Higher diet-dependent renal acid load associates with higher glucocorticoid secretion and potentially bioactive free glucocorticoids in healthy children

Kidney International

Volumn 90, Issue 2, 2016, Pages 325-333

  Esche, Jonas ^a   Shi, Lijie ^a   Sánchez Guijo, Alberto ^b   Hartmann, Michaela F ^b   Wudy, Stefan A ^b   Remer, Thomas ^a  

^a UNIVERSITY OF BONN   (Germany)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

cortisone; glucocorticoids; healthy children; net acid excretion; urinary potential renal acid load

Indexed keywords

20ALPHA DIHYDROCORTISOL; 6BETA HYDROXYHYDROCORTISONE; CORTISONE; GLUCOCORTICOID; HYDRALLOSTANE; HYDROCORTISONE; STEROID 5BETA REDUCTASE; UNCLASSIFIED DRUG; 20-HYDROXYCORTISOL; 6 BETA-HYDROXYCORTISOL;

ARTICLE; CATABOLISM; CHILD; CONTROLLED STUDY; DIET; FEMALE; HORMONE DETERMINATION; HORMONE RELEASE; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; MALE; MASS FRAGMENTOGRAPHY; MASS SPECTROMETRY; METABOLITE; NORMAL HUMAN; PRIORITY JOURNAL; RENAL ACID LOAD; RENAL SYSTEM PARAMETERS; URINALYSIS; ACIDOSIS; ANALOGS AND DERIVATIVES; COMPARATIVE STUDY; KIDNEY; METABOLISM; REFERENCE VALUE; SECRETION (PROCESS); URINARY EXCRETION; URINE;

ACIDOSIS; CHILD; CORTISONE; DIET; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLUCOCORTICOIDS; HEALTHY VOLUNTEERS; HUMANS; HYDROCORTISONE; KIDNEY; MALE; REFERENCE VALUES; RENAL ELIMINATION;

EID: 84992529967     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1016/j.kint.2016.02.033     Document Type: Article

References (59)

1. 1 Compston, J., Management of glucocorticoid-induced osteoporosis. Nat Rev Rheumatol 6 (2010), 82–88.
2. 2 Orth, D.N., Cushing's syndrome. N Engl J Med 332 (1995), 791–803.
3. 3 Cetin, A., Gökçe-Kutsal, Y., Celiker, R., Predictors of bone mineral density in healthy males. Rheumatol Int 21 (2001), 85–88.
4. 4 Bedford, J.L., Barr, S.I., The relationship between 24-h urinary cortisol and bone in healthy young women. Int J Behav Med 17 (2010), 207–215.
5. 5 Dennison, E., Hindmarsh, P., Fall, C., et al. Profiles of endogenous circulating cortisol and bone mineral density in healthy elderly men. J Clin Endocrinol Metab 84 (1999), 3058–3063.
6. 6 Reynolds, R.M., Dennison, E.M., Walker, B.R., et al. Cortisol secretion and rate of bone loss in a population-based cohort of elderly men and women. Calcif Tissue Int 77 (2005), 134–138.
7. 7 Greendale, G.A., Unger, J.B., Rowe, J.W., Seeman, T.E., The relation between cortisol excretion and fractures in healthy older people: results from the MacArthur studies-Mac. J Am Geriatr Soc 47 (1999), 799–803.
8. 8 Shi, L., Sánchez-Guijo, A., Hartmann, M.F., et al. Higher glucocorticoid secretion in the physiological range is associated with lower bone strength at the proximal radius in healthy children: importance of protein intake adjustment. J Bone Miner Res 30 (2015), 240–248.
9. 9 Hamm, L.L., Ambühl, P.M., Alpern, R.J., Role of glucocorticoids in acidosis. Am J Kidney Dis 34 (1999), 960–965.
10. 10 Bailey, J.L., Mitch, W.E., Twice-told tales of metabolic acidosis, glucocorticoids, and protein wasting: what do results from rats tell us about patients with kidney disease?. Semin Dial 13 (2000), 227–231.
11. 11 Welbourne, T.C., Acidosis activation of the pituitary-adrenal-renal glutaminase I axis. Endocrinology 99 (1976), 1071–1079.
12. 12 Welbourne, T.C., Glucocorticoid control of ammoniagenesis in the proximal tubule. Semin Nephrol 10 (1990), 339–349.
13. 13 Perez, G.O., Oster, J.R., Katz, F.H., Vaamonde, C.A., The effect of acute metabolic acidosis on plasma cortisol, renin activity and aldosterone. Horm Res 11 (1979), 12–21.
14. 14 Sartorius, O.W., Calhoon, D., Pitts, R.F., Studies on the interrelationships of the adrenal cortex and renal ammonia excretion by the rat. Endocrinology 52 (1953), 256–265.
15. 15 Frassetto, L.A., Morris, R.C. Jr., Sebastian, A., A practical approach to the balance between acid production and renal acid excretion in humans. J Nephrol 19:suppl 9 (2006), S33–S40.
16. 16 Remer, T., Manz, F., Estimation of the renal net acid excretion by adults consuming diets containing variable amounts of protein. Am J Clin Nutr 59 (1994), 1356–1361.
17. 17 Maurer, M., Riesen, W., Muser, J., et al. Neutralization of Western diet inhibits bone resorption independently of K intake and reduces cortisol secretion in humans. Am J Physiol Renal Physiol 284 (2003), F32–F40.
18. 18 Buehlmeier, J., Remer, T., Frings-Meuthen, P., et al. Glucocorticoid activity and metabolism with NaCl-induced low-grade metabolic acidosis and oral alkalization: results of two randomized controlled trials. Endocrine 52 (2016), 139–147.
19. 19 Raff, H., Auchus, R.J., Findling, J.W., Nieman, L.K., Urine free cortisol in the diagnosis of Cushing's syndrome: is it worth doing and, if so, how?. J Clin Endocrinol Metab 100 (2015), 395–397.
20. 20 Dunn, J.F., Nisula, B.C., Rodbard, D., Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma. J Clin Endocrinol Metab 53 (1981), 58–68.
21. 21 Shi, L., Wudy, S.A., Maser-Gluth, C., et al. Urine volume dependency of specific dehydroepiandrosterone (DHEA) and cortisol metabolites in healthy children. Steroids 76 (2011), 140–144.
22. 22 Montenegro-Bethancourt, G., Johner, S.A., Remer, T., Contribution of fruit and vegetable intake to hydration status in schoolchildren. Am J Clin Nutr 98 (2013), 1103–1112.
23. 23 Penczynski KJ, Krupp D, Bring A, et al. Relative validation of 24-h urinary hippuric acid excretion as a biomarker for dietary flavonoid intake from fruit and vegetables in healthy adolescents [e-pub ahead of print]. Eur J Nutr. http://dx.doi.org/10.1007/s00394-015-1121-9.
24. 24 Karinch, A.M., Lin, C., Meng, Q., et al. Glucocorticoids have a role in renal cortical expression of the SNAT3 glutamine transporter during chronic metabolic acidosis. Am J Physiol Renal Physiol 292 (2007), F448–F455.
25. 25 Dimitriou, T., Maser-Gluth, C., Remer, T., Adrenocortical activity in healthy children is associated with fat mass. Am J Clin Nutr 77 (2003), 731–736.
26. 26 Krupp, D., Shi, L., Maser-Gluth, C., et al. 11β Hydroxysteroid dehydrogenase type 2 and dietary acid load are independently associated with blood pressure in healthy children and adolescents. Am J Clin Nutr 97 (2013), 612–620.
27. 27 Remer, T., Manz, F., Potential renal acid load of foods and its influence on urine pH. J Am Diet Assoc 95 (1995), 791–797.
28. 28 Gluck, S.L., Acid-base. Lancet 352 (1998), 474–479.
29. 29 Hulter, H.N., Licht, J.H., Bonner, E.L. Jr., et al. Effects of glucocorticoid steroids on renal and systemic acid-base metabolism. Am J Physiol 239 (1980), F30–F43.
30. 30 Morineau, G., Sulmont, V., Salomon, R., et al. Apparent mineralocorticoid excess: report of six new cases and extensive personal experience. J Am Soc Nephrol 17 (2006), 3176–3184.
31. 31 Gathercole, L.L., Lavery, G.G., Morgan, S.A., et al. 11β-Hydroxysteroid dehydrogenase 1: translational and therapeutic aspects. Endocr Rev 34 (2013), 525–555.
32. 32 Tomlinson, J.W., Walker, E.A., Bujalska, I.J., et al. 11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response. Endocr Rev 25 (2004), 831–866.
33. 33 Remer, T., Maser-Gluth, C., Wudy, S.A., Glucocorticoid measurements in health and disease—metabolic implications and the potential of 24-h urine analyses. Mini Rev Med Chem 8 (2008), 153–170.
34. 34 Remer, T., Maser-Gluth, C., Simultaneous measurements of urinary free cortisol and cortisone for the assessment of functional glucocorticoid activity. Clin Chem 53 (2007), 1870–1871.
35. 35 Morineau, G., Boudi, A., Barka, A., et al. Radioimmunoassay of cortisone in serum, urine, and saliva to assess the status of the cortisol-cortisone shuttle. Clin Chem 43 (1997), 1397–1407.
36. 36 Remer, T., Berkemeyer, S., Manz, F., Acid base considerations in stone-age farming sweet potato eaters, modern-day sweet potato eaters, and high-protein consumers. Open Nutr J, 2008, 23–28.
37. 37 Lee, Y.S., Lorenzo, B.J., Koufis, T., Reidenberg, M.M., Grapefruit juice and its flavonoids inhibit 11 beta-hydroxysteroid dehydrogenase. Clin Pharmacol Ther 59 (1996), 62–71.
38. 38 Zhang, Y.D., Lorenzo, B., Reidenberg, M.M., Inhibition of 11 beta-hydroxysteroid dehydrogenase obtained from guinea pig kidney by furosemide, naringenin and some other compounds. J Steroid Biochem Mol Biol 49 (1994), 81–85.
39. 39 Darling, A.L., Millward, D.J., Torgerson, D.J., et al. Dietary protein and bone health: a systematic review and meta-analysis. Am J Clin Nutr 90 (2009), 1674–1692.
40. 40 Remer, T., Krupp, D., Shi, L., Dietary protein's and dietary acid load's influence on bone health. Crit Rev Food Sci Nutr 54 (2014), 1140–1150.
41. 41 Anagnostis, P., Athyros, V.G., Tziomalos, K., et al. Clinical review: the pathogenetic role of cortisol in the metabolic syndrome: a hypothesis. J Clin Endocrinol Metab 94 (2009), 2692–2701.
42. 42 Bushinsky, D.A., Net calcium efflux from live bone during chronic metabolic, but not respiratory, acidosis. Am J Physiol 256 (1989), F836–F842.
43. 43 Bushinsky, D.A., Stimulated osteoclastic and suppressed osteoblastic activity in metabolic but not respiratory acidosis. Am J Physiol 268 (1995), C80–C88.
44. 44 Wang, X.H., Mitch, W.E., Mechanisms of muscle wasting in chronic kidney disease. Nat Rev Nephrol 10 (2014), 504–516.
45. 45 Cooper, M.S., Syddall, H.E., Fall, C.H., et al. Circulating cortisone levels are associated with biochemical markers of bone formation and lumbar spine BMD: the Hertfordshire Cohort Study. Clin Endocrinol (Oxf) 62 (2005), 692–697.
46. 46 Lewicka, S., Nowicki, M., Vecsei, P., Effect of sodium restriction on urinary excretion of cortisol and its metabolites in humans. Steroids 63 (1998), 401–405.
47. 47 Buyken, A.E., Alexy, U., Kersting, M., Remer, T., Die DONALD Kohorte. Ein aktueller Überblick zu 25 Jahren Forschung im Rahmen der Dortmund Nutritional and Anthropometric Longitudinally Designed Study. [The DONALD cohort: an updated overview on 25 years of research based on the Dortmund Nutritional and Anthropometric Longitudinally Designed study]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 55 (2012), 875–884 [in German].
48. 48 Remer, T., Boye, K.R., Hartmann, M.F., Wudy, S.A., Urinary markers of adrenarche: reference values in healthy subjects, aged 3–18 years. J Clin Endocrinol Metab 90 (2005), 2015–2021.
49. 49 Remer, T., Montenegro-Bethancourt, G., Shi, L., Long-term urine biobanking: storage stability of clinical chemical parameters under moderate freezing conditions without use of preservatives. Clin Biochem 47 (2014), 307–311.
50. 50 Lüthy, C., Moser, C., Oetliker, O., Dreistufige Säure-Basen-Titration im Urin. [Acid-base determination of urine in 3 steps]. Med Lab (Stuttg) 30 (1977), 174–181 [in German].
51. 51 Relman, A.S., Lennon, E.J., Lemann, J. Jr., Endogenous production of fixed acid and the measurement of the net balance of acid in normal subjects. J Clin Invest 40 (1961), 1621–1630.
52. 52 Remer, T., Dimitriou, T., Manz, F., Dietary potential renal acid load and renal net acid excretion in healthy, free-living children and adolescents. Am J Clin Nutr 77 (2003), 1255–1260.
53. 53 Wudy, S.A., Hartmann, M.F., Remer, T., Sexual dimorphism in cortisol secretion starts after age 10 in healthy children: urinary cortisol metabolite excretion rates during growth. Am J Physiol Endocrinol Metab 293 (2007), E970–E976.
54. 54 Sánchez-Guijo, A., Hartmann, M.F., Shi, L., et al. Determination of free cortisol and free cortisone in human urine by on-line turbulent flow chromatography coupled to fused-core chromatography-tandem mass spectrometry (TFC-HPLC-MS/MS). Anal Bioanal Chem 406 (2014), 793–801.
55. 55 Palermo, M., Shackleton, C.H., Mantero, F., Stewart, P.M., Urinary free cortisone and the assessment of 11 beta-hydroxysteroid dehydrogenase activity in man. Clin Endocrinol (Oxf) 45 (1996), 605–611.
56. 56 Best, R., Walker, B.R., Additional value of measurement of urinary cortisone and unconjugated cortisol metabolites in assessing the activity of 11 beta-hydroxysteroid dehydrogenase in vivo. Clin Endocrinol (Oxf) 47 (1997), 231–236.
57. 57 Ferrari, P., Sansonnens, A., Dick, B., Frey, F.J., In vivo 11beta-HSD-2 activity: variability, salt-sensitivity, and effect of licorice. Hypertension 38 (2001), 1330–1336.
58. 58 Slag, M.F., Ahmad, M., Gannon, M.C., Nuttall, F.Q., Meal stimulation of cortisol secretion: a protein induced effect. Metabolism 30 (1981), 1104–1108.
59. 59 Benedict, C., Hallschmid, M., Scheibner, J., et al. Gut protein uptake and mechanisms of meal-induced cortisol release. J Clin Endocrinol Metab 90 (2005), 1692–1696.