biol. Med. 45 (2008), 1695–1704.
    • (2008) Free Radic. Biol. Med. , vol.45 , pp. 1695-1704
    • Ramanan, S.1    Kooshki, M.2    Zhao, W.3    Hsu, F.C.4    Robbins, M.E.5
  • 39
    • 84863104065 scopus 로고    scopus 로고
    • PPARs at the crossroads of lipid signaling and inflammation
    • [39] Wahli, W., Michalik, L., PPARs at the crossroads of lipid signaling and inflammation. Trends Endocrinol. Metab. 23 (2012), 351–363.
    • (2012) Trends Endocrinol. Metab. , vol.23 , pp. 351-363
    • Wahli, W.1    Michalik, L.2
  • 40
    • 84867409492 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor (PPAR) suppresses hypoxia-inducible factor-1 (HIF-1) signaling in cancer cells
    • [40] Zhou, J., Zhang, S., Xue, J., Avery, J., Wu, J., Lind, S.E., et al. Activation of peroxisome proliferator-activated receptor (PPAR) suppresses hypoxia-inducible factor-1 (HIF-1) signaling in cancer cells. J. Biol. Chem. 287 (2012), 35161–35169.
    • (2012) J. Biol. Chem. , vol.287 , pp. 35161-35169
    • Zhou, J.1    Zhang, S.2    Xue, J.3    Avery, J.4    Wu, J.5    Lind, S.E.6
  • 41
    • 38949145780 scopus 로고    scopus 로고
    • PPARalpha agonist fenofibrate suppresses tumor growth through direct and indirect angiogenesis inhibition
    • [41] Panigrahy, D., Kaipainen, A., Huang, S., et al. PPARalpha agonist fenofibrate suppresses tumor growth through direct and indirect angiogenesis inhibition. Proc. Natl. Acad. Sci. USA 105 (2008), 985–990.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 985-990
    • Panigrahy, D.1    Kaipainen, A.2    Huang, S.3
  • 42
    • 0033625677 scopus 로고    scopus 로고
    • Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta (delta)
    • [42] Peters, J.M., Lee, S.S., Li, W., et al. Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta (delta). Mol. Cell Biol. 20 (2000), 5119–5128.
    • (2000) Mol. Cell Biol. , vol.20 , pp. 5119-5128
    • Peters, J.M.1    Lee, S.S.2    Li, W.3
  • 43
    • 33644645013 scopus 로고    scopus 로고
    • PPAR delta: a dagger in the heart of the metabolic syndrome
    • [43] Barish, G.D., Narkar, V.A., Evans, R.M., PPAR delta: a dagger in the heart of the metabolic syndrome. J. Clin. Investig. 116 (2007), 590–597.
    • (2007) J. Clin. Investig. , vol.116 , pp. 590-597
    • Barish, G.D.1    Narkar, V.A.2    Evans, R.M.3
  • 45
    • 4544274752 scopus 로고    scopus 로고
    • The direct peroxisome proliferator-activated receptor target fasting-induced adipose factor (FIAF/PGAR/ANGPTL4) is present in blood plasma as a truncated protein that is increased by fenofibrate treatment
    • [45] Mandard, S., Zandbergen, F., Nguan, S.T., et al. The direct peroxisome proliferator-activated receptor target fasting-induced adipose factor (FIAF/PGAR/ANGPTL4) is present in blood plasma as a truncated protein that is increased by fenofibrate treatment. J. Biol. Chem. 279 (2004), 34411–34420.
    • (2004) J. Biol. Chem. , vol.279 , pp. 34411-34420
    • Mandard, S.1    Zandbergen, F.2    Nguan, S.T.3
  • 46
    • 2342579597 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR)-β/δ stimulates differentiation and lipid accumulation in keratinocytes
    • [46] Schmuth, M., Haqq, C.M., Cairns, W.J., et al. Peroxisome proliferator-activated receptor (PPAR)-β/δ stimulates differentiation and lipid accumulation in keratinocytes. J. Investig. Dermatol. 122 (2004), 971–983.
    • (2004) J. Investig. Dermatol. , vol.122 , pp. 971-983
    • Schmuth, M.1    Haqq, C.M.2    Cairns, W.J.3
  • 47
    • 54349124329 scopus 로고    scopus 로고
    • Ligand-mediated regulation of peroxisome proliferator- activated receptor (PPAR) β: a comparative analysis of PPAR-selective agonists and all-trans retinoic acid
    • [47] Rieck, M., Meissner, W., Ries, S., Mu, S., Mu, R., Ligand-mediated regulation of peroxisome proliferator- activated receptor (PPAR) β: a comparative analysis of PPAR-selective agonists and all-trans retinoic acid. Mol. Pharmcol. 74 (2008), 1269–1277.
    • (2008) Mol. Pharmcol. , vol.74 , pp. 1269-1277
    • Rieck, M.1    Meissner, W.2    Ries, S.3    Mu, S.4    Mu, R.5
  • 48
    • 0037453718 scopus 로고    scopus 로고
    • Peroxisome-proliferator-activated receptor δ activates fat metabolism to prevent obesity
    • [48] Wang, Y.X., Lee, C.H., Tiep, S., et al. Peroxisome-proliferator-activated receptor δ activates fat metabolism to prevent obesity. Cell 113 (2003), 159–170.
    • (2003) Cell , vol.113 , pp. 159-170
    • Wang, Y.X.1    Lee, C.H.2    Tiep, S.3
  • 49
    • 8844276054 scopus 로고    scopus 로고
    • Regulation of muscle fiber type and running endurance by PPARδ
    • [49] Wang, Y.X., Zhang, C.L., Yu, R.T., et al. Regulation of muscle fiber type and running endurance by PPARδ. PLoS Biol. 2 (2004), 1532–1539.
    • (2004) PLoS Biol. , vol.2 , pp. 1532-1539
    • Wang, Y.X.1    Zhang, C.L.2    Yu, R.T.3
  • 50
    • 0033618281 scopus 로고    scopus 로고
    • Expression of peroxisome proliferator-activated receptor PPARdelta promotes induction of PPARgamma and adipocyte differentiation in 3T3C2 fibroblasts
    • [50] Bastie, C., Holst, D., Gaillard, D., Jehl-Pietri, C., Grimaldi, P., Expression of peroxisome proliferator-activated receptor PPARdelta promotes induction of PPARgamma and adipocyte differentiation in 3T3C2 fibroblasts. J. Biol. Chem. 274 (1999), 21920–21925.
    • (1999) J. Biol. Chem. , vol.274 , pp. 21920-21925
    • Bastie, C.1    Holst, D.2    Gaillard, D.3    Jehl-Pietri, C.4    Grimaldi, P.5
  • 51
    • 0035893364 scopus 로고    scopus 로고
    • Critical roles of PPAR β/δ in keratinocyte response to inflammation
    • [51] Tan, N.S., Michalik, L., Noy, N., et al. Critical roles of PPAR β/δ in keratinocyte response to inflammation. Genes Dev. 15 (2001), 3263–3277.
    • (2001) Genes Dev. , vol.15 , pp. 3263-3277
    • Tan, N.S.1    Michalik, L.2    Noy, N.3
  • 53
    • 0032582349 scopus 로고    scopus 로고
    • PPARγ3 mRNA: a distinct PPARγ mRNA subtype transcribed from an independent promoter
    • [53] Fajas, L., Fruchart, J.C., Auwerx, J., PPARγ3 mRNA: a distinct PPARγ mRNA subtype transcribed from an independent promoter. FEBS Lett. 438 (1998), 55–60.
    • (1998) FEBS Lett. , vol.438 , pp. 55-60
    • Fajas, L.1    Fruchart, J.C.2    Auwerx, J.3
  • 54
    • 0035851187 scopus 로고    scopus 로고
    • PPARϒ: a nuclear regulator of metabolism, differentiation, and cell growth
    • [54] Rosen, E.D., Spiegelman, B.M., PPARϒ: a nuclear regulator of metabolism, differentiation, and cell growth. J. Biol. Chem. 276 (2001), 7731–7734.
    • (2001) J. Biol. Chem. , vol.276 , pp. 7731-7734
    • Rosen, E.D.1    Spiegelman, B.M.2
  • 55
    • 11144310564 scopus 로고    scopus 로고
    • An overview on biological mechanisms of PPARs
    • [55] Kota, B.P., Huang, T.H.W., Roufogalis, B.D., An overview on biological mechanisms of PPARs. Pharmcol. Res. 51 (2005), 85–94.
    • (2005) Pharmcol. Res. , vol.51 , pp. 85-94
    • Kota, B.P.1    Huang, T.H.W.2    Roufogalis, B.D.3
  • 56
    • 0036183630 scopus 로고    scopus 로고
    • The mechanisms of action of ppars
    • [56] Berger, J., Moller, D.E., The mechanisms of action of ppars. Annu. Rev. Med. 53 (2002), 409–435.
    • (2002) Annu. Rev. Med. , vol.53 , pp. 409-435
    • Berger, J.1    Moller, D.E.2
  • 57
    • 0027972524 scopus 로고    scopus 로고
    • Altered gene expression for tumor necrosis factor -α and its receptors during drug and dietary modulation of insulin resistance
    • [57] Hoffman, C., Lorenz, K., Braithwaite, S., et al. Altered gene expression for tumor necrosis factor -α and its receptors during drug and dietary modulation of insulin resistance. Endocrinology 134 (2015), 264–270.
    • (2015) Endocrinology , vol.134 , pp. 264-270
    • Hoffman, C.1    Lorenz, K.2    Braithwaite, S.3
  • 58
    • 0030661983 scopus 로고    scopus 로고
    • TNF-α-induced insulin resistance in vivo and its prevention by troglitazone
    • [58] Miles, P.D.G., Romeo, O.M., Higo, K., Cohen, A., Rafaat, K., Olefsky, J.M., TNF-α-induced insulin resistance in vivo and its prevention by troglitazone. Diabetes 46 (1997), 1678–1683.
    • (1997) Diabetes , vol.46 , pp. 1678-1683
    • Miles, P.D.G.1    Romeo, O.M.2    Higo, K.3    Cohen, A.4    Rafaat, K.5    Olefsky, J.M.6
  • 59
    • 84925269720 scopus 로고    scopus 로고
    • Butter naturally enriched in cis-9, trans-11 CLA prevents hyperinsulinemia and increases both serum HDL cholesterol and triacylglycerol levels in rats
    • [59] de Almeida, M., Luquetti, S., Sabarense, C., et al. Butter naturally enriched in cis-9, trans-11 CLA prevents hyperinsulinemia and increases both serum HDL cholesterol and triacylglycerol levels in rats. Lipids Health Dis., 13, 2015, 200.
    • (2015) Lipids Health Dis. , vol.13 , pp. 200
    • de Almeida, M.1    Luquetti, S.2    Sabarense, C.3
  • 60
    • 0029994543 scopus 로고    scopus 로고
    • Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression
    • [60] Schoonjans, K., Staels, B., Auwerx, J., Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J. Lipid Res. 37 (1996), 907–925.
    • (1996) J. Lipid Res. , vol.37 , pp. 907-925
    • Schoonjans, K.1    Staels, B.2    Auwerx, J.3
  • 62
    • 34948903774 scopus 로고    scopus 로고
    • Regulation of gene transcription by fatty acids
    • [62] Salter, A.M., Tarling, E.J., Regulation of gene transcription by fatty acids. Animal 1 (2007), 1314–1320.
    • (2007) Animal , vol.1 , pp. 1314-1320
    • Salter, A.M.1    Tarling, E.J.2
  • 63
    • 0032819001 scopus 로고    scopus 로고
    • Essential fatty acids in health and chronic disease 1, 2
    • [63] Simopoulos, A.P., Essential fatty acids in health and chronic disease 1, 2. Am. J. Clin. Nutr. 70 (1999), 560–569.
    • (1999) Am. J. Clin. Nutr. , vol.70 , pp. 560-569
    • Simopoulos, A.P.1
  • 64
    • 77954143472 scopus 로고    scopus 로고
    • Decreased liver fatty acid delta-6 and delta-5 desaturase activity in obese patients
    • [64] Araya, J., Rodrigo, R., Pettinelli, P., Araya, A.V., Poniachik, J., Videla, L.A., Decreased liver fatty acid delta-6 and delta-5 desaturase activity in obese patients. Obesity 18 (2010), 1460–1463.
    • (2010) Obesity , vol.18 , pp. 1460-1463
    • Araya, J.1    Rodrigo, R.2    Pettinelli, P.3    Araya, A.V.4    Poniachik, J.5    Videla, L.A.6
  • 65
    • 73349125811 scopus 로고    scopus 로고
    • Enhancement in liver SREBP-1c/PPAR-alpha ratio and steatosis in obese patients: correlations with insulin resistance and n-3 long-chain polyunsaturated fatty acid depletion
    • [65] Pettinelli, P., del Pozo, T., Araya, J., et al. Enhancement in liver SREBP-1c/PPAR-alpha ratio and steatosis in obese patients: correlations with insulin resistance and n-3 long-chain polyunsaturated fatty acid depletion. Biochim. Biophys. Acta 1792 (2009), 1080–1086.
    • (2009) Biochim. Biophys. Acta , vol.1792 , pp. 1080-1086
    • Pettinelli, P.1    del Pozo, T.2    Araya, J.3
  • 66
    • 2942706241 scopus 로고    scopus 로고
    • Increase in long-chain polyunsaturated fatty acid n-6/n-3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease
    • [66] Araya, J., Rodrigo, R., Videla, L.A., et al. Increase in long-chain polyunsaturated fatty acid n-6/n-3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease. Clin. Sci. 106 (2004), 635–643.
    • (2004) Clin. Sci. , vol.106 , pp. 635-643
    • Araya, J.1    Rodrigo, R.2    Videla, L.A.3
  • 67
    • 84856650278 scopus 로고    scopus 로고
    • The importance of the long-chain polyunsaturated fatty acid n-6/n-3 ratio in development of non-alcoholic fatty liver associated with obesity
    • [67] Valenzuela, R., Videla, L.A., The importance of the long-chain polyunsaturated fatty acid n-6/n-3 ratio in development of non-alcoholic fatty liver associated with obesity. Food Funct. 2 (2011), 644–648.
    • (2011) Food Funct. , vol.2 , pp. 644-648
    • Valenzuela, R.1    Videla, L.A.2
  • 68
    • 67349085771 scopus 로고    scopus 로고
    • Liver NF-κB and AP-1 DNA binding in obese patients
    • [68] Videla, L.A., Tapia, G., Rodrigo, R., et al. Liver NF-κB and AP-1 DNA binding in obese patients. Obesity 17 (2009), 973–979.
    • (2009) Obesity , vol.17 , pp. 973-979
    • Videla, L.A.1    Tapia, G.2    Rodrigo, R.3
  • 69
    • 84872162978 scopus 로고    scopus 로고
    • Recent advances in liver preconditioning: thyroid hormone, n-3 long-chain polyunsaturated fatty acids and iron
    • [69] Fernández, V., Tapia, G., Videla, L.A., Recent advances in liver preconditioning: thyroid hormone, n-3 long-chain polyunsaturated fatty acids and iron. World J. Hepatol. 4 (2012), 119–128.
    • (2012) World J. Hepatol. , vol.4 , pp. 119-128
    • Fernández, V.1    Tapia, G.2    Videla, L.A.3
  • 70
    • 34047273206 scopus 로고    scopus 로고
    • Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin
    • [70] Gao, L., Wang, J., Sekhat, K.R., et al. Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin. J. Biol. Chem. 282 (2007), 2529–2537.
    • (2007) J. Biol. Chem. , vol.282 , pp. 2529-2537
    • Gao, L.1    Wang, J.2    Sekhat, K.R.3
  • 71
    • 69549107757 scopus 로고    scopus 로고
    • Long-chain n-3 polyunsaturated fatty acids: new insights into mechanisms relating to inflammatory and coronary heart disease
    • [71] de Roos, B., Mavrommatis, Y., Brouwer, I.A., Long-chain n-3 polyunsaturated fatty acids: new insights into mechanisms relating to inflammatory and coronary heart disease. Br. J. Pharmcol. 158 (2009), 413–428.
    • (2009) Br. J. Pharmcol. , vol.158 , pp. 413-428
    • de Roos, B.1    Mavrommatis, Y.2    Brouwer, I.A.3
  • 72
    • 0026541591 scopus 로고
    • The mouse peroxisome proliferator activated receptor recognizes a responseelement in the 5’ flanking sequence of the rat acyl CoA oxidase gene
    • [72] Tugwood, J.D., Issemann, I., Anderson, R.G., Bundell, K.R., McPheat, W.L., Green, S., The mouse peroxisome proliferator activated receptor recognizes a responseelement in the 5’ flanking sequence of the rat acyl CoA oxidase gene. EMBO J. 11 (1992), 433–439.
    • (1992) EMBO J. , vol.11 , pp. 433-439
    • Tugwood, J.D.1    Issemann, I.2    Anderson, R.G.3    Bundell, K.R.4    McPheat, W.L.5    Green, S.6
  • 73
    • 79955650290 scopus 로고    scopus 로고
    • Up-regulation of PPAR-γ mRNA expression in the liver of obese patients: an additional reinforcing lipogenic mechanism to SREBP-1c induction
    • [73] Pettinelli, P., Videla, L.A., Up-regulation of PPAR-γ mRNA expression in the liver of obese patients: an additional reinforcing lipogenic mechanism to SREBP-1c induction. J. Clin. Endocrinol. Metab. 96 (2011), 1424–1430.
    • (2011) J. Clin. Endocrinol. Metab. , vol.96 , pp. 1424-1430
    • Pettinelli, P.1    Videla, L.A.2
  • 74
    • 84929728792 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors as targets to treat non-alcoholic fatty liver disease
    • [74] Souza-Mello, V., Peroxisome proliferator-activated receptors as targets to treat non-alcoholic fatty liver disease. World J. Hepatol. 7 (2015), 1012–1019.
    • (2015) World J. Hepatol. , vol.7 , pp. 1012-1019
    • Souza-Mello, V.1
  • 75
    • 0033080354 scopus 로고    scopus 로고
    • Transcriptional regulation of cellular retinol-binding protein, type II gene expression in small intestine by dietary fat
    • [75] Suruga, K., Mochizuki, K., Kitagawa, M., et al. Transcriptional regulation of cellular retinol-binding protein, type II gene expression in small intestine by dietary fat. Arch. Biochem. Biophys. 362 (1999), 159–166.
    • (1999) Arch. Biochem. Biophys. , vol.362 , pp. 159-166
    • Suruga, K.1    Mochizuki, K.2    Kitagawa, M.3
  • 76
    • 0142091723 scopus 로고    scopus 로고
    • A low fish oil inhibits SREBP-1 proteolytic cascade, while a high-fish-oil feeding decreases SREBP-1 mRNA in mice liver: relationship to anti-obesity
    • [76] Nakatani, T., Kim, H., Kaburagi, Y., Yasuda, K., Ezaki, O., A low fish oil inhibits SREBP-1 proteolytic cascade, while a high-fish-oil feeding decreases SREBP-1 mRNA in mice liver: relationship to anti-obesity. J. Lipid Res. 44 (2003), 369–379.
    • (2003) J. Lipid Res. , vol.44 , pp. 369-379
    • Nakatani, T.1    Kim, H.2    Kaburagi, Y.3    Yasuda, K.4    Ezaki, O.5
  • 77
    • 84942191631 scopus 로고    scopus 로고
    • Protective effect of unsaturated fatty acids on palmitic acid-induced toxicity in skeletal muscle cells is not mediated by PPARδ activation
    • [77] Tumova, J., Malisova, L., Andel, M., Trnka, J., Protective effect of unsaturated fatty acids on palmitic acid-induced toxicity in skeletal muscle cells is not mediated by PPARδ activation. Lipids 50 (2015), 955–964.
    • (2015) Lipids , vol.50 , pp. 955-964
    • Tumova, J.1    Malisova, L.2    Andel, M.3    Trnka, J.4
  • 78
    • 84861082428 scopus 로고    scopus 로고
    • Regulation of the human endogenous retroviral Syncytin-1 and cell-cell fusion by the nuclear hormone receptors PPARgamma/RXRalpha in placentogenesis
    • [78] Ruebner, M., Langbein, M., Strissel, P.L., et al. Regulation of the human endogenous retroviral Syncytin-1 and cell-cell fusion by the nuclear hormone receptors PPARgamma/RXRalpha in placentogenesis. J. Cell Biochem. 113 (2012), 2383–2396.
    • (2012) J. Cell Biochem. , vol.113 , pp. 2383-2396
    • Ruebner, M.1    Langbein, M.2    Strissel, P.L.3
  • 79
    • 17544387857 scopus 로고    scopus 로고
    • Differential expression of peroxisome proliferator-activated receptors (PPARs) in the developing human fetal digestive tract
    • [79] Huin, C., Corriveau, L., Bianchi, A., et al. Differential expression of peroxisome proliferator-activated receptors (PPARs) in the developing human fetal digestive tract. J. Histochem. Cytochem. 48 (2002), 603–611.
    • (2002) J. Histochem. Cytochem. , vol.48 , pp. 603-611
    • Huin, C.1    Corriveau, L.2    Bianchi, A.3
  • 80
    • 0036234471 scopus 로고    scopus 로고
    • Localization and expression of messenger RNAs for the peroxisome proliferator-activated receptors in ovarian tissue from naturally cycling and pseudopregnant rats
    • [80] Komar, C.M., Curry, T.E., Localization and expression of messenger RNAs for the peroxisome proliferator-activated receptors in ovarian tissue from naturally cycling and pseudopregnant rats. J. Control Release 66 (2002), 1531–1539.
    • (2002) J. Control Release , vol.66 , pp. 1531-1539
    • Komar, C.M.1    Curry, T.E.2
  • 81
    • 33646810470 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors in reproductive tissues: from gametogenesis to parturition
    • [81] Froment, P., Gizard, F., Defever, D., Staels, B., Dupont, J., Monget, P., Peroxisome proliferator-activated receptors in reproductive tissues: from gametogenesis to parturition. J. Endocrinol. 189 (2006), 199–209.
    • (2006) J. Endocrinol. , vol.189 , pp. 199-209
    • Froment, P.1    Gizard, F.2    Defever, D.3    Staels, B.4    Dupont, J.5    Monget, P.6
  • 82
    • 0034801962 scopus 로고    scopus 로고
    • PPARϒ / RXRα heterodimers are involved in human CGβ synthesis and human trophoblast differentiation
    • [82] Tarrade, A., Schoonjans, K., Guibourdenche, J., et al. PPARϒ / RXRα heterodimers are involved in human CGβ synthesis and human trophoblast differentiation. Endocrinology 142 (2001), 4504–4514.
    • (2001) Endocrinology , vol.142 , pp. 4504-4514
    • Tarrade, A.1    Schoonjans, K.2    Guibourdenche, J.3
  • 83
    • 84945463756 scopus 로고    scopus 로고
    • Maternal nutrition influences angiogenesis in the placenta through peroxisome proliferator activated receptors: a novel hypothesis
    • [83] Meher, A., Sundrani, D., Joshi, S., Maternal nutrition influences angiogenesis in the placenta through peroxisome proliferator activated receptors: a novel hypothesis. Mol. Reprod. Dev. 82 (2015), 726–734.
    • (2015) Mol. Reprod. Dev. , vol.82 , pp. 726-734
    • Meher, A.1    Sundrani, D.2    Joshi, S.3
  • 84
    • 84938532019 scopus 로고    scopus 로고
    • PPARγ stimulates expression of L-type amino acid and taurine transporters in human placentas: the evidence of PPARγ regulating fetal growth
    • [84] Chen, Z., He, P., Ding, X., Huang, Y., Gu, H., Ni, X., PPARγ stimulates expression of L-type amino acid and taurine transporters in human placentas: the evidence of PPARγ regulating fetal growth. Sci. Rep. 5 (2015), 1–13.
    • (2015) Sci. Rep. , vol.5 , pp. 1-13
    • Chen, Z.1    He, P.2    Ding, X.3    Huang, Y.4    Gu, H.5    Ni, X.6
  • 85
    • 34247508639 scopus 로고    scopus 로고
    • Epigenetic mechanisms and the mismatch concept of the developmental origins of health and disease
    • [85] Godfrey, K.M., Lillycrop, K.A., Burdge, G.C., Gluckman, P.D., Hanson, M.A., Epigenetic mechanisms and the mismatch concept of the developmental origins of health and disease. Pedia. Res. 61 (2007), 31–36.
    • (2007) Pedia. Res. , vol.61 , pp. 31-36
    • Godfrey, K.M.1    Lillycrop, K.A.2    Burdge, G.C.3    Gluckman, P.D.4    Hanson, M.A.5
  • 86
    • 20444411948 scopus 로고    scopus 로고
    • Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring
    • [86] Lillycrop, K.A., Phillips, E.S., Jackson, A.A., Hanson, M.A., Burdge, G.C., Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J. Nutr. 135 (2005), 1382–1386.
    • (2005) J. Nutr. , vol.135 , pp. 1382-1386
    • Lillycrop, K.A.1    Phillips, E.S.2    Jackson, A.A.3    Hanson, M.A.4    Burdge, G.C.5
  • 87
    • 0142010520 scopus 로고    scopus 로고
    • Regulation of human delta-6 desaturase gene transcription: identification of a functional direct repeat-1 element
    • [87] Tang, C., Cho, H.P., Nakamura, M.T., Clarke, S.D., Regulation of human delta-6 desaturase gene transcription: identification of a functional direct repeat-1 element. J. Lipid Res. 44 (2003), 686–695.
    • (2003) J. Lipid Res. , vol.44 , pp. 686-695
    • Tang, C.1    Cho, H.P.2    Nakamura, M.T.3    Clarke, S.D.4
  • 88
    • 0042563136 scopus 로고    scopus 로고
    • Effect of reduced maternal protein intake in pregnancy in the rat on the fatty acid composition of brain, liver, plasma, heart and lung phospholipids of the offspring after weaning
    • [88] Burdge, C., Delange, E., Dubois, L., et al. Effect of reduced maternal protein intake in pregnancy in the rat on the fatty acid composition of brain, liver, plasma, heart and lung phospholipids of the offspring after weaning. Br. J. Nutr. 90 (2003), 345–352.
    • (2003) Br. J. Nutr. , vol.90 , pp. 345-352
    • Burdge, C.1    Delange, E.2    Dubois, L.3
  • 89
    • 83155175246 scopus 로고    scopus 로고
    • Evidence implicating peroxisome proliferator-activated receptor-ϒ in the pathogenesis of preeclampsia
    • [89] McCarthy, F.P., Drewlo, S., English, F.A., et al. Evidence implicating peroxisome proliferator-activated receptor-ϒ in the pathogenesis of preeclampsia. Hypertension 58 (2011), 882–887.
    • (2011) Hypertension , vol.58 , pp. 882-887
    • McCarthy, F.P.1    Drewlo, S.2    English, F.A.3
  • 90
    • 80051471606 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-ϒ as a potential therapeutic target in the treatment of preeclampsia
    • [90] McCarthy, F.P., Drewlo, S., Kingdom, J., Johns, E.J., Walsh, S.K., Kenny, L.C., Peroxisome proliferator-activated receptor-ϒ as a potential therapeutic target in the treatment of preeclampsia. Hypertension 58 (2011), 280–286.
    • (2011) Hypertension , vol.58 , pp. 280-286
    • McCarthy, F.P.1    Drewlo, S.2    Kingdom, J.3    Johns, E.J.4    Walsh, S.K.5    Kenny, L.C.6
  • 91
    • 64349104448 scopus 로고    scopus 로고
    • Metabolomics of the interaction between PPAR-alpha and age in the PPAR-alpha-null mouse
    • [91] Atherton, H.J., Gulston, M.K., Bailey, N.J., et al. Metabolomics of the interaction between PPAR-alpha and age in the PPAR-alpha-null mouse. Mol. Syst. Biol. 5 (2009), 1–10.
    • (2009) Mol. Syst. Biol. , vol.5 , pp. 1-10
    • Atherton, H.J.1    Gulston, M.K.2    Bailey, N.J.3
  • 92
    • 84893827588 scopus 로고    scopus 로고
    • Decreased liver peroxisomal β-oxidation accompanied by changes inbrain fatty acid composition in aged rats
    • [92] Yang, L., Zhang, Y., Wang, S., Zhang, W., Shi, R., Decreased liver peroxisomal β-oxidation accompanied by changes inbrain fatty acid composition in aged rats. Neurol. Sci. 35 (2014), 289–293.
    • (2014) Neurol. Sci. , vol.35 , pp. 289-293
    • Yang, L.1    Zhang, Y.2    Wang, S.3    Zhang, W.4    Shi, R.5
  • 93
    • 0029984062 scopus 로고    scopus 로고
    • Antioxidant and redox regulation of gene transcription
    • [93] Sen, C.K., Packer, L., Antioxidant and redox regulation of gene transcription. FASEB J. 10 (1996), 709–720.
    • (1996) FASEB J. , vol.10 , pp. 709-720
    • Sen, C.K.1    Packer, L.2
  • 94
    • 84877654967 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR) ϒ and PPARα agonists modulate mitochondrial fusion-fission dynamics: relevance to reactive oxygen species (ROS)-related neurodegenerative disorders?
    • [94] Zolezzi, J.M., Silva-Alvarez, C., Ordenes, D., et al. Peroxisome proliferator-activated receptor (PPAR) ϒ and PPARα agonists modulate mitochondrial fusion-fission dynamics: relevance to reactive oxygen species (ROS)-related neurodegenerative disorders?. PLoS ONE 8 (2013), 1–10.
    • (2013) PLoS ONE , vol.8 , pp. 1-10
    • Zolezzi, J.M.1    Silva-Alvarez, C.2    Ordenes, D.3
  • 95
    • 84964318278 scopus 로고    scopus 로고
    • Environmental enrichment, age, and PPARα interact to regulate proliferation in neurogenic niches
    • [95] Pérez-Martín, M., Rivera, P., Blanco, E., et al. Environmental enrichment, age, and PPARα interact to regulate proliferation in neurogenic niches. Front Neurosci. 10 (2016), 1–12.
    • (2016) Front Neurosci. , vol.10 , pp. 1-12
    • Pérez-Martín, M.1    Rivera, P.2    Blanco, E.3
  • 96
    • 84869170925 scopus 로고    scopus 로고
    • Fish oil and postoperative atrial fibrillation: the omega-3 fatty acids for prevention of post-operative atrial fibrillation (OPERA) randomized trial
    • [96] Mozaffarian, D., Marchioli, R., Macchia, A., et al. Fish oil and postoperative atrial fibrillation: the omega-3 fatty acids for prevention of post-operative atrial fibrillation (OPERA) randomized trial. JAMA 308 (2012), 2001–2011.
    • (2012) JAMA , vol.308 , pp. 2001-2011
    • Mozaffarian, D.1    Marchioli, R.2    Macchia, A.3
  • 97
    • 79959484739 scopus 로고    scopus 로고
    • n-3 fatty acids in cardiovascular disease
    • [97] De Caterina, R., n-3 fatty acids in cardiovascular disease. N. Engl. J. Med. 364 (2011), 2439–2450.
    • (2011) N. Engl. J. Med. , vol.364 , pp. 2439-2450
    • De Caterina, R.1
  • 98
    • 79961054708 scopus 로고    scopus 로고
    • Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events
    • [98] Mozaffarian, D., Wu, J.H., Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events. J. Am. Coll. Cardiol. 58 (2011), 2047–2067.
    • (2011) J. Am. Coll. Cardiol. , vol.58 , pp. 2047-2067
    • Mozaffarian, D.1    Wu, J.H.2
  • 99
    • 77957362125 scopus 로고    scopus 로고
    • Liver NF-κB and AP-1 activation and PPAR-α expression are negatively correlated in obese patients: pro-inflammatory implications
    • [99] Videla, L.A., Liver NF-κB and AP-1 activation and PPAR-α expression are negatively correlated in obese patients: pro-inflammatory implications. Clin. Nutr. 29 (2010), 687–688.
    • (2010) Clin. Nutr. , vol.29 , pp. 687-688
    • Videla, L.A.1
  • 100
    • 84930429781 scopus 로고    scopus 로고
    • Long-term treatment with n-3 polyunsaturated fatty acids as a monotherapy in children with nonalcoholic fatty liver disease
    • [100] Boyraz, M., Pirgon, Ö., Dündar, B., et al. Long-term treatment with n-3 polyunsaturated fatty acids as a monotherapy in children with nonalcoholic fatty liver disease. J. Clin. Res. Pedia. Endocrinol. 7 (2015), 121–127.
    • (2015) J. Clin. Res. Pedia. Endocrinol. , vol.7 , pp. 121-127
    • Boyraz, M.1    Pirgon, Ö.2    Dündar, B.3
  • 101
    • 84937513927 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled randomized trial to evaluate the efficacy of docosahexaenoic acid supplementation on hepatic fat and associated cardiovascular risk factors in overweight children with nonalcoholic fatty liver disease
    • [101] Pacifico, L., Bonci, E., Di Martino, M., et al. A double-blind, placebo-controlled randomized trial to evaluate the efficacy of docosahexaenoic acid supplementation on hepatic fat and associated cardiovascular risk factors in overweight children with nonalcoholic fatty liver disease. Nutr. Metab. Cardiovasc. Dis. 25 (2015), 734–741.
    • (2015) Nutr. Metab. Cardiovasc. Dis. , vol.25 , pp. 734-741
    • Pacifico, L.1    Bonci, E.2    Di Martino, M.3
  • 102
    • 84927776586 scopus 로고    scopus 로고
    • Effects of purified eicosapentaenoic and docosahexaenoic acids in nonalcoholic fatty liver disease: results from the Welcome* study
    • [102] Scorletti, E., Bhatia, L., McCormick, K.G., et al. Effects of purified eicosapentaenoic and docosahexaenoic acids in nonalcoholic fatty liver disease: results from the Welcome* study. Hepatology 60 (2014), 1211–1221.
    • (2014) Hepatology , vol.60 , pp. 1211-1221
    • Scorletti, E.1    Bhatia, L.2    McCormick, K.G.3
  • 103
    • 84939173471 scopus 로고    scopus 로고
    • A randomized, double-blind study of the effects of omega-3 fatty acids (Omegaven) on outcome after major liver resection
    • [103] Linecker, M., Limani, P., Botea, F., et al. A randomized, double-blind study of the effects of omega-3 fatty acids (Omegaven) on outcome after major liver resection. BMC Gastroenterol., 15, 2015, 102.
    • (2015) BMC Gastroenterol. , vol.15 , pp. 102
    • Linecker, M.1    Limani, P.2    Botea, F.3
  • 104
    • 82955188750 scopus 로고    scopus 로고
    • N-3 PUFA supplementation triggers PPAR-α activation and PPAR-α/NF-κB interaction: anti-inflammatory implications in liver ischemia-reperfusion injury
    • [104] Zúñiga, J., Cancino, M., Medina, F., et al. N-3 PUFA supplementation triggers PPAR-α activation and PPAR-α/NF-κB interaction: anti-inflammatory implications in liver ischemia-reperfusion injury. PLoS One, 6, 2011, e28502.
    • (2011) PLoS One , vol.6 , pp. e28502
    • Zúñiga, J.1    Cancino, M.2    Medina, F.3
  • 105
    • 84901940803 scopus 로고    scopus 로고
    • N-3 long-chain PUFA supplementation prevents high fat diet induced mouse liver steatosis and inflammation in relation to PPAR-α upregulation and NF-κB DNA binding abrogation
    • [105] Tapia, G., Valenzuela, R., Espinosa, A., et al. N-3 long-chain PUFA supplementation prevents high fat diet induced mouse liver steatosis and inflammation in relation to PPAR-α upregulation and NF-κB DNA binding abrogation. Mol. Nutr. Food Res. 58 (2014), 1333–1341.
    • (2014) Mol. Nutr. Food Res. , vol.58 , pp. 1333-1341
    • Tapia, G.1    Valenzuela, R.2    Espinosa, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.