Dose effect on the uptake and accumulation of hydroxytyrosol and its metabolites in target tissues in rats

Molecular Nutrition and Food Research

Volumn 59, Issue 7, 2015, Pages 1395-1399

  López de las Hazas, Maria Carmen ^a   Rubió, Laura ^a   Kotronoulas, Aristotelis ^b,c   de la Torre, Rafael ^b   Solà, Rosa ^d   Motilva, Maria José ^a  

^a UNIVERSITY OF LLEIDA   (Spain)

^b HOSPITAL DEL MAR   (Spain)

^c UNIVERSITAT POMPEU FABRA   (Spain)

^d HOSPITAL UNIVERSITARI SANT JOAN DE REUS   (Spain)

Author keywords

Biodistribution; Dose uptake; Hydroxytyrosol; Phenol metabolites; Tissue disposition

Indexed keywords

3,4-DIHYDROXYPHENYLETHANOL; OLIVE OIL; PHENETHYL ALCOHOL;

ANALOGS AND DERIVATIVES; ANIMAL; DOSE RESPONSE; FEMALE; MALE; METABOLISM; RAT; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MALE; OLIVE OIL; PHENYLETHYL ALCOHOL; RATS; TANDEM MASS SPECTROMETRY; TISSUE DISTRIBUTION;

EID: 84934441501     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201500048     Document Type: Article

References (23)

1. EFSA Panel on Dietetic Products Nutrition and Allergies (NDA), Scientific opinion on the substantiation of health claims related to polyphenols in olive. Pursuant to Article 13(1) of Regulation (EC) No 1924/2006. EFSA J. 2011, 9, 2033.
2. Commission Regulation (EU) 432/2012 of 16 May 2012 establishing a list of permitted health claims made on foods, other than those referring to the reduction of disease risk and to children's development and health. O.J. 2012, L136/1.
3. Konstantinidou, V., Covas, M. I., Muñoz-Aguayo, D., Khymenets, O. et al., In vivo nutrigenomic effects of virgin olive oil polyphenols within the frame of the Mediterranean diet: a randomized controlled trial. FASEB J. 2010, 24, 2546-2557.
4. Rohn, S., Possibilities and limitations in the analysis of covalent interactions between phenolic compounds and proteins. Food Res. Int. 2014, 65, 13-19.
5. D'Angelo, E., Manna, C., Migliardi, V., Mazzoni, O. et al., Pharmacokinetics and metabolism of hydroxytyrosol, a natural antioxidant from olive oil. Drug. Metabol. Dis. 2001, 29, 1492-1498.
6. Serra, A., Rubió, L., Borràs, X., Macià, A. et al., Distribution of olive oil phenolic compounds in rat tissues after administration of a phenolic extract from olive cake. Mol Nutr. Food Res. 2012, 56, 486-496.
7. Kotronoulas, A., Pizarro, N., Serra, A., Robledo, P. et al., Dose-dependent metabolic disposition of hydroxytyrosol and formation of mercapturates in rats. Pharmacol. Res. 2013, 77, 47-56.
8. Rubió, L., Valls, R. M., Macià, A., Pedret, A. et al., Impact of olive oil phenolic concentration on human plasmatic phenolic metabolites. Food Chem. 2012, 135, 2922-2929.
9. Deiana, M., Incani, A., Rosa, A., Atzeri, A. et al., Hydroxytyrosol glucuronides protect renal tubular epithelial cells against H(2)O(2) induced oxidative damage. Chem. Biol. Interact 2011, 193, 232-239.
10. Giordano, E., Davalos, A., Nicod, N., Visioli, F., Hydroxytyrosol attenuates tunicamycin-induced endoplasmic reticulum stress in human hepatocarcinoma cells. Mol. Nutr. Food Res. 2014, 58, 954-962.
11. Pan, S., Liu, L., Pan, H., Ma, Y. et al., Protective effects of hydroxytyrosol on liver ischemia/reperfusion injury in mice. Mol. Nutr. Food Res. 2013, 57, 1218-1227
12. Poudyal, H., Campbell, F., Brown, L. Olive leaf extract attenuates cardiac, hepatic, and metabolic changes in high carbohydrate-, high fat-fed rats J. Nutr. 2010 140, 946-953.
13. Khymenets, O., Fito, M., Tourino, S., Munoz-Aguayo, D. et al. Antioxidant activities of hydroxytyrosol main metabolites do not contribute to beneficial health effects after olive oil ingestion. Drug Metab. Dispos. 2010, 38, 1417-1421.
14. Kang, N. J., Shin, S. H., Lee, H. J., Lee, K. W., Polyphenols as small molecular inhibitors of signaling cascades in carcinogenesis. Pharmacol. Ther. 2011, 130, 310-324.
15. Gallardo, E., Madrona, A., Palma-Valdés, R., Trujillo, M. et al., The effect of hydroxytyrosol and its nitroderivatives on catechol-O-methyl transferase activity in rat striatal tissue. RSC Adv. 2014, 4, 61086-61091.
16. Schaffer, S., Podstawa, M., Visioli, F., Bogani, P. et al., Hydroxytyrosol-rich olive mill wastewater extract protects brain cells in vitro and ex vivo. J. Agric. Food Chem. 2007, 55, 5043-5049.
17. Wu, Y. T., Lin, L. C, Tsai, T. H., Measurement of free hydroxytyrosol in microdialysates from blood and brain of anesthetized rats by liquid chromatography with fluorescence detection. J. Chromatogr. A. 2009, 1216, 3501-3507.
18. Carluccio, M. A., Siculella, L., Ancora, M. A., Massaro, M. et al., Olive oil and red wine antioxidant polyphenols inhibit endothelial activation: Antiatherogenic properties of Mediterranean diet phytochemicals. Arterioscl. Thromb.Vasc. Biol. 2003, 23, 622-629.
19. Visioli, F., Caruso, D., Virgin olive oil study (VOLOS): vasoprotective potential of extra virgin olive oil in mildly dyslipidemic patients. Eur. J. Clin. Nutr. 2005, 44, 121-127.
20. Priora, R., Summa, D., Administration of minor polar compound-enriched extra virgin olive oil decreases platelet aggregation and the plasma concentration of reduced homocysteine in rats. J. Nutr. 2008, 138, 36-41.
21. Kulkarni, K. H., Yang, Z., Niu, T., Hu, M., Effects of estrogen and estrus cycle on pharmacokinetics, absorption, and disposition of genistein in female Sprague-Dawley rats. J. Agric. Food Chem. 2012, 60, 7949-7956.
22. Buckley, D. B., Klaassen, C. D., Mechanism of gender-divergent UDP-glucuronosyltransferase mRNA expression in mouse liver and kidney. Drug Metab. Dispos. 2009, 37, 834-840.
23. Waxman, D. J., Holloway, M. G., Sex differences in the expression of hepatic drug metabolizing enzymes. Mol. Pharmacol. 2009, 76, 215-228.