-
2
-
-
0030293676
-
Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo
-
Borchelt D. R., Thinakaran G., Eckman C. B., Lee M. K., Davenport F., Ratovitsky T., Prada C.-M., Kim G., Seekins S., Yager D., Slunt H. H., Wang R., Seeger M., Levey A. I., Gandy S. E., Copeland N. G., Jenkins N. A., Price D. L., Younkin S. G., Sisodia S. S. Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo. Neuron. 17:1996;1005-1013.
-
(1996)
Neuron
, vol.17
, pp. 1005-1013
-
-
Borchelt, D.R.1
Thinakaran, G.2
Eckman, C.B.3
Lee, M.K.4
Davenport, F.5
Ratovitsky, T.6
Prada, C.-M.7
Kim, G.8
Seekins, S.9
Yager, D.10
Slunt, H.H.11
Wang, R.12
Seeger, M.13
Levey, A.I.14
Gandy, S.E.15
Copeland, N.G.16
Jenkins, N.A.17
Price, D.L.18
Younkin, S.G.19
Sisodia, S.S.20
more..
-
3
-
-
16944362157
-
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice
-
Citron M., Westaway D., Xia W., Carlson G., Diehl T., Levesque G., Johnson-Wood K., Lee M., Seubert P., Davis A., Kholodenko D., Motter R., Sherrington R., Perry B., Yao H., Strome R., Lieberburg I., Rommens J., Kim S., Schenk D., Fraser P., St. George Hyslop P., Selkoe D. J. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice. Nature Med. 3:1997;67-72.
-
(1997)
Nature Med.
, vol.3
, pp. 67-72
-
-
Citron, M.1
Westaway, D.2
Xia, W.3
Carlson, G.4
Diehl, T.5
Levesque, G.6
Johnson-Wood, K.7
Lee, M.8
Seubert, P.9
Davis, A.10
Kholodenko, D.11
Motter, R.12
Sherrington, R.13
Perry, B.14
Yao, H.15
Strome, R.16
Lieberburg, I.17
Rommens, J.18
Kim, S.19
Schenk, D.20
Fraser, P.21
St. George Hyslop, P.22
Selkoe, D.J.23
more..
-
4
-
-
16044366039
-
Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1
-
Duff K., Eckman C., Zehr C., Yu X., Prada C.-M., Perez-tur J., Hutton M., Buee L., Harigaya Y., Yager D., Morgan D., Gordon M. N., Holcomb L., Refolo L., Zenk B., Hardy J., Younkin S. Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1. Nature. 383:1996;710-713.
-
(1996)
Nature
, vol.383
, pp. 710-713
-
-
Duff, K.1
Eckman, C.2
Zehr, C.3
Yu, X.4
Prada, C.-M.5
Perez-Tur, J.6
Hutton, M.7
Buee, L.8
Harigaya, Y.9
Yager, D.10
Morgan, D.11
Gordon, M.N.12
Holcomb, L.13
Refolo, L.14
Zenk, B.15
Hardy, J.16
Younkin, S.17
-
5
-
-
0028985574
-
Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
-
Games D., Adams D., Alessandrini R., Barbour R., Berthelette P., Blackwell C., Carr T., Clemens J., Donaldson T., Gillespie F., Guido T., Hagopian S., Johnson-Wood K., Khan K., Lee M., Leibowitz P., Lieberburg I., Little S., Masliah E., McConlogue L., Montoya-Zavala M., Mucke L., Paganini L., Penniman E., Power M., Schenk D., Seubert P., Snyder B., Soriano F., Tan H., Vitale J., Wadsworth S., Wolozin B., Zhao J. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature. 373:1995;523-527.
-
(1995)
Nature
, vol.373
, pp. 523-527
-
-
Games, D.1
Adams, D.2
Alessandrini, R.3
Barbour, R.4
Berthelette, P.5
Blackwell, C.6
Carr, T.7
Clemens, J.8
Donaldson, T.9
Gillespie, F.10
Guido, T.11
Hagopian, S.12
Johnson-Wood, K.13
Khan, K.14
Lee, M.15
Leibowitz, P.16
Lieberburg, I.17
Little, S.18
Masliah, E.19
McConlogue, L.20
Montoya-Zavala, M.21
Mucke, L.22
Paganini, L.23
Penniman, E.24
Power, M.25
Schenk, D.26
Seubert, P.27
Snyder, B.28
Soriano, F.29
Tan, H.30
Vitale, J.31
Wadsworth, S.32
Wolozin, B.33
Zhao, J.34
more..
-
6
-
-
0028915895
-
Amyloid β protein (Aβ) in Alzheimer's disease brain
-
Gravina S. A., Ho L., Eckman C. B., Long K. E., Otvos L. Jr, Younkin L. H., Suzuki N., Younkin S. G. Amyloid β protein (Aβ) in Alzheimer's disease brain. J. Biol. Chem. 270:1995;7013-7016.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 7013-7016
-
-
Gravina, S.A.1
Ho, L.2
Eckman, C.B.3
Long, K.E.4
Otvos L., Jr.5
Younkin, L.H.6
Suzuki, N.7
Younkin, S.G.8
-
7
-
-
0027333557
-
Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-protein
-
Haass C., Selkoe D. J. Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-protein. Cell. 75:1993;1039-1042.
-
(1993)
Cell
, vol.75
, pp. 1039-1042
-
-
Haass, C.1
Selkoe, D.J.2
-
8
-
-
0345141285
-
Biochemical analysis of amyloid β protein with amino-terminal pyroglutamate 3 in Alzheimer's disease brains
-
Harigaya Y., Eckman C. B., Prada C.-M., Saido T. C., Younkin S. G. Biochemical analysis of amyloid β protein with amino-terminal pyroglutamate 3 in Alzheimer's disease brains. Soc. Neurosci. 26:1996;1170.
-
(1996)
Soc. Neurosci.
, vol.26
, pp. 1170
-
-
Harigaya, Y.1
Eckman, C.B.2
Prada, C.-M.3
Saido, T.C.4
Younkin, S.G.5
-
9
-
-
0029742199
-
Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice
-
Hsiao K., Chapman P., Nilsen S., Eckman C., Harigaya Y., Younkin S., Yang F., Cole G. Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice. Science. 274:1996;99-102.
-
(1996)
Science
, vol.274
, pp. 99-102
-
-
Hsiao, K.1
Chapman, P.2
Nilsen, S.3
Eckman, C.4
Harigaya, Y.5
Younkin, S.6
Yang, F.7
Cole, G.8
-
10
-
-
0028983163
-
Decrease in cytoplasmic aspartyl-aminopeptidase but not in alanyl-aminopeptidase in the frontal cortex of the aged rat
-
Iribar C., Esteban M. J., Martinez J. M., Peinado J. M. Decrease in cytoplasmic aspartyl-aminopeptidase but not in alanyl-aminopeptidase in the frontal cortex of the aged rat. Brain Res. 687:1995;211-2113.
-
(1995)
Brain Res.
, vol.687
, pp. 211-2113
-
-
Iribar, C.1
Esteban, M.J.2
Martinez, J.M.3
Peinado, J.M.4
-
11
-
-
0028169925
-
Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited Aβ species is Aβ42(43)
-
Iwatsubo T., Odaka A., Suzuki N., Mizusawa H., Nukina N., Ihara Y. Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals evidence that an initially deposited Aβ species is Aβ42(43) . Neuron. 13:1994;45-53.
-
(1994)
Neuron
, vol.13
, pp. 45-53
-
-
Iwatsubo, T.1
Odaka, A.2
Suzuki, N.3
Mizusawa, H.4
Nukina, N.5
Ihara, Y.6
-
12
-
-
0029849644
-
Full-length Aβ(1-42(43)) as well as amino-terminally modified and truncated Aβ42(43) deposit in diffuse plaques
-
Iwatsubo T., Saido T. C., Mann D. M. A., Lee V. M.-Y., Trojanowski J. Q. Full-length Aβ(1-42(43)) as well as amino-terminally modified and truncated Aβ42(43) deposit in diffuse plaques. Am. J. Pathol. 149:1996;1823-1830.
-
(1996)
Am. J. Pathol.
, vol.149
, pp. 1823-1830
-
-
Iwatsubo, T.1
Saido, T.C.2
Mann, D.M.A.3
Lee, V.M.-Y.4
Trojanowski, J.Q.5
-
13
-
-
0031584845
-
Reduction of plasma glutamyl aminopeptidase activity in sporadic Alzheimer's disease: A potential biochemical marker
-
Kuda T., Shoji M., Arai H., Kawashima S., Saido T. C. Reduction of plasma glutamyl aminopeptidase activity in sporadic Alzheimer's disease A potential biochemical marker . Biochem. Biophys. Res. Commun. 231:1997;526-530.
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.231
, pp. 526-530
-
-
Kuda, T.1
Shoji, M.2
Arai, H.3
Kawashima, S.4
Saido, T.C.5
-
14
-
-
16044365171
-
The E280A Presenilin 1 mutation leads to a distinct Alzheimer's disease phenotype: Increased Aβ42 deposition and severe cerebellar pathology
-
Lemere, C. A.; Lopera, F.; Kosik, K. S.; Lendon, C. L.; Ossa, J.; Saido, T. C.; Yamaguchi, H.; Ruiz, A.; Martinez, A.; Madrigal, L.; Hincapie, L.; Arango, L., J. C.; Anthony, D. C.; Koo, E. H.; Goate, A. M.; Selkoe, D. J.; Arango V., J. C. The E280A Presenilin 1 mutation leads to a distinct Alzheimer's disease phenotype: Increased Aβ42 deposition and severe cerebellar pathology. Nature Med. 2:1146-1150; 1996.
-
(1996)
Nature Med.
, vol.2
, pp. 1146-1150
-
-
Lemere, C.A.1
Lopera, F.2
Kosik, K.S.3
Lendon, C.L.4
Ossa, J.5
Saido, T.C.6
Yamaguchi, H.7
Ruiz, A.8
Martinez, A.9
Madrigal, L.10
Hincapie, L.11
Arango, L.J.C.12
Anthony, D.C.13
Koo, E.H.14
Goate, A.M.15
Selkoe, D.J.16
Arango, V.J.C.17
-
15
-
-
0023861064
-
The site of the earliest lesions of Alzheimer's disease
-
Mann D. M. A., Esiri M. M. The site of the earliest lesions of Alzheimer's disease. N. Engl. J. Med. 318:1988;789-790.
-
(1988)
N. Engl. J. Med.
, vol.318
, pp. 789-790
-
-
Mann, D.M.A.1
Esiri, M.M.2
-
16
-
-
9444276544
-
Amyloid β protein (Aβ) deposition in chromosome 14-linked Alzheimer's disease: Predominance of Aβ42(43)
-
Mann D. M. A., Iwatsubo T., Cairns N. J., Lantos P. L., Nochlin D., Sumi S. M., Bird T. D., Poorkaj P., Hardy J., Hutton M., Prihar G., Crook R., Rossor M. N., Haltia M. Amyloid β protein (Aβ) deposition in chromosome 14-linked Alzheimer's disease Predominance of Aβ42(43) . Ann. Neurol. 40:1996;149-156.
-
(1996)
Ann. Neurol.
, vol.40
, pp. 149-156
-
-
Mann, D.M.A.1
Iwatsubo, T.2
Cairns, N.J.3
Lantos, P.L.4
Nochlin, D.5
Sumi, S.M.6
Bird, T.D.7
Poorkaj, P.8
Hardy, J.9
Hutton, M.10
Prihar, G.11
Crook, R.12
Rossor, M.N.13
Haltia, M.14
-
17
-
-
0029869667
-
Predominant deposition of amyloid-β42(43) in plaques in cases of Alzheimer's disease and hereditary cerebral hemorrhage associated with mutations in the amyloid precursor protein gene
-
Mann D. M. A., Iwatsubo T., Ihara Y., Cairns N. J., Lantos P. L., Bogdanovic N., Lannfelt L., Winbland B., Maat-Schieman M. L., Rossor M. N. Predominant deposition of amyloid-β42(43) in plaques in cases of Alzheimer's disease and hereditary cerebral hemorrhage associated with mutations in the amyloid precursor protein gene. Am. J. Pathol. 148:1996;1257-1266.
-
(1996)
Am. J. Pathol.
, vol.148
, pp. 1257-1266
-
-
Mann, D.M.A.1
Iwatsubo, T.2
Ihara, Y.3
Cairns, N.J.4
Lantos, P.L.5
Bogdanovic, N.6
Lannfelt, L.7
Winbland, B.8
Maat-Schieman, M.L.9
Rossor, M.N.10
-
20
-
-
0028055038
-
Down's syndrome: Up-regulation of β-amyloid protein precursor and τ mRNAs and their defective coordination
-
Oyama F., Cairns N. J., Shimada H., Oyama R., Titani K., Ihara Y. Down's syndrome up-regulation of β-amyloid protein precursor and τ mRNAs and their defective coordination . J. Neurochem. 62:1994;1062-1066.
-
(1994)
J. Neurochem.
, vol.62
, pp. 1062-1066
-
-
Oyama, F.1
Cairns, N.J.2
Shimada, H.3
Oyama, R.4
Titani, K.5
Ihara, Y.6
-
21
-
-
0028885682
-
Amino-terminal deletions enhance aggregation of β-amyloid peptides in vitro
-
Pike C. J., Overman M. J., Cotman C. W. Amino-terminal deletions enhance aggregation of β-amyloid peptides in vitro. J. Biol. Chem. 270:1995;23895-23898.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 23895-23898
-
-
Pike, C.J.1
Overman, M.J.2
Cotman, C.W.3
-
22
-
-
0027058880
-
Daily rhythm of aspartate aminopeptidase activity in the retina, pineal gland and occipital cortex of the rat
-
Ramirez M., Sanchez B., Arechaga G., Lardelli P., Garcia S., Ozaita A., de Gandarias J. M. Daily rhythm of aspartate aminopeptidase activity in the retina, pineal gland and occipital cortex of the rat. Neuroendocrinol. 56:1992;926-929.
-
(1992)
Neuroendocrinol.
, vol.56
, pp. 926-929
-
-
Ramirez, M.1
Sanchez, B.2
Arechaga, G.3
Lardelli, P.4
Garcia, S.5
Ozaita, A.6
De Gandarias, J.M.7
-
23
-
-
0029263312
-
Inflammation as a pathogenic mechanism in Alzheimer's disease
-
Rogers J. Inflammation as a pathogenic mechanism in Alzheimer's disease. Arzneimittel-Forschung/Drug Res. 45:1995;439-442.
-
(1995)
Arzneimittel-Forschung/Drug Res.
, vol.45
, pp. 439-442
-
-
Rogers, J.1
-
24
-
-
0030742712
-
Heterogeneity of water-soluble amyloid β-peptide in Alzheimer's disease and Down's syndrome brains
-
Russo C., Saido T. C., DeBusk L. M., Tabaton M., Gambetti P., Teller J. K. Heterogeneity of water-soluble amyloid β-peptide in Alzheimer's disease and Down's syndrome brains. FEBS Lett. 409:1997;411-416.
-
(1997)
FEBS Lett.
, vol.409
, pp. 411-416
-
-
Russo, C.1
Saido, T.C.2
Debusk, L.M.3
Tabaton, M.4
Gambetti, P.5
Teller, J.K.6
-
25
-
-
0028855851
-
N3(pE), in senile plaques
-
N3(pE), in senile plaques. Neuron. 14:1995;457-466.
-
(1995)
Neuron
, vol.14
, pp. 457-466
-
-
Saido, T.C.1
Iwatsubo, T.2
Mann, D.M.A.3
Shimada, H.4
Ihara, Y.5
Kawashima, S.6
-
26
-
-
0345141279
-
Aminopeptidase hypothesis for β-amyloid (Aβ)catabolism in brain
-
Saido T. C. Aminopeptidase hypothesis for β-amyloid (Aβ)catabolism in brain. Soc. Neurosci. 26:1996;1660.
-
(1996)
Soc. Neurosci.
, vol.26
, pp. 1660
-
-
Saido, T.C.1
-
27
-
-
0030582387
-
Amino- And carboxyl-terminal heterogeneity of β-amyloid peptides deposited in human brain
-
Saido T. C., Yamao-Harigaya W., Iwatsubo T., Kawashima S. Amino- and carboxyl-terminal heterogeneity of β-amyloid peptides deposited in human brain. Neurosci. Lett. 215:1996;173-176.
-
(1996)
Neurosci. Lett.
, vol.215
, pp. 173-176
-
-
Saido, T.C.1
Yamao-Harigaya, W.2
Iwatsubo, T.3
Kawashima, S.4
-
28
-
-
0344972635
-
Post-secretory catabolism of β-amyloid in brain
-
K. Iqbal, B. Winblad, T. Nishimura, M. Takeda, & H.M. Wisniewski. Chichester: John Wiley & Sons Ltd
-
Saido T. C., Yokota M., Tani E., Kawashima S. Post-secretory catabolism of β-amyloid in brain. Iqbal K., Winblad B., Nishimura T., Takeda M., Wisniewski H.M. Alzheimer's Disease Biology, Diagnosis and Therapeutics . 1997;339-348 John Wiley & Sons Ltd, Chichester.
-
(1997)
Alzheimer's Disease: Biology, Diagnosis and Therapeutics
, pp. 339-348
-
-
Saido, T.C.1
Yokota, M.2
Tani, E.3
Kawashima, S.4
-
29
-
-
16044373524
-
Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
Scheuner D., Eckman C., Jensen M., Song X., Citron M., Suzuki N., Bird T. D., Hardy J., Hutton M., Kukull W., Larson E., Levy-Lahad E., Viitanen M., Peskind E., Poorkaj P., Schellenberg G., Tanzi R., Wasco W., Lannfelt L., Selkoe D., Younkin S. Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nature Med. 2:1996;864-870.
-
(1996)
Nature Med.
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
Song, X.4
Citron, M.5
Suzuki, N.6
Bird, T.D.7
Hardy, J.8
Hutton, M.9
Kukull, W.10
Larson, E.11
Levy-Lahad, E.12
Viitanen, M.13
Peskind, E.14
Poorkaj, P.15
Schellenberg, G.16
Tanzi, R.17
Wasco, W.18
Lannfelt, L.19
Selkoe, D.20
Younkin, S.21
more..
-
30
-
-
0026760261
-
Production of the Alzheimer amyloid β protein by normal proteolytic processing
-
Shoji M., Golde T. E., Ghiso J., Cheung T. T., Estus S., Shaffer L. M., Cai X.-D., McKay D. M., Tintner R., Frangione B., Younkin S. G. Production of the Alzheimer amyloid β protein by normal proteolytic processing. Science. 258:1992;126-129.
-
(1992)
Science
, vol.258
, pp. 126-129
-
-
Shoji, M.1
Golde, T.E.2
Ghiso, J.3
Cheung, T.T.4
Estus, S.5
Shaffer, L.M.6
Cai, X.-D.7
McKay, D.M.8
Tintner, R.9
Frangione, B.10
Younkin, S.G.11
-
31
-
-
0028985799
-
Role of the β-amyloid in Alzheimer's disease
-
Sisodia S. S., Price D. L. Role of the β-amyloid in Alzheimer's disease. FASEB J. 9:1995;366-370.
-
(1995)
FASEB J.
, vol.9
, pp. 366-370
-
-
Sisodia, S.S.1
Price, D.L.2
-
32
-
-
0028322017
-
717) mutants
-
717) mutants. Science. 264:1994;1336-1340.
-
(1994)
Science
, vol.264
, pp. 1336-1340
-
-
Suzuki, N.1
Cheung, T.2
Cai, X.-D.3
Odaka, A.4
Otvos L., Jr.5
Eckman, C.6
Golde, T.E.7
Younkin, S.G.8
-
33
-
-
12644258498
-
The presenilin 2 mutation (N141I) linked to familial Alzheimer's disease (Volga German families) increases the secretion of amyloid β-protein ending at Aβ42(43)
-
Tomita, T.; Maruyama, K.; Saido, T. C.; Kume, H.; Shinozaki, K.; Tokuhiro, S.; Capell, A.; Walter, J.; Gruenberg, J.; Haass, C.; Iwatsubo, T.; Obata, K. The presenilin 2 mutation (N141I) linked to familial Alzheimer's disease (Volga German families) increases the secretion of amyloid β-protein ending at Aβ42(43). Proc. Natl. Acad. Sci. USA 94:2025-; 1997.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 2025
-
-
Tomita, T.1
Maruyama, K.2
Saido, T.C.3
Kume, H.4
Shinozaki, K.5
Tokuhiro, S.6
Capell, A.7
Walter, J.8
Gruenberg, J.9
Haass, C.10
Iwatsubo, T.11
Obata, K.12
-
34
-
-
0006232114
-
Prevalence of dementia in older Japanese-American Men in Hawaii, the Honolulu-Asia aging study
-
White L., Petrovitch H., Ross W., Masaki K. H., Abbott R. D., Teng E. L., Rodriguez B. L., Blanchette P. L., Havlik R. J., Wergowske G., Chiu D., Foley D. J., Murdaugh C., Curb D. J. Prevalence of dementia in older Japanese-American Men in Hawaii, the Honolulu-Asia aging study. J. Am. Med. Assoc. 276:1996;955-960.
-
(1996)
J. Am. Med. Assoc.
, vol.276
, pp. 955-960
-
-
White, L.1
Petrovitch, H.2
Ross, W.3
Masaki, K.H.4
Abbott, R.D.5
Teng, E.L.6
Rodriguez, B.L.7
Blanchette, P.L.8
Havlik, R.J.9
Wergowske, G.10
Chiu, D.11
Foley, D.J.12
Murdaugh, C.13
Curb, D.J.14
|