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Volumn 8, Issue MAR, 2017, Pages

The P2X7 receptor-interleukin-1 liaison

Author keywords

Caspase 1; Inflammation; Interleukin 1 ; NLRP3 inflammasome; P2X7 receptor

Indexed keywords

CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1; INTERLEUKIN 1BETA; PURINERGIC P2X7 RECEPTOR;

EID: 85016152268     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2017.00123     Document Type: Review
Times cited : (146)

References (124)
  • 1
    • 84919385996 scopus 로고    scopus 로고
    • Dendritic cell IL-1alpha and IL-1beta are polyubiquitinated and degraded by the proteasome
    • Ainscough, J. S., Frank Gerberick, G., Zahedi-Nejad, M., Lopez-Castejon, G., Brough, D., Kimber, I., et al. (2014). Dendritic cell IL-1alpha and IL-1beta are polyubiquitinated and degraded by the proteasome. J. Biol. Chem. 289, 35582-35592. doi: 10.1074/jbc.M114.595686
    • (2014) J. Biol. Chem , vol.289 , pp. 35582-35592
    • Ainscough, J.S.1    Frank Gerberick, G.2    Zahedi-Nejad, M.3    Lopez-Castejon, G.4    Brough, D.5    Kimber, I.6
  • 3
    • 0032923377 scopus 로고    scopus 로고
    • The secretory route of the leaderless protein interleukin 1beta involves exocytosis of endolysosome-related vesicles
    • Andrei, C., Dazzi, C., Lotti, L., Torrisi, M. R., Chimini, G., and Rubartelli, A. (1999). The secretory route of the leaderless protein interleukin 1beta involves exocytosis of endolysosome-related vesicles. Mol. Biol. Cell 10, 1463-1475. doi: 10.1091/mbc.10.5.1463
    • (1999) Mol. Biol. Cell , vol.10 , pp. 1463-1475
    • Andrei, C.1    Dazzi, C.2    Lotti, L.3    Torrisi, M.R.4    Chimini, G.5    Rubartelli, A.6
  • 4
    • 3042800587 scopus 로고    scopus 로고
    • Phospholipases C and A2 control lysosome-mediated IL-1 beta secretion: implications for inflammatory processes
    • Andrei, C., Margiocco, P., Poggi, A., Lotti, L. V., Torrisi, M. R., and Rubartelli, A. (2004). Phospholipases C and A2 control lysosome-mediated IL-1 beta secretion: implications for inflammatory processes. Proc. Natl. Acad. Sci. U.S.A. 101, 9745-9750. doi: 10.1073/pnas.0308558101
    • (2004) Proc. Natl. Acad. Sci. U.S.A , vol.101 , pp. 9745-9750
    • Andrei, C.1    Margiocco, P.2    Poggi, A.3    Lotti, L.V.4    Torrisi, M.R.5    Rubartelli, A.6
  • 5
    • 84857998516 scopus 로고    scopus 로고
    • Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism
    • Antonucci, F., Turola, E., Riganti, L., Caleo, M., Gabrielli, M., Perrotta, C., et al. (2012). Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism. EMBO J. 31, 1231-1240. doi: 10.1038/emboj.2011.489
    • (2012) EMBO J , vol.31 , pp. 1231-1240
    • Antonucci, F.1    Turola, E.2    Riganti, L.3    Caleo, M.4    Gabrielli, M.5    Perrotta, C.6
  • 6
    • 84870055576 scopus 로고    scopus 로고
    • The participation of plasma membrane hemichannels to purinergic signaling
    • Baroja-Mazo, A., Barbera-Cremades, M., and Pelegrin, P. (2013). The participation of plasma membrane hemichannels to purinergic signaling. Biochim. Biophys. Acta 1828, 79-93. doi: 10.1016/j.bbamem.2012.01.002
    • (2013) Biochim. Biophys. Acta , vol.1828 , pp. 79-93
    • Baroja-Mazo, A.1    Barbera-Cremades, M.2    Pelegrin, P.3
  • 7
    • 84908232996 scopus 로고    scopus 로고
    • The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease
    • Bartlett, R., Stokes, L., and Sluyter, R. (2014). The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease. Pharmacol. Rev. 66, 638-675. doi: 10.1124/pr.113.008003
    • (2014) Pharmacol. Rev , vol.66 , pp. 638-675
    • Bartlett, R.1    Stokes, L.2    Sluyter, R.3
  • 8
    • 0000302792 scopus 로고
    • Temperature-elevating effect of a substance obtained from polymorphonuclear leucocytes
    • Beeson, P. B. (1948). Temperature-elevating effect of a substance obtained from polymorphonuclear leucocytes. J. Clin. Invest. 27, 524.
    • (1948) J. Clin. Invest , vol.27 , pp. 524
    • Beeson, P.B.1
  • 9
    • 51849103168 scopus 로고    scopus 로고
    • The microbial and danger signals that activate Nod-like receptors
    • Benko, S., Philpott, D. J., and Girardin, S. E. (2008). The microbial and danger signals that activate Nod-like receptors. Cytokine 43, 368-373. doi: 10.1016/j.cyto.2008.07.013
    • (2008) Cytokine , vol.43 , pp. 368-373
    • Benko, S.1    Philpott, D.J.2    Girardin, S.E.3
  • 10
    • 58449083290 scopus 로고    scopus 로고
    • Pyroptosis: host cell death and inflammation
    • Bergsbaken, T., Fink, S. L., and Cookson, B. T. (2009). Pyroptosis: host cell death and inflammation. Nat. Rev. Microbiol. 7, 99-109. doi: 10.1038/nrmicro2070
    • (2009) Nat. Rev. Microbiol , vol.7 , pp. 99-109
    • Bergsbaken, T.1    Fink, S.L.2    Cookson, B.T.3
  • 11
    • 67349114201 scopus 로고    scopus 로고
    • Acid sphingomyelinase activity triggers microparticle release from glial cells
    • Bianco, F., Perrotta, C., Novellino, L., Francolini, M., Riganti, L., Menna, E., et al. (2009). Acid sphingomyelinase activity triggers microparticle release from glial cells. EMBO J. 28, 1043-1054. doi: 10.1038/emboj.2009.45
    • (2009) EMBO J , vol.28 , pp. 1043-1054
    • Bianco, F.1    Perrotta, C.2    Novellino, L.3    Francolini, M.4    Riganti, L.5    Menna, E.6
  • 12
    • 18944380607 scopus 로고    scopus 로고
    • Astrocyte-derived ATP induces vesicle shedding and IL-1 beta release from microglia
    • Bianco, F., Pravettoni, E., Colombo, A., Schenk, U., Moller, T., Matteoli, M., et al. (2005). Astrocyte-derived ATP induces vesicle shedding and IL-1 beta release from microglia. J. Immunol. 174, 7268-7277. doi: 10.4049/jimmunol.174.11.7268
    • (2005) J. Immunol , vol.174 , pp. 7268-7277
    • Bianco, F.1    Pravettoni, E.2    Colombo, A.3    Schenk, U.4    Moller, T.5    Matteoli, M.6
  • 14
    • 0014192623 scopus 로고
    • Release of endogenous pyrogen by human monocytes
    • Bodel, P., and Atkins, E. (1967). Release of endogenous pyrogen by human monocytes. N. Engl. J. Med. 276, 1002-1008. doi: 10.1056/NEJM196705042761803
    • (1967) N. Engl. J. Med , vol.276 , pp. 1002-1008
    • Bodel, P.1    Atkins, E.2
  • 15
    • 84961801288 scopus 로고    scopus 로고
    • The IL-1 cytokine family and its role in inflammation and fibrosis in the lung
    • Borthwick, L. A. (2016). The IL-1 cytokine family and its role in inflammation and fibrosis in the lung. Semin. Immunopathol. 38, 517-534. doi: 10.1007/s00281-016-0559-z
    • (2016) Semin. Immunopathol , vol.38 , pp. 517-534
    • Borthwick, L.A.1
  • 16
    • 33749261659 scopus 로고    scopus 로고
    • Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation
    • Bours, M. J., Swennen, E. L., Di Virgilio, F., Cronstein, B. N., and Dagnelie, P. C. (2006). Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol. Ther. 112, 358-404. doi: 10.1016/j.pharmthera.2005.04.013
    • (2006) Pharmacol. Ther , vol.112 , pp. 358-404
    • Bours, M.J.1    Swennen, E.L.2    Di Virgilio, F.3    Cronstein, B.N.4    Dagnelie, P.C.5
  • 17
    • 0037443542 scopus 로고    scopus 로고
    • Ca2+ stores and Ca2+ entry differentially contribute to the release of IL-1 beta and IL-1 alpha from murine macrophages
    • Brough, D., Le Feuvre, R. A., Wheeler, R. D., Solovyova, N., Hilfiker, S., Rothwell, N. J., et al. (2003). Ca2+ stores and Ca2+ entry differentially contribute to the release of IL-1 beta and IL-1 alpha from murine macrophages. J. Immunol. 170, 3029-3036. doi: 10.4049/jimmunol.170.6.3029
    • (2003) J. Immunol , vol.170 , pp. 3029-3036
    • Brough, D.1    Le Feuvre, R.A.2    Wheeler, R.D.3    Solovyova, N.4    Hilfiker, S.5    Rothwell, N.J.6
  • 18
    • 84976516826 scopus 로고    scopus 로고
    • Inflammasomes: mechanism of assembly, regulation and signalling
    • Broz, P., and Dixit, V. M. (2016). Inflammasomes: mechanism of assembly, regulation and signalling. Nat. Rev. Immunol. 16, 407-420. doi: 10.1038/nri.2016.58
    • (2016) Nat. Rev. Immunol , vol.16 , pp. 407-420
    • Broz, P.1    Dixit, V.M.2
  • 19
    • 0035189834 scopus 로고    scopus 로고
    • Electrodiffusional ATP movement through CFTR and other ABC transporters
    • Cantiello, H. F. (2001). Electrodiffusional ATP movement through CFTR and other ABC transporters. Pflugers. Arch. 443(Suppl. 1), S22-S27. doi: 10.1007/s004240100639
    • (2001) Pflugers. Arch , vol.443 , pp. S22-S27
    • Cantiello, H.F.1
  • 20
    • 33748135979 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors prevent exocytosis of interleukin-1beta-containing secretory lysosomes: role of microtubules
    • Carta, S., Tassi, S., Semino, C., Fossati, G., Mascagni, P., Dinarello, C. A., et al. (2006). Histone deacetylase inhibitors prevent exocytosis of interleukin-1beta-containing secretory lysosomes: role of microtubules. Blood 108, 1618-1626. doi: 10.1182/blood-2006-03-014126
    • (2006) Blood , vol.108 , pp. 1618-1626
    • Carta, S.1    Tassi, S.2    Semino, C.3    Fossati, G.4    Mascagni, P.5    Dinarello, C.A.6
  • 21
    • 84959559428 scopus 로고    scopus 로고
    • Purinergic regulation of the immune system
    • Cekic, C., and Linden, J. (2016). Purinergic regulation of the immune system. Nat. Rev. Immunol. 16, 177-192. doi: 10.1038/nri.2016.4
    • (2016) Nat. Rev. Immunol , vol.16 , pp. 177-192
    • Cekic, C.1    Linden, J.2
  • 22
    • 84930982265 scopus 로고    scopus 로고
    • ATP release through pannexon channels
    • Dahl, G. (2015). ATP release through pannexon channels. Philos. Trans. R. Soc. Lond. B Biol. Sci. 370:20140191. doi: 10.1098/rstb.2014.0191
    • (2015) Philos. Trans. R. Soc. Lond. B Biol. Sci , vol.370
    • Dahl, G.1
  • 24
    • 0028850665 scopus 로고
    • The P2Z purinoceptor: an intriguing role in immunity, inflammation and cell death
    • Di Virgilio, F. (1995). The P2Z purinoceptor: an intriguing role in immunity, inflammation and cell death. Immunol. Today 16, 524-528. doi: 10.1016/0167-5699(95)80045-X
    • (1995) Immunol. Today , vol.16 , pp. 524-528
    • Di Virgilio, F.1
  • 25
    • 0034601273 scopus 로고    scopus 로고
    • Dr. Jekyll/Mr. Hyde: the dual role of extracellular ATP
    • Di Virgilio, F. (2000). Dr. Jekyll/Mr. Hyde: the dual role of extracellular ATP. J. Auton. Nerv. Syst. 81, 59-63. doi: 10.1016/S0165-1838(00)00114-4
    • (2000) J. Auton. Nerv. Syst , vol.81 , pp. 59-63
    • Di Virgilio, F.1
  • 26
    • 84876350807 scopus 로고    scopus 로고
    • The therapeutic potential of modifying inflammasomes and NOD-like receptors
    • Di Virgilio, F. (2013). The therapeutic potential of modifying inflammasomes and NOD-like receptors. Pharmacol. Rev. 65, 872-905. doi: 10.1124/pr.112.006171
    • (2013) Pharmacol. Rev , vol.65 , pp. 872-905
    • Di Virgilio, F.1
  • 27
    • 84926471604 scopus 로고    scopus 로고
    • P2X receptors and inflammation
    • Di Virgilio, F. (2015). P2X receptors and inflammation. Curr. Med. Chem. 22, 866-877. doi: 10.2174/0929867322666141210155311
    • (2015) Curr. Med. Chem , vol.22 , pp. 866-877
    • Di Virgilio, F.1
  • 30
    • 0029979369 scopus 로고    scopus 로고
    • Biologic basis for interleukin-1 in disease
    • Dinarello, C. A. (1996). Biologic basis for interleukin-1 in disease. Blood 87, 2095-2147.
    • (1996) Blood , vol.87 , pp. 2095-2147
    • Dinarello, C.A.1
  • 31
    • 18644374105 scopus 로고    scopus 로고
    • Blocking IL-1 in systemic inflammation
    • Dinarello, C. A. (2005). Blocking IL-1 in systemic inflammation. J. Exp. Med. 201, 1355-1359. doi: 10.1084/jem.20050640
    • (2005) J. Exp. Med , vol.201 , pp. 1355-1359
    • Dinarello, C.A.1
  • 32
    • 79953813107 scopus 로고    scopus 로고
    • Interleukin-1 in the pathogenesis and treatment of inflammatory diseases
    • Dinarello, C. A. (2011). Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood 117, 3720-3732. doi: 10.1182/blood-2010-07-273417
    • (2011) Blood , vol.117 , pp. 3720-3732
    • Dinarello, C.A.1
  • 33
    • 0019863205 scopus 로고
    • Ability of human leukocytic pyrogen to stimulate brain prostaglandin synthesis in vitro
    • Dinarello, C. A., and Bernheim, H. A. (1981). Ability of human leukocytic pyrogen to stimulate brain prostaglandin synthesis in vitro. J. Neurochem. 37, 702-708. doi: 10.1111/j.1471-4159.1982.tb12544.x
    • (1981) J. Neurochem , vol.37 , pp. 702-708
    • Dinarello, C.A.1    Bernheim, H.A.2
  • 34
    • 36349004825 scopus 로고    scopus 로고
    • Go it alone no more-P2X7 joins the society of heteromeric ATP-gated receptor channels
    • Dubyak, G. R. (2007). Go it alone no more-P2X7 joins the society of heteromeric ATP-gated receptor channels. Mol. Pharmacol. 72, 1402-1405. doi: 10.1124/mol.107.042077
    • (2007) Mol. Pharmacol , vol.72 , pp. 1402-1405
    • Dubyak, G.R.1
  • 35
    • 84867652682 scopus 로고    scopus 로고
    • P2X7 receptor regulation of non-classical secretion from immune effector cells
    • Dubyak, G. R. (2012). P2X7 receptor regulation of non-classical secretion from immune effector cells. Cell Microbiol. 14, 1697-1706. doi: 10.1111/cmi.12001
    • (2012) Cell Microbiol , vol.14 , pp. 1697-1706
    • Dubyak, G.R.1
  • 36
    • 68649102975 scopus 로고    scopus 로고
    • Mechanisms of interleukin-1beta release
    • Eder, C. (2009). Mechanisms of interleukin-1beta release. Immunobiology 214, 543-553. doi: 10.1016/j.imbio.2008.11.007
    • (2009) Immunobiology , vol.214 , pp. 543-553
    • Eder, C.1
  • 37
    • 84871048026 scopus 로고    scopus 로고
    • Purinergic signaling during inflammation
    • Eltzschig, H. K., Sitkovsky, M. V., and Robson, S. C. (2012). Purinergic signaling during inflammation. N. Engl. J. Med. 367, 2322-2333. doi: 10.1056/NEJMra1205750
    • (2012) N. Engl. J. Med , vol.367 , pp. 2322-2333
    • Eltzschig, H.K.1    Sitkovsky, M.V.2    Robson, S.C.3
  • 38
    • 33745528139 scopus 로고    scopus 로고
    • The gap junction cellular internet: connexin hemichannels enter the signalling limelight
    • Evans, W. H., De Vuyst, E., and Leybaert, L. (2006). The gap junction cellular internet: connexin hemichannels enter the signalling limelight. Biochem. J. 397, 1-14. doi: 10.1042/BJ20060175
    • (2006) Biochem. J , vol.397 , pp. 1-14
    • Evans, W.H.1    De Vuyst, E.2    Leybaert, L.3
  • 39
    • 84934917374 scopus 로고    scopus 로고
    • Toll-like receptors 2,-3 and-4 prime microglia but not astrocytes across central nervous system regions for ATP-dependent interleukin-1beta release
    • Facci, L., Barbierato, M., Marinelli, C., Argentini, C., Skaper, S. D., and Giusti, P. (2014). Toll-like receptors 2,-3 and-4 prime microglia but not astrocytes across central nervous system regions for ATP-dependent interleukin-1beta release. Sci. Rep. 4:6824. doi: 10.1038/srep06824
    • (2014) Sci. Rep , vol.4 , pp. 6824
    • Facci, L.1    Barbierato, M.2    Marinelli, C.3    Argentini, C.4    Skaper, S.D.5    Giusti, P.6
  • 40
    • 0031568401 scopus 로고    scopus 로고
    • Response to local inflammation of IL-1 beta-converting enzyme-deficient mice
    • Fantuzzi, G., Ku, G., Harding, M. W., Livingston, D. J., Sipe, J. D., Kuida, K., et al. (1997). Response to local inflammation of IL-1 beta-converting enzyme-deficient mice. J. Immunol. 158, 1818-1824.
    • (1997) J. Immunol , vol.158 , pp. 1818-1824
    • Fantuzzi, G.1    Ku, G.2    Harding, M.W.3    Livingston, D.J.4    Sipe, J.D.5    Kuida, K.6
  • 41
    • 0031201476 scopus 로고    scopus 로고
    • Extracellular ATP triggers IL-1 beta release by activating the purinergic P2Z receptor of human macrophages
    • Ferrari, D., Chiozzi, P., Falzoni, S., Dal Susino, M., Melchiorri, L., Baricordi, O. R., et al. (1997). Extracellular ATP triggers IL-1 beta release by activating the purinergic P2Z receptor of human macrophages. J. Immunol. 159, 1451-1458.
    • (1997) J. Immunol , vol.159 , pp. 1451-1458
    • Ferrari, D.1    Chiozzi, P.2    Falzoni, S.3    Dal Susino, M.4    Melchiorri, L.5    Baricordi, O.R.6
  • 42
    • 33646072818 scopus 로고    scopus 로고
    • The P2X7 receptor: a key player in IL-1 processing and release
    • Ferrari, D., Pizzirani, C., Adinolfi, E., Lemoli, R. M., Curti, A., Idzko, M., et al. (2006). The P2X7 receptor: a key player in IL-1 processing and release. J. Immunol. 176, 3877-3883. doi: 10.4049/jimmunol.176.7.3877
    • (2006) J. Immunol , vol.176 , pp. 3877-3883
    • Ferrari, D.1    Pizzirani, C.2    Adinolfi, E.3    Lemoli, R.M.4    Curti, A.5    Idzko, M.6
  • 44
    • 84933557676 scopus 로고    scopus 로고
    • The P2X7 receptor directly interacts with the NLRP3 inflammasome scaffold protein
    • Franceschini, A., Capece, M., Chiozzi, P., Falzoni, S., Sanz, J. M., Sarti, A. C., et al. (2015). The P2X7 receptor directly interacts with the NLRP3 inflammasome scaffold protein. FASEB J. 29, 2450-2461. doi: 10.1096/fj.14-268714
    • (2015) FASEB J , vol.29 , pp. 2450-2461
    • Franceschini, A.1    Capece, M.2    Chiozzi, P.3    Falzoni, S.4    Sanz, J.M.5    Sarti, A.C.6
  • 45
    • 77950627242 scopus 로고    scopus 로고
    • IL-1 pathways in inflammation and human diseases
    • Gabay, C., Lamacchia, C., and Palmer, G. (2010). IL-1 pathways in inflammation and human diseases. Nat. Rev. Rheumatol. 6, 232-241. doi: 10.1038/nrrheum.2010.4
    • (2010) Nat. Rev. Rheumatol , vol.6 , pp. 232-241
    • Gabay, C.1    Lamacchia, C.2    Palmer, G.3
  • 46
    • 0032695108 scopus 로고    scopus 로고
    • Natural adjuvants: endogenous activators of dendritic cells
    • Gallucci, S., Lolkema, M., and Matzinger, P. (1999). Natural adjuvants: endogenous activators of dendritic cells. Nat. Med. 5, 1249-1255. doi: 10.1038/15200
    • (1999) Nat. Med , vol.5 , pp. 1249-1255
    • Gallucci, S.1    Lolkema, M.2    Matzinger, P.3
  • 47
    • 84890235827 scopus 로고    scopus 로고
    • The interleukin-1 family: back to the future
    • Garlanda, C., Dinarello, C. A., and Mantovani, A. (2013). The interleukin-1 family: back to the future. Immunity 39, 1003-1018. doi: 10.1016/j.immuni.2013.11.010
    • (2013) Immunity , vol.39 , pp. 1003-1018
    • Garlanda, C.1    Dinarello, C.A.2    Mantovani, A.3
  • 48
    • 0015365707 scopus 로고
    • Potentiation of the T-lymphocyte response to mitogens. II. The cellular source of potentiating mediator(s)
    • Gery, I., and Waksman, B. H. (1972). Potentiation of the T-lymphocyte response to mitogens. II. The cellular source of potentiating mediator(s). J. Exp. Med. 136, 143-155. doi: 10.1084/jem.136.1.143
    • (1972) J. Exp. Med , vol.136 , pp. 143-155
    • Gery, I.1    Waksman, B.H.2
  • 50
    • 84926436169 scopus 로고    scopus 로고
    • Purinergic P2X receptors: structural and functional features depicted by X-ray and molecular modelling studies
    • Grimes, L., and Young, M. T. (2015). Purinergic P2X receptors: structural and functional features depicted by X-ray and molecular modelling studies. Curr. Med. Chem. 22, 783-798. doi: 10.2174/0929867321999141212131457
    • (2015) Curr. Med. Chem , vol.22 , pp. 783-798
    • Grimes, L.1    Young, M.T.2
  • 51
    • 0042242912 scopus 로고    scopus 로고
    • Essential role for Ca2+ in regulation of IL-1beta secretion by P2X7 nucleotide receptor in monocytes, macrophages, and HEK-293 cells
    • Gudipaty, L., Munetz, J., Verhoef, P. A., and Dubyak, G. R. (2003). Essential role for Ca2+ in regulation of IL-1beta secretion by P2X7 nucleotide receptor in monocytes, macrophages, and HEK-293 cells. Am. J. Physiol. Cell Physiol. 285, C286-C299. doi: 10.1152/ajpcell.00070.2003
    • (2003) Am. J. Physiol. Cell Physiol , vol.285 , pp. C286-C299
    • Gudipaty, L.1    Munetz, J.2    Verhoef, P.A.3    Dubyak, G.R.4
  • 52
    • 84936891896 scopus 로고    scopus 로고
    • Inflammasomes: mechanism of action, role in disease, and therapeutics
    • Guo, H., Callaway, J. B., and Ting, J. P. (2015). Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat. Med. 21, 677-687. doi: 10.1038/nm.3893
    • (2015) Nat. Med , vol.21 , pp. 677-687
    • Guo, H.1    Callaway, J.B.2    Ting, J.P.3
  • 53
    • 84937690389 scopus 로고    scopus 로고
    • Barrier epithelial cells and the control of type 2 immunity
    • Hammad, H., and Lambrecht, B. N. (2015). Barrier epithelial cells and the control of type 2 immunity. Immunity 43, 29-40. doi: 10.1016/j.immuni.2015.07.007
    • (2015) Immunity , vol.43 , pp. 29-40
    • Hammad, H.1    Lambrecht, B.N.2
  • 54
    • 84860785529 scopus 로고    scopus 로고
    • Molecular mechanism of ATP binding and ion channel activation in P2X receptors
    • Hattori, M., and Gouaux, E. (2012). Molecular mechanism of ATP binding and ion channel activation in P2X receptors. Nature 485, 207-212. doi: 10.1038/nature11010
    • (2012) Nature , vol.485 , pp. 207-212
    • Hattori, M.1    Gouaux, E.2
  • 55
    • 0022596285 scopus 로고
    • Intracellular epidermal interleukin 1-like factors in the human epidermoid carcinoma cell line A431
    • Hauser, C., Dayer, J. M., Jaunin, F., de Rochemonteix, B., and Saurat, J. H. (1986). Intracellular epidermal interleukin 1-like factors in the human epidermoid carcinoma cell line A431. Cell Immunol. 100, 89-96. doi: 10.1016/0008-8749(86)90009-2
    • (1986) Cell Immunol , vol.100 , pp. 89-96
    • Hauser, C.1    Dayer, J.M.2    Jaunin, F.3    de Rochemonteix, B.4    Saurat, J.H.5
  • 56
    • 84949091051 scopus 로고    scopus 로고
    • Gasdermin D is an executor of pyroptosis and required for interleukin-1beta secretion
    • He, W. T., Wan, H., Hu, L., Chen, P., Wang, X., Huang, Z., et al. (2015). Gasdermin D is an executor of pyroptosis and required for interleukin-1beta secretion. Cell Res. 25, 1285-1298. doi: 10.1038/cr.2015.139
    • (2015) Cell Res , vol.25 , pp. 1285-1298
    • He, W.T.1    Wan, H.2    Hu, L.3    Chen, P.4    Wang, X.5    Huang, Z.6
  • 57
    • 84995751273 scopus 로고    scopus 로고
    • Mechanism and regulation of NLRP3 inflammasome activation
    • He, Y., Hara, H., and Nunez, G. (2016a). Mechanism and regulation of NLRP3 inflammasome activation. Trends Biochem. Sci. 41, 1012-1021. doi: 10.1016/j.tibs.2016.09.002
    • (2016) Trends Biochem. Sci , vol.41 , pp. 1012-1021
    • He, Y.1    Hara, H.2    Nunez, G.3
  • 58
    • 84958971929 scopus 로고    scopus 로고
    • NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux
    • He, Y., Zeng, M. Y., Yang, D., Motro, B., and Nunez, G. (2016b). NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux. Nature 530, 354-357. doi: 10.1038/nature16959
    • (2016) Nature , vol.530 , pp. 354-357
    • He, Y.1    Zeng, M.Y.2    Yang, D.3    Motro, B.4    Nunez, G.5
  • 59
    • 84887446052 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species induces NLRP3-dependent lysosomal damage and inflammasome activation
    • Heid, M. E., Keyel, P. A., Kamga, C., Shiva, S., Watkins, S. C., and Salter, R. D. (2013). Mitochondrial reactive oxygen species induces NLRP3-dependent lysosomal damage and inflammasome activation. J. Immunol. 191, 5230-5238. doi: 10.4049/jimmunol.1301490
    • (2013) J. Immunol , vol.191 , pp. 5230-5238
    • Heid, M.E.1    Keyel, P.A.2    Kamga, C.3    Shiva, S.4    Watkins, S.C.5    Salter, R.D.6
  • 61
    • 84900530332 scopus 로고    scopus 로고
    • Nucleotide signalling during inflammation
    • Idzko, M., Ferrari, D., and Eltzschig, H. K. (2014). Nucleotide signalling during inflammation. Nature 509, 310-317. doi: 10.1038/nature13085
    • (2014) Nature , vol.509 , pp. 310-317
    • Idzko, M.1    Ferrari, D.2    Eltzschig, H.K.3
  • 62
    • 84951309922 scopus 로고    scopus 로고
    • Medicinal chemistry of adenosine, P2Y and P2X receptors
    • Jacobson, K. A., and Muller, C. E. (2016). Medicinal chemistry of adenosine, P2Y and P2X receptors. Neuropharmacology 104, 31-49. doi: 10.1016/j.neuropharm.2015.12.001
    • (2016) Neuropharmacology , vol.104 , pp. 31-49
    • Jacobson, K.A.1    Muller, C.E.2
  • 63
    • 0035912764 scopus 로고    scopus 로고
    • How the immune system works to protect the host from infection: a personal view
    • Janeway, C. A. Jr. (2001). How the immune system works to protect the host from infection: a personal view. Proc. Natl. Acad. Sci. U.S.A. 98, 7461-7468. doi: 10.1073/pnas.131202998
    • (2001) Proc. Natl. Acad. Sci. U.S.A , vol.98 , pp. 7461-7468
    • Janeway, C.A.1
  • 64
    • 84881489108 scopus 로고    scopus 로고
    • Insights into the molecular mechanisms underlying Mammalian P2X7 receptor functions and contributions in diseases, revealed by structural modeling and single nucleotide polymorphisms
    • Jiang, L. H., Baldwin, J. M., Roger, S., and Baldwin, S. A. (2013). Insights into the molecular mechanisms underlying Mammalian P2X7 receptor functions and contributions in diseases, revealed by structural modeling and single nucleotide polymorphisms. Front. Pharmacol. 4:55. doi: 10.3389/fphar.2013.00055
    • (2013) Front. Pharmacol , vol.4 , pp. 55
    • Jiang, L.H.1    Baldwin, J.M.2    Roger, S.3    Baldwin, S.A.4
  • 65
    • 73249144903 scopus 로고    scopus 로고
    • Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta
    • Joosten, L. A., Netea, M. G., Fantuzzi, G., Koenders, M. I., Helsen, M. M., Sparrer, H., et al. (2009). Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta. Arthritis Rheum. 60, 3651-3662. doi: 10.1002/art.25006
    • (2009) Arthritis Rheum , vol.60 , pp. 3651-3662
    • Joosten, L.A.1    Netea, M.G.2    Fantuzzi, G.3    Koenders, M.I.4    Helsen, M.M.5    Sparrer, H.6
  • 66
    • 79952192382 scopus 로고    scopus 로고
    • Immune cell regulation by autocrine purinergic signalling
    • Junger, W. G. (2011). Immune cell regulation by autocrine purinergic signalling. Nat. Rev. Immunol. 11, 201-212. doi: 10.1038/nri2938
    • (2011) Nat. Rev. Immunol , vol.11 , pp. 201-212
    • Junger, W.G.1
  • 67
    • 0015742688 scopus 로고
    • Sources of leukocytic endogenous mediator in the rat
    • Kampschmidt, R. F., Pulliam, L. A., and Upchurch, H. F. (1973). Sources of leukocytic endogenous mediator in the rat. Proc. Soc. Exp. Biol. Med. 144, 882-886. doi: 10.3181/00379727-144-37703
    • (1973) Proc. Soc. Exp. Biol. Med , vol.144 , pp. 882-886
    • Kampschmidt, R.F.1    Pulliam, L.A.2    Upchurch, H.F.3
  • 68
    • 85006870202 scopus 로고    scopus 로고
    • Structural basis for subtype-specific inhibition of the P2X7 receptor
    • Karasawa, A., and Kawate, T. (2016). Structural basis for subtype-specific inhibition of the P2X7 receptor. Elife 5:e22153. doi: 10.7554/eLife.22153
    • (2016) Elife , vol.5
    • Karasawa, A.1    Kawate, T.2
  • 69
    • 84958230881 scopus 로고    scopus 로고
    • Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1beta secretion in response to ATP
    • Karmakar, M., Katsnelson, M. A., Dubyak, G. R., and Pearlman, E. (2016). Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1beta secretion in response to ATP. Nat. Commun. 7:10555. doi: 10.1038/ncomms10555
    • (2016) Nat. Commun , vol.7 , pp. 10555
    • Karmakar, M.1    Katsnelson, M.A.2    Dubyak, G.R.3    Pearlman, E.4
  • 70
    • 84927669849 scopus 로고    scopus 로고
    • K+ efflux agonists induce NLRP3 inflammasome activation independently of Ca2+ signaling
    • Katsnelson, M. A., Rucker, L. G., Russo, H. M., and Dubyak, G. R. (2015). K+ efflux agonists induce NLRP3 inflammasome activation independently of Ca2+ signaling. J. Immunol. 194, 3937-3952. doi: 10.4049/jimmunol.1402658
    • (2015) J. Immunol , vol.194 , pp. 3937-3952
    • Katsnelson, M.A.1    Rucker, L.G.2    Russo, H.M.3    Dubyak, G.R.4
  • 71
    • 67949117176 scopus 로고    scopus 로고
    • Crystal structure of the ATP-gated P2X(4) ion channel in the closed state
    • Kawate, T., Michel, J. C., Birdsong, W. T., and Gouaux, E. (2009). Crystal structure of the ATP-gated P2X(4) ion channel in the closed state. Nature 460, 592-598. doi: 10.1038/nature08198
    • (2009) Nature , vol.460 , pp. 592-598
    • Kawate, T.1    Michel, J.C.2    Birdsong, W.T.3    Gouaux, E.4
  • 72
    • 84942856523 scopus 로고    scopus 로고
    • Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
    • Kayagaki, N., Stowe, I. B., Lee, B. L., O'Rourke, K., Anderson, K., Warming, S., et al. (2015). Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature 526, 666-671. doi: 10.1038/nature15541
    • (2015) Nature , vol.526 , pp. 666-671
    • Kayagaki, N.1    Stowe, I.B.2    Lee, B.L.3    O'Rourke, K.4    Anderson, K.5    Warming, S.6
  • 74
    • 84949741912 scopus 로고    scopus 로고
    • NOD-like receptors in infection, immunity, and diseases
    • Kim, Y. K., Shin, J. S., and Nahm, M. H. (2016). NOD-like receptors in infection, immunity, and diseases. Yonsei Med. J. 57, 5-14. doi: 10.3349/ymj.2016.57.1.5
    • (2016) Yonsei Med. J , vol.57 , pp. 5-14
    • Kim, Y.K.1    Shin, J.S.2    Nahm, M.H.3
  • 75
    • 0021745716 scopus 로고
    • Cloning and expression of murine interleukin-1 cDNA in Escherichia coli
    • Lomedico, P. T., Gubler, U., Hellmann, C. P., Dukovich, M., Giri, J. G., Pan, Y. C., et al. (1984). Cloning and expression of murine interleukin-1 cDNA in Escherichia coli. Nature 312, 458-462. doi: 10.1038/312458a0
    • (1984) Nature , vol.312 , pp. 458-462
    • Lomedico, P.T.1    Gubler, U.2    Hellmann, C.P.3    Dukovich, M.4    Giri, J.G.5    Pan, Y.C.6
  • 76
    • 0035655395 scopus 로고    scopus 로고
    • Rapid secretion of interleukin-1beta by microvesicle shedding
    • MacKenzie, A., Wilson, H. L., Kiss-Toth, E., Dower, S. K., North, R. A., and Surprenant, A. (2001). Rapid secretion of interleukin-1beta by microvesicle shedding. Immunity 15, 825-835. doi: 10.1016/S1074-7613(01)00229-1
    • (2001) Immunity , vol.15 , pp. 825-835
    • MacKenzie, A.1    Wilson, H.L.2    Kiss-Toth, E.3    Dower, S.K.4    North, R.A.5    Surprenant, A.6
  • 77
    • 84990236600 scopus 로고    scopus 로고
    • X-ray structures define human P2X3 receptor gating cycle and antagonist action
    • Mansoor, S. E., Lu, W., Oosterheert, W., Shekhar, M., Tajkhorshid, E., and Gouaux, E. (2016). X-ray structures define human P2X3 receptor gating cycle and antagonist action. Nature 538, 66-71. doi: 10.1038/nature19367
    • (2016) Nature , vol.538 , pp. 66-71
    • Mansoor, S.E.1    Lu, W.2    Oosterheert, W.3    Shekhar, M.4    Tajkhorshid, E.5    Gouaux, E.6
  • 78
    • 3142654767 scopus 로고    scopus 로고
    • Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
    • Mariathasan, S., Newton, K., Monack, D. M., Vucic, D., French, D. M., Lee, W. P., et al. (2004). Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430, 213-218. doi: 10.1038/nature02664
    • (2004) Nature , vol.430 , pp. 213-218
    • Mariathasan, S.1    Newton, K.2    Monack, D.M.3    Vucic, D.4    French, D.M.5    Lee, W.P.6
  • 79
    • 32944470765 scopus 로고    scopus 로고
    • Cryopyrin activates the inflammasome in response to toxins and ATP
    • Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., et al. (2006). Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 440, 228-232. doi: 10.1038/nature04515
    • (2006) Nature , vol.440 , pp. 228-232
    • Mariathasan, S.1    Weiss, D.S.2    Newton, K.3    McBride, J.4    O'Rourke, K.5    Roose-Girma, M.6
  • 80
    • 0036671894 scopus 로고    scopus 로고
    • The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
    • Martinon, F., Burns, K., and Tschopp, J. (2002). The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol. Cell. 10, 417-426. doi: 10.1016/S1097-2765(02)00599-3
    • (2002) Mol. Cell , vol.10 , pp. 417-426
    • Martinon, F.1    Burns, K.2    Tschopp, J.3
  • 81
  • 82
    • 37049198188 scopus 로고
    • Studies on the isolation of the factor responsible for tissue injury in inflammation
    • Menkin, V. (1943). Studies on the isolation of the factor responsible for tissue injury in inflammation. Science 97, 165-167. doi: 10.1126/science.97.2511.165
    • (1943) Science , vol.97 , pp. 165-167
    • Menkin, V.1
  • 83
    • 84879577117 scopus 로고    scopus 로고
    • Human astrocytes express a novel NLRP2 inflammasome
    • Minkiewicz, J., de Rivero Vaccari, J. P., and Keane, R. W. (2013). Human astrocytes express a novel NLRP2 inflammasome. Glia 61, 1113-1121. doi: 10.1002/glia.22499
    • (2013) Glia , vol.61 , pp. 1113-1121
    • Minkiewicz, J.1    de Rivero Vaccari, J.P.2    Keane, R.W.3
  • 84
    • 84879596906 scopus 로고    scopus 로고
    • K(+) efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter
    • Munoz-Planillo, R., Kuffa, P., Martinez-Colon, G., Smith, B. L., Rajendiran, T. M., and Nunez, G. (2013). K(+) efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. Immunity 38, 1142-1153. doi: 10.1016/j.immuni.2013.05.016
    • (2013) Immunity , vol.38 , pp. 1142-1153
    • Munoz-Planillo, R.1    Kuffa, P.2    Martinez-Colon, G.3    Smith, B.L.4    Rajendiran, T.M.5    Nunez, G.6
  • 85
    • 0027530024 scopus 로고
    • Oxidized ATP. An irreversible inhibitor of the macrophage purinergic P2Z receptor
    • Murgia, M., Hanau, S., Pizzo, P., Rippa, M., and Di Virgilio, F. (1993). Oxidized ATP. An irreversible inhibitor of the macrophage purinergic P2Z receptor. J. Biol. Chem. 268, 8199-8203.
    • (1993) J. Biol. Chem , vol.268 , pp. 8199-8203
    • Murgia, M.1    Hanau, S.2    Pizzo, P.3    Rippa, M.4    Di Virgilio, F.5
  • 86
    • 79951642032 scopus 로고    scopus 로고
    • Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
    • Nakahira, K., Haspel, J. A., Rathinam, V. A., Lee, S. J., Dolinay, T., Lam, H. C., et al. (2011). Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat. Immunol. 12, 222-230. doi: 10.1038/ni.1980
    • (2011) Nat. Immunol , vol.12 , pp. 222-230
    • Nakahira, K.1    Haspel, J.A.2    Rathinam, V.A.3    Lee, S.J.4    Dolinay, T.5    Lam, H.C.6
  • 87
    • 84963830347 scopus 로고    scopus 로고
    • Alarmins and antitumor immunity
    • Nie, Y., Yang, D., and Oppenheim, J. J. (2016). Alarmins and antitumor immunity. Clin. Ther. 38, 1042-1053. doi: 10.1016/j.clinthera.2016.03.021
    • (2016) Clin. Ther , vol.38 , pp. 1042-1053
    • Nie, Y.1    Yang, D.2    Oppenheim, J.J.3
  • 89
    • 33747191203 scopus 로고    scopus 로고
    • The inflammasome: first line of the immune response to cell stress
    • Ogura, Y., Sutterwala, F. S., and Flavell, R. A. (2006). The inflammasome: first line of the immune response to cell stress. Cell 126, 659-662. doi: 10.1016/j.cell.2006.08.002
    • (2006) Cell , vol.126 , pp. 659-662
    • Ogura, Y.1    Sutterwala, F.S.2    Flavell, R.A.3
  • 90
    • 47249144272 scopus 로고    scopus 로고
    • P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage
    • Pelegrin, P., Barroso-Gutierrez, C., and Surprenant, A. (2008). P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage. J. Immunol. 180, 7147-7157. doi: 10.4049/jimmunol.180.11.7147
    • (2008) J. Immunol , vol.180 , pp. 7147-7157
    • Pelegrin, P.1    Barroso-Gutierrez, C.2    Surprenant, A.3
  • 91
    • 34047270416 scopus 로고    scopus 로고
    • Pannexin-1 couples to maitotoxin-and nigericin-induced interleukin-1beta release through a dye uptake-independent pathway
    • Pelegrin, P., and Surprenant, A. (2007). Pannexin-1 couples to maitotoxin-and nigericin-induced interleukin-1beta release through a dye uptake-independent pathway. J. Biol. Chem. 282, 2386-2394. doi: 10.1074/jbc.M610351200
    • (2007) J. Biol. Chem , vol.282 , pp. 2386-2394
    • Pelegrin, P.1    Surprenant, A.2
  • 92
    • 23044473247 scopus 로고    scopus 로고
    • A novel recombinant plasma membrane-targeted luciferase reveals a new pathway for ATP secretion
    • Pellegatti, P., Falzoni, S., Pinton, P., Rizzuto, R., and Di Virgilio, F. (2005). A novel recombinant plasma membrane-targeted luciferase reveals a new pathway for ATP secretion. Mol. Biol. Cell 16, 3659-3665. doi: 10.1091/mbc.E05-03-0222
    • (2005) Mol. Biol. Cell , vol.16 , pp. 3659-3665
    • Pellegatti, P.1    Falzoni, S.2    Pinton, P.3    Rizzuto, R.4    Di Virgilio, F.5
  • 93
    • 0026751492 scopus 로고
    • IL-1 beta maturation: evidence that mature cytokine formation can be induced specifically by nigericin
    • Perregaux, D., Barberia, J., Lanzetti, A. J., Geoghegan, K. F., Carty, T. J., and Gabel, C. A. (1992). IL-1 beta maturation: evidence that mature cytokine formation can be induced specifically by nigericin. J. Immunol. 149, 1294-1303.
    • (1992) J. Immunol , vol.149 , pp. 1294-1303
    • Perregaux, D.1    Barberia, J.2    Lanzetti, A.J.3    Geoghegan, K.F.4    Carty, T.J.5    Gabel, C.A.6
  • 94
    • 0028175838 scopus 로고
    • Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity
    • Perregaux, D., and Gabel, C. A. (1994). Interleukin-1 beta maturation and release in response to ATP and nigericin. Evidence that potassium depletion mediated by these agents is a necessary and common feature of their activity. J. Biol. Chem. 269, 15195-15203.
    • (1994) J. Biol. Chem , vol.269 , pp. 15195-15203
    • Perregaux, D.1    Gabel, C.A.2
  • 95
    • 34247353273 scopus 로고    scopus 로고
    • Stimulation of P2 receptors causes release of IL-1beta-loaded microvesicles from human dendritic cells
    • Pizzirani, C., Ferrari, D., Chiozzi, P., Adinolfi, E., Sandona, D., Savaglio, E., et al. (2007). Stimulation of P2 receptors causes release of IL-1beta-loaded microvesicles from human dendritic cells. Blood 109, 3856-3864. doi: 10.1182/blood-2005-06-031377
    • (2007) Blood , vol.109 , pp. 3856-3864
    • Pizzirani, C.1    Ferrari, D.2    Chiozzi, P.3    Adinolfi, E.4    Sandona, D.5    Savaglio, E.6
  • 96
    • 85010916994 scopus 로고    scopus 로고
    • Recent insights into the molecular mechanisms of the NLRP3 inflammasome activation
    • Prochnicki, T., Mangan, M. S., and Latz, E. (2016). Recent insights into the molecular mechanisms of the NLRP3 inflammasome activation. F1000Res 5:F1000. doi: 10.12688/f1000research.8614.1
    • (2016) F1000Res , vol.5 , pp. F1000
    • Prochnicki, T.1    Mangan, M.S.2    Latz, E.3
  • 97
    • 34548614009 scopus 로고    scopus 로고
    • Nonclassical IL-1 beta secretion stimulated by P2X7 receptors is dependent on inflammasome activation and correlated with exosome release in murine macrophages
    • Qu, Y., Franchi, L., Nunez, G., and Dubyak, G. R. (2007). Nonclassical IL-1 beta secretion stimulated by P2X7 receptors is dependent on inflammasome activation and correlated with exosome release in murine macrophages. J. Immunol. 179, 1913-1925. doi: 10.4049/jimmunol.179.3.1913
    • (2007) J. Immunol , vol.179 , pp. 1913-1925
    • Qu, Y.1    Franchi, L.2    Nunez, G.3    Dubyak, G.R.4
  • 98
    • 65249164404 scopus 로고    scopus 로고
    • P2X7 receptor-stimulated secretion of MHC class II-containing exosomes requires the ASC/NLRP3 inflammasome but is independent of caspase-1
    • Qu, Y., Ramachandra, L., Mohr, S., Franchi, L., Harding, C. V., Nunez, G., et al. (2009). P2X7 receptor-stimulated secretion of MHC class II-containing exosomes requires the ASC/NLRP3 inflammasome but is independent of caspase-1. J. Immunol. 182, 5052-5062. doi: 10.4049/jimmunol.0802968
    • (2009) J. Immunol , vol.182 , pp. 5052-5062
    • Qu, Y.1    Ramachandra, L.2    Mohr, S.3    Franchi, L.4    Harding, C.V.5    Nunez, G.6
  • 99
    • 84939889550 scopus 로고    scopus 로고
    • NLRP3 inflammasome activation and interleukin-1beta release in macrophages require calcium but are independent of calcium-activated NADPH oxidases
    • Rada, B., Park, J. J., Sil, P., Geiszt, M., and Leto, T. L. (2014). NLRP3 inflammasome activation and interleukin-1beta release in macrophages require calcium but are independent of calcium-activated NADPH oxidases. Inflamm. Res. 63, 821-830. doi: 10.1007/s00011-014-0756-y
    • (2014) Inflamm. Res , vol.63 , pp. 821-830
    • Rada, B.1    Park, J.J.2    Sil, P.3    Geiszt, M.4    Leto, T.L.5
  • 100
    • 78649956456 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis synergizes with ATP to induce release of microvesicles and exosomes containing major histocompatibility complex class II molecules capable of antigen presentation
    • Ramachandra, L., Qu, Y., Wang, Y., Lewis, C. J., Cobb, B. A., Takatsu, K., et al. (2010). Mycobacterium tuberculosis synergizes with ATP to induce release of microvesicles and exosomes containing major histocompatibility complex class II molecules capable of antigen presentation. Infect. Immun. 78, 5116-5125. doi: 10.1128/IAI.01089-09
    • (2010) Infect. Immun , vol.78 , pp. 5116-5125
    • Ramachandra, L.1    Qu, Y.2    Wang, Y.3    Lewis, C.J.4    Cobb, B.A.5    Takatsu, K.6
  • 101
    • 84965107840 scopus 로고    scopus 로고
    • Inflammasome complexes: emerging mechanisms and effector functions
    • Rathinam, V. A., and Fitzgerald, K. A. (2016). Inflammasome complexes: emerging mechanisms and effector functions. Cell 165, 792-800. doi: 10.1016/j.cell.2016.03.046
    • (2016) Cell , vol.165 , pp. 792-800
    • Rathinam, V.A.1    Fitzgerald, K.A.2
  • 102
    • 0025255629 scopus 로고
    • A novel secretory pathway for interleukin-1 beta, a protein lacking a signal sequence
    • Rubartelli, A., Cozzolino, F., Talio, M., and Sitia, R. (1990). A novel secretory pathway for interleukin-1 beta, a protein lacking a signal sequence. EMBO J. 9, 1503-1510.
    • (1990) EMBO J , vol.9 , pp. 1503-1510
    • Rubartelli, A.1    Cozzolino, F.2    Talio, M.3    Sitia, R.4
  • 103
    • 85018192984 scopus 로고    scopus 로고
    • Involvement of the P2X7-NLRP3 axis in leukemic cell proliferation and death
    • Salaro, E., Rambaldi, A., Falzoni, S., Amoroso, F. S., Franceschini, A., Sarti, A. C., et al. (2016). Involvement of the P2X7-NLRP3 axis in leukemic cell proliferation and death. Sci. Rep. 6:26280. doi: 10.1038/srep26280
    • (2016) Sci. Rep , vol.6 , pp. 26280
    • Salaro, E.1    Rambaldi, A.2    Falzoni, S.3    Amoroso, F.S.4    Franceschini, A.5    Sarti, A.C.6
  • 104
    • 84978767585 scopus 로고    scopus 로고
    • Bifunctional probes of cathepsin protease activity and pH reveal alterations in endolysosomal pH during bacterial infection
    • Sanman, L. E., van der Linden, W. A., Verdoes, M., and Bogyo, M. (2016). Bifunctional probes of cathepsin protease activity and pH reveal alterations in endolysosomal pH during bacterial infection. Cell Chem. Biol. 23, 793-804. doi: 10.1016/j.chembiol.2016.05.019
    • (2016) Cell Chem. Biol , vol.23 , pp. 793-804
    • Sanman, L.E.1    van der Linden, W.A.2    Verdoes, M.3    Bogyo, M.4
  • 105
    • 64249169414 scopus 로고    scopus 로고
    • Activation of microglia by amyloid (beta) requires P2X7 receptor expression
    • Sanz, J. M., Chiozzi, P., Ferrari, D., Colaianna, M., Idzko, M., Falzoni, S., et al. (2009). Activation of microglia by amyloid (beta) requires P2X7 receptor expression. J. Immunol. 182, 4378-4385. doi: 10.4049/jimmunol.0803612
    • (2009) J. Immunol , vol.182 , pp. 4378-4385
    • Sanz, J.M.1    Chiozzi, P.2    Ferrari, D.3    Colaianna, M.4    Idzko, M.5    Falzoni, S.6
  • 106
    • 77950362382 scopus 로고    scopus 로고
    • The inflammasomes
    • Schroder, K., and Tschopp, J. (2010). The inflammasomes. Cell 140, 821-832. doi: 10.1016/j.cell.2010.01.040
    • (2010) Cell , vol.140 , pp. 821-832
    • Schroder, K.1    Tschopp, J.2
  • 107
    • 84942892037 scopus 로고    scopus 로고
    • Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
    • Shi, J., Zhao, Y., Wang, K., Shi, X., Wang, Y., Huang, H., et al. (2015). Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature 526, 660-665. doi: 10.1038/nature15514
    • (2015) Nature , vol.526 , pp. 660-665
    • Shi, J.1    Zhao, Y.2    Wang, K.3    Shi, X.4    Wang, Y.5    Huang, H.6
  • 108
    • 84906571225 scopus 로고    scopus 로고
    • Inflammatory caspases are innate immune receptors for intracellular LPS
    • Shi, J., Zhao, Y., Wang, Y., Gao, W., Ding, J., Li, P., et al. (2014). Inflammatory caspases are innate immune receptors for intracellular LPS. Nature 514, 187-192. doi: 10.1038/nature13683
    • (2014) Nature , vol.514 , pp. 187-192
    • Shi, J.1    Zhao, Y.2    Wang, Y.3    Gao, W.4    Ding, J.5    Li, P.6
  • 109
    • 84862777872 scopus 로고    scopus 로고
    • Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
    • Shimada, K., Crother, T. R., Karlin, J., Dagvadorj, J., Chiba, N., Chen, S., et al. (2012). Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity 36, 401-414. doi: 10.1016/j.immuni.2012.01.009
    • (2012) Immunity , vol.36 , pp. 401-414
    • Shimada, K.1    Crother, T.R.2    Karlin, J.3    Dagvadorj, J.4    Chiba, N.5    Chen, S.6
  • 110
    • 0021286985 scopus 로고
    • Pharmacological evidence that adenosine triphosphate and noradrenaline are co-transmitters in the guinea-pig vas deferens
    • Sneddon, P., and Westfall, D. P. (1984). Pharmacological evidence that adenosine triphosphate and noradrenaline are co-transmitters in the guinea-pig vas deferens. J. Physiol. 347, 561-580. doi: 10.1113/jphysiol.1984.sp015083
    • (1984) J. Physiol , vol.347 , pp. 561-580
    • Sneddon, P.1    Westfall, D.P.2
  • 111
    • 0035808396 scopus 로고    scopus 로고
    • Altered cytokine production in mice lacking P2X(7) receptors
    • Solle, M., Labasi, J., Perregaux, D. G., Stam, E., Petrushova, N., Koller, B. H., et al. (2001). Altered cytokine production in mice lacking P2X(7) receptors. J. Biol. Chem. 276, 125-132. doi: 10.1074/jbc.M006781200
    • (2001) J. Biol. Chem , vol.276 , pp. 125-132
    • Solle, M.1    Labasi, J.2    Perregaux, D.G.3    Stam, E.4    Petrushova, N.5    Koller, B.H.6
  • 112
    • 32544448639 scopus 로고    scopus 로고
    • P2X7 receptors mediate ATP release and amplification of astrocytic intercellular Ca2+ signaling
    • Suadicani, S. O., Brosnan, C. F., and Scemes, E. (2006). P2X7 receptors mediate ATP release and amplification of astrocytic intercellular Ca2+ signaling. J. Neurosci. 26, 1378-1385. doi: 10.1523/JNEUROSCI.3902-05.2006
    • (2006) J. Neurosci , vol.26 , pp. 1378-1385
    • Suadicani, S.O.1    Brosnan, C.F.2    Scemes, E.3
  • 113
    • 0029665112 scopus 로고    scopus 로고
    • The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)
    • Surprenant, A., Rassendren, F., Kawashima, E., North, R. A., and Buell, G. (1996). The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7). Science 272, 735-738. doi: 10.1126/science.272.5262.735
    • (1996) Science , vol.272 , pp. 735-738
    • Surprenant, A.1    Rassendren, F.2    Kawashima, E.3    North, R.A.4    Buell, G.5
  • 114
    • 0026507126 scopus 로고
    • A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes
    • Thornberry, N. A., Bull, H. G., Calaycay, J. R., Chapman, K. T., Howard, A. D., Kostura, M. J., et al. (1992). A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature 356, 768-774. doi: 10.1038/356768a0
    • (1992) Nature , vol.356 , pp. 768-774
    • Thornberry, N.A.1    Bull, H.G.2    Calaycay, J.R.3    Chapman, K.T.4    Howard, A.D.5    Kostura, M.J.6
  • 115
    • 84866425004 scopus 로고    scopus 로고
    • Microglial microvesicle secretion and intercellular signaling
    • Turola, E., Furlan, R., Bianco, F., Matteoli, M., and Verderio, C. (2012). Microglial microvesicle secretion and intercellular signaling. Front. Physiol. 3:149. doi: 10.3389/fphys.2012.00149
    • (2012) Front. Physiol , vol.3 , pp. 149
    • Turola, E.1    Furlan, R.2    Bianco, F.3    Matteoli, M.4    Verderio, C.5
  • 116
    • 84941284605 scopus 로고    scopus 로고
    • DAMPs from cell death to new life
    • Venereau, E., Ceriotti, C., and Bianchi, M. E. (2015). DAMPs from cell death to new life. Front. Immunol. 6:422. doi: 10.3389/fimmu.2015.00422
    • (2015) Front. Immunol , vol.6 , pp. 422
    • Venereau, E.1    Ceriotti, C.2    Bianchi, M.E.3
  • 117
    • 84866343704 scopus 로고    scopus 로고
    • Myeloid microvesicles are a marker and therapeutic target for neuroinflammation
    • Verderio, C., Muzio, L., Turola, E., Bergami, A., Novellino, L., Ruffini, F., et al. (2012). Myeloid microvesicles are a marker and therapeutic target for neuroinflammation. Ann. Neurol. 72, 610-624. doi: 10.1002/ana.23627
    • (2012) Ann. Neurol , vol.72 , pp. 610-624
    • Verderio, C.1    Muzio, L.2    Turola, E.3    Bergami, A.4    Novellino, L.5    Ruffini, F.6
  • 118
    • 84945542875 scopus 로고    scopus 로고
    • Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes
    • Vigano, E., Diamond, C. E., Spreafico, R., Balachander, A., Sobota, R. M., and Mortellaro, A. (2015). Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes. Nat. Commun. 6:8761. doi: 10.1038/ncomms9761
    • (2015) Nat. Commun , vol.6 , pp. 8761
    • Vigano, E.1    Diamond, C.E.2    Spreafico, R.3    Balachander, A.4    Sobota, R.M.5    Mortellaro, A.6
  • 119
    • 84962861111 scopus 로고    scopus 로고
    • The intersection of cell death and inflammasome activation
    • Vince, J. E., and Silke, J. (2016). The intersection of cell death and inflammasome activation. Cell Mol. Life Sci. 73, 2349-2367. doi: 10.1007/s00018-016-2205-2
    • (2016) Cell Mol. Life Sci , vol.73 , pp. 2349-2367
    • Vince, J.E.1    Silke, J.2
  • 120
    • 0028989337 scopus 로고
    • Potassium-inhibited processing of IL-1 beta in human monocytes
    • Walev, I., Reske, K., Palmer, M., Valeva, A., and Bhakdi, S. (1995). Potassium-inhibited processing of IL-1 beta in human monocytes. EMBO J. 14, 1607-1614.
    • (1995) EMBO J , vol.14 , pp. 1607-1614
    • Walev, I.1    Reske, K.2    Palmer, M.3    Valeva, A.4    Bhakdi, S.5
  • 121
    • 84885615786 scopus 로고    scopus 로고
    • Autophagy-dependent ATP release from dying cells via lysosomal exocytosis
    • Wang, Y., Martins, I., Ma, Y., Kepp, O., Galluzzi, L., and Kroemer, G. (2013). Autophagy-dependent ATP release from dying cells via lysosomal exocytosis. Autophagy 9, 1624-1625. doi: 10.4161/auto.25873
    • (2013) Autophagy , vol.9 , pp. 1624-1625
    • Wang, Y.1    Martins, I.2    Ma, Y.3    Kepp, O.4    Galluzzi, L.5    Kroemer, G.6
  • 122
    • 3142660196 scopus 로고    scopus 로고
    • IL-1beta: an endosomal exit
    • Wewers, M. D. (2004). IL-1beta: an endosomal exit. Proc. Natl. Acad. Sci. U.S.A. 101, 10241-10242. doi: 10.1073/pnas.0403971101
    • (2004) Proc. Natl. Acad. Sci. U.S.A , vol.101 , pp. 10241-10242
    • Wewers, M.D.1
  • 123
    • 84947441282 scopus 로고    scopus 로고
    • Caspase-11 requires the pannexin-1 channel and the purinergic P2X7 pore to mediate pyroptosis and endotoxic shock
    • Yang, D., He, Y., Munoz-Planillo, R., Liu, Q., and Nunez, G. (2015). Caspase-11 requires the pannexin-1 channel and the purinergic P2X7 pore to mediate pyroptosis and endotoxic shock. Immunity 43, 923-932. doi: 10.1016/j.immuni.2015.10.009
    • (2015) Immunity , vol.43 , pp. 923-932
    • Yang, D.1    He, Y.2    Munoz-Planillo, R.3    Liu, Q.4    Nunez, G.5
  • 124
    • 78651393239 scopus 로고    scopus 로고
    • A role for mitochondria in NLRP3 inflammasome activation
    • Zhou, R., Yazdi, A. S., Menu, P., and Tschopp, J. (2011). A role for mitochondria in NLRP3 inflammasome activation. Nature 469, 221-225. doi: 10.1038/nature09663
    • (2011) Nature , vol.469 , pp. 221-225
    • Zhou, R.1    Yazdi, A.S.2    Menu, P.3    Tschopp, J.4


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