Daily oral sodium bicarbonate preserves glomerular filtration rate by slowing its decline in early hypertensive nephropathy

Kidney International

Volumn 78, Issue 3, 2010, Pages 303-309

  Mahajan, Ashutosh ^a,b   Simoni, Jan ^c   Sheather, Simon J ^d   Broglio, Kristine R ^b,d   Rajab, M H ^b   Wesson, Donald E ^a,b  

^a TEXAS A M COLLEGE OF MEDICINE   (United States)

^b SCOTT AND WHITE MEMORIAL HOSPITAL   (United States)

^c TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

^d TEXAS A AND M UNIVERSITY   (United States)

Author keywords

acidosis; albuminuria; chronic kidney disease; chronic metabolic acidosis; hypertension

Indexed keywords

ANTIHYPERTENSIVE AGENT; BICARBONATE; CYSTATIN C; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; PLACEBO; SODIUM CHLORIDE;

ADULT; ALBUMINURIA; ARTICLE; BLOOD PRESSURE REGULATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; ETHNICITY; FEMALE; GLOMERULUS FILTRATION RATE; HUMAN; HYPERTENSIVE NEPHROPATHY; KIDNEY DISEASE; KIDNEY FUNCTION; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RENOVASCULAR HYPERTENSION; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; ADULT; ALBUMINURIA; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; CYSTATIN C; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; GLOMERULAR FILTRATION RATE; HUMANS; HYPERTENSION; KIDNEY; KIDNEY DISEASES; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; SODIUM BICARBONATE;

EID: 77954757756     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2010.129     Document Type: Article

References (35)

1. US Renal Data System. USRDS 2007 Annual Data Report: The National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA, 2008.
2. Appel LJ, Wright JT, Greene T , et al. Long-term effects of renin- angiotensin-system-blocking therapy and a low blood pressure goal on progression of hypertensive chronic kidney disease in African Americans. Arch Int Med 2008;168: 832-839.
3. Widmer B, Gerhardt RE, Harrington JT , et al. The influence of graded degrees of chronic renal failure. Arch Int Med 1979;139: 1099-1102.
4. de Brito-Ashurst I, Varagunam M, Raferty MJ , et al. Bicarbonate supplementation slows progression of CKD and improves nutritional status. J Am Soc Nephrol 2009;20: 2075-2084.
5. Phisitkul S, Khanna A, Simoni J , et al. Amelioration of metabolic acidosis in subjects with low GFR reduces kidney endothelin production, reduces kidney injury, and better preserves GFR. Kid Int 2010;77: 617-623.
6. Wesson DE, Simoni J. Increased tissue acid mediates progressive GFR decline in animals with reduced nephron mass. Kid Int 2009; 75: 929-935.
7. Phisitkul S, Hacker C, Simoni J , et al. Dietary protein causes a decline in the glomerular filtration rate of the remnant kidney mediated by metabolic acidosis and endothelin receptors. Kid Int 2008;73: 192-199.
8. Wesson DE, Nathan T, Rose T , et al. Dietary protein induces endothelin- mediated kidney injury through enhanced intrinsic acid production. Kid Int 2007;71: 210-217.
9. Olsen JL. Renal disease in hypertension. In: Jennette CJ, Olsen JL, Schwartz MM, Silva FG (eds). Pathology of the Kidney, vol.2, 6th edn. Lippincott Williams and Wilkins: Philadelphia, 2007, p 947.
10. D'Amico G. Tubulo-interstitial damage in glomerular diseases: its role in the progression of the renal damage. Nephrol Dial Transplant 1998; 13(Suppl 1): 80-85.
11. Remer T. Influence of nutrition on acid-base balance-metabolic aspects. Eur J Nutr 2001;40: 214-220.
12. National Kidney Foundation. K/DOQI clinical practice guidelines for nutrition in chronic renal failure. Am J Kid Dis 2000;35: S1-S140.
13. Go AS, Chertow GM, Fan D , et al. Chronic kidney disease and the risk of death, cardiovascular events, and hospitalization. New Eng J Med 2004; 351: 1296-1305.
14. Shilpak MG, Katz R, Kestenbaum B , et al. Rapid decline of kidney function increases cardiovascular risk in the elderly. J Am Soc Nephrol 2009;20: 2625-2630.
15. Stevens LA, Coresh J, Greene T , et al. Assessing kidney function - measured and estimated glomerular filtration rate. New Engl J Med 2006; 354: 2473-2483.
16. Stevens LA, Coresh J, Schmid CH , et al. Estimating GFR using serum cystatin C alone and in combination with serum creatinine: a pooled analysis of 3,418 individuals with CKD. Am J Kid Dis 2008;51: 395-406.
17. Astor BC, Levey AS, Stevens LA , et al. Method of glomerular filtration rate estimation affects prediction of mortality risk. J Am Soc Nephrol 2009;20: 2214-2222.
18. Klahr S, Levey AS, Beck GJ , et al. The effects of dietary protein restriction and blood-pressure control on the progression of chronic renal disease. Modification of Diet in Renal Disease Study Group. New Engl J Med 1994; 330: 877-884. (Pubitemid 24094966)
19. Erlandsen DJ, Randers E, Kristensen JH. Evaluation of the Dade Behring N Latex Cystatin C assay on the Dade Behring Nephelometer II System. Scand J Clin Invest 1999;59: 1-8.
20. Warmoth L, Simoni J, Wesson DE. Cigarette smoking and urine albumin excretion predict subsequent GFR decline in severe primary hypertension despite improved blood pressure control. Am J Med Sci 2005;330: 111-119.
21. Nolan C, Califano JR, Butzin CA. Influence of calcium acetate or calcium citrate on intestinal aluminum absorption. Kid Int 1990;38: 937-941.
22. Remuzzi G, Bertani T. Pathophysiology of progressive nephropathies. New Engl J Med 1998;339: 1448-1456.
23. Costigan M, Rustom R, Shenkin A , et al. Origin and significance of urinary N-acetyl p-D-glucosaminidase (NAG), in renal patients with variable function, pathology and proteinuria. Clin Chimica Acta 1996; 255: 133-344.
24. Wesson DE. Endogenous endothelins mediate increased distal tubule acidification induced by dietary acid in rats. J Clin Invest 1997;99: 2203-2211.
25. Remuzzi G. Role of endothelin in the development of glomerulosclerosis. Kid Blood Press Res 1996;19: 182-183.
26. Feldman DL, Mogelesky TC, Chou M , et al. Enhanced expression of renal endothelin-converting enzyme-1 and endothelin-A-receptor mRNA in rats with interstitial fibrosis following ureter ligation. J Cardiovasc Pharmacol 2000;36(5 Suppl 1): S255-S259.
27. Regalado M, Yang S, Wesson DE. Cigarette smoking is associated with augmented progression of renal insufficiency in severe essential hypertension. Am J Kid Dis 2000;35: 687-694.
28. Chobanion AV, Bakris GL, Black HR , et al. The seventh report of the Joint National Commission on Detection, Evaluation, and Treatment of High Blood Pressure: The JNC 7 Report. JAMA 2003; 289: 2560-2572.
29. Remer T, Manz F. Potential renal acid load of foods and its influence on urine pH. J Am Dietetic Assn 1995;95: 791-797.
30. Chuahirun T, Wesson DE. Cigarette smoking predicts faster progression of Type 2 established diabetic nephropathy despite angiotensin converting enzyme inhibition. Am J Kid Dis 2002;39: 376-382.
31. Wesson DE. Dietary HCO3 reduces distal tubule acidification by increasing cellular HCO3 secretion. Am J Physiol 1996;271 (Renal Fluid and Electrolyte Physiol. 40): F132-F140.
32. Cunarro JA, Weiner MW. A comparison of methods for measuring urinary ammonium. Kid Int 1974;5: 303-305.
33. Phisitkul S, Khanna A, Simoni J , et al. Oral alkali reduces urine endothelin and rate of GFR decline in hypertensive nephropathy. J Am Soc Nephrol 2006;18: 43A. [Abstract].
34. Sheather SJ. Mixed models. In: Sheather SJ (ed). A Modern Approach to Regression with R. Springer Science+Business Media, College Station, Texas, USA, LLC, 2009, pp 331-368.
35. Fitzmaurice GM, Laird NM, Ware JH. Applied Longitudinal Analysis. Wiley: New York, 2004, p 169.