Insulin sensitivity of muscle protein metabolism is altered in patients with chronic kidney disease and metabolic acidosis

Kidney International

Volumn 88, Issue 6, 2015, Pages 1419-1426

  Garibotto, Giacomo ^a   Sofia, Antonella ^a   Russo, Rodolfo ^a   Paoletti, Ernesto ^a   Bonanni, Alice ^a   Parodi, Emanuele L ^a   Viazzi, Francesca ^a   Verzola, Daniela ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

Chronic renal disease; Insulin resistance; Protein; Skeletal muscle

Indexed keywords

BICARBONATE; GLUCOSE; INSULIN; MUSCLE PROTEIN; PHENYLALANINE; RECOMBINANT HUMAN INSULIN;

ADULT; ARTICLE; BICARBONATE BLOOD LEVEL; BODY COMPOSITION; CHRONIC KIDNEY DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG DOSE COMPARISON; FEMALE; FOREARM; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; GLYCEMIC CONTROL; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULINEMIA; LIMB PERFUSION; MALE; METABOLIC ACIDOSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM;

EID: 84951569218     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2015.247     Document Type: Article

References (46)

1. Rigalleau V, Gin H. Carbohydrate metabolism in uraemia. Curr Opin Clin Nutr Metab Care 2005; 8: 463-469
2. Fliser D, Pacini G, Engelleiter R. et al. Insulin resistance and hyperinsulinemia are already present in patients with incipient renal disease. Kidney Int 1998; 53: 1343-1347
3. Kobayashi S, Maesato K, Moriya H et al. Insulin resistance in patients with chronic kidney disease. Am J Kidney Dis 2005; 45: 275-280
4. DeFronzo RA, Smith D, Alvestrand A. Insulin action in uremia. Kidney Int 1983; 24: S102-S114
5. Alvestrand A, Mujagic M, Wajngot A et al. Glucose intolerance in uremic patients: the relative contributions of impaired beta-cell function and insulin resistance. Clin Nephrol 1989; 31: 175-183
6. DeFronzo RA, Alvestrand A, Smith D et al. Insulin resistance in uremia. J Clin Invest 1981; 67: 563-568
7. Deferrari G, Garibotto G, Robaudo C et al. Glucose interorgan exchange in chronic renal failure. Kidney Int 1983: S115-S120
8. Chen J, Muntner P, Lee Ham L et al. Insulin resistance and the risk of chronic kidney disease in nondiabetic US adults. J Am Soc Nephrol 2003; 14: 469-477
9. Shinohara K, Shoji T, Emoto M et al. Insulin resistance as an independent predictor of cardiovascular mortality in patients with end-stage renal disease. J Am Soc Nephrol 2002; 13: 1894-1900
10. Teta D. Insulin resistance as a therapeutic target for chronic kidney disease. J Ren Nutr 2015; 25: 226-229
11. Tessari P, Cecchet D, Cosma A et al. Insulin resistance of amino acid and protein metabolism in type 2 diabetes. Clin Nutr 2011; 30: 267-272
12. Wang XH, Mitch WE. Mechanisms of muscle wasting in chronic kidney disease. Nat Rev Nephrol 2014; 10: 504-516
13. Deger SM, Sundell MB, Siew ED et al. Insulin resistance and protein metabolism in chronic hemodialysis patients. J Ren Nutr 2013; 23: e59-e66
14. Bailey JL, Zheng B, Hu Z et al. Chronic kidney disease causes defects in signalling through the insulin receptor substrate/phosphatidylinositol 3-kinase/Akt pathway: implications for muscle atrophy. J Am Soc Nephrol 2006; 17: 1388-1394
15. Thomas SS, Dong Y, Zhang L et al. Signal regulatory protein-interacts with the insulin receptor contributing to muscle wasting in chronic kidney disease. Kidney Int 2013; 84: 308-316
16. Rajan V, Mitch WE. Ubiquitin, proteasomes and proteolytic mechanisms activated by kidney disease. Biochim Biophys Acta 2008; 1782: 795-799
17. Reaich D, Channon SM, Scrimgeour CM et al. Correction of acidosis in humans with CRF decreases protein degradation and amino acid oxidation. Am J Physiol 1993; 265: E230-E235
18. Chevalier S, Marliss EB, Morais JA et al. Whole-body protein anabolic response is resistant to the action of insulin in obese women. Am J Clin Nutr 2005; 82: 355-365
19. Pupim LB, Flakoll PJ, Majchrzak KM et al. Increased muscle protein breakdown in chronic hemodialysis patients with type 2 diabetes mellitus. Kidney Int 2005; 68: 1857-1865
20. Siew ED, Pupim LB, Majchrzak KM et al. Insulin resistance is associated with skeletal muscle protein breakdown in non-diabetic chronic hemodialysis patients. Kidney Int 2007; 71: 146-152
21. Garibotto G, Russo R, Sofia A et al. Skeletal muscle protein synthesis and degradation in patients with chronic renal failure. Kidney Int 1994; 45: 1432-1439
22. Alvestrand A, Defronzo RA, Smith D et al. Influence of hyperinsulinaemia on intracellular amino acid levels and amino acid exchange across splanchnic and leg tissues in uraemia. Clin Sci 1988; 74: 155-163
23. Castellino P, Luzi L, Giordano M et al. Effects of insulin and amino acids on glucose and leucine metabolism in CAPD patients. J Am Soc Nephrol 1999; 10: 1050-1058
24. Reaich KA, Graham KA, Channon SM et al. Insulin-mediated changes in PD and glucose uptake after correction of acidosis in humans with CRF. Am J Physiol Endocrinol Metab 1995; 268: E121-E126
25. Louard RJ, Fryburg DA, Gelfand RA et al. Insulin sensitivity of protein and glucose metabolism in human forearm skeletal muscle. J Clin Invest 1992; 90: 2348-2354
26. Westervelt FB Jr. Abnormal carbohydrate metabolism in uremia. Am J Clin Nutr 1968; 21: 423-524
27. Smith D, DeFronzo RA. Insulin resistance in uremia mediated by postbinding defects. Kidney Int 1982; 22: 54-62
28. DeFronzo RA, Tobin JD, Rowe JW et al. Glucose intolerance in uremia: quantification of pancreatic beta cell sensitivity to glucose and tissue sensitivity to insulin. J Clin Invest 1978; 62: 425-435
29. Verzola D, Procopio V, Sofia A et al. Apoptosis and myostatin mRNA are upregulated in the skeletal muscle of patients with chronic kidney disease. Kidney Int 2011; 79: 773-782
30. Miyamoto T, Rashid Qureshi A, Yamamoto T et al. Postprandial metabolic response to a fat-and carbohydrate-rich meal in patients with chronic kidney disease. Nephrol Dial Transplant 2011; 26: 2231-2237
31. Fukagawa NK, Minaker KL, Rowe JW et al. Insulin-mediated reduction of whole body protein breakdown: dose-response effects on leucine metabolism in postabsorptive man. J Clin Invest 1985; 76: 2306-2311
32. Tessari P, Trevisan R, Inchiostro S. et al. Dose-response curves of effects of insulin on leucine kinetics in humans. Am J Physiol Endocrinol Metab 1986; 251: E334-E342
33. Liu Z, Long W, Hillier T et al. Insulin regulation of protein metabolism in vivo. Diabetes Nutr Metab 1999; 12: 421-428
34. Sandri M, Sandri C, Gilbert A et al. Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell 2004; 117: 399-412
35. Kim DH, Kim JY, Yu BP et al. The activation of NF-kappaB through Akt-induced FOXO1 phosphorylation during aging and its modulation by calorie restriction. Biogerontology 2008; 9: 33-47
36. Tang ED, Nunez G, Barr FG et al. Negative regulation of the forkhead transcription factor FKHR by Akt. J Biol Chem 1999; 274: 16741-16746
37. Bodine SC, Latres E, Baumhueter S et al. Identification of ubiquitin ligases required for skeletal muscle atrophy. Science 2001; 294: 1704-1708
38. Greenhaff PL, Karagounis LG, Peirce N et al. Disassociation between the effects of amino acids and insulin on signaling, ubiquitin ligases, and protein turnover in human muscle. Am J Physiol Endocrinol Metab 2008; 295: E595-E604
39. Franch HA, Raissi S, Wang X et al. Acidosis impairs insulin receptor substrate-1-associated phosphoinositide 3-kinase signaling in muscle cells: consequences on proteolysis. Am J Physiol Renal Physiol 2004; 287: F700-F706
40. Löfberg E, Gutierrez A, Anderstam B et al. Effect of bicarbonate on muscle protein in patients receiving hemodialysis. Am J Kidney Dis 2006; 48: 419-429
41. Vincent MA, Dawson D, Clark AD et al. Skeletal muscle microvascular recruitment by physiological hyperinsulinemia precedes increases in total blood flow. Diabetes 2002; 5: 42-48
42. Bradley JR, Anderson JR, Evans DB et al. Impaired nutritive skeletal muscle blood flow in patients with chronic renal failure. Clin Sci 1990; 79: 239-247
43. Rasmussen BB, Fujita S, Wolfe R et al. Insulin resistance of muscle protein metabolism in aging. Diabetologia 2009; 52: 1889-1898
44. Levey AS, Stevens LA. Estimating GFR using the CKD epidemiology collaboration (CKD-EPI) creatinine equation: more accurate GFR estimates, lower CKD prevalence estimates, and better risk predictions. Am J Kidney Dis 2010; 55: 622-627
45. Tessari P, Deferrari G, Robaudo C et al. Phenylalanine hydroxylation across the kidney in humans. Kidney Int 1999; 56: 2168-2172
46. Heymsfield SB, Mc Manus C, Smith J et al. Anthropometric measurement of muscle mass: revised equations for calculating bone-free arm muscle area. Am J Clin Nutr 1982; 36: 680-690.