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Volumn 17, Issue 4, 2017, Pages

Role of Acid-Base Homeostasis in Diabetic Kidney Disease

Author keywords

Acid load; Acidosis; CKD; CKD progression; Diabetes; Diabetic nephropathy; Insulin resistance

Indexed keywords

IRBESARTAN; LOSARTAN;

EID: 85016147901     PISSN: 15344827     EISSN: 15390829     Source Type: Journal    
DOI: 10.1007/s11892-017-0855-6     Document Type: Review
Times cited : (13)

References (108)
  • 1
    • 84955506314 scopus 로고    scopus 로고
    • USRDS annual data report: epidemiology of Kidney Disease in the United States
    • United States Renal Data System. 2015 USRDS annual data report: epidemiology of Kidney Disease in the United States. Bethesda, MD; 2015.
    • (2015) Bethesda, MD , pp. 2015
    • System, U.S.R.D.1
  • 2
    • 84981201088 scopus 로고    scopus 로고
    • Clinical manifestations of kidney disease among US adults with diabetes, 1988-2014
    • PID: 27532915
    • Afkarian M, Zelnick LR, Hall YN, Heagerty PJ, Tuttle K, Weiss NS, et al. Clinical manifestations of kidney disease among US adults with diabetes, 1988-2014. JAMA. 2016;316(6):602–10.
    • (2016) JAMA , vol.316 , Issue.6 , pp. 602-610
    • Afkarian, M.1    Zelnick, L.R.2    Hall, Y.N.3    Heagerty, P.J.4    Tuttle, K.5    Weiss, N.S.6
  • 3
    • 45149133036 scopus 로고    scopus 로고
    • Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
    • COI: 1:CAS:528:DC%2BD1cXnt1yht7s%3D, PID: 18539916
    • Patel A, MacMahon S, Chalmers J, Neal B, Billot L, et al. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med. 2008;358(24):2560–72.
    • (2008) N Engl J Med , vol.358 , Issue.24 , pp. 2560-2572
    • Patel, A.1    MacMahon, S.2    Chalmers, J.3    Neal, B.4    Billot, L.5
  • 4
    • 84930077401 scopus 로고    scopus 로고
    • Comparative efficacy and safety of blood pressure-lowering agents in adults with diabetes and kidney disease: a network meta-analysis
    • COI: 1:CAS:528:DC%2BC2MXpt1Ojsb8%3D, PID: 26009228
    • Palmer SC, Mavridis D, Navarese E, Craig JC, Tonelli M, Salanti G, et al. Comparative efficacy and safety of blood pressure-lowering agents in adults with diabetes and kidney disease: a network meta-analysis. Lancet. 2015;385(9982):2047–56.
    • (2015) Lancet , vol.385 , Issue.9982 , pp. 2047-2056
    • Palmer, S.C.1    Mavridis, D.2    Navarese, E.3    Craig, J.C.4    Tonelli, M.5    Salanti, G.6
  • 5
    • 33644912981 scopus 로고    scopus 로고
    • Independent and additive impact of blood pressure control and angiotensin II receptor blockade on renal outcomes in the irbesartan diabetic nephropathy trial: clinical implications and limitations
    • COI: 1:CAS:528:DC%2BD2MXhtFegtLnE, PID: 16120823
    • Pohl MA, Blumenthal S, Cordonnier DJ, De Alvaro F, Deferrari G, Eisner G, et al. Independent and additive impact of blood pressure control and angiotensin II receptor blockade on renal outcomes in the irbesartan diabetic nephropathy trial: clinical implications and limitations. J Am Soc Nephrol. 2005;16(10):3027–37.
    • (2005) J Am Soc Nephrol , vol.16 , Issue.10 , pp. 3027-3037
    • Pohl, M.A.1    Blumenthal, S.2    Cordonnier, D.J.3    De Alvaro, F.4    Deferrari, G.5    Eisner, G.6
  • 6
    • 0038155497 scopus 로고    scopus 로고
    • Effects of blood pressure level on progression of diabetic nephropathy: results from the RENAAL study
    • PID: 12860578
    • Bakris GL, Weir MR, Shanifar S, Zhang Z, Douglas J, van Dijk DJ, et al. Effects of blood pressure level on progression of diabetic nephropathy: results from the RENAAL study. Arch Intern Med. 2003;163(13):1555–65.
    • (2003) Arch Intern Med , vol.163 , Issue.13 , pp. 1555-1565
    • Bakris, G.L.1    Weir, M.R.2    Shanifar, S.3    Zhang, Z.4    Douglas, J.5    van Dijk, D.J.6
  • 7
    • 0037472879 scopus 로고    scopus 로고
    • Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes
    • PID: 12556541
    • Gæde P, Vedel P, Larsen N, Jensen GVH, Parving H-H, Pedersen O. Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes. N Engl J Med. 2003;348(5):383–93.
    • (2003) N Engl J Med , vol.348 , Issue.5 , pp. 383-393
    • Gæde, P.1    Vedel, P.2    Larsen, N.3    Jensen, G.V.H.4    Parving, H.-H.5    Pedersen, O.6
  • 8
    • 67650424024 scopus 로고    scopus 로고
    • Serum bicarbonate levels and the progression of kidney disease: a cohort study
    • COI: 1:CAS:528:DC%2BD1MXht1Whtb7I, PID: 19394734
    • Shah SN, Abramowitz M, Hostetter TH, Melamed ML. Serum bicarbonate levels and the progression of kidney disease: a cohort study. Am J Kidney Dis. 2009;54(2):270–7.
    • (2009) Am J Kidney Dis , vol.54 , Issue.2 , pp. 270-277
    • Shah, S.N.1    Abramowitz, M.2    Hostetter, T.H.3    Melamed, M.L.4
  • 9
    • 84884534769 scopus 로고    scopus 로고
    • Association of serum bicarbonate with risk of renal and cardiovascular outcomes in CKD: a report from the Chronic Renal Insufficiency Cohort (CRIC) study
    • COI: 1:CAS:528:DC%2BC3sXjvVOhs7w%3D, PID: 23489677
    • Dobre M, Yang W, Chen J, Drawz P, Hamm LL, Horwitz E, et al. Association of serum bicarbonate with risk of renal and cardiovascular outcomes in CKD: a report from the Chronic Renal Insufficiency Cohort (CRIC) study. Am J Kidney Dis. 2013;62(4):670–8.
    • (2013) Am J Kidney Dis , vol.62 , Issue.4 , pp. 670-678
    • Dobre, M.1    Yang, W.2    Chen, J.3    Drawz, P.4    Hamm, L.L.5    Horwitz, E.6
  • 10
    • 78651410325 scopus 로고    scopus 로고
    • Higher serum bicarbonate levels within the normal range are associated with better survival and renal outcomes in African Americans
    • COI: 1:CAS:528:DC%2BC3MXlsFKrtw%3D%3D, PID: 20962743
    • Raphael KL, Wei G, Baird BC, Greene T, Beddhu S. Higher serum bicarbonate levels within the normal range are associated with better survival and renal outcomes in African Americans. Kidney Int. 2011;79(3):356–62.
    • (2011) Kidney Int , vol.79 , Issue.3 , pp. 356-362
    • Raphael, K.L.1    Wei, G.2    Baird, B.C.3    Greene, T.4    Beddhu, S.5
  • 11
    • 84908136257 scopus 로고    scopus 로고
    • Low serum bicarbonate and kidney function decline: the Multi-Ethnic Study of Atherosclerosis (MESA)
    • COI: 1:CAS:528:DC%2BC2cXhtVemtb%2FM, PID: 24953891
    • Driver TH, Shlipak MG, Katz R, Goldenstein L, Sarnak MJ, Hoofnagle AN, et al. Low serum bicarbonate and kidney function decline: the Multi-Ethnic Study of Atherosclerosis (MESA). Am J Kidney Dis. 2014;64(4):534–41.
    • (2014) Am J Kidney Dis , vol.64 , Issue.4 , pp. 534-541
    • Driver, T.H.1    Shlipak, M.G.2    Katz, R.3    Goldenstein, L.4    Sarnak, M.J.5    Hoofnagle, A.N.6
  • 12
    • 84908146019 scopus 로고    scopus 로고
    • Serum bicarbonate concentrations and kidney disease progression in community-living elders: the Health, Aging, and Body Composition (Health ABC) Study
    • COI: 1:CAS:528:DC%2BC2cXhtVemtb%2FO, PID: 24953890
    • Goldenstein L, Driver TH, Fried LF, Rifkin DE, Patel KV, Yenchek RH, et al. Serum bicarbonate concentrations and kidney disease progression in community-living elders: the Health, Aging, and Body Composition (Health ABC) Study. Am J Kidney Dis. 2014;64(4):542–9.
    • (2014) Am J Kidney Dis , vol.64 , Issue.4 , pp. 542-549
    • Goldenstein, L.1    Driver, T.H.2    Fried, L.F.3    Rifkin, D.E.4    Patel, K.V.5    Yenchek, R.H.6
  • 13
    • 84939568110 scopus 로고    scopus 로고
    • •• Schutte E, Lambers Heerspink HJ, Lutgers HL, Bakker SJ, Vart P, Wolffenbuttel BH, et al. Serum bicarbonate and kidney disease progression and cardiovascular outcome in patients with diabetic nephropathy: a post hoc analysis of the RENAAL (Reduction of End Points in Non-Insulin-Dependent Diabetes With the Angiotensin II Antagonist Losartan) Study and IDNT (Irbesartan Diabetic Nephropathy Trial).66(3):450–8. Among approximately 2600 patients with type 2 diabetes and kidney disease enrolled in clinical trials of angiotensin receptor blockers, lower serum bicarbonate at enrollment was not associated with risk of progression to ESKD or doubling of serum creatinine after adjustment for kidney function
    • •• Schutte E, Lambers Heerspink HJ, Lutgers HL, Bakker SJ, Vart P, Wolffenbuttel BH, et al. Serum bicarbonate and kidney disease progression and cardiovascular outcome in patients with diabetic nephropathy: a post hoc analysis of the RENAAL (Reduction of End Points in Non-Insulin-Dependent Diabetes With the Angiotensin II Antagonist Losartan) Study and IDNT (Irbesartan Diabetic Nephropathy Trial). Am J Kidney Dis. 2015;66(3):450–8. Among approximately 2600 patients with type 2 diabetes and kidney disease enrolled in clinical trials of angiotensin receptor blockers, lower serum bicarbonate at enrollment was not associated with risk of progression to ESKD or doubling of serum creatinine after adjustment for kidney function.
    • (2015) Am J Kidney Dis.
  • 14
    • 20444402680 scopus 로고    scopus 로고
    • Metabolic acidosis of CKD: diagnosis, clinical characteristics, and treatment
    • COI: 1:CAS:528:DC%2BD2MXlvVSjsro%3D, PID: 15957126
    • Kraut JA, Kurtz I. Metabolic acidosis of CKD: diagnosis, clinical characteristics, and treatment. Am J Kidney Dis. 2005;45(6):978–93.
    • (2005) Am J Kidney Dis , vol.45 , Issue.6 , pp. 978-993
    • Kraut, J.A.1    Kurtz, I.2
  • 15
    • 59949087149 scopus 로고    scopus 로고
    • Mechanisms in hyperkalemic renal tubular acidosis
    • COI: 1:CAS:528:DC%2BD1MXjtFCrt70%3D, PID: 19193780
    • Karet FE. Mechanisms in hyperkalemic renal tubular acidosis. J Am Soc Nephrol. 2009;20(2):251–4.
    • (2009) J Am Soc Nephrol , vol.20 , Issue.2 , pp. 251-254
    • Karet, F.E.1
  • 16
    • 69849104461 scopus 로고    scopus 로고
    • Bicarbonate supplementation slows progression of CKD and improves nutritional status
    • PID: 19608703
    • de Brito-Ashurst I, Varagunam M, Raftery MJ, Yaqoob MM. Bicarbonate supplementation slows progression of CKD and improves nutritional status. J Am Soc Nephrol. 2009;20(9):2075–84.
    • (2009) J Am Soc Nephrol , vol.20 , Issue.9 , pp. 2075-2084
    • de Brito-Ashurst, I.1    Varagunam, M.2    Raftery, M.J.3    Yaqoob, M.M.4
  • 17
    • 77954757756 scopus 로고    scopus 로고
    • Daily oral sodium bicarbonate preserves glomerular filtration rate by slowing its decline in early hypertensive nephropathy
    • COI: 1:CAS:528:DC%2BC3cXovFKgtLY%3D, PID: 20445497
    • Mahajan A, Simoni J, Sheather SJ, Broglio KR, Rajab MH, Wesson DE. Daily oral sodium bicarbonate preserves glomerular filtration rate by slowing its decline in early hypertensive nephropathy. Kidney Int. 2010;78(3):303–9.
    • (2010) Kidney Int , vol.78 , Issue.3 , pp. 303-309
    • Mahajan, A.1    Simoni, J.2    Sheather, S.J.3    Broglio, K.R.4    Rajab, M.H.5    Wesson, D.E.6
  • 18
    • 79958045521 scopus 로고    scopus 로고
    • Activation of intrarenal renin-angiotensin system during metabolic acidosis
    • COI: 1:CAS:528:DC%2BC3MXovFOhs7g%3D, PID: 21659740
    • Ng HY, Chen HC, Tsai YC, Yang YK, Lee CT. Activation of intrarenal renin-angiotensin system during metabolic acidosis. Am J Nephrol. 2011;34(1):55–63.
    • (2011) Am J Nephrol , vol.34 , Issue.1 , pp. 55-63
    • Ng, H.Y.1    Chen, H.C.2    Tsai, Y.C.3    Yang, Y.K.4    Lee, C.T.5
  • 19
    • 84929575391 scopus 로고    scopus 로고
    • Angiotensin II-mediated GFR decline in subtotal nephrectomy is due to acid retention associated with reduced GFR
    • PID: 25527741
    • Wesson DE, Jo CH, Simoni J. Angiotensin II-mediated GFR decline in subtotal nephrectomy is due to acid retention associated with reduced GFR. Nephrol Dial Transplant. 2015;30(5):762–70.
    • (2015) Nephrol Dial Transplant , vol.30 , Issue.5 , pp. 762-770
    • Wesson, D.E.1    Jo, C.H.2    Simoni, J.3
  • 20
    • 33747062680 scopus 로고    scopus 로고
    • Long-term regulation of proximal tubule acid-base transporter abundance by angiotensin II
    • COI: 1:CAS:528:DC%2BD28XnvVylt7g%3D, PID: 16807546
    • Turban S, Beutler KT, Morris RG, Masilamani S, Fenton RA, Knepper MA, et al. Long-term regulation of proximal tubule acid-base transporter abundance by angiotensin II. Kidney Int. 2006;70(4):660–8.
    • (2006) Kidney Int , vol.70 , Issue.4 , pp. 660-668
    • Turban, S.1    Beutler, K.T.2    Morris, R.G.3    Masilamani, S.4    Fenton, R.A.5    Knepper, M.A.6
  • 21
    • 78349308678 scopus 로고    scopus 로고
    • Acid retention during kidney failure induces endothelin and aldosterone production which lead to progressive GFR decline, a situation ameliorated by alkali diet
    • COI: 1:CAS:528:DC%2BC3cXhsVWmsrnJ, PID: 20861823
    • Wesson DE, Simoni J. Acid retention during kidney failure induces endothelin and aldosterone production which lead to progressive GFR decline, a situation ameliorated by alkali diet. Kidney Int. 2010;78(11):1128–35.
    • (2010) Kidney Int , vol.78 , Issue.11 , pp. 1128-1135
    • Wesson, D.E.1    Simoni, J.2
  • 22
    • 77949541141 scopus 로고    scopus 로고
    • Amelioration of metabolic acidosis in patients with low GFR reduced kidney endothelin production and kidney injury, and better preserved GFR
    • COI: 1:CAS:528:DC%2BC3cXjtFSntbo%3D, PID: 20072112
    • Phisitkul S, Khanna A, Simoni J, Broglio K, Sheather S, Rajab MH, et al. Amelioration of metabolic acidosis in patients with low GFR reduced kidney endothelin production and kidney injury, and better preserved GFR. Kidney Int. 2010;77(7):617–23.
    • (2010) Kidney Int , vol.77 , Issue.7 , pp. 617-623
    • Phisitkul, S.1    Khanna, A.2    Simoni, J.3    Broglio, K.4    Sheather, S.5    Rajab, M.H.6
  • 23
    • 37549007188 scopus 로고    scopus 로고
    • Dietary protein causes a decline in the glomerular filtration rate of the remnant kidney mediated by metabolic acidosis and endothelin receptors
    • COI: 1:CAS:528:DC%2BD2sXhsVylt7fE, PID: 17978813
    • Phisitkul S, Hacker C, Simoni J, Tran RM, Wesson DE. Dietary protein causes a decline in the glomerular filtration rate of the remnant kidney mediated by metabolic acidosis and endothelin receptors. Kidney Int. 2008;73(2):192–9.
    • (2008) Kidney Int , vol.73 , Issue.2 , pp. 192-199
    • Phisitkul, S.1    Hacker, C.2    Simoni, J.3    Tran, R.M.4    Wesson, D.E.5
  • 24
    • 0021886145 scopus 로고
    • Pathophysiology of chronic tubulo-interstitial disease in rats. Interactions of dietary acid load, ammonia, and complement component C3
    • COI: 1:CAS:528:DyaL2MXlsFymtr8%3D, PID: 2993363
    • Nath KA, Hostetter MK, Hostetter TH. Pathophysiology of chronic tubulo-interstitial disease in rats. Interactions of dietary acid load, ammonia, and complement component C3. J Clin Invest. 1985;76(2):667–75.
    • (1985) J Clin Invest , vol.76 , Issue.2 , pp. 667-675
    • Nath, K.A.1    Hostetter, M.K.2    Hostetter, T.H.3
  • 25
    • 0023175237 scopus 로고
    • Hypokalemic nephropathy in the rat. Role of ammonia in chronic tubular injury
    • COI: 1:CAS:528:DyaL2sXkt1Wmtrs%3D, PID: 3553240
    • Tolins JP, Hostetter MK, Hostetter TH. Hypokalemic nephropathy in the rat. Role of ammonia in chronic tubular injury. J Clin Invest. 1987;79(5):1447–58.
    • (1987) J Clin Invest , vol.79 , Issue.5 , pp. 1447-1458
    • Tolins, J.P.1    Hostetter, M.K.2    Hostetter, T.H.3
  • 26
    • 84871895229 scopus 로고    scopus 로고
    • Acid stress increases gene expression of proinflammatory cytokines in Madin-Darby canine kidney cells
    • COI: 1:CAS:528:DC%2BC3sXit1ygtbw%3D, PID: 23077097
    • Raj S, Scott DR, Nguyen T, Sachs G, Kraut JA. Acid stress increases gene expression of proinflammatory cytokines in Madin-Darby canine kidney cells. Am J Physiol Renal Physiol. 2013;304(1):F41–8.
    • (2013) Am J Physiol Renal Physiol. , vol.304 , Issue.1 , pp. F41-F48
    • Raj, S.1    Scott, D.R.2    Nguyen, T.3    Sachs, G.4    Kraut, J.A.5
  • 27
    • 84921776185 scopus 로고    scopus 로고
    • Autophagic clearance of mitochondria in the kidney copes with metabolic acidosis
    • COI: 1:CAS:528:DC%2BC2cXhvFGjt7bF, PID: 24700866
    • Namba T, Takabatake Y, Kimura T, Takahashi A, Yamamoto T, Matsuda J, et al. Autophagic clearance of mitochondria in the kidney copes with metabolic acidosis. J Am Soc Nephrol. 2014;25(10):2254–66.
    • (2014) J Am Soc Nephrol , vol.25 , Issue.10 , pp. 2254-2266
    • Namba, T.1    Takabatake, Y.2    Kimura, T.3    Takahashi, A.4    Yamamoto, T.5    Matsuda, J.6
  • 28
    • 0036092207 scopus 로고    scopus 로고
    • The effect of pH and nucleophiles on complement activation by human proximal tubular epithelial cells
    • COI: 1:CAS:528:DC%2BD38XksVWitrc%3D, PID: 11981058
    • Peake PW, Pussell BA, Mackinnon B, Charlesworth JA. The effect of pH and nucleophiles on complement activation by human proximal tubular epithelial cells. Nephrol Dial Transplant. 2002;17(5):745–52.
    • (2002) Nephrol Dial Transplant , vol.17 , Issue.5 , pp. 745-752
    • Peake, P.W.1    Pussell, B.A.2    Mackinnon, B.3    Charlesworth, J.A.4
  • 29
    • 34249812091 scopus 로고    scopus 로고
    • Standardizing terminology for estimating the diet-dependent net acid load to the metabolic system
    • COI: 1:CAS:528:DC%2BD2sXmt1eksL8%3D, PID: 17513412
    • Frassetto LA, Lanham-New SA, Macdonald HM, Remer T, Sebastian A, Tucker KL, et al. Standardizing terminology for estimating the diet-dependent net acid load to the metabolic system. J Nutr. 2007;137(6):1491–2.
    • (2007) J Nutr , vol.137 , Issue.6 , pp. 1491-1492
    • Frassetto, L.A.1    Lanham-New, S.A.2    Macdonald, H.M.3    Remer, T.4    Sebastian, A.5    Tucker, K.L.6
  • 30
    • 0001254767 scopus 로고
    • Endogenous production of fixed acid and the measurement of the net balance of acid in normal subjects
    • COI: 1:CAS:528:DyaF38XitVyrtw%3D%3D, PID: 13740723
    • Relman AS, Lennon EJ, Lemann Jr J. Endogenous production of fixed acid and the measurement of the net balance of acid in normal subjects. J Clin Invest. 1961;40:1621–30.
    • (1961) J Clin Invest , vol.40 , pp. 1621-1630
    • Relman, A.S.1    Lennon, E.J.2    Lemann, J.3
  • 31
    • 0001479292 scopus 로고
    • The influence of dietary sulphur on the urinary output of acid in man
    • COI: 1:CAS:528:DyaG2sXisFSr, PID: 13317121
    • Hunt JN. The influence of dietary sulphur on the urinary output of acid in man. Clin Sci. 1956;15(1):119–34.
    • (1956) Clin Sci , vol.15 , Issue.1 , pp. 119-134
    • Hunt, J.N.1
  • 32
    • 0014289967 scopus 로고
    • Influence of diet composition on endogenous fixed acid production
    • COI: 1:CAS:528:DyaF1cXhtVaqu7o%3D, PID: 5649464
    • Lennon EJ, Lemann Jr J. Influence of diet composition on endogenous fixed acid production. Am J Clin Nutr. 1968;21(5):451–6.
    • (1968) Am J Clin Nutr , vol.21 , Issue.5 , pp. 451-456
    • Lennon, E.J.1    Lemann, J.2
  • 33
    • 84874277164 scopus 로고    scopus 로고
    • Dietary acid load: a novel nutritional target in chronic kidney disease?
    • PID: 23439373
    • Scialla JJ, Anderson CA. Dietary acid load: a novel nutritional target in chronic kidney disease? Adv Chronic Kidney Dis. 2013;20(2):141–9.
    • (2013) Adv Chronic Kidney Dis , vol.20 , Issue.2 , pp. 141-149
    • Scialla, J.J.1    Anderson, C.A.2
  • 34
    • 0029079026 scopus 로고
    • Potential renal acid load of foods and its influence on urine pH
    • COI: 1:STN:280:DyaK2MzhvVChsg%3D%3D, PID: 7797810
    • Remer T, Manz F. Potential renal acid load of foods and its influence on urine pH. J Am Diet Assoc. 1995;95(7):791–7.
    • (1995) J Am Diet Assoc , vol.95 , Issue.7 , pp. 791-797
    • Remer, T.1    Manz, F.2
  • 35
    • 0034221201 scopus 로고    scopus 로고
    • Influence of diet on acid-base balance
    • COI: 1:STN:280:DC%2BD3M%2Flt1Cnug%3D%3D, PID: 10923348
    • Remer T. Influence of diet on acid-base balance. Semin Dial. 2000;13(4):221–6.
    • (2000) Semin Dial , vol.13 , Issue.4 , pp. 221-226
    • Remer, T.1
  • 36
    • 82655173691 scopus 로고    scopus 로고
    • Estimated GFR, albuminuria, and complications of chronic kidney disease
    • PID: 21965377
    • Inker LA, Coresh J, Levey AS, Tonelli M, Muntner P. Estimated GFR, albuminuria, and complications of chronic kidney disease. J Am Soc Nephrol. 2011;22(12):2322–31.
    • (2011) J Am Soc Nephrol , vol.22 , Issue.12 , pp. 2322-2331
    • Inker, L.A.1    Coresh, J.2    Levey, A.S.3    Tonelli, M.4    Muntner, P.5
  • 38
    • 0001756271 scopus 로고
    • Production, excretion, and net balance of fixed acid in patients with renal acidosis
    • COI: 1:STN:280:DyaF2M%2Fot1Ogtw%3D%3D, PID: 14278166
    • Goodman AD, Lemann Jr J, Lennon EJ, Relman AS. Production, excretion, and net balance of fixed acid in patients with renal acidosis. J Clin Invest. 1965;44:495–506.
    • (1965) J Clin Invest , vol.44 , pp. 495-506
    • Goodman, A.D.1    Lemann, J.2    Lennon, E.J.3    Relman, A.S.4
  • 39
    • 0031985433 scopus 로고    scopus 로고
    • Acid production in chronic hemodialysis patients
    • COI: 1:STN:280:DyaK1c7gtlaluw%3D%3D, PID: 9440095
    • Uribarri J, Zia M, Mahmood J, Marcus RA, Oh MS. Acid production in chronic hemodialysis patients. J Am Soc Nephrol. 1998;9(1):114–20.
    • (1998) J Am Soc Nephrol , vol.9 , Issue.1 , pp. 114-120
    • Uribarri, J.1    Zia, M.2    Mahmood, J.3    Marcus, R.A.4    Oh, M.S.5
  • 40
    • 84934276827 scopus 로고    scopus 로고
    • The balance of the evidence on acid-base homeostasis and progression of chronic kidney disease
    • COI: 1:CAS:528:DC%2BC2MXhtlSjtL3J, PID: 26126088
    • Scialla JJ. The balance of the evidence on acid-base homeostasis and progression of chronic kidney disease. Kidney Int. 2015;88(1):9–11.
    • (2015) Kidney Int , vol.88 , Issue.1 , pp. 9-11
    • Scialla, J.J.1
  • 41
    • 34548395873 scopus 로고    scopus 로고
    • Effect of dietary protein intake on serum total CO2 concentration in chronic kidney disease: Modification of Diet in Renal Disease study findings
    • COI: 1:CAS:528:DC%2BD28XjvV2hu7k%3D, PID: 17699190
    • Gennari FJ, Hood VL, Greene T, Wang X, Levey AS. Effect of dietary protein intake on serum total CO2 concentration in chronic kidney disease: Modification of Diet in Renal Disease study findings. Clin J Am Soc Nephrol. 2006;1(1):52–7.
    • (2006) Clin J Am Soc Nephrol , vol.1 , Issue.1 , pp. 52-57
    • Gennari, F.J.1    Hood, V.L.2    Greene, T.3    Wang, X.4    Levey, A.S.5
  • 42
    • 79960312924 scopus 로고    scopus 로고
    • Estimated net endogenous acid production and serum bicarbonate in African Americans with chronic kidney disease
    • COI: 1:CAS:528:DC%2BC3MXhtValsLfP, PID: 21700817
    • Scialla JJ, Appel LJ, Astor BC, Miller 3rd ER, Beddhu S, Woodward M, et al. Estimated net endogenous acid production and serum bicarbonate in African Americans with chronic kidney disease. Clin J Am Soc Nephrol. 2011;6(7):1526–32.
    • (2011) Clin J Am Soc Nephrol , vol.6 , Issue.7 , pp. 1526-1532
    • Scialla, J.J.1    Appel, L.J.2    Astor, B.C.3    Miller, E.R.4    Beddhu, S.5    Woodward, M.6
  • 43
    • 0021013005 scopus 로고
    • Effect of diet on plasma acid-base composition in normal humans
    • COI: 1:CAS:528:DyaL2cXjtlGnsA%3D%3D, PID: 6663989
    • Kurtz I, Maher T, Hulter HN, Schambelan M, Sebastian A. Effect of diet on plasma acid-base composition in normal humans. Kidney Int. 1983;24(5):670–80.
    • (1983) Kidney Int , vol.24 , Issue.5 , pp. 670-680
    • Kurtz, I.1    Maher, T.2    Hulter, H.N.3    Schambelan, M.4    Sebastian, A.5
  • 44
    • 84958104184 scopus 로고    scopus 로고
    • Dietary acid load is associated with serum bicarbonate but not insulin sensitivity in chronic kidney disease
    • COI: 1:CAS:528:DC%2BC2MXhs12qt7zP, PID: 26508542
    • Ikizler HO, Zelnick L, Ruzinski J, Curtin L, Utzschneider KM, Kestenbaum B, et al. Dietary acid load is associated with serum bicarbonate but not insulin sensitivity in chronic kidney disease. J Ren Nutr. 2016;26(2):93–102.
    • (2016) J Ren Nutr , vol.26 , Issue.2 , pp. 93-102
    • Ikizler, H.O.1    Zelnick, L.2    Ruzinski, J.3    Curtin, L.4    Utzschneider, K.M.5    Kestenbaum, B.6
  • 45
    • 84889784861 scopus 로고    scopus 로고
    • Dietary acid, age, and serum bicarbonate levels among adults in the United States
    • COI: 1:CAS:528:DC%2BC2cXosFGhsQ%3D%3D, PID: 24052219
    • Amodu A, Abramowitz MK. Dietary acid, age, and serum bicarbonate levels among adults in the United States. Clin J Am Soc Nephrol. 2013;8(12):2034–42.
    • (2013) Clin J Am Soc Nephrol , vol.8 , Issue.12 , pp. 2034-2042
    • Amodu, A.1    Abramowitz, M.K.2
  • 46
    • 84907812376 scopus 로고    scopus 로고
    • Prevalence of and risk factors for reduced serum bicarbonate in chronic kidney disease
    • COI: 1:CAS:528:DC%2BC2cXhs1KhtLfP, PID: 25066359
    • Raphael KL, Zhang Y, Ying J, Greene T. Prevalence of and risk factors for reduced serum bicarbonate in chronic kidney disease. Nephrology. 2014;19(10):648–54.
    • (2014) Nephrology , vol.19 , Issue.10 , pp. 648-654
    • Raphael, K.L.1    Zhang, Y.2    Ying, J.3    Greene, T.4
  • 47
    • 80053925445 scopus 로고    scopus 로고
    • Serum bicarbonate and mortality in stage 3 and stage 4 chronic kidney disease
    • COI: 1:CAS:528:DC%2BC3MXhs1WgtrjI, PID: 21885787
    • Navaneethan SD, Schold JD, Arrigain S, Jolly SE, Wehbe E, Raina R, et al. Serum bicarbonate and mortality in stage 3 and stage 4 chronic kidney disease. Clin J Am Soc Nephrol. 2011;6(10):2395–402.
    • (2011) Clin J Am Soc Nephrol , vol.6 , Issue.10 , pp. 2395-2402
    • Navaneethan, S.D.1    Schold, J.D.2    Arrigain, S.3    Jolly, S.E.4    Wehbe, E.5    Raina, R.6
  • 48
    • 1642520802 scopus 로고    scopus 로고
    • The metabolic syndrome and uric acid nephrolithiasis: novel features of renal manifestation of insulin resistance
    • COI: 1:CAS:528:DC%2BD2cXhsVSns7c%3D, PID: 14717908
    • Abate N, Chandalia M, Cabo-Chan AV, Moe OW, Sakhaee K. The metabolic syndrome and uric acid nephrolithiasis: novel features of renal manifestation of insulin resistance. Kidney Int. 2004;65(2):386–92.
    • (2004) Kidney Int , vol.65 , Issue.2 , pp. 386-392
    • Abate, N.1    Chandalia, M.2    Cabo-Chan, A.V.3    Moe, O.W.4    Sakhaee, K.5
  • 49
    • 84938836695 scopus 로고    scopus 로고
    • Electrolyte and Acid-Base disturbances in patients with diabetes mellitus
    • PID: 26244308
    • Palmer BF, Clegg DJ. Electrolyte and Acid-Base disturbances in patients with diabetes mellitus. N Engl J Med. 2015;373(6):548–59.
    • (2015) N Engl J Med , vol.373 , Issue.6 , pp. 548-559
    • Palmer, B.F.1    Clegg, D.J.2
  • 50
    • 33846883310 scopus 로고    scopus 로고
    • Characterization of the regulation of renal Na+/H+ exchanger NHE3 by insulin
    • COI: 1:CAS:528:DC%2BD2sXjt1Gmsbw%3D, PID: 17018843
    • Fuster DG, Bobulescu IA, Zhang J, Wade J, Moe OW. Characterization of the regulation of renal Na+/H+ exchanger NHE3 by insulin. Am J Physiol Renal Physiol. 2007;292(2):F577–85.
    • (2007) Am J Physiol Renal Physiol. , vol.292 , Issue.2 , pp. F577-F585
    • Fuster, D.G.1    Bobulescu, I.A.2    Zhang, J.3    Wade, J.4    Moe, O.W.5
  • 51
    • 77954805668 scopus 로고    scopus 로고
    • Metabolic basis for low urine pH in type 2 diabetes
    • COI: 1:CAS:528:DC%2BC3cXhtVehu7vF, PID: 20413437
    • Maalouf NM, Cameron MA, Moe OW, Sakhaee K. Metabolic basis for low urine pH in type 2 diabetes. Clin J Am Soc Nephrol. 2010;5(7):1277–81.
    • (2010) Clin J Am Soc Nephrol , vol.5 , Issue.7 , pp. 1277-1281
    • Maalouf, N.M.1    Cameron, M.A.2    Moe, O.W.3    Sakhaee, K.4
  • 52
    • 33646383355 scopus 로고    scopus 로고
    • Urine composition in type 2 diabetes: predisposition to uric acid nephrolithiasis
    • COI: 1:CAS:528:DC%2BD28XkvVKrtr8%3D, PID: 16597681
    • Cameron MA, Maalouf NM, Adams-Huet B, Moe OW, Sakhaee K. Urine composition in type 2 diabetes: predisposition to uric acid nephrolithiasis. J Am Soc Nephrol. 2006;17(5):1422–8.
    • (2006) J Am Soc Nephrol , vol.17 , Issue.5 , pp. 1422-1428
    • Cameron, M.A.1    Maalouf, N.M.2    Adams-Huet, B.3    Moe, O.W.4    Sakhaee, K.5
  • 53
    • 84887573182 scopus 로고    scopus 로고
    • Renal ammonium excretion after an acute acid load: blunted response in uric acid stone formers but not in patients with type 2 diabetes
    • Bobulescu IA, Maalouf NM, Capolongo G, Adams-Huet B, Rosenthal TR, Moe OW, et al. Renal ammonium excretion after an acute acid load: blunted response in uric acid stone formers but not in patients with type 2 diabetes. Am J Physiol Renal Physiol. 2013;305(10): F1498-F503.
    • (2013) Am J Physiol Renal Physiol , vol.305 , Issue.10 , pp. F1498-F1503
    • Bobulescu, I.A.1    Maalouf, N.M.2    Capolongo, G.3    Adams-Huet, B.4    Rosenthal, T.R.5    Moe, O.W.6
  • 54
    • 85006459161 scopus 로고    scopus 로고
    • •• Scialla JJ, Asplin J, Dobre M, Chang AR, Lash J, Hsu CY, et al. Higher net acid excretion is associated with a lower risk of kidney disease progression in patients with diabetes. 91(1):204–15. In this study of 980 participants with CKD, higher urine net acid excretion was associated with lower risk of progression to ESKD or 50% decline in kidney function among participants with diabetes, but not those without. Higher urine net acid excretion was independently associated with lower serum bicarbonate suggesting that it represented a higher non-volatile acid load. Interestingly, diet-dependent acid load ascertained by food frequency questionnaire was not associated with progression of CKD among the participants with diabetes, suggesting that the risk associated with low acid excretion could be related to diet-independent acid production
    • •• Scialla JJ, Asplin J, Dobre M, Chang AR, Lash J, Hsu CY, et al. Higher net acid excretion is associated with a lower risk of kidney disease progression in patients with diabetes. Kidney Int. 2017;91(1):204–15. In this study of 980 participants with CKD, higher urine net acid excretion was associated with lower risk of progression to ESKD or 50% decline in kidney function among participants with diabetes, but not those without. Higher urine net acid excretion was independently associated with lower serum bicarbonate suggesting that it represented a higher non-volatile acid load. Interestingly, diet-dependent acid load ascertained by food frequency questionnaire was not associated with progression of CKD among the participants with diabetes, suggesting that the risk associated with low acid excretion could be related to diet-independent acid production.
    • (2017) Kidney Int.
  • 55
    • 84887108045 scopus 로고    scopus 로고
    • Metabolomics reveals signature of mitochondrial dysfunction in diabetic kidney disease
    • COI: 1:CAS:528:DC%2BC3sXhslymsL7N, PID: 23949796
    • Sharma K, Karl B, Mathew AV, Gangoiti JA, Wassel CL, Saito R, et al. Metabolomics reveals signature of mitochondrial dysfunction in diabetic kidney disease. J Am Soc Nephrol. 2013;24(11):1901–12.
    • (2013) J Am Soc Nephrol , vol.24 , Issue.11 , pp. 1901-1912
    • Sharma, K.1    Karl, B.2    Mathew, A.V.3    Gangoiti, J.A.4    Wassel, C.L.5    Saito, R.6
  • 56
    • 84878883760 scopus 로고    scopus 로고
    • • Mandel EI, Taylor EN, Curhan GC. Dietary and lifestyle factors and medical conditions associated with urinary citrate excretion.8(6):901–8. Using a subset of participants from the Health Professionals Follow up Study and the Nurses Health Study with 24-hour urine collections available, these investigators found an independent association between diabetes mellitus and higher urine citrate. Typically, urine citrate falls with metabolic acidosis and lower urine pH, both common in diabetes. This finding may suggest that the production or reabsorption of citrate is impaired in diabetes
    • • Mandel EI, Taylor EN, Curhan GC. Dietary and lifestyle factors and medical conditions associated with urinary citrate excretion. Clin J Am Soc Nephrol. 2013;8(6):901–8. Using a subset of participants from the Health Professionals Follow up Study and the Nurses Health Study with 24-hour urine collections available, these investigators found an independent association between diabetes mellitus and higher urine citrate. Typically, urine citrate falls with metabolic acidosis and lower urine pH, both common in diabetes. This finding may suggest that the production or reabsorption of citrate is impaired in diabetes.
    • (2013) Clin J Am Soc Nephrol
  • 57
    • 78649764303 scopus 로고    scopus 로고
    • Association of blood lactate with type 2 diabetes: the Atherosclerosis Risk in Communities Carotid MRI Study
    • PID: 20797988
    • Crawford SO, Hoogeveen RC, Brancati FL, Astor BC, Ballantyne CM, Schmidt MI, et al. Association of blood lactate with type 2 diabetes: the Atherosclerosis Risk in Communities Carotid MRI Study. Int J Epidemiol. 2010;39(6):1647–55.
    • (2010) Int J Epidemiol , vol.39 , Issue.6 , pp. 1647-1655
    • Crawford, S.O.1    Hoogeveen, R.C.2    Brancati, F.L.3    Astor, B.C.4    Ballantyne, C.M.5    Schmidt, M.I.6
  • 58
    • 84891539539 scopus 로고    scopus 로고
    • Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men
    • COI: 1:CAS:528:DC%2BC3sXhsFOhtLnM, PID: 23557707
    • Mahendran Y, Vangipurapu J, Cederberg H, Stancakova A, Pihlajamaki J, Soininen P, et al. Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men. Diabetes. 2013;62(10):3618–26.
    • (2013) Diabetes , vol.62 , Issue.10 , pp. 3618-3626
    • Mahendran, Y.1    Vangipurapu, J.2    Cederberg, H.3    Stancakova, A.4    Pihlajamaki, J.5    Soininen, P.6
  • 59
    • 27444433127 scopus 로고    scopus 로고
    • Metabolic syndrome and the risk for chronic kidney disease among nondiabetic adults
    • PID: 15901764
    • Kurella M, Lo JC, Chertow GM. Metabolic syndrome and the risk for chronic kidney disease among nondiabetic adults. J Am Soc Nephrol. 2005;16(7):2134–40.
    • (2005) J Am Soc Nephrol , vol.16 , Issue.7 , pp. 2134-2140
    • Kurella, M.1    Lo, J.C.2    Chertow, G.M.3
  • 60
    • 0018462128 scopus 로고
    • Glucose intolerance following chronic metabolic acidosis in man
    • COI: 1:CAS:528:DyaE1MXhvVCgt7o%3D
    • DeFronzo RA, Beckles AD. Glucose intolerance following chronic metabolic acidosis in man. Am J Phys. 1979;236(4):E328–34.
    • (1979) Am J Phys , vol.236 , Issue.4 , pp. E328-E334
    • DeFronzo, R.A.1    Beckles, A.D.2
  • 61
    • 0031818196 scopus 로고    scopus 로고
    • Insulin resistance and hyperinsulinemia are already present in patients with incipient renal disease
    • COI: 1:STN:280:DyaK1c3jsVKgsA%3D%3D, PID: 9573550
    • Fliser D, Pacini G, Engelleiter R, Kautzky-Willer A, Prager R, Franek E, et al. Insulin resistance and hyperinsulinemia are already present in patients with incipient renal disease. Kidney Int. 1998;53(5):1343–7.
    • (1998) Kidney Int , vol.53 , Issue.5 , pp. 1343-1347
    • Fliser, D.1    Pacini, G.2    Engelleiter, R.3    Kautzky-Willer, A.4    Prager, R.5    Franek, E.6
  • 63
    • 84903692695 scopus 로고    scopus 로고
    • Clinical correlates of insulin sensitivity and its association with mortality among men with CKD stages 3 and 4
    • COI: 1:CAS:528:DC%2BC2cXps1Wnt7s%3D, PID: 24436478
    • Xu H, Huang X, Arnlov J, Cederholm T, Stenvinkel P, Lindholm B, et al. Clinical correlates of insulin sensitivity and its association with mortality among men with CKD stages 3 and 4. Clin J Am Soc Nephrol. 2014;9(4):690–7.
    • (2014) Clin J Am Soc Nephrol , vol.9 , Issue.4 , pp. 690-697
    • Xu, H.1    Huang, X.2    Arnlov, J.3    Cederholm, T.4    Stenvinkel, P.5    Lindholm, B.6
  • 64
    • 21344446701 scopus 로고    scopus 로고
    • Renal insulin resistance syndrome, adiponectin and cardiovascular events in patients with kidney disease: the mild and moderate kidney disease study
    • COI: 1:CAS:528:DC%2BD2MXjsVWqt78%3D, PID: 15743998
    • Becker B, Kronenberg F, Kielstein JT, Haller H, Morath C, Ritz E, et al. Renal insulin resistance syndrome, adiponectin and cardiovascular events in patients with kidney disease: the mild and moderate kidney disease study. J Am Soc Nephrol. 2005;16(4):1091–8.
    • (2005) J Am Soc Nephrol , vol.16 , Issue.4 , pp. 1091-1098
    • Becker, B.1    Kronenberg, F.2    Kielstein, J.T.3    Haller, H.4    Morath, C.5    Ritz, E.6
  • 65
    • 15944406797 scopus 로고    scopus 로고
    • Insulin resistance in patients with chronic kidney disease
    • COI: 1:CAS:528:DC%2BD2MXit1yitL8%3D, PID: 15685504
    • Kobayashi S, Maesato K, Moriya H, Ohtake T, Ikeda T. Insulin resistance in patients with chronic kidney disease. Am J Kidney Dis. 2005;45(2):275–80.
    • (2005) Am J Kidney Dis , vol.45 , Issue.2 , pp. 275-280
    • Kobayashi, S.1    Maesato, K.2    Moriya, H.3    Ohtake, T.4    Ikeda, T.5
  • 66
    • 84951569218 scopus 로고    scopus 로고
    • Insulin sensitivity of muscle protein metabolism is altered in patients with chronic kidney disease and metabolic acidosis
    • COI: 1:CAS:528:DC%2BC2MXhsVeqt73M, PID: 26308671
    • Garibotto G, Sofia A, Russo R, Paoletti E, Bonanni A, Parodi EL, et al. Insulin sensitivity of muscle protein metabolism is altered in patients with chronic kidney disease and metabolic acidosis. Kidney Int. 2015;88(6):1419–26.
    • (2015) Kidney Int , vol.88 , Issue.6 , pp. 1419-1426
    • Garibotto, G.1    Sofia, A.2    Russo, R.3    Paoletti, E.4    Bonanni, A.5    Parodi, E.L.6
  • 67
    • 0028894394 scopus 로고
    • Insulin-mediated changes in PD and glucose uptake after correction of acidosis in humans with CRF
    • COI: 1:CAS:528:DyaK2MXktFWqsL0%3D
    • Reaich D, Graham KA, Channon SM, Hetherington C, Scrimgeour CM, Wilkinson R, et al. Insulin-mediated changes in PD and glucose uptake after correction of acidosis in humans with CRF. Am J Phys. 1995;268(1 Pt 1):E121–6.
    • (1995) Am J Phys , vol.268 , Issue.1 , pp. E121-E126
    • Reaich, D.1    Graham, K.A.2    Channon, S.M.3    Hetherington, C.4    Scrimgeour, C.M.5    Wilkinson, R.6
  • 68
    • 0031848209 scopus 로고    scopus 로고
    • Effect of metabolic acidosis on insulin action and secretion in uremia
    • COI: 1:STN:280:DyaK1czlsVKrtw%3D%3D, PID: 9690228
    • Mak RH. Effect of metabolic acidosis on insulin action and secretion in uremia. Kidney Int. 1998;54(2):603–7.
    • (1998) Kidney Int , vol.54 , Issue.2 , pp. 603-607
    • Mak, R.H.1
  • 69
    • 84992214354 scopus 로고    scopus 로고
    • Correction of metabolic acidosis improves insulin resistance in chronic kidney disease
    • PID: 27770799, In this post hoc analysis of 145 participants with type 2 diabetes, kidney disease, and serum bicarbonate less than 24 mEq/L, treatment with sodium bicarbonate vs. control for 1 year resulted in improvements in glucose control (HgA1c) and insulin resistance (homeostatic model assessment of insulin resistance). Improvement in these parameters correlated with the degree of improvement in serum bicarbonate
    • • Bellasi A, Di Micco L, Santoro D, Marzocco S, De Simone E, Cozzolino M, et al. Correction of metabolic acidosis improves insulin resistance in chronic kidney disease. BMC Nephrol. 2016;17(1):158. In this post hoc analysis of 145 participants with type 2 diabetes, kidney disease, and serum bicarbonate less than 24 mEq/L, treatment with sodium bicarbonate vs. control for 1 year resulted in improvements in glucose control (HgA1c) and insulin resistance (homeostatic model assessment of insulin resistance). Improvement in these parameters correlated with the degree of improvement in serum bicarbonate.
    • (2016) BMC Nephrol , vol.17 , Issue.1 , pp. 158
    • Bellasi, A.1    Di Micco, L.2    Santoro, D.3    Marzocco, S.4    De Simone, E.5    Cozzolino, M.6
  • 70
    • 84883744221 scopus 로고    scopus 로고
    • Established dietary estimates of net acid production do not predict measured net acid excretion in patients with type 2 diabetes on Paleolithic-Hunter-Gatherer-type diets
    • COI: 1:CAS:528:DC%2BC3sXhsVWqsr%2FJ, PID: 23859996
    • Frassetto LA, Shi L, Schloetter M, Sebastian A, Remer T. Established dietary estimates of net acid production do not predict measured net acid excretion in patients with type 2 diabetes on Paleolithic-Hunter-Gatherer-type diets. Eur J Clin Nutr. 2013;67(9):899–903.
    • (2013) Eur J Clin Nutr , vol.67 , Issue.9 , pp. 899-903
    • Frassetto, L.A.1    Shi, L.2    Schloetter, M.3    Sebastian, A.4    Remer, T.5
  • 71
    • 84938973110 scopus 로고    scopus 로고
    • Metabolic and physiologic effects from consuming a hunter-gatherer (Paleolithic)-type diet in type 2 diabetes
    • COI: 1:CAS:528:DC%2BC2MXls1arurg%3D, PID: 25828624
    • Masharani U, Sherchan P, Schloetter M, Stratford S, Xiao A, Sebastian A, et al. Metabolic and physiologic effects from consuming a hunter-gatherer (Paleolithic)-type diet in type 2 diabetes. Eur J Clin Nutr. 2015;69(8):944–8.
    • (2015) Eur J Clin Nutr , vol.69 , Issue.8 , pp. 944-948
    • Masharani, U.1    Sherchan, P.2    Schloetter, M.3    Stratford, S.4    Xiao, A.5    Sebastian, A.6
  • 72
    • 68549104418 scopus 로고    scopus 로고
    • Metabolic and physiologic improvements from consuming a paleolithic, hunter-gatherer type diet
    • COI: 1:CAS:528:DC%2BD1MXps1Wmu7Y%3D, PID: 19209185
    • Frassetto LA, Schloetter M, Mietus-Synder M, Morris Jr RC, Sebastian A. Metabolic and physiologic improvements from consuming a paleolithic, hunter-gatherer type diet. Eur J Clin Nutr. 2009;63(8):947–55.
    • (2009) Eur J Clin Nutr , vol.63 , Issue.8 , pp. 947-955
    • Frassetto, L.A.1    Schloetter, M.2    Mietus-Synder, M.3    Morris, R.C.4    Sebastian, A.5
  • 73
    • 49649100850 scopus 로고    scopus 로고
    • Serum bicarbonate, anion gap and insulin resistance in the National Health and Nutrition Examination Survey
    • COI: 1:CAS:528:DC%2BD1cXpvFyiur0%3D, PID: 18644066
    • Farwell WR, Taylor EN. Serum bicarbonate, anion gap and insulin resistance in the National Health and Nutrition Examination Survey. Diabet Med. 2008;25(7):798–804.
    • (2008) Diabet Med , vol.25 , Issue.7 , pp. 798-804
    • Farwell, W.R.1    Taylor, E.N.2
  • 74
    • 84960496354 scopus 로고    scopus 로고
    • High dietary acid load is associated with insulin resistance: the Furukawa Nutrition and Health Study
    • COI: 1:CAS:528:DC%2BC2MXlslCltbg%3D, PID: 25863769
    • Akter S, Eguchi M, Kuwahara K, Kochi T, Ito R, Kurotani K, et al. High dietary acid load is associated with insulin resistance: the Furukawa Nutrition and Health Study. Clin Nutr. 2016;35(2):453–9.
    • (2016) Clin Nutr , vol.35 , Issue.2 , pp. 453-459
    • Akter, S.1    Eguchi, M.2    Kuwahara, K.3    Kochi, T.4    Ito, R.5    Kurotani, K.6
  • 75
    • 84978971757 scopus 로고    scopus 로고
    • Association between dietary acid load and insulin resistance: Tehran lipid and glucose study
    • PID: 27390726
    • Moghadam SK, Bahadoran Z, Mirmiran P, Tohidi M, Azizi F. Association between dietary acid load and insulin resistance: Tehran lipid and glucose study. Prev Nutr Food Sci. 2016;21(2):104–9.
    • (2016) Prev Nutr Food Sci , vol.21 , Issue.2 , pp. 104-109
    • Moghadam, S.K.1    Bahadoran, Z.2    Mirmiran, P.3    Tohidi, M.4    Azizi, F.5
  • 76
    • 84904729848 scopus 로고    scopus 로고
    • Dietary acid load, insulin sensitivity and risk of type 2 diabetes in community-dwelling older men
    • COI: 1:CAS:528:DC%2BC2cXptVarsbo%3D, PID: 24875749
    • Xu H, Jia T, Huang X, Riserus U, Cederholm T, Arnlov J, et al. Dietary acid load, insulin sensitivity and risk of type 2 diabetes in community-dwelling older men. Diabetologia. 2014;57(8):1561–8.
    • (2014) Diabetologia , vol.57 , Issue.8 , pp. 1561-1568
    • Xu, H.1    Jia, T.2    Huang, X.3    Riserus, U.4    Cederholm, T.5    Arnlov, J.6
  • 77
    • 84896708561 scopus 로고    scopus 로고
    • Lowered extracellular pH is involved in the pathogenesis of skeletal muscle insulin resistance
    • COI: 1:CAS:528:DC%2BC2cXislKqsbo%3D, PID: 24502946
    • Hayata H, Miyazaki H, Niisato N, Yokoyama N, Marunaka Y. Lowered extracellular pH is involved in the pathogenesis of skeletal muscle insulin resistance. Biochem Biophys Res Commun. 2014;445(1):170–4.
    • (2014) Biochem Biophys Res Commun , vol.445 , Issue.1 , pp. 170-174
    • Hayata, H.1    Miyazaki, H.2    Niisato, N.3    Yokoyama, N.4    Marunaka, Y.5
  • 78
    • 0037214031 scopus 로고    scopus 로고
    • Neutralization of Western diet inhibits bone resorption independently of K intake and reduces cortisol secretion in humans
    • COI: 1:CAS:528:DC%2BD3sXmvF2lsw%3D%3D, PID: 12388390
    • Maurer M, Riesen W, Muser J, Hulter HN, Krapf R. Neutralization of Western diet inhibits bone resorption independently of K intake and reduces cortisol secretion in humans. Am J Physiol Renal Physiol. 2003;284(1):F32–40.
    • (2003) Am J Physiol Renal Physiol , vol.284 , Issue.1 , pp. F32-F40
    • Maurer, M.1    Riesen, W.2    Muser, J.3    Hulter, H.N.4    Krapf, R.5
  • 79
    • 11144332589 scopus 로고    scopus 로고
    • Acid-base balance may influence risk for insulin resistance syndrome by modulating cortisol output
    • COI: 1:CAS:528:DC%2BD2cXhtVyrsrfP, PID: 15607573
    • McCarty MF. Acid-base balance may influence risk for insulin resistance syndrome by modulating cortisol output. Med Hypotheses. 2005;64(2):380–4.
    • (2005) Med Hypotheses , vol.64 , Issue.2 , pp. 380-384
    • McCarty, M.F.1
  • 80
    • 1542466784 scopus 로고    scopus 로고
    • Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice
    • COI: 1:CAS:528:DC%2BD2cXjsVGlsQ%3D%3D, PID: 14702113
    • Yakar S, Setser J, Zhao H, Stannard B, Haluzik M, Glatt V, et al. Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice. J Clin Invest. 2004;113(1):96–105.
    • (2004) J Clin Invest , vol.113 , Issue.1 , pp. 96-105
    • Yakar, S.1    Setser, J.2    Zhao, H.3    Stannard, B.4    Haluzik, M.5    Glatt, V.6
  • 81
    • 0031047919 scopus 로고    scopus 로고
    • Effect of chronic metabolic acidosis on the growth hormone/IGF-1 endocrine axis: new cause of growth hormone insensitivity in humans
    • COI: 1:CAS:528:DyaK2sXoslWrsw%3D%3D, PID: 8995736
    • Brungger M, Hulter HN, Krapf R. Effect of chronic metabolic acidosis on the growth hormone/IGF-1 endocrine axis: new cause of growth hormone insensitivity in humans. Kidney Int. 1997;51(1):216–21.
    • (1997) Kidney Int , vol.51 , Issue.1 , pp. 216-221
    • Brungger, M.1    Hulter, H.N.2    Krapf, R.3
  • 82
    • 84992529967 scopus 로고    scopus 로고
    • Higher diet-dependent renal acid load associates with higher glucocorticoid secretion and potentially bioactive free glucocorticoids in healthy children
    • COI: 1:CAS:528:DC%2BC28XhtFOltr7F, PID: 27165611
    • Esche J, Shi L, Sánchez-Guijo A, Hartmann MF, Wudy SA, Remer T. Higher diet-dependent renal acid load associates with higher glucocorticoid secretion and potentially bioactive free glucocorticoids in healthy children. Kidney Int. 2016;90(2):325–33.
    • (2016) Kidney Int , vol.90 , Issue.2 , pp. 325-333
    • Esche, J.1    Shi, L.2    Sánchez-Guijo, A.3    Hartmann, M.F.4    Wudy, S.A.5    Remer, T.6
  • 83
    • 84940983480 scopus 로고    scopus 로고
    • Glucocorticoid activity and metabolism with NaCl-induced low-grade metabolic acidosis and oral alkalization: results of two randomized controlled trials
    • COI: 1:CAS:528:DC%2BC2MXhsVygtrvI, PID: 26349936
    • Buehlmeier J, Remer T, Frings-Meuthen P, Maser-Gluth C, Heer M. Glucocorticoid activity and metabolism with NaCl-induced low-grade metabolic acidosis and oral alkalization: results of two randomized controlled trials. Endocrine. 2016;52(1):139–47.
    • (2016) Endocrine , vol.52 , Issue.1 , pp. 139-147
    • Buehlmeier, J.1    Remer, T.2    Frings-Meuthen, P.3    Maser-Gluth, C.4    Heer, M.5
  • 84
    • 11444267472 scopus 로고    scopus 로고
    • Metabolic acidosis and malnutrition-inflammation complex syndrome in chronic renal failure
    • PID: 15660576
    • Kalantar-Zadeh K, Mehrotra R, Fouque D, Kopple JD. Metabolic acidosis and malnutrition-inflammation complex syndrome in chronic renal failure. Semin Dial. 2004;17(6):455–65.
    • (2004) Semin Dial , vol.17 , Issue.6 , pp. 455-465
    • Kalantar-Zadeh, K.1    Mehrotra, R.2    Fouque, D.3    Kopple, J.D.4
  • 85
    • 58049087587 scopus 로고    scopus 로고
    • Correction of metabolic acidosis to ameliorate wasting in chronic kidney disease: goals and strategies
    • COI: 1:CAS:528:DC%2BD1MXitVWiu7w%3D, PID: 19121476
    • Chiu YW, Kopple JD, Mehrotra R. Correction of metabolic acidosis to ameliorate wasting in chronic kidney disease: goals and strategies. Semin Nephrol. 2009;29(1):67–74.
    • (2009) Semin Nephrol , vol.29 , Issue.1 , pp. 67-74
    • Chiu, Y.W.1    Kopple, J.D.2    Mehrotra, R.3
  • 86
    • 84866540105 scopus 로고    scopus 로고
    • Plasma bicarbonate and risk of type 2 diabetes mellitus
    • PID: 22825995
    • Mandel EI, Curhan GC, Hu FB, Taylor EN. Plasma bicarbonate and risk of type 2 diabetes mellitus. CMAJ. 2012;184(13):E719–25.
    • (2012) CMAJ , vol.184 , Issue.13 , pp. E719-E725
    • Mandel, E.I.1    Curhan, G.C.2    Hu, F.B.3    Taylor, E.N.4
  • 87
    • 84893646969 scopus 로고    scopus 로고
    • Dietary acid load and risk of type 2 diabetes: the E3N-EPIC cohort study
    • COI: 1:CAS:528:DC%2BC3sXhslKqt7%2FL, PID: 24232975, Among over 60,000 women in this French cohort, the risk of a new diagnosis of diabetes over 14 years of follow-up was higher for women consuming diets with higher diet-dependent acid load independent of total calorie intake and other lifestyle variables. Diet was assessed by self-report with a food frequency questionnaire, and results were similar if acid load was quantified as the potential renal acid load or the net endogenous acid production
    • •• Fagherazzi G, Vilier A, Bonnet F, Lajous M, Balkau B, Boutron-Rualt MC, et al. Dietary acid load and risk of type 2 diabetes: the E3N-EPIC cohort study. Diabetologia. 2014;57(2):313–20. Among over 60,000 women in this French cohort, the risk of a new diagnosis of diabetes over 14 years of follow-up was higher for women consuming diets with higher diet-dependent acid load independent of total calorie intake and other lifestyle variables. Diet was assessed by self-report with a food frequency questionnaire, and results were similar if acid load was quantified as the potential renal acid load or the net endogenous acid production.
    • (2014) Diabetologia , vol.57 , Issue.2 , pp. 313-320
    • Fagherazzi, G.1    Vilier, A.2    Bonnet, F.3    Lajous, M.4    Balkau, B.5    Boutron-Rualt, M.C.6
  • 88
    • 84978842697 scopus 로고    scopus 로고
    • High dietary acid load score is associated with increased risk of type 2 diabetes in Japanese men: the Japan Public Health Center-based Prospective Study
    • COI: 1:CAS:528:DC%2BC28XhsVSgt77K, PID: 27052540
    • Akter S, Kurotani K, Kashino I, Goto A, Mizoue T, Noda M, et al. High dietary acid load score is associated with increased risk of type 2 diabetes in Japanese men: the Japan Public Health Center-based Prospective Study. J Nutr. 2016;146(5):1076–83.
    • (2016) J Nutr , vol.146 , Issue.5 , pp. 1076-1083
    • Akter, S.1    Kurotani, K.2    Kashino, I.3    Goto, A.4    Mizoue, T.5    Noda, M.6
  • 89
    • 84995810843 scopus 로고    scopus 로고
    • Diet-dependent acid load and type 2 diabetes: pooled results from three prospective cohort studies
    • COI: 1:CAS:528:DC%2BC28XhvFSls7bO, PID: 27858141
    • Kiefte-de Jong JC, Li Y, Chen M, Curhan GC, Mattei J, Malik VS, et al. Diet-dependent acid load and type 2 diabetes: pooled results from three prospective cohort studies. Diabetologia. 2017;60(2):270–9.
    • (2017) Diabetologia , vol.60 , Issue.2 , pp. 270-279
    • Kiefte-de Jong, J.C.1    Li, Y.2    Chen, M.3    Curhan, G.C.4    Mattei, J.5    Malik, V.S.6
  • 90
    • 0025039172 scopus 로고
    • Salt sensitivity in humans is associated with abnormal acid-base regulation
    • COI: 1:CAS:528:DyaK3MXhs1Wrsr8%3D, PID: 2210808
    • Sharma AM, Kribben A, Schattenfroh S, Cetto C, Distler A. Salt sensitivity in humans is associated with abnormal acid-base regulation. Hypertension. 1990;16(4):407–13.
    • (1990) Hypertension , vol.16 , Issue.4 , pp. 407-413
    • Sharma, A.M.1    Kribben, A.2    Schattenfroh, S.3    Cetto, C.4    Distler, A.5
  • 91
    • 84868192585 scopus 로고    scopus 로고
    • Salt sensitivity of blood pressure is associated with polymorphisms in the sodium-bicarbonate cotransporter
    • COI: 1:CAS:528:DC%2BC38XhsFagtL%2FF, PID: 22987918
    • Carey RM, Schoeffel CD, Gildea JJ, Jones JE, McGrath HE, Gordon LN, et al. Salt sensitivity of blood pressure is associated with polymorphisms in the sodium-bicarbonate cotransporter. Hypertension. 2012;60(5):1359–66.
    • (2012) Hypertension , vol.60 , Issue.5 , pp. 1359-1366
    • Carey, R.M.1    Schoeffel, C.D.2    Gildea, J.J.3    Jones, J.E.4    McGrath, H.E.5    Gordon, L.N.6
  • 92
    • 84856951870 scopus 로고    scopus 로고
    • Targeted mutation of SLC4A5 induces arterial hypertension and renal metabolic acidosis
    • PID: 22082831
    • Groger N, Vitzthum H, Frohlich H, Kruger M, Ehmke H, Braun T, et al. Targeted mutation of SLC4A5 induces arterial hypertension and renal metabolic acidosis. Hum Mol Genet. 2012;21(5):1025–36.
    • (2012) Hum Mol Genet , vol.21 , Issue.5 , pp. 1025-1036
    • Groger, N.1    Vitzthum, H.2    Frohlich, H.3    Kruger, M.4    Ehmke, H.5    Braun, T.6
  • 93
    • 84890461750 scopus 로고    scopus 로고
    • Plasma bicarbonate and odds of incident hypertension
    • COI: 1:CAS:528:DC%2BC3sXhslGgs7vL, PID: 23942654
    • Mandel EI, Forman JP, Curhan GC, Taylor EN. Plasma bicarbonate and odds of incident hypertension. Am J Hypertens. 2013;26(12):1405–12.
    • (2013) Am J Hypertens , vol.26 , Issue.12 , pp. 1405-1412
    • Mandel, E.I.1    Forman, J.P.2    Curhan, G.C.3    Taylor, E.N.4
  • 94
    • 34547640267 scopus 로고    scopus 로고
    • Serum anion gap and blood pressure in the national health and nutrition examination survey
    • COI: 1:CAS:528:DC%2BD2sXnsFOjtr8%3D, PID: 17562979
    • Taylor EN, Forman JP, Farwell WR. Serum anion gap and blood pressure in the national health and nutrition examination survey. Hypertension. 2007;50(2):320–4.
    • (2007) Hypertension , vol.50 , Issue.2 , pp. 320-324
    • Taylor, E.N.1    Forman, J.P.2    Farwell, W.R.3
  • 95
    • 70349677348 scopus 로고    scopus 로고
    • Diet-dependent net acid load and risk of incident hypertension in United States women
    • COI: 1:CAS:528:DC%2BD1MXhtFSns7rN, PID: 19667248
    • Zhang L, Curhan GC, Forman JP. Diet-dependent net acid load and risk of incident hypertension in United States women. Hypertension. 2009;54(4):751–5.
    • (2009) Hypertension , vol.54 , Issue.4 , pp. 751-755
    • Zhang, L.1    Curhan, G.C.2    Forman, J.P.3
  • 96
    • 84920884249 scopus 로고    scopus 로고
    • High dietary acid load is associated with increased prevalence of hypertension: the Furukawa Nutrition and Health Study
    • COI: 1:CAS:528:DC%2BC2MXhtFGrtrY%3D, PID: 25592007
    • Akter S, Eguchi M, Kurotani K, Kochi T, Pham NM, Ito R, et al. High dietary acid load is associated with increased prevalence of hypertension: the Furukawa Nutrition and Health Study. Nutrition. 2015;31(2):298–303.
    • (2015) Nutrition , vol.31 , Issue.2 , pp. 298-303
    • Akter, S.1    Eguchi, M.2    Kurotani, K.3    Kochi, T.4    Pham, N.M.5    Ito, R.6
  • 97
    • 49649129739 scopus 로고    scopus 로고
    • Association between dietary acid-base load and cardiometabolic risk factors in young Japanese women
    • COI: 1:CAS:528:DC%2BD1cXht1Snt7zN, PID: 18279559
    • Murakami K, Sasaki S, Takahashi Y, Uenishi K. Association between dietary acid-base load and cardiometabolic risk factors in young Japanese women. Br J Nutr. 2008;100(3):642–51.
    • (2008) Br J Nutr , vol.100 , Issue.3 , pp. 642-651
    • Murakami, K.1    Sasaki, S.2    Takahashi, Y.3    Uenishi, K.4
  • 98
    • 84891561642 scopus 로고    scopus 로고
    • Longitudinal relationships between diet-dependent renal acid load and blood pressure development in healthy children
    • COI: 1:CAS:528:DC%2BC3sXhsVCqtbnM, PID: 24025638
    • Krupp D, Shi L, Remer T. Longitudinal relationships between diet-dependent renal acid load and blood pressure development in healthy children. Kidney Int. 2014;85(1):204–10.
    • (2014) Kidney Int , vol.85 , Issue.1 , pp. 204-210
    • Krupp, D.1    Shi, L.2    Remer, T.3
  • 99
    • 84922183749 scopus 로고    scopus 로고
    • Estimated dietary acid load is not associated with blood pressure or hypertension incidence in men who are approximately 70 years old
    • PID: 25644353
    • Luis D, Huang X, Riserus U, Sjogren P, Lindholm B, Arnlov J, et al. Estimated dietary acid load is not associated with blood pressure or hypertension incidence in men who are approximately 70 years old. J Nutr. 2015;145(2):315–21.
    • (2015) J Nutr , vol.145 , Issue.2 , pp. 315-321
    • Luis, D.1    Huang, X.2    Riserus, U.3    Sjogren, P.4    Lindholm, B.5    Arnlov, J.6
  • 101
    • 65349120865 scopus 로고    scopus 로고
    • Association of serum bicarbonate levels with mortality in patients with non-dialysis-dependent CKD
    • COI: 1:CAS:528:DC%2BD1MXjsFeks70%3D, PID: 19015169
    • Kovesdy CP, Anderson JE, Kalantar-Zadeh K. Association of serum bicarbonate levels with mortality in patients with non-dialysis-dependent CKD. Nephrol Dial Transplant. 2009;24(4):1232–7.
    • (2009) Nephrol Dial Transplant , vol.24 , Issue.4 , pp. 1232-1237
    • Kovesdy, C.P.1    Anderson, J.E.2    Kalantar-Zadeh, K.3
  • 104
    • 84957073008 scopus 로고    scopus 로고
    • Bicarbonate concentration, acid-base status, and mortality in the health, aging, and body composition study
    • COI: 1:CAS:528:DC%2BC28XitFSksLjO, PID: 26769766
    • Raphael KL, Murphy RA, Shlipak MG, Satterfield S, Huston HK, Sebastian A, et al. Bicarbonate concentration, acid-base status, and mortality in the health, aging, and body composition study. Clin J Am Soc Nephrol. 2016;11(2):308–16.
    • (2016) Clin J Am Soc Nephrol , vol.11 , Issue.2 , pp. 308-316
    • Raphael, K.L.1    Murphy, R.A.2    Shlipak, M.G.3    Satterfield, S.4    Huston, H.K.5    Sebastian, A.6
  • 105
    • 83655201399 scopus 로고    scopus 로고
    • Dietary acid reduction with fruits and vegetables or bicarbonate attenuates kidney injury in patients with a moderately reduced glomerular filtration rate due to hypertensive nephropathy
    • COI: 1:CAS:528:DC%2BC3MXhs1ejsr%2FE, PID: 21881553
    • Goraya N, Simoni J, Jo C, Wesson DE. Dietary acid reduction with fruits and vegetables or bicarbonate attenuates kidney injury in patients with a moderately reduced glomerular filtration rate due to hypertensive nephropathy. Kidney Int. 2012;81(1):86–93.
    • (2012) Kidney Int , vol.81 , Issue.1 , pp. 86-93
    • Goraya, N.1    Simoni, J.2    Jo, C.3    Wesson, D.E.4
  • 106
    • 84934767676 scopus 로고    scopus 로고
    • • Banerjee T, Crews DC, Wesson DE, Tilea AM, Saran R, Rios-Burrows N, et al. High dietary acid load predicts ESRD among adults with CKD. 26(7):1693–700. This study evaluated the relationship between higher diet-dependent acid load and risk of CKD progression to ESKD using data from participants with CKD 3-4 in the National Health and Nutrition Examination Survey. Diet-dependent acid load was estimated from dietary recalls. They found higher independent risk of ESKD with higher baseline diet-dependent acid load using competing risk regression to account for death. The risk was most pronounced in the group with albuminuria. Although the study included approximately 30% of participants with diabetes, stratified results were not described in this subgroup
    • • Banerjee T, Crews DC, Wesson DE, Tilea AM, Saran R, Rios-Burrows N, et al. High dietary acid load predicts ESRD among adults with CKD. J Am Soc Nephrol. 2015;26(7):1693–700. This study evaluated the relationship between higher diet-dependent acid load and risk of CKD progression to ESKD using data from participants with CKD 3-4 in the National Health and Nutrition Examination Survey. Diet-dependent acid load was estimated from dietary recalls. They found higher independent risk of ESKD with higher baseline diet-dependent acid load using competing risk regression to account for death. The risk was most pronounced in the group with albuminuria. Although the study included approximately 30% of participants with diabetes, stratified results were not described in this subgroup.
    • (2015) J Am Soc Nephrol
  • 107
    • 84983098697 scopus 로고    scopus 로고
    • Dietary acid load and incident chronic kidney disease: results from the ARIC study
    • COI: 1:CAS:528:DC%2BC28XivFGksr0%3D, PID: 26789417, In this analysis out of the Atherosclerosis Risk in Communities Study in over 15,000 individuals, higher diet-dependent acid load ascertained by a food frequency questionnaire associated with new onset CKD over 21 years of follow-up. The study population included ∼11% who had diabetes, but stratified results were not described
    • • Rebholz CM, Coresh J, Grams ME, Steffen LM, Anderson CA, Appel LJ, et al. Dietary acid load and incident chronic kidney disease: results from the ARIC study. Am J Nephrol. 2015;42(6):427–35. In this analysis out of the Atherosclerosis Risk in Communities Study in over 15,000 individuals, higher diet-dependent acid load ascertained by a food frequency questionnaire associated with new onset CKD over 21 years of follow-up. The study population included ∼11% who had diabetes, but stratified results were not described.
    • (2015) Am J Nephrol , vol.42 , Issue.6 , pp. 427-435
    • Rebholz, C.M.1    Coresh, J.2    Grams, M.E.3    Steffen, L.M.4    Anderson, C.A.5    Appel, L.J.6
  • 108
    • 84862493248 scopus 로고    scopus 로고
    • Net endogenous acid production is associated with a faster decline in GFR in African Americans
    • COI: 1:CAS:528:DC%2BC38Xos1yks7c%3D, PID: 22475819
    • Scialla JJ, Appel LJ, Astor BC, Miller 3rd ER, Beddhu S, Woodward M, et al. Net endogenous acid production is associated with a faster decline in GFR in African Americans. Kidney Int. 2012;82(1):106–12.
    • (2012) Kidney Int , vol.82 , Issue.1 , pp. 106-112
    • Scialla, J.J.1    Appel, L.J.2    Astor, B.C.3    Miller, E.R.4    Beddhu, S.5    Woodward, M.6


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