X-ray structures define human P2X 3 receptor gating cycle and antagonist action

Nature

Volumn 538, Issue 7623, 2016, Pages 66-71

  Mansoor, Steven E ^a,b   Lü, Wei ^a   Oosterheert, Wout ^a,d   Shekhar, Mrinal ^c   Tajkhorshid, Emad ^c   Gouaux, Eric ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^d UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

2',3' DIDEOXYADENOSINE TRIPHOSPHATE; 5 [[(3 PHENOXYBENZYL)(1,2,3,4 TETRAHYDRO 1 NAPHTHYL)AMINO]CARBONYL]TRIMELLITIC ACID; ION CHANNEL; PHOSPHOLIPID; PURINERGIC P2X RECEPTOR AGONIST; PURINERGIC P2X RECEPTOR ANTAGONIST; PURINERGIC P2X3 RECEPTOR; APOPROTEIN; LIGAND; PURINERGIC RECEPTOR STIMULATING AGENT;

CRYSTAL STRUCTURE; CYTOPLASM; DISEASE TREATMENT; IMMUNE SYSTEM; INHIBITION; MOLECULAR ANALYSIS; PROTEIN; SENSORY SYSTEM;

ARTICLE; CHANNEL GATING; COMPETITIVE INHIBITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOPLASM; HUMAN; ION TRANSPORT; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN MOTIF; PROTEIN STABILITY; PROTEIN STRUCTURE; RECEPTOR DOWN REGULATION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY; AGONISTS; ANTAGONISTS AND INHIBITORS; BINDING COMPETITION; BINDING SITE; CHEMISTRY; CRYSTALLIZATION; DRUG EFFECTS; METABOLISM; MOLECULAR MODEL; POROSITY;

APOPROTEINS; BINDING SITES; BINDING, COMPETITIVE; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; HUMANS; ION CHANNEL GATING; ION TRANSPORT; LIGANDS; MODELS, MOLECULAR; POROSITY; PROTEIN CONFORMATION; PURINERGIC AGONISTS; PURINERGIC P2X RECEPTOR ANTAGONISTS; RECEPTORS, PURINERGIC P2X3;

EID: 84990236600     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature19367     Document Type: Article

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