GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1

Immunity

Volumn 15, Issue 4, 2001, Pages 557-567

  Shibata, Yoko ^a   Berclaz, Pierre Yves ^a   Chroneos, Zissis C ^a   Yoshida, Mitsuhiro ^a   Whitsett, Jeffrey A ^a   Trapnell, Bruce C ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; LIPOPOLYSACCHARIDE; MANNOSE; PEPTIDOGLYCAN; SURFACTANT; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; BACTERICIDAL ACTIVITY; CELL ADHESION; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE RELEASE; HOST RESISTANCE; IMMUNE RESPONSE; IMMUNITY; IMMUNOPATHOLOGY; IN VIVO STUDY; LIPOLYSIS; LUNG; LUNG ALVEOLUS MACROPHAGE; LUNG ALVEOLUS PROTEINOSIS; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RESPIRATORY TRACT INFECTION; RETROVIRUS; TRANSGENIC MOUSE;

EID: 0034748924     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(01)00218-7     Document Type: Article

References (58)

1. Toll-like receptors in the induction of the innate immune response
2. Effects of granulocyte-macrophage colony-stimulating factor and colony-stimulating factor-1 on the proliferation and differentiation of murine alveolar macrophages
3. Myeloid development is selectively disrupted in PU.1 null mice
4. Neutrophils deficient in PU.1 do not terminally differentiate or become functionally competent
5. PU.1 and the granulocyte- and macrophage colony-stimulating factor receptors play distinct roles in late-stage myeloid cell differentiation
6. Human recombinant granulocyte-macrophage colony-stimulating factor increases cell-to-cell adhesion and surface expression of adhesion-promoting surface glycoproteins on mature granulocytes
7. Increased tolerance to endotoxin by granulocyte-macrophage colony-stimulating factor-deficient mice
8. Surfactant protein A is degraded by alveolar macrophages
9. The transcription factor PU.1 is involved in macrophage proliferation
10. Role of granulocyte/macrophage colony-stimulating factor in the regulation of murine alveolar macrophage proliferation and differentiation
11. Neutrophils and monocytes express high levels of PU.1 (Spi-1) but not Spi-B
12. Urokinase receptor-dependent and -independent p56/59(hck) activation state is a molecular switch between myelomonocytic cell motility and adherence
13. Differential regulation of the mannose and SP-A receptors on macrophages
14. Granulocyte-macrophage colony-stimulating factor enhances selective effector functions of tissue-derived macrophages
15. Global expression analysis of extracellular matrix-integrin interactions in monocytes
16. Regulation of B lymphocyte and macrophage development by graded expression of PU.1
17. PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors
18. Stimulation of haematopoiesis in primates by continuous infusion of recombinant human GM-CSF
19. Involvement of granulocyte-macrophage colony-stimulating factor in pulmonary homeostasis
20. Murine macrophage mannose receptor promoter is regulated by the transcription factors PU.1 and SP1
21. Cloning of the murine beta 5 integrin subunit promoter. Identification of a novel sequence mediating granulocyte-macrophage colony-stimulating factor-dependent repression of beta5 integrin gene transcription
22. Phenotypic and functional characterization of normal rat pleural macrophages in comparison with autologous peritoneal and alveolar macrophages
23. Serial analysis of gene expression in human monocytes and macrophages
24. Commitment to the monocytic lineage occurs in the absence of the transcription factor PU.1
25. Pulmonary epithelial cell expression of GM-CSF corrects the alveolar proteinosis in GM-CSF-deficient mice
26. GM-CSF enhances lung growth and causes alveolar type II epithelial cell hyperplasia in transgenic mice
27. The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80. Relationship between macrophages, Langerhans cells, reticular cells, and dendritic cells in lymphoid and hematopoietic organs
28. Surfactant metabolism in transgenic mice after granulocyte macrophage-colony stimulating factor ablation
29. Mature monocytic cells enter tissues and engraft
30. The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene
31. GM-CSF-deficient mice are susceptible to pulmonary group B streptococcal infection
32. Functional overlap in the src gene family: Inactivation of hck and fgr impairs natural immunity
33. MH-S, a murine alveolar macrophage cell line: Morphological, cytochemical, and functional characteristics
34. Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities
35. The transcription factor PU.1 does not regulate lineage commitment but has lineage-specific effects
36. Hematopoiesis in mice lacking the entire granulocyte-macrophage colony-stimulating factor/interleukin-3/interleukin-5 functions
37. The pulmonary alveolar proteinosis in granulocyte macrophage colony-stimulating factor/interleukins 3/5 beta c receptor-deficient mice is reversed by bone marrow transplantation
38. PU.1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation
39. Nonspecific inflammation inhibits adenovirus-mediated pulmonary gene transfer and expression independent of specific acquired immune responses
40. The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter
41. Granulocyte-macrophage colony-stimulating factor in the innate immune response to Pneumocystis carinii pneumonia in mice
42. Granulocyte-macrophage colony stimulating factor
43. Aerosolized GM-CSF ameliorates pulmonary alveolar proteinosis in GM-CSF- deficient mice
44. PU.1 and interferon consensus sequence-binding protein regulate the myeloid expression of the human Toll-like receptor 4 gene
45. Hematopoietic and lung abnormalities in mice with a null mutation of the common beta subunit of the receptors for granulocyte-macrophage colony-stimulating factor and interleukins 3 and 5
46. Human alveolar macrophage subpopulations isolated on discontinuous albumin gradients: Functional data in normals and sarcoid patients
47. Signal transduction by the high-affinity GM-CSF receptor: Two distinct cytoplasmic regions of the common beta subunit responsible for different signaling
48. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages
49. Alveolar macrophage deficiency in M-CSF-deficient, osteopetrotic mice spontaneously corrects with age and is associated with matrix metalloprotease expression and emphysema
50. Transcription factors, normal myeloid development, and leukemia
51. Direct evidence for a bone marrow origin of the alveolar macrophage in man
52. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
53. Inhibition of hematopoiesis by competitive binding of transcription factor PU.1
54. Differential expression and regulation of macrophage inflammatory protein (MIP)-1alpha and MIP-2 genes by alveolar and peritoneal macrophages in LPS-hyporesponsive C3H/HeJ mice
55. Recombinant human granulocyte/macrophage colony-stimulating factor activates intracellular killing of Leishmania donovani by human monocyte-derived macrophages
56. GM-CSF regulates surfacant Protein-A and lipid catabolism by alveolar macrohpages
57. Adenovirus-mediated granulocyte-macrophage colony-stimulating factor improves lung pathology of pulmonary alveolar proteinosis in granulocyte-macrophage colony-stimulating factor-deficient mice
58. Internalization of adenovirus by alveolar macrophages initiates early proinflammatory signaling during acute respiratory tract infection