Tumour necrosis factor alpha-induced neuronal loss is mediated by microglial phagocytosis

FEBS Letters

Volumn 588, Issue 17, 2014, Pages 2952-2956

  Neniskyte, Urte ^a,b   Vilalta, Anna ^a   Brown, Guy C ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY EMBL   (Italy)

Author keywords

Lactadherin; Neurodegeneration; Neuroinflammation; Phagoptosis; Vitronectin receptor

Indexed keywords

OPSONIN; PURINERGIC P2Y6 RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; VITRONECTIN;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CELL ACTIVATION; CELL PROLIFERATION; COCULTURE; CONTROLLED STUDY; GLIA; MICROGLIA; MOUSE; NERVE CELL NECROSIS; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; RAT;

LACTADHERIN; NEURODEGENERATION; NEUROINFLAMMATION; PHAGOPTOSIS; VITRONECTIN RECEPTOR;

ANIMALS; EXTRACELLULAR SPACE; MICE; MICROGLIA; NEURONS; PHAGOCYTOSIS; RATS; SOLUBILITY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84906229172     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2014.05.046     Document Type: Article

References (33)

1. S. Allan, and N. Rothwell Cytokines and acute neurodegeneration Nat. Rev. Neurosci. 2 10 2001 734 744
2. N. Badiola, C. Malagelada, N. Llecha, J. Hidalgo, J.X. Comella, J. Sabria, and J. Rodriguez-Alvarez Activation of caspase-8 by tumour necrosis factor receptor 1 is necessary for caspase-3 activation and apoptosis in oxygen-glucose deprived cultured cortical cells Neurobiol. Dis. 35 3 2009 438 447
3. A. Bal-Price, and G. Brown Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity J. Neurosci. 21 17 2001 6480 6491
4. T. Barichello, I. dos Santos, G.D. Savi, A.F. Florentino, C. Silvestre, C.M. Comim, G. Feier, D. Sachs, M.M. Teixeira, A.L. Teixeira, and J. Quevedo Tumor necrosis factor alpha (TNF-alpha) levels in the brain and cerebrospinal fluid after meningitis induced by Streptococcus pneumoniae Neurosci. Lett. 467 2009 217 219
5. A.A. Beg, T.S. Finco, P.V. Nantermet, and A.S. Baldwin Jr. Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation Mol. Cell. Biol. 13 6 1993 3301 3310
6. G.C. Brown, and J.J. Neher Eaten alive! Cell death by primary phagocytosis: 'phagoptosis' Trends Biochem. Sci. 37 8 2012 325 332
7. G.C. Brown, and J.J. Neher Microglial phagocytosis of live neurons Nat. Rev. Neurosci 15 4 2014 209 216
8. I.A. Clark, L.M. Alleva, and B. Vissel The roles of TNF in brain dysfunction and disease Pharmacol. Ther. 128 3 2010 519 548
9. C.K. Combs, J.C. Karlo, S.C. Kao, and G.E. Landreth beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis J. Neurosci. 21 4 2001 1179 1188
10. A.L. De Lella Ezcurra, M. Chertoff, C. Ferrari, M. Graciarena, and F. Pitossi Chronic expression of low levels of tumor necrosis factor-alpha in the substantia nigra elicits progressive neurodegeneration, delayed motor symptoms and microglia/macrophage activation Neurobiol. Dis. 37 3 2010 630 640
11. J.M. Dopp, A. Mackenzie-Graham, G.C. Otero, and J.E. Merrill Differential expression, cytokine modulation, and specific functions of type-1 and type-2 tumor necrosis factor receptors in rat glia J. Neuroimmunol. 75 1-2 1997 104 112
12. M. Fricker, J.J. Neher, J.W. Zhao, C. Théry, A.M. Tolkovsky, and G.C. Brown MFG-E8 mediates primary phagocytosis of viable neurons during neuroinflammation J. Neurosci. 32 8 2012 2657 2666
13. 2 derived from NADPH oxidase: a cell culture study J. Neuroinflammation 3 2006 24
14. K.A. Kigerl, D.P. Ankeny, S.K. Garg, P. Wei, Z. Guan, W. Lai, D.M. McTigue, R. Banerjee, and P.G. Popovich System xc - regulates microglia and macrophage glutamate excitotoxicity in vivo Exp. Neurol. 233 2012 333 341
15. A. Kinsner, M. Boveri, L. Hareng, G. Brown, S. Coecke, T. Hartung, and A. Bal-Price Highly purified lipoteichoic acid induced pro-inflammatory signalling in primary culture of rat microglia through Toll-like receptor 2: selective potentiation of nitric oxide production by muramyl dipeptide J. Neurochem. 99 2 2006 596 607
16. A. Kinsner, V. Pilotto, S. Deininger, G. Brown, S. Coecke, T. Hartung, and A. Bal-Price Inflammatory neurodegeneration induced by lipoteichoic acid from Staphylococcus aureus is mediated by glia activation, nitrosative and oxidative stress, and caspase activation J. Neurochem. 95 4 2005 1132 1143
17. S. Koizumi, Y. Shigemoto-Mogami, K. Nasu-Tada, Y. Shinozaki, K. Ohsawa, M. Tsuda, B. Joshi, K. Jacobson, S. Kohsaka, and K. Inoue UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis Nature 446 7139 2007 1091 1095
18. M. Lotz, S. Ebert, H. Esselmann, A.I. Iliev, M. Prinz, N. Wiazewicz, J. Wiltfang, J. Gerber, and R. Nau Amyloid beta peptide 1-40 enhances the action of Toll-like receptor-2 and -4 agonists but antagonizes Toll-like receptor-9-induced inflammation in primary mouse microglial cell cultures J. Neurochem. 94 2 2005 289 298
19. P. Mander, and G. Brown Activation of microglial NADPH oxidase is synergistic with glial iNOS expression in inducing neuronal death: a dual-key mechanism of inflammatory neurodegeneration J. Neuroinflammation 2 2005 20
20. P. Mander, A. Jekabsone, and G. Brown Microglia proliferation is regulated by hydrogen peroxide from NADPH oxidase J. Immunol. 176 2 2006 1046 1052
21. R. Medeiros, and F.M. LaFerla Astrocytes: conductors of the Alzheimer disease neuroinflammatory symphony Exp. Neurol. 239 2013 133 138
22. S.L. Montgomery, and W.J. Bowers Tumor necrosis factor-alpha and the roles it plays in homeostatic and degenerative processes within the central nervous system J. Neuroimmune Pharmacol. 7 1 2012 42 59
23. J.J. Neher, U. Neniskyte, J.W. Zhao, A. Bal-Price, A.M. Tolkovsky, and G.C. Brown Inhibition of microglial phagocytosis is sufficient to prevent inflammatory neuronal death J. Immunol. 186 8 2011 4973 4983
24. J.J. Neher, J.V. Emmrich, M. Fricker, P.K. Mander, C. Thery, and G.C. Brown Phagocytosis executes delayed neuronal death after focal brain ischemia Proc. Natl. Acad. Sci. U.S.A. 110 43 2013 E4098 4107
25. 6 purinergic signaling prevents phagocytosis of viable neurons by activated microglia in vitro and in vivo. Glia.
26. U. Neniskyte, and G.C. Brown Lactadherin/MFG-E8 is essential for microglia-mediated neuronal loss and phagoptosis induced by amyloid beta J. Neurochem. 126 3 2013 312 317
27. U. Neniskyte, J.J. Neher, and G.C. Brown Neuronal death induced by nanomolar amyloid β is mediated by primary phagocytosis of neurons by microglia J. Biol. Chem. 286 46 2011 39904 39913
28. K.S. Ravichandran, and U. Lorenz Engulfment of apoptotic cells: signals for a good meal Nat. Rev. Immunol. 7 12 2007 964 974
29. M. Santello, and A. Volterra TNFalpha in synaptic function: switching gears Trends Neurosci. 35 10 2012 638 647
30. J.S. Silvestre, C. Théry, G. Hamard, J. Boddaert, B. Aguilar, A. Delcayre, C. Houbron, R. Tamarat, O. Blanc-Brude, S. Heeneman, M. Clergue, M. Duriez, R. Merval, B. Lévy, A. Tedgui, S. Amigorena, and Z. Mallat Lactadherin promotes VEGF-dependent neovascularization Nat. Med. 11 5 2005 499 506
31. J.A. Smith, A. Das, S.K. Ray, and N.L. Banik Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases Brain Res. Bull. 87 1 2012 10 20
32. E. Tarkowski, A. Wallin, K. Blennow, and A. Tarkowski Local production of TNF-α, a potent neuroprotective agent, in Alzheimer disease and vascular dementia J. Clin. Immunol. 19 1999 223 230
33. S. Walter, M. Letiembre, Y. Liu, H. Heine, B. Penke, W. Hao, B. Bode, N. Manietta, J. Walter, W. Schulz-Schuffer, and K. Fassbender Role of the toll-like receptor 4 in neuroinflammation in Alzheimer's disease Cell. Physiol. Biochem. 20 6 2007 947 956