High dietary acid load is associated with insulin resistance: The Furukawa Nutrition and Health Study

Clinical Nutrition

Volumn 35, Issue 2, 2016, Pages 453-459

  Akter, Shamima ^a   Eguchi, Masafumi ^b   Kuwahara, Keisuke ^a,c   Kochi, Takeshi ^b   Ito, Rie ^b   Kurotani, Kayo ^a   Tsuruoka, Hiroko ^b   Nanri, Akiko ^a   Kabe, Isamu ^b   Mizoue, Tetsuya ^a  

^a NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^b FURUKAWA ELECTRIC CO LTD   (Japan)

^c TEIKYO UNIVERSITY   (Japan)

Author keywords

Dietary acid load; Glucose metabolism; Insulin resistance; Japanese

Indexed keywords

ACID; BIOLOGICAL MARKER; GLUCOSE; HEMOGLOBIN A1C; INSULIN; GLUCOSE BLOOD LEVEL; GLYCOSYLATED HEMOGLOBIN;

ACID SECRETION; ADULT; AGE DISTRIBUTION; AGED; ARTICLE; BRIEF SELF ADMINISTERED DIET HISTORY QUESTIONNAIRE; CONFOUNDING VARIABLE; CONTROLLED STUDY; DIETARY INTAKE; FEMALE; GLUCOSE BLOOD LEVEL; HEALTH SURVEY; HUMAN; INDUSTRIAL WORKER; INSULIN RELEASE; INSULIN RESISTANCE; JAPANESE (PEOPLE); MAJOR CLINICAL STUDY; MALE; NUTRIENT UPTAKE; NUTRITIONAL ASSESSMENT; PANCREAS ISLET BETA CELL; PERIODIC MEDICAL EXAMINATION; QUESTIONNAIRE; SCORING SYSTEM; ACID-BASE IMBALANCE; ADOLESCENT; BLOOD; BODY MASS; CARDIOVASCULAR DISEASES; CROSS-SECTIONAL STUDY; DIABETES MELLITUS, TYPE 2; DIET; METABOLIC SYNDROME X; METABOLISM; MIDDLE AGED; MULTILEVEL ANALYSIS; STATISTICAL MODEL; YOUNG ADULT;

ACID-BASE IMBALANCE; ADOLESCENT; ADULT; AGED; BIOMARKERS; BLOOD GLUCOSE; BODY MASS INDEX; CARDIOVASCULAR DISEASES; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 2; DIET; FEMALE; HEALTH SURVEYS; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; INSULIN; INSULIN RESISTANCE; LINEAR MODELS; MALE; METABOLIC SYNDROME X; MIDDLE AGED; MULTILEVEL ANALYSIS; NUTRITION ASSESSMENT; SURVEYS AND QUESTIONNAIRES; YOUNG ADULT;

EID: 84960496354     PISSN: 02615614     EISSN: 15321983     Source Type: Journal    
DOI: 10.1016/j.clnu.2015.03.008     Document Type: Article

References (31)

1. Lozano R., Naghavi M., Foreman K., Lim S., Shibuya K., Aboyans V., et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the global burden of disease study 2010. Lancet 2012, 380(9859):2095-2128.
2. Murray C.J., Vos T., Lozano R., Naghavi M., Flaxman A.D., Michaud C., et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the global burden of disease study 2010. Lancet 2012, 380(9859):2197-2223.
3. International Diabetes Federation (IDF) Country estimates table 2011. IDF diabetes atlas 2012, Available from, [accessed 07.06.13]. http://www.idf.org/sites/default/files/EN_6E_Atlas_Full_0.pdf, 6th ed.
4. Souto G., Donapetry C., Calvino J., Adeva M.M. Metabolic acidosis-induced insulin resistance and cardiovascular risk. Metab Syndr Relat Disord 2011, 9(4):247-253.
5. Cameron M.A., Maalouf N.M., Adams-Huet B., Moe O.W., Sakhaee K. Urine composition in type 2 diabetes: predisposition to uric acid nephrolithiasis. J Am Soc Nephrol 2006, 17(5):1422-1428.
6. Maalouf N.M., Cameron M.A., Moe O.W., Sakhaee K. Metabolic basis for low urine pH in type 2 diabetes. Clin J Am Soc Nephrol 2010, 5(7):1277-1281.
7. Maalouf N.M., Cameron M.A., Moe O.W., Adams-Huet B., Sakhaee K. Low urine pH: a novel feature of the metabolic syndrome. Clin J Am Soc Nephrol 2007, 2(5):883-888.
8. Farwell W.R., Taylor E.N. Serum bicarbonate, anion gap and insulin resistance in the national health and nutrition examination survey. Diabet Med 2008, 25(7):798-804.
9. Cupisti A., Meola M., D'Alessandro C., Bernabini G., Pasquali E., Carpi A., et al. Insulin resistance and low urinary citrate excretion in calcium stone formers. Biomed Pharmacother 2007, 61(1):86-90.
10. Takahashi S., Inokuchi T., Kobayashi T., Ka T., Tsutsumi Z., Moriwaki Y., et al. Relationship between insulin resistance and low urinary pH in patients with gout, and effects of PPARα agonists on urine pH. Horm Metab Res 2007, 39(07):511-514.
11. Frassetto L.A., Todd K.M., Morris R.C., Sebastian A. Estimation of net endogenous noncarbonic acid production in humans from diet potassium and protein contents. Am J Clin Nutr 1998, 68(3):576-583.
12. Remer T., Manz F. Estimation of the renal net acid excretion by adults consuming diets containing variable amounts of protein. Am J Clin Nutr 1994, 59(6):1356-1361.
13. Remer T., Dimitriou T., Manz F. Dietary potential renal acid load and renal net acid excretion in healthy, free-living children and adolescents. Am J Clin Nutr 2003, 77(5):1255-1260.
14. Fagherazzi G., Vilier A., Bonnet F., Lajous M., Balkau B., Boutron-Ruault M.C., et al. Dietary acid load and risk of type 2 diabetes: the E3N-EPIC cohort study. Diabetologia 2014, 57(2):313-320.
15. Murakami K., Sasaki S., Takahashi Y., Uenishi K. Japan dietetic students' study for nutrition and biomarkers group. Association between dietary acid-base load and cardiometabolic risk factors in young Japanese women. Br J Nutr 2008, 100(3):642-651.
16. Xu H., Jia T., Huang X., Riserus U., Cederholm T., Arnlov J., et al. Dietary acid load, insulin sensitivity and risk of type 2 diabetes in community-dwelling older men. Diabetologia 2014, 57(8):1561-1568.
17. Akter S., Eguchi M., Kurotani K., Kochi T., Pham N.M., Ito R., et al. High dietary acid load is associated with increased prevalence of hypertension: the Furukawa nutrition and health Study. Nutrition 2015, 31(2):298-303.
18. Matthews D.R., Hosker J.P., Rudenski A.S., Naylor B.A., Treacher D.F., Turner R.C. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985, 28(7):412-419.
19. Science and Technology Agency Standard tables of food composition in Japan 2005, 5th revised and enlarged ed., Printing Bureau of the Ministry of Finance, Tokyo.
20. WHO expert consultation Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet 2004, 363(9403):157-163.
21. Rebolledo O.R., Hernandez R.E., Zanetta A.C., Gagliardino J.J. Insulin secretion during acid-base alterations. Am J Physiol 1978, 234(4):E426-E429.
22. Rebolledo O.R., Gagliardino J.J. Glucagon and insulin-secretion during acid-base alterations. Acta Diabetol Lat 1983, 20(3):211-220.
23. Maurer M., Riesen W., Muser J., Hulter H.N., Krapf R. Neutralization of western diet inhibits bone resorption independently of K intake and reduces cortisol secretion in humans. Am J Physiol Ren Physiol 2003, 284(1):F32-F40.
24. Rizza R.A., Mandarino L.J., Gerich J.E. Cortisol-induced insulin resistance in man - impaired suppression of glucose-production and stimulation of glucose-utilization due to a postreceptor defect of insulin action. J Clin Endocrinol Metab 1982, 54(1):131-138.
25. Mardon J., Habauzit V., Trzeciakiewicz A., Davicco M.J., Lebecque P., Mercier S., et al. Long-term intake of a high-protein diet with or without potassium citrate modulates acid-base metabolism, but not bone status, in male rats. J Nutr 2008, 138(4):718-724.
26. Sakhaee K., Adams-Huet B., Moe O.W., Pak C.Y. Pathophysiologic basis for normouricosuric uric acid nephrolithiasis. Kidney Int 2002, 62(3):971-979.
27. Abate N., Chandalia M., Cabo-Chan A.V., Moe O.W., Sakhaee K. The metabolic syndrome and uric acid nephrolithiasis: novel features of renal manifestation of insulin resistance. Kidney Int 2004, 65(2):386-392.
28. Rylander R., Tallheden T., Vormann J. Acid-base conditions regulate calcium and magnesium homeostasis. Magnes Res 2009, 22(4):262-265.
29. Hagström E., Hellman P., Lundgren E., Lind L., Ärnlöv J. Serum calcium is independently associated with insulin sensitivity measured with euglycaemic-hyperinsulinaemic clamp in a community-based cohort. Diabetologia 2007, 50(2):317-324.
30. Nadler J.L., Buchanan T., Natarajan R., Antonipillai I., Bergman R., Rude R. Magnesium deficiency produces insulin resistance and increased thromboxane synthesis. Hypertension 1993, 21(6 Pt 2):1024-1029.
31. Wallace T.M., Levy J.C., Matthews D.R. Use and abuse of HOMA modeling. Diabetes Care 2004, 27(6):1487-1495.