Serum Bicarbonate Levels and the Progression of Kidney Disease: A Cohort Study

American Journal of Kidney Diseases

Volumn 54, Issue 2, 2009, Pages 270-277

  Shah, Samir N ^a   Abramowitz, Matthew ^a   Hostetter, Thomas H ^a   Melamed, Michal L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

kidney disease progression; metabolic acidosis; Serum bicarbonate

Indexed keywords

BICARBONATE; CREATININE;

ADULT; ARTICLE; BICARBONATE BLOOD LEVEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE COURSE; FEMALE; GLOMERULUS FILTRATION RATE; HUMAN; KIDNEY DISEASE; MAJOR CLINICAL STUDY; MALE; PROGNOSIS; SENSITIVITY ANALYSIS;

BICARBONATES; COHORT STUDIES; DISEASE PROGRESSION; FEMALE; HUMANS; KIDNEY DISEASES; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES;

EID: 67650424024     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.ajkd.2009.02.014     Document Type: Article

References (35)

1. Coresh J., Selvin E., Stevens L.A., et al. Prevalence of chronic kidney disease in the United States. JAMA 298 (2007) 2038-2047
2. Levey A.S., Coresh J., Balk E., et al. National Kidney Foundation practice guidelines for chronic kidney disease: Evaluation, classification, and stratification. Ann Intern Med 139 (2003) 137-147
3. O'Hare A.M., Choi A.I., Bertenthal D., et al. Age affects outcomes in chronic kidney disease. J Am Soc Nephrol 18 (2007) 2758-2765
4. Lewis E.J., Hunsicker L.G., Clarke W.R., et al. Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. N Engl J Med 345 (2001) 851-860
5. Lewis E.J., Hunsicker L.G., Bain R.P., and Rohde R.D. The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group. N Engl J Med 329 (1993) 1456-1462
6. Brenner B.M., Cooper M.E., de Zeeuw D., et al. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 345 (2001) 861-869
7. US Renal Data System. USRDS 2006 Annual Data Report (2006), The National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Disease, Bethesda, MD
8. Nath K.A., Hostetter M.K., and Hostetter T.H. Ammonia-complement interaction in the pathogenesis of progressive renal injury. Kidney Int Suppl 27 (1989) S52-S54
9. Nath K.A., Hostetter M.K., and Hostetter T.H. Pathophysiology of chronic tubulo-interstitial disease in rats. Interactions of dietary acid load, ammonia, and complement component C3. J Clin Invest 76 (1985) 667-675
10. Gadola L., Noboa O., Marquez M.N., et al. Calcium citrate ameliorates the progression of chronic renal injury. Kidney Int 65 (2004) 1224-1230
11. Throssell D., Brown J., Harris K.P., and Walls J. Metabolic acidosis does not contribute to chronic renal injury in the rat. Clin Sci (Lond) 89 (1995) 643-650
12. Southern W.N., Berger M.A., Bellin E.Y., Hailpern S.M., and Arnsten J.H. Hospitalist care and length of stay in patients requiring complex discharge planning and close clinical monitoring. Arch Intern Med 167 (2007) 1869-1874
13. Tarver-Carr M.E., Powe N.R., Eberhardt M.S., et al. Excess risk of chronic kidney disease among African American versus white subjects in the United States: A population-based study of potential explanatory factors. J Am Soc Nephrol 13 (2002) 2363-2370
14. Torres V.E., Cowley Jr. B.D., Branden M.G., Yoshida I., and Gattone V.H. Long-term ammonium chloride or sodium bicarbonate treatment in two models of polycystic kidney disease. Exp Nephrol 9 (2001) 171-180
15. MacClean A.J., and Hayslett J.P. Adaptive change in ammonia excretion in renal insufficiency. Kidney Int 17 (1980) 595-606
16. Pangburn M.K., Schreiber R.D., and Muller-Eberhard H.J. Formation of the initial C3 convertase of the alternative complement pathway. Acquisition of C3b-like activities by spontaneous hydrolysis of the putative thioester in native C3. J Exp Med 154 (1981) 856-867
17. Nath K.A., Hostetter M.K., and Hostetter T.H. Increased ammoniagenesis as a determinant of progressive renal injury. Am J Kidney Dis 17 (1991) 654-657
18. Widmer B., Gerhardt R.E., Harrington J.T., and Cohen J.J. Serum electrolyte and acid base composition. The influence of graded degrees of chronic renal failure. Arch Intern Med 139 (1979) 1099-1102
19. Eustace J.A., Astor B., Muntner P.M., Ikizler T.A., and Coresh J. Prevalence of acidosis and inflammation and their association with low serum albumin in chronic kidney disease. Kidney Int 65 (2004) 1031-1040
20. 2 concentration in chronic kidney disease: Modification of Diet in Renal Disease Study findings. Clin J Am Soc Nephrol 1 (2006) 52-57
21. Huang M.C., Chen M.E., Hung H.C., et al. Inadequate energy and excess protein intakes may be associated with worsening renal function in chronic kidney disease. J Ren Nutr 18 (2008) 187-194
22. Bailey J.L., Zheng B., Hu Z., Price S.R., and Mitch W.E. Chronic kidney disease causes defects in signaling through the insulin receptor substrate/phosphatidylinositol 3-kinase/Akt pathway: Implications for muscle atrophy. J Am Soc Nephrol 17 (2006) 1388-1394
23. Mitch W.E. Malnutrition: A frequent misdiagnosis for hemodialysis patients. J Clin Invest 110 (2002) 437-439
24. Movilli E., Zani R., Carli O., et al. Correction of metabolic acidosis increases serum albumin concentrations and decreases kinetically evaluated protein intake in haemodialysis patients: A prospective study. Nephrol Dial Transplant 13 (1998) 1719-1722
25. Lefebvre A., de Vernejoul M.C., Gueris J., Goldfarb B., Graulet A.M., and Morieux C. Optimal correction of acidosis changes progression of dialysis osteodystrophy. Kidney Int 36 (1989) 1112-1118
26. Stein A., Moorhouse J., Iles-Smith H., et al. Role of an improvement in acid-base status and nutrition in CAPD patients. Kidney Int 52 (1997) 1089-1095
27. Szeto C.C., Wong T.Y., Chow K.M., Leung C.B., and Li P.K. Oral sodium bicarbonate for the treatment of metabolic acidosis in peritoneal dialysis patients: A randomized placebo-control trial. J Am Soc Nephrol 14 (2003) 2119-2126
28. Lofberg E., Wernerman J., Anderstam B., and Bergstrom J. Correction of acidosis in dialysis patients increases branched-chain and total essential amino acid levels in muscle. Clin Nephrol 48 (1997) 230-237
29. Reaich D., Graham K.A., Channon S.M., et al. Insulin-mediated changes in PD and glucose uptake after correction of acidosis in humans with CRF. Am J Physiol 268 (1995) E121-E126
30. Rustom R., Grime J.S., Costigan M., et al. Oral sodium bicarbonate reduces proximal renal tubular peptide catabolism, ammoniogenesis, and tubular damage in renal patients. Ren Fail 20 (1998) 371-382
31. Ashurst I.V.M., and Yaqoob M. A randomized trial to study the effect of bicarbonate supplementation on the rate of progression of renal failure and nutritional status in chronic kidney disease stage 4 and 5 patients. J Am Soc Nephrol 17 (2006) 37A (abstr)
32. Roderick P., Willis N.S., Blakeley S., Jones C., and Tomson C. Correction of chronic metabolic acidosis for chronic kidney disease patients. Cochrane Database Syst Rev (2007) CD001890
33. Schainuck L.I., Striker G.E., Cutler R.E., and Benditt E.P. Structural-functional correlations in renal disease. II. The correlations. Hum Pathol 1 (1970) 631-641
34. Levey A.S., Bosch J.P., Lewis J.B., Greene T., Rogers N., and Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: A new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 130 (1999) 461-470
35. Kirschbaum B. Spurious metabolic acidosis in hemodialysis patients. Am J Kidney Dis 35 (2000) 1068-1071