Acid retention during kidney failure induces endothelin and aldosterone production which lead to progressive GFR decline, a situation ameliorated by alkali diet

Kidney International

Volumn 78, Issue 11, 2010, Pages 1128-1135

  Wesson, Donald E ^a   Simoni, Jan ^b  

^a TEXAS A M COLLEGE OF MEDICINE   (United States)

^b TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

Author keywords

aldosterone; chronic kidney disease; darusentan; endothelin; eplerenone; microdialysis

Indexed keywords

ACID; ALDOSTERONE; ALDOSTERONE ANTAGONIST; CALCIUM CARBONATE; DARUSENTAN; ENDOTHELIN; ENDOTHELIN RECEPTOR ANTAGONIST; EPLERENONE;

ACID BASE BALANCE; ALDOSTERONE RELEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; DIET THERAPY; FEMALE; GLOMERULAR DYSFUNCTION; GLOMERULUS FILTRATION RATE; KIDNEY ACIDIFYING CAPACITY; KIDNEY FAILURE; MALE; METABOLIC ACIDOSIS; MICRODIALYSIS; NEPHRECTOMY; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; RAT;

EID: 78349308678     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2010.348     Document Type: Article

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