메뉴 건너뛰기




Volumn 6, Issue 11, 2016, Pages

The human BDNF gene: peripheral gene expression and protein levels as biomarkers for psychiatric disorders

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; BRAIN; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETIC MARKER; GENETIC TRANSCRIPTION; GENETICS; HUMAN; MENTAL DISEASE; METABOLISM; REFERENCE VALUE;

EID: 85014517698     PISSN: None     EISSN: 21583188     Source Type: Journal    
DOI: 10.1038/TP.2016.214     Document Type: Review
Times cited : (169)

References (115)
  • 1
    • 77949754231 scopus 로고    scopus 로고
    • Postsynaptic BDNF-TrkB signaling in synapse maturation, plasticity, and disease
    • Yoshii A, Constantine-Paton M. Postsynaptic BDNF-TrkB signaling in synapse maturation, plasticity, and disease. Dev Neurobiol 2010; 70: 304–322.
    • (2010) Dev Neurobiol , vol.70 , pp. 304-322
    • Yoshii, A.1    Constantine-Paton, M.2
  • 2
    • 84964395184 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor: Three ligands, many actions
    • Hempstead BL. Brain-derived neurotrophic factor: three ligands, many actions. Trans Am Clin Clim Assoc 2015; 126: 9–19.
    • (2015) Trans am Clin Clim Assoc , vol.126 , pp. 9-19
    • Hempstead, B.L.1
  • 3
    • 84920116533 scopus 로고    scopus 로고
    • BDNF as a biomarker for successful treatment of mood disorders: A systematic & quantitative meta-analysis
    • Polyakova M, Stuke K, Schuemberg K, Mueller K, Schoenknecht P, Schroeter ML. BDNF as a biomarker for successful treatment of mood disorders: a systematic & quantitative meta-analysis. J Affect Disord 2015; 174: 432–440.
    • (2015) J Affect Disord , vol.174 , pp. 432-440
    • Polyakova, M.1    Stuke, K.2    Schuemberg, K.3    Mueller, K.4    Schoenknecht, P.5    Schroeter, M.L.6
  • 4
    • 84907667345 scopus 로고    scopus 로고
    • Brain derived neurotrophic factor: Epigenetic regulation in psychiatric disorders
    • Mitchelmore C, Gede L. Brain derived neurotrophic factor: epigenetic regulation in psychiatric disorders. Brain Res 2014; 1586: 162–172.
    • (2014) Brain Res , vol.1586 , pp. 162-172
    • Mitchelmore, C.1    Gede, L.2
  • 5
    • 84858165817 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor and neuropsychiatric disorders
    • Autry AE, Monteggia LM. Brain-derived neurotrophic factor and neuropsychiatric disorders. Pharmacol Rev 2012; 64: 238–258.
    • (2012) Pharmacol Rev , vol.64 , pp. 238-258
    • Autry, A.E.1    Monteggia, L.M.2
  • 6
    • 75149129421 scopus 로고    scopus 로고
    • Molecular and genetic substrates linking stress and addiction
    • Briand LA, Blendy JA. Molecular and genetic substrates linking stress and addiction. Brain Res 2010; 1314: 219–234.
    • (2010) Brain Res , vol.1314 , pp. 219-234
    • Briand, L.A.1    Blendy, J.A.2
  • 7
    • 84875244668 scopus 로고    scopus 로고
    • Dysfunctions of leptin, ghrelin, BDNF and endocannabi-noids in eating disorders: Beyond the homeostatic control of food intake
    • Monteleone P, Maj M. Dysfunctions of leptin, ghrelin, BDNF and endocannabi-noids in eating disorders: beyond the homeostatic control of food intake. Psy-choneuroendocrinology 2013; 38: 312–330.
    • (2013) Psy-Choneuroendocrinology , vol.38 , pp. 312-330
    • Monteleone, P.1    Maj, M.2
  • 8
    • 0042154427 scopus 로고    scopus 로고
    • Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects
    • Dwivedi Y, Rizavi HS, Conley RR, Roberts RC, Tamminga CA, Pandey GN. Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjects. Arch Gen Psychiatry 2003; 60: 804–815.
    • (2003) Arch Gen Psychiatry , vol.60 , pp. 804-815
    • Dwivedi, Y.1    Rizavi, H.S.2    Conley, R.R.3    Roberts, R.C.4    Tamminga, C.A.5    Pandey, G.N.6
  • 9
    • 4444233748 scopus 로고    scopus 로고
    • Neurotrophins as mediators of drug effects on mood, addiction, and neuroprotection
    • Castren E. Neurotrophins as mediators of drug effects on mood, addiction, and neuroprotection. Mol Neurobiol 2004; 29: 289–302.
    • (2004) Mol Neurobiol , vol.29 , pp. 289-302
    • Castren, E.1
  • 10
    • 55549121274 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor and tyrosine kinase B receptor signalling in post-mortem brain of teenage suicide victims
    • Pandey GN, Ren X, Rizavi HS, Conley RR, Roberts RC, Dwivedi Y. Brain-derived neurotrophic factor and tyrosine kinase B receptor signalling in post-mortem brain of teenage suicide victims. Int J Neuropsychopharmacol 2008; 11: 1047–1061.
    • (2008) Int J Neuropsychopharmacol , vol.11 , pp. 1047-1061
    • Pandey, G.N.1    Ren, X.2    Rizavi, H.S.3    Conley, R.R.4    Roberts, R.C.5    Dwivedi, Y.6
  • 11
    • 49749101642 scopus 로고    scopus 로고
    • Serum brain-derived neurotrophic factor, depres-sion, and antidepressant medications: Meta-analyses and implications
    • Sen S, Duman R, Sanacora G. Serum brain-derived neurotrophic factor, depres-sion, and antidepressant medications: meta-analyses and implications. Biol Psychiatry 2008; 64: 527–532.
    • (2008) Biol Psychiatry , vol.64 , pp. 527-532
    • Sen, S.1    Duman, R.2    Sanacora, G.3
  • 14
    • 84872500205 scopus 로고    scopus 로고
    • Candidate genes expression profile associated with antidepressants response in the GENDEP study: Differentiating between baseline 'predictors' and longitudinal 'targets
    • Cattaneo A, Gennarelli M, Uher R, Breen G, Farmer A, Aitchison KJ et al. Candidate genes expression profile associated with antidepressants response in the GENDEP study: differentiating between baseline 'predictors' and longitudinal 'targets'. Neuropsychopharmacology 2013; 38: 377–385.
    • (2013) Neuropsychopharmacology , vol.38 , pp. 377-385
    • Cattaneo, A.1    Gennarelli, M.2    Uher, R.3    Breen, G.4    Farmer, A.5    Aitchison, K.J.6
  • 15
    • 84939194287 scopus 로고    scopus 로고
    • Lurasidone exerts antidepressant properties in the chronic mild stress model through the regulation of synaptic and neuroplastic mechanisms in the rat prefrontal cortex
    • Luoni A, Macchi F, Papp M, Molteni R, Riva MA. Lurasidone exerts antidepressant properties in the chronic mild stress model through the regulation of synaptic and neuroplastic mechanisms in the rat prefrontal cortex. Int J Neuropsycho-pharmacol 2015; 18: pii: pyu061.
    • (2015) Int J Neuropsycho-Pharmacol , vol.18
    • Luoni, A.1    Macchi, F.2    Papp, M.3    Molteni, R.4    Riva, M.A.5
  • 16
    • 84923533467 scopus 로고    scopus 로고
    • Exposure to early life stress regulates Bdnf expression in SERT mutant rats in an anatomically selective fashion
    • Calabrese F, van der Doelen RH, Guidotti G, Racagni G, Kozicz T, Homberg JR et al. Exposure to early life stress regulates Bdnf expression in SERT mutant rats in an anatomically selective fashion. J Neurochem 2015; 132: 146–154.
    • (2015) J Neurochem , vol.132 , pp. 146-154
    • Calabrese, F.1    van der Doelen, R.H.2    Guidotti, G.3    Racagni, G.4    Kozicz, T.5    Homberg, J.R.6
  • 17
    • 1642412555 scopus 로고    scopus 로고
    • Postnatal repeated maternal deprivation produces age-dependent changes of brain-derived neu-rotrophic factor expression in selected rat brain regions
    • Roceri M, Cirulli F, Pessina C, Peretto P, Racagni G, Riva MA. Postnatal repeated maternal deprivation produces age-dependent changes of brain-derived neu-rotrophic factor expression in selected rat brain regions. Biol Psychiatry 2004; 55: 708–714.
    • (2004) Biol Psychiatry , vol.55 , pp. 708-714
    • Roceri, M.1    Cirulli, F.2    Pessina, C.3    Peretto, P.4    Racagni, G.5    Riva, M.A.6
  • 18
    • 77951075407 scopus 로고    scopus 로고
    • Long-Term duloxetine treatment normalizes altered brain-derived neurotrophic factor expression in serotonin transporter knockout rats through the modulation of specific neurotrophin isoforms
    • Calabrese F, Molteni R, Cattaneo A, Macchi F, Racagni G, Gennarelli M et al. Long-Term duloxetine treatment normalizes altered brain-derived neurotrophic factor expression in serotonin transporter knockout rats through the modulation of specific neurotrophin isoforms. Mol Pharmacol 2010; 77: 846–853.
    • (2010) Mol Pharmacol , vol.77 , pp. 846-853
    • Calabrese, F.1    Molteni, R.2    Cattaneo, A.3    Macchi, F.4    Racagni, G.5    Gennarelli, M.6
  • 19
    • 34548395111 scopus 로고    scopus 로고
    • The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior
    • Schmidt HD, Duman RS. The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior. Behav Pharmacol 2007; 18: 391–418.
    • (2007) Behav Pharmacol , vol.18 , pp. 391-418
    • Schmidt, H.D.1    Duman, R.S.2
  • 20
    • 84950980409 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor and antidepressive effect of electro-convulsive therapy: Systematic review and meta-analyses of the preclinical and clinical literature
    • Polyakova M, Schroeter ML, Elzinga BM, Holiga S, Schoenknecht P, de Kloet ER et al. Brain-derived neurotrophic factor and antidepressive effect of electro-convulsive therapy: systematic review and meta-analyses of the preclinical and clinical literature. PLoS One 2015; 10: e0141564.
    • (2015) Plos One , vol.10
    • Polyakova, M.1    Schroeter, M.L.2    Elzinga, B.M.3    Holiga, S.4    Schoenknecht, P.5    de Kloet, E.R.6
  • 21
    • 84929070828 scopus 로고    scopus 로고
    • Chronic depression is associated with a pronounced decrease in serum brain-derived neurotrophic factor over time
    • Bus BA, Molendijk ML, Tendolkar I, Penninx BW, Prickaerts J, Elzinga BM et al. Chronic depression is associated with a pronounced decrease in serum brain-derived neurotrophic factor over time. Mol Psychiatry 2015; 20: 602–608.
    • (2015) Mol Psychiatry , vol.20 , pp. 602-608
    • Bus, B.A.1    Molendijk, M.L.2    Tendolkar, I.3    Penninx, B.W.4    Prickaerts, J.5    Elzinga, B.M.6
  • 22
    • 80054848287 scopus 로고    scopus 로고
    • Serum levels of brain-derived neurotrophic factor in major depressive disorder: State-trait issues, clinical features and pharmacological treatment
    • Molendijk ML, Bus BA, Spinhoven P, Penninx BW, Kenis G, Prickaerts J et al. Serum levels of brain-derived neurotrophic factor in major depressive disorder: state-trait issues, clinical features and pharmacological treatment. Mol Psychiatry 2011; 16: 1088–1095.
    • (2011) Mol Psychiatry , vol.16 , pp. 1088-1095
    • Molendijk, M.L.1    Bus, B.A.2    Spinhoven, P.3    Penninx, B.W.4    Kenis, G.5    Prickaerts, J.6
  • 23
    • 0000754856 scopus 로고    scopus 로고
    • Abnormal expression of brain-derived neurotrophic factor and its receptor in the corticolimbic system of schizophrenic patients
    • Takahashi M, Shirakawa O, Toyooka K, Kitamura N, Hashimoto T, Maeda K et al. Abnormal expression of brain-derived neurotrophic factor and its receptor in the corticolimbic system of schizophrenic patients. Mol Psychiatry 2000; 5: 293–300.
    • (2000) Mol Psychiatry , vol.5 , pp. 293-300
    • Takahashi, M.1    Shirakawa, O.2    Toyooka, K.3    Kitamura, N.4    Hashimoto, T.5    Maeda, K.6
  • 24
    • 0043133769 scopus 로고    scopus 로고
    • Immunohistochemical study of brain-derived neurotrophic factor and its receptor, TrkB, in the hippocampal formation of schizophrenic brains
    • Iritani S, Niizato K, Nawa H, Ikeda K, Emson PC. Immunohistochemical study of brain-derived neurotrophic factor and its receptor, TrkB, in the hippocampal formation of schizophrenic brains. Progr Neuropsychopharmacol Biol Psychiatry 2003; 27: 801–807.
    • (2003) Progr Neuropsychopharmacol Biol Psychiatry , vol.27 , pp. 801-807
    • Iritani, S.1    Niizato, K.2    Nawa, H.3    Ikeda, K.4    Emson, P.C.5
  • 27
    • 12144270390 scopus 로고    scopus 로고
    • Relationship of brain-derived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia
    • Hashimoto T, Bergen SE, Nguyen QL, Xu B, Monteggia LM, Pierri JN et al. Relationship of brain-derived neurotrophic factor and its receptor TrkB to altered inhibitory prefrontal circuitry in schizophrenia. J Neurosci 2005; 25: 372–383.
    • (2005) J Neurosci , vol.25 , pp. 372-383
    • Hashimoto, T.1    Bergen, S.E.2    Nguyen, Q.L.3    Xu, B.4    Monteggia, L.M.5    Pierri, J.N.6
  • 28
    • 45149112715 scopus 로고    scopus 로고
    • Erythropoietin pre-vents haloperidol treatment-induced neuronal apoptosis through regulation of BDNF
    • Pillai A, Dhandapani KM, Pillai BA, Terry AV Jr., Mahadik SP. Erythropoietin pre-vents haloperidol treatment-induced neuronal apoptosis through regulation of BDNF. Neuropsychopharmacology 2008; 33: 1942–1951.
    • (2008) Neuropsychopharmacology , vol.33 , pp. 1942-1951
    • Pillai, A.1    Dhandapani, K.M.2    Pillai, B.A.3    Terry, A.V.4    Mahadik, S.P.5
  • 29
    • 4444320149 scopus 로고    scopus 로고
    • Neurotrophic factors and the pathophysiology of schizophrenic psychoses
    • Durany N, Thome J. Neurotrophic factors and the pathophysiology of schizophrenic psychoses. Eur Psychiatry 2004; 19: 326–337.
    • (2004) Eur Psychiatry , vol.19 , pp. 326-337
    • Durany, N.1    Thome, J.2
  • 30
    • 80052048908 scopus 로고    scopus 로고
    • Brain-derived neu-rotrophic factor levels in schizophrenia: A systematic review with meta-analysis
    • Green MJ, Matheson SL, Shepherd A, Weickert CS, Carr VJ. Brain-derived neu-rotrophic factor levels in schizophrenia: a systematic review with meta-analysis. Mol Psychiatry 2011; 16: 960–972.
    • (2011) Mol Psychiatry , vol.16 , pp. 960-972
    • Green, M.J.1    Matheson, S.L.2    Shepherd, A.3    Weickert, C.S.4    Carr, V.J.5
  • 31
    • 84940435921 scopus 로고    scopus 로고
    • Peripheral brain-derived neurotrophic factor in schizophrenia and the role of anti-psychotics: Meta-analysis and implications
    • Fernandes BS, Steiner J, Berk M, Molendijk ML, Gonzalez-Pinto A, Turck CW et al. Peripheral brain-derived neurotrophic factor in schizophrenia and the role of anti-psychotics: meta-analysis and implications. Mol Psychiatry 2015; 20: 1108–1119.
    • (2015) Mol Psychiatry , vol.20 , pp. 1108-1119
    • Fernandes, B.S.1    Steiner, J.2    Berk, M.3    Molendijk, M.L.4    Gonzalez-Pinto, A.5    Turck, C.W.6
  • 32
    • 84959135514 scopus 로고    scopus 로고
    • Peripheral brain-derived neurotrophic factor (BDNF) as a biomarker in bipolar disorder: A meta-analysis of 52 studies
    • Fernandes BS, Molendijk ML, Kohler CA, Soares JC, Leite CM, Machado-Vieira R et al. Peripheral brain-derived neurotrophic factor (BDNF) as a biomarker in bipolar disorder: a meta-analysis of 52 studies. BMC Med 2015; 13: 289.
    • (2015) BMC Med , vol.13
    • Fernandes, B.S.1    Molendijk, M.L.2    Kohler, C.A.3    Soares, J.C.4    Leite, C.M.5    Machado-Vieira, R.6
  • 34
    • 84966454892 scopus 로고    scopus 로고
    • Peripheral blood mRNA expressions of stress biomarkers in manic episode and subsequent remission
    • Kose Cinar R, Sonmez MB, Gorgulu Y. Peripheral blood mRNA expressions of stress biomarkers in manic episode and subsequent remission. Psychoneur-oendocrinology 2016; 70: 10–16.
    • (2016) Psychoneur-Oendocrinology , vol.70 , pp. 10-16
    • Kose Cinar, R.1    Sonmez, M.B.2    Gorgulu, Y.3
  • 36
    • 84946196370 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor serum levels in genetically isolated populations: Gender-specific association with anxiety disorder subtypes but not with anxiety levels or Val66Met polymorphism
    • Carlino D, Francavilla R, Baj G, Kulak K, d'Adamo P, Ulivi S et al. Brain-derived neurotrophic factor serum levels in genetically isolated populations: gender-specific association with anxiety disorder subtypes but not with anxiety levels or Val66Met polymorphism. PeerJ 2015; 3: e1252.
    • (2015) Peerj , vol.3
    • Carlino, D.1    Francavilla, R.2    Baj, G.3    Kulak, K.4    D'adamo, P.5    Ulivi, S.6
  • 37
    • 84885373929 scopus 로고    scopus 로고
    • Maternal generalized anxiety disorder during pregnancy and fetal brain development: A comparative study on cord blood brain-derived neurotrophic factor levels
    • Uguz F, Sonmez EO, Sahingoz M, Gokmen Z, Basaran M, Gezginc K et al. Maternal generalized anxiety disorder during pregnancy and fetal brain development: a comparative study on cord blood brain-derived neurotrophic factor levels. J Psychosom Res 2013; 75: 346–350.
    • (2013) J Psychosom Res , vol.75 , pp. 346-350
    • Uguz, F.1    Sonmez, E.O.2    Sahingoz, M.3    Gokmen, Z.4    Basaran, M.5    Gezginc, K.6
  • 39
    • 84980373446 scopus 로고    scopus 로고
    • Cortisol and brain-derived neurotrophic factor levels prior to treatment in children with obsessive-compulsive disorder
    • Simsek S, Gencoglan S, Yuksel T, Kaplan I, Alaca R. Cortisol and brain-derived neurotrophic factor levels prior to treatment in children with obsessive-compulsive disorder. J Clin Psychiatry 2016; 77: e855–e859.
    • (2016) J Clin Psychiatry , vol.77 , pp. e855-e859
    • Simsek, S.1    Gencoglan, S.2    Yuksel, T.3    Kaplan, I.4    Alaca, R.5
  • 40
    • 34547499702 scopus 로고    scopus 로고
    • Dissecting the human BDNF locus: Bidirectional transcription, complex splicing, and multiple promoters
    • Pruunsild P, Kazantseva A, Aid T, Palm K, Timmusk T. Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters. Genomics 2007; 90: 397–406.
    • (2007) Genomics , vol.90 , pp. 397-406
    • Pruunsild, P.1    Kazantseva, A.2    Aid, T.3    Palm, K.4    Timmusk, T.5
  • 41
    • 84926675566 scopus 로고    scopus 로고
    • New insight in expression, transport, and secretion of brain-derived neurotrophic factor: Implications in brain-related diseases
    • Adachi N, Numakawa T, Richards M, Nakajima S, Kunugi H. New insight in expression, transport, and secretion of brain-derived neurotrophic factor: Implications in brain-related diseases. World J Biol Chem 2014; 5: 409–428.
    • (2014) World J Biol Chem , vol.5 , pp. 409-428
    • Adachi, N.1    Numakawa, T.2    Richards, M.3    Nakajima, S.4    Kunugi, H.5
  • 42
    • 67650450676 scopus 로고    scopus 로고
    • Mechanisms, locations, and kinetics of synaptic BDNF secretion: An update
    • Lessmann V, Brigadski T. Mechanisms, locations, and kinetics of synaptic BDNF secretion: an update. Neurosci Res 2009; 65: 11–22.
    • (2009) Neurosci Res , vol.65 , pp. 11-22
    • Lessmann, V.1    Brigadski, T.2
  • 43
    • 0035918236 scopus 로고    scopus 로고
    • Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor
    • Mowla SJ, Farhadi HF, Pareek S, Atwal JK, Morris SJ, Seidah NG et al. Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor. J Biol Chem 2001; 276: 12660–12666.
    • (2001) J Biol Chem , vol.276 , pp. 12660-12666
    • Mowla, S.J.1    Farhadi, H.F.2    Pareek, S.3    Atwal, J.K.4    Morris, S.J.5    Seidah, N.G.6
  • 44
    • 0035976524 scopus 로고    scopus 로고
    • Regulation of cell survival by secreted proneurotrophins
    • Lee R, Kermani P, Teng KK, Hempstead BL. Regulation of cell survival by secreted proneurotrophins. Science 2001; 294: 1945–1948.
    • (2001) Science , vol.294 , pp. 1945-1948
    • Lee, R.1    Kermani, P.2    Teng, K.K.3    Hempstead, B.L.4
  • 45
    • 84899992416 scopus 로고    scopus 로고
    • proBDNF negatively regulates neuronal remodeling, synaptic transmission, and synaptic plasticity in hippocampus
    • Yang J, Harte-Hargrove LC, Siao CJ, Marinic T, Clarke R, Ma Q et al. proBDNF negatively regulates neuronal remodeling, synaptic transmission, and synaptic plasticity in hippocampus. Cell Rep 2014; 7: 796–806.
    • (2014) Cell Rep , vol.7 , pp. 796-806
    • Yang, J.1    Harte-Hargrove, L.C.2    Siao, C.J.3    Marinic, T.4    Clarke, R.5    Ma, Q.6
  • 46
    • 52049117013 scopus 로고    scopus 로고
    • A biological function for the neuronal activity-dependent component of Bdnf transcription in the development of cortical inhibition
    • Hong EJ, McCord AE, Greenberg ME. A biological function for the neuronal activity-dependent component of Bdnf transcription in the development of cortical inhibition. Neuron 2008; 60: 610–624.
    • (2008) Neuron , vol.60 , pp. 610-624
    • Hong, E.J.1    McCord, A.E.2    Greenberg, M.E.3
  • 47
    • 77949652896 scopus 로고    scopus 로고
    • Peripheral brain-derived neurotrophic factor (BDNF) as a biomarker for affective disorders?
    • Gass P, Hellweg R. Peripheral brain-derived neurotrophic factor (BDNF) as a biomarker for affective disorders? Int J Neuropsychopharmacol 2010; 13: 1–4.
    • (2010) Int J Neuropsychopharmacol , vol.13 , pp. 1-4
    • Gass, P.1    Hellweg, R.2
  • 48
    • 84937514043 scopus 로고    scopus 로고
    • Can we observe epigenetic effects on human brain function?
    • Nikolova YS, Hariri AR. Can we observe epigenetic effects on human brain function? Trends Cogn Sci 2015; 19: 366–373.
    • (2015) Trends Cogn Sci , vol.19 , pp. 366-373
    • Nikolova, Y.S.1    Hariri, A.R.2
  • 52
    • 84875243278 scopus 로고    scopus 로고
    • Aging is associated with altered inflammatory, arachidonic acid cascade, and synaptic markers, influenced by epigenetic modifications, in the human frontal cortex
    • Keleshian VL, Modi HR, Rapoport SI, Rao JS. Aging is associated with altered inflammatory, arachidonic acid cascade, and synaptic markers, influenced by epigenetic modifications, in the human frontal cortex. J Neurochem 2013; 125: 63–73.
    • (2013) J Neurochem , vol.125 , pp. 63-73
    • Keleshian, V.L.1    Modi, H.R.2    Rapoport, S.I.3    Rao, J.S.4
  • 53
    • 41149140859 scopus 로고    scopus 로고
    • Epigenomic profiling reveals DNA-methylation changes associated with major psychosis
    • Mill J, Tang T, Kaminsky Z, Khare T, Yazdanpanah S, Bouchard L et al. Epigenomic profiling reveals DNA-methylation changes associated with major psychosis. Am J Hum Genet 2008; 82: 696–711.
    • (2008) Am J Hum Genet , vol.82 , pp. 696-711
    • Mill, J.1    Tang, T.2    Kaminsky, Z.3    Khare, T.4    Yazdanpanah, S.5    Bouchard, L.6
  • 54
    • 52949109849 scopus 로고    scopus 로고
    • A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex
    • Mellios N, Huang HS, Grigorenko A, Rogaev E, Akbarian S. A set of differentially expressed miRNAs, including miR-30a-5p, act as post-transcriptional inhibitors of BDNF in prefrontal cortex. Hum Mol Genet 2008; 17: 3030–3042.
    • (2008) Hum Mol Genet , vol.17 , pp. 3030-3042
    • Mellios, N.1    Huang, H.S.2    Grigorenko, A.3    Rogaev, E.4    Akbarian, S.5
  • 55
    • 79960372183 scopus 로고    scopus 로고
    • The epigenetic effects of antidepressant treatment on human prefrontal cortex BDNF expression
    • Chen ES, Ernst C, Turecki G. The epigenetic effects of antidepressant treatment on human prefrontal cortex BDNF expression. Int J Neuropsychopharmacol 2011; 14: 427–429.
    • (2011) Int J Neuropsychopharmacol , vol.14 , pp. 427-429
    • Chen, E.S.1    Ernst, C.2    Turecki, G.3
  • 57
    • 84862215678 scopus 로고    scopus 로고
    • Dynamic Roles of microRNAs in Neurogenesis
    • Lang MF, Shi Y. Dynamic Roles of microRNAs in Neurogenesis. Front Neurosci 2012; 6: 71.
    • (2012) Front Neurosci , vol.6 , pp. 71
    • Lang, M.F.1    Shi, Y.2
  • 58
    • 84930652644 scopus 로고    scopus 로고
    • MicroRNAs: Small molecules with big roles in neurodevelopment and diseases
    • Sun E, Shi Y. MicroRNAs: small molecules with big roles in neurodevelopment and diseases. Exp Neurol 2015; 268: 46–53.
    • (2015) Exp Neurol , vol.268 , pp. 46-53
    • Sun, E.1    Shi, Y.2
  • 59
    • 33751254116 scopus 로고    scopus 로고
    • The neuronal microRNA system
    • Kosik KS. The neuronal microRNA system. Nat Rev Neurosci 2006; 7: 911–920.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 911-920
    • Kosik, K.S.1
  • 61
    • 67349117808 scopus 로고    scopus 로고
    • Molecular determinants of dysregulated GABAergic gene expression in the prefrontal cortex of subjects with schizophrenia
    • Mellios N, Huang HS, Baker SP, Galdzicka M, Ginns E, Akbarian S. Molecular determinants of dysregulated GABAergic gene expression in the prefrontal cortex of subjects with schizophrenia. Biol Psychiatry 2009; 65: 1006–1014.
    • (2009) Biol Psychiatry , vol.65 , pp. 1006-1014
    • Mellios, N.1    Huang, H.S.2    Baker, S.P.3    Galdzicka, M.4    Ginns, E.5    Akbarian, S.6
  • 62
    • 84941181377 scopus 로고    scopus 로고
    • Pathogenetic and therapeutic applications of microRNAs in major depressive disorder
    • Dwivedi Y. Pathogenetic and therapeutic applications of microRNAs in major depressive disorder. Progr Neuropsychopharmacol Biol Psychiatry 2016; 64: 341–348.
    • (2016) Progr Neuropsychopharmacol Biol Psychiatry , vol.64 , pp. 341-348
    • Dwivedi, Y.1
  • 63
    • 84930650455 scopus 로고    scopus 로고
    • Genetic variants in the promoters of let-7 family are associated with an increased risk of major depressive disorder
    • Liang Y, Zhao G, Sun R, Mao Y, Li G, Chen X et al. Genetic variants in the promoters of let-7 family are associated with an increased risk of major depressive disorder. J Affect Disord 2015; 183: 295–299.
    • (2015) J Affect Disord , vol.183 , pp. 295-299
    • Liang, Y.1    Zhao, G.2    Sun, R.3    Mao, Y.4    Li, G.5    Chen, X.6
  • 64
    • 84924272069 scopus 로고    scopus 로고
    • Preliminary investigation of miRNA expression in individuals at high familial risk of bipolar disorder
    • Walker RM, Rybka J, Anderson SM, Torrance HS, Boxall R, Sussmann JE et al. Preliminary investigation of miRNA expression in individuals at high familial risk of bipolar disorder. J Psychiatr Res 2015; 62: 48–55.
    • (2015) J Psychiatr Res , vol.62 , pp. 48-55
    • Walker, R.M.1    Rybka, J.2    Anderson, S.M.3    Torrance, H.S.4    Boxall, R.5    Sussmann, J.E.6
  • 66
    • 84866866864 scopus 로고    scopus 로고
    • The emerging role of microRNAs in schizophrenia and autism spectrum disorders
    • Mellios N, Sur M. The emerging role of microRNAs in schizophrenia and autism spectrum disorders. Front Psychiatry 2012; 3: 39.
    • (2012) Front Psychiatry , vol.3 , pp. 39
    • Mellios, N.1    Sur, M.2
  • 67
    • 84939956122 scopus 로고    scopus 로고
    • From microRNA target validation to therapy: Lessons learned from studies on BDNF
    • Varendi K, Matlik K, Andressoo JO. From microRNA target validation to therapy: lessons learned from studies on BDNF. Cell Mol Life Sci 2015; 72: 1779–1794.
    • (2015) Cell Mol Life Sci , vol.72 , pp. 1779-1794
    • Varendi, K.1    Matlik, K.2    Andressoo, J.O.3
  • 68
    • 85027955850 scopus 로고    scopus 로고
    • Effects of remote ischemic preconditioning and myocardial ischemia on microRNA-1 expression in the rat heart in vivo
    • Brandenburger T, Grievink H, Heinen N, Barthel F, Huhn R, Stachuletz F et al. Effects of remote ischemic preconditioning and myocardial ischemia on microRNA-1 expression in the rat heart in vivo. Shock 2014; 42: 234–238.
    • (2014) Shock , vol.42 , pp. 234-238
    • Brandenburger, T.1    Grievink, H.2    Heinen, N.3    Barthel, F.4    Huhn, R.5    Stachuletz, F.6
  • 69
    • 80054950828 scopus 로고    scopus 로고
    • A Shh/ miR-206/BDNF cascade coordinates innervation and formation of airway smooth muscle
    • Radzikinas K, Aven L, Jiang Z, Tran T, Paez-Cortez J, Boppidi K et al. A Shh/ miR-206/BDNF cascade coordinates innervation and formation of airway smooth muscle. J Neurosci 2011; 31: 15407–15415.
    • (2011) J Neurosci , vol.31 , pp. 15407-15415
    • Radzikinas, K.1    Aven, L.2    Jiang, Z.3    Tran, T.4    Paez-Cortez, J.5    Boppidi, K.6
  • 70
    • 84865582770 scopus 로고    scopus 로고
    • miR-206 regulates brain-derived neurotrophic factor in Alzheimer disease model
    • Lee ST, Chu K, Jung KH, Kim JH, Huh JY, Yoon H et al. miR-206 regulates brain-derived neurotrophic factor in Alzheimer disease model. Ann Neurol 2012; 72: 269–277.
    • (2012) Ann Neurol , vol.72 , pp. 269-277
    • Lee, S.T.1    Chu, K.2    Jung, K.H.3    Kim, J.H.4    Huh, J.Y.5    Yoon, H.6
  • 71
    • 84897911224 scopus 로고    scopus 로고
    • MicroRNA-206 in rat medial prefrontal cortex regulates BDNF expression and alcohol drinking
    • Tapocik JD, Barbier E, Flanigan M, Solomon M, Pincus A, Pilling A et al. MicroRNA-206 in rat medial prefrontal cortex regulates BDNF expression and alcohol drinking. J Neurosci 2014; 34: 4581–4588.
    • (2014) J Neurosci , vol.34 , pp. 4581-4588
    • Tapocik, J.D.1    Barbier, E.2    Flanigan, M.3    Solomon, M.4    Pincus, A.5    Pilling, A.6
  • 72
    • 33748102321 scopus 로고    scopus 로고
    • Muscle-specific microRNA miR-206 promotes muscle differentiation
    • Kim HK, Lee YS, Sivaprasad U, Malhotra A, Dutta A. Muscle-specific microRNA miR-206 promotes muscle differentiation. J Cell Biol 2006; 174: 677–687.
    • (2006) J Cell Biol , vol.174 , pp. 677-687
    • Kim, H.K.1    Lee, Y.S.2    Sivaprasad, U.3    Malhotra, A.4    Dutta, A.5
  • 73
    • 84155163076 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor expression is repressed during myogenic differentiation by miR-206
    • Miura P, Amirouche A, Clow C, Belanger G, Jasmin BJ. Brain-derived neurotrophic factor expression is repressed during myogenic differentiation by miR-206. J Neurochem 2012; 120: 230–238.
    • (2012) J Neurochem , vol.120 , pp. 230-238
    • Miura, P.1    Amirouche, A.2    Clow, C.3    Belanger, G.4    Jasmin, B.J.5
  • 74
    • 84871377399 scopus 로고    scopus 로고
    • Genomic loss of tumor suppressor miRNA-204 promotes cancer cell migration and invasion by activating AKT/mTOR/Rac1 signaling and actin reorganization
    • Imam JS, Plyler JR, Bansal H, Prajapati S, Bansal S, Rebeles J et al. Genomic loss of tumor suppressor miRNA-204 promotes cancer cell migration and invasion by activating AKT/mTOR/Rac1 signaling and actin reorganization. PLoS One 2012; 7: e52397.
    • (2012) Plos One , vol.7
    • Imam, J.S.1    Plyler, J.R.2    Bansal, H.3    Prajapati, S.4    Bansal, S.5    Rebeles, J.6
  • 75
    • 71749100911 scopus 로고    scopus 로고
    • An integrated approach for experimental target identification of hypoxia-induced miR-210
    • Fasanaro P, Greco S, Lorenzi M, Pescatori M, Brioschi M, Kulshreshtha R et al. An integrated approach for experimental target identification of hypoxia-induced miR-210. J Biol Chem 2009; 284: 35134–35143.
    • (2009) J Biol Chem , vol.284 , pp. 35134-35143
    • Fasanaro, P.1    Greco, S.2    Lorenzi, M.3    Pescatori, M.4    Brioschi, M.5    Kulshreshtha, R.6
  • 76
    • 84942550565 scopus 로고    scopus 로고
    • MicroRNA-30a-5p in the prefrontal cortex controls the transition from moderate to excessive alcohol consumption
    • Darcq E, Warnault V, Phamluong K, Besserer GM, Liu F, Ron D. MicroRNA-30a-5p in the prefrontal cortex controls the transition from moderate to excessive alcohol consumption. Mol Psychiatry 2015; 20: 1219–1231.
    • (2015) Mol Psychiatry , vol.20 , pp. 1219-1231
    • Darcq, E.1    Warnault, V.2    Phamluong, K.3    Besserer, G.M.4    Liu, F.5    Ron, D.6
  • 77
    • 77957682512 scopus 로고    scopus 로고
    • Distinct 3'UTRs differentially regulate activity-dependent translation of brain-derived neurotrophic factor (BDNF)
    • Lau AG, Irier HA, Gu J, Tian D, Ku L, Liu G et al. Distinct 3'UTRs differentially regulate activity-dependent translation of brain-derived neurotrophic factor (BDNF). Proc Natl Acad Sci USA 2010; 107: 15945–15950.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 15945-15950
    • Lau, A.G.1    Irier, H.A.2    Gu, J.3    Tian, D.4    Ku, L.5    Liu, G.6
  • 78
    • 84881638445 scopus 로고    scopus 로고
    • Effects of with-drawal from repeated amphetamine exposure in peri-puberty on neuroplasticity-related genes in mice
    • Calabrese F, Richetto J, Racagni G, Feldon J, Meyer U, Riva MA. Effects of with-drawal from repeated amphetamine exposure in peri-puberty on neuroplasticity-related genes in mice. Neuroscience 2013; 250: 222–231.
    • (2013) Neuroscience , vol.250 , pp. 222-231
    • Calabrese, F.1    Richetto, J.2    Racagni, G.3    Feldon, J.4    Meyer, U.5    Riva, M.A.6
  • 79
    • 84877964436 scopus 로고    scopus 로고
    • Alterations of serum levels of BDNF-related miRNAs in patients with depression
    • Li YJ, Xu M, Gao ZH, Wang YQ, Yue Z, Zhang YX et al. Alterations of serum levels of BDNF-related miRNAs in patients with depression. PLoS One 2013; 8: e63648.
    • (2013) Plos One , vol.8
    • Li, Y.J.1    Xu, M.2    Gao, Z.H.3    Wang, Y.Q.4    Yue, Z.5    Zhang, Y.X.6
  • 81
    • 84867301311 scopus 로고    scopus 로고
    • Abnormal hippocampal BDNF and miR-16 expression is associated with depression-like behaviors induced by stress during early life
    • Bai M, Zhu X, Zhang Y, Zhang S, Zhang L, Xue L et al. Abnormal hippocampal BDNF and miR-16 expression is associated with depression-like behaviors induced by stress during early life. PLoS One 2012; 7: e46921.
    • (2012) Plos One , vol.7
    • Bai, M.1    Zhu, X.2    Zhang, Y.3    Zhang, S.4    Zhang, L.5    Xue, L.6
  • 82
    • 84945944459 scopus 로고    scopus 로고
    • Integrated analyses to reconstruct microRNA-mediated regulatory networks in mouse liver using high-throughput profiling
    • Hsu SD, Huang HY, Chou CH, Sun YM, Hsu MT, Tsou AP. Integrated analyses to reconstruct microRNA-mediated regulatory networks in mouse liver using high-throughput profiling. BMC Genomics 2015; 16(Suppl 2): S12.
    • (2015) BMC Genomics , vol.16
    • Hsu, S.D.1    Huang, H.Y.2    Chou, C.H.3    Sun, Y.M.4    Hsu, M.T.5    Tsou, A.P.6
  • 83
    • 84937717957 scopus 로고    scopus 로고
    • Towards a classification of biomarkers of neuropsychiatric disease: From encompass to compass
    • Davis J, Maes M, Andreazza A, McGrath JJ, Tye SJ, Berk M. Towards a classification of biomarkers of neuropsychiatric disease: from encompass to compass. Mol Psychiatry 2015; 20: 152–153.
    • (2015) Mol Psychiatry , vol.20 , pp. 152-153
    • Davis, J.1    Maes, M.2    Andreazza, A.3    McGrath, J.J.4    Tye, S.J.5    Berk, M.6
  • 84
    • 84865427931 scopus 로고    scopus 로고
    • Reliable biomarkers and predictors of schizophrenia and its treatment
    • Pillai A, Buckley PF. Reliable biomarkers and predictors of schizophrenia and its treatment. Psychiatr Clin N Am 2012; 35: 645–659.
    • (2012) Psychiatr Clin N Am , vol.35 , pp. 645-659
    • Pillai, A.1    Buckley, P.F.2
  • 85
    • 80054756091 scopus 로고    scopus 로고
    • Functional biomarkers of depression: Diagnosis, treatment, and pathophysiology
    • Schmidt HD, Shelton RC, Duman RS. Functional biomarkers of depression: diagnosis, treatment, and pathophysiology. Neuropsychopharmacology 2011; 36: 2375–2394.
    • (2011) Neuropsychopharmacology , vol.36 , pp. 2375-2394
    • Schmidt, H.D.1    Shelton, R.C.2    Duman, R.S.3
  • 86
    • 84911439383 scopus 로고    scopus 로고
    • BDNF Val66Met genotype interacts with childhood adversity and influences the formation of hippocampal subfields
    • Frodl T, Skokauskas N, Frey EM, Morris D, Gill M, Carballedo A. BDNF Val66Met genotype interacts with childhood adversity and influences the formation of hippocampal subfields. Hum Brain Mapp 2014; 35: 5776–5783.
    • (2014) Hum Brain Mapp , vol.35 , pp. 5776-5783
    • Frodl, T.1    Skokauskas, N.2    Frey, E.M.3    Morris, D.4    Gill, M.5    Carballedo, A.6
  • 87
    • 84874179053 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor Val66Met polymorphism and early life adversity affect hippocampal volume
    • Carballedo A, Morris D, Zill P, Fahey C, Reinhold E, Meisenzahl E et al. Brain-derived neurotrophic factor Val66Met polymorphism and early life adversity affect hippocampal volume. Am J Mel Genet B 2013; 162B: 183–190.
    • (2013) Am J Mel Genet B , vol.162B , pp. 183-190
    • Carballedo, A.1    Morris, D.2    Zill, P.3    Fahey, C.4    Reinhold, E.5    Meisenzahl, E.6
  • 88
    • 78751627945 scopus 로고    scopus 로고
    • The association between brain-derived neurotrophic factor polymorphism (BDNF Val66Met) and suicide
    • Pregelj P, Nedic G, Paska AV, Zupanc T, Nikolac M, Balazic J et al. The association between brain-derived neurotrophic factor polymorphism (BDNF Val66Met) and suicide. J Affect Disord 2011; 128: 287–290.
    • (2011) J Affect Disord , vol.128 , pp. 287-290
    • Pregelj, P.1    Nedic, G.2    Paska, A.V.3    Zupanc, T.4    Nikolac, M.5    Balazic, J.6
  • 89
    • 84855354000 scopus 로고    scopus 로고
    • Genetic epistasis between the brain-derived neurotrophic factor Val66Met polymorph-ism and the 5-HTT promoter polymorphism moderates the susceptibility to depressive disorders after childhood abuse
    • Grabe HJ, Schwahn C, Mahler J, Appel K, Schulz A, Spitzer C et al. Genetic epistasis between the brain-derived neurotrophic factor Val66Met polymorph-ism and the 5-HTT promoter polymorphism moderates the susceptibility to depressive disorders after childhood abuse. Progr Neuropsychopharmacol Biol Psychiatry 2012; 36: 264–270.
    • (2012) Progr Neuropsychopharmacol Biol Psychiatry , vol.36 , pp. 264-270
    • Grabe, H.J.1    Schwahn, C.2    Mahler, J.3    Appel, K.4    Schulz, A.5    Spitzer, C.6
  • 90
    • 67649964222 scopus 로고    scopus 로고
    • Early adversity and 5-HTT/BDNF genes: New evidence of gene-environment interactions on depressive symptoms in a general population
    • Aguilera M, Arias B, Wichers M, Barrantes-Vidal N, Moya J, Villa H et al. Early adversity and 5-HTT/BDNF genes: new evidence of gene-environment interactions on depressive symptoms in a general population. Psychol Med 2009; 39: 1425–1432.
    • (2009) Psychol Med , vol.39 , pp. 1425-1432
    • Aguilera, M.1    Arias, B.2    Wichers, M.3    Barrantes-Vidal, N.4    Moya, J.5    Villa, H.6
  • 91
    • 38949149652 scopus 로고    scopus 로고
    • The relationship between childhood abuse and dissociation. Is it influenced by catechol-O-methyltransferase (COMT) activity?
    • Savitz JB, van der Merwe L, Newman TK, Solms M, Stein DJ, Ramesar RS. The relationship between childhood abuse and dissociation. Is it influenced by catechol-O-methyltransferase (COMT) activity? Int J Neuropsychopharmacol 2008; 11: 149–161.
    • (2008) Int J Neuropsychopharmacol , vol.11 , pp. 149-161
    • Savitz, J.B.1    van der Merwe, L.2    Newman, T.K.3    Solms, M.4    Stein, D.J.5    Ramesar, R.S.6
  • 92
    • 0033079596 scopus 로고    scopus 로고
    • Neurotrophins and depression
    • Altar CA. Neurotrophins and depression. Trends Pharmacol Sci 1999; 20: 59–61.
    • (1999) Trends Pharmacol Sci , vol.20 , pp. 59-61
    • Altar, C.A.1
  • 94
    • 1542327619 scopus 로고    scopus 로고
    • et al. Induction of brain-derived neurotrophic factor in plaque-associated glial cells of aged APP23 transgenic mice
    • Burbach GJ, Hellweg R, Haas CA, Del Turco D, Deicke U, Abramowski D et al. Induction of brain-derived neurotrophic factor in plaque-associated glial cells of aged APP23 transgenic mice. J Neurosci 2004; 24: 2421–2430.
    • (2004) J Neurosci , vol.24 , pp. 2421-2430
    • Burbach, G.J.1    Hellweg, R.2    Haas, C.A.3    Del Turco, D.4    Deicke, U.5    Abramowski, D.6
  • 95
    • 84867570315 scopus 로고    scopus 로고
    • Finding the needle in the haystack: A review of microarray gene expression research into schizophrenia
    • Kumarasinghe N, Tooney PA, Schall U. Finding the needle in the haystack: a review of microarray gene expression research into schizophrenia. Aust N Z J Psychiatry 2012; 46: 598–610.
    • (2012) Aust N Z J Psychiatry , vol.46 , pp. 598-610
    • Kumarasinghe, N.1    Tooney, P.A.2    Schall, U.3
  • 96
    • 84873056640 scopus 로고    scopus 로고
    • Genome-wide expression profiling of schizophrenia using a large combined cohort
    • Mistry M, Gillis J, Pavlidis P. Genome-wide expression profiling of schizophrenia using a large combined cohort. Mol Psychiatry 2013; 18: 215–225.
    • (2013) Mol Psychiatry , vol.18 , pp. 215-225
    • Mistry, M.1    Gillis, J.2    Pavlidis, P.3
  • 97
    • 55549139122 scopus 로고    scopus 로고
    • A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: Implications for the role of neuro-plasticity in depression
    • Brunoni AR, Lopes M, Fregni F. A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuro-plasticity in depression. Int J Neuropsychopharmacol 2008; 11: 1169–1180.
    • (2008) Int J Neuropsychopharmacol , vol.11 , pp. 1169-1180
    • Brunoni, A.R.1    Lopes, M.2    Fregni, F.3
  • 98
    • 0036202956 scopus 로고    scopus 로고
    • Decreased serum brain-derived neurotrophic factor levels in major depressed patients
    • Karege F, Perret G, Bondolfi G, Schwald M, Bertschy G, Aubry JM. Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry Res 2002; 109: 143–148.
    • (2002) Psychiatry Res , vol.109 , pp. 143-148
    • Karege, F.1    Perret, G.2    Bondolfi, G.3    Schwald, M.4    Bertschy, G.5    Aubry, J.M.6
  • 99
    • 18144416532 scopus 로고    scopus 로고
    • Low brain-derived neurotrophic factor (BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivity
    • Karege F, Bondolfi G, Gervasoni N, Schwald M, Aubry JM, Bertschy G. Low brain-derived neurotrophic factor (BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivity. Biol Psychiatry 2005; 57: 1068–1072.
    • (2005) Biol Psychiatry , vol.57 , pp. 1068-1072
    • Karege, F.1    Bondolfi, G.2    Gervasoni, N.3    Schwald, M.4    Aubry, J.M.5    Bertschy, G.6
  • 101
    • 84903584769 scopus 로고    scopus 로고
    • Serum BDNF concentrations as peripheral manifestations of depression: Evidence from a systematic review and meta-analyses on 179 associations (N = 9484)
    • Molendijk ML, Spinhoven P, Polak M, Bus BA, Penninx BW, Elzinga BM. Serum BDNF concentrations as peripheral manifestations of depression: evidence from a systematic review and meta-analyses on 179 associations (N = 9484). Mol Psychiatry 2014; 19: 791–800.
    • (2014) Mol Psychiatry , vol.19 , pp. 791-800
    • Molendijk, M.L.1    Spinhoven, P.2    Polak, M.3    Bus, B.A.4    Penninx, B.W.5    Elzinga, B.M.6
  • 102
    • 84926214776 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor (BDNF) and neurocognitive deficits in people with schizophrenia: A meta-analysis
    • Ahmed AO, Mantini AM, Fridberg DJ, Buckley PF. Brain-derived neurotrophic factor (BDNF) and neurocognitive deficits in people with schizophrenia: a meta-analysis. Psychiatry Res 2015; 226: 1–13.
    • (2015) Psychiatry Res , vol.226 , pp. 1-13
    • Ahmed, A.O.1    Mantini, A.M.2    Fridberg, D.J.3    Buckley, P.F.4
  • 103
    • 84976211565 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor levels in first episode of psy-chosis: A systematic review
    • Toll A, Mane A. Brain-derived neurotrophic factor levels in first episode of psy-chosis: a systematic review. World J Psychiatry 2015; 5: 154–159.
    • (2015) World J Psychiatry , vol.5 , pp. 154-159
    • Toll, A.1    Mane, A.2
  • 104
    • 0032404127 scopus 로고    scopus 로고
    • Transport of brain-derived neurotrophic factor across the blood-brain barrier
    • Pan W, Banks WA, Fasold MB, Bluth J, Kastin AJ. Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology 1998; 37: 1553–1561.
    • (1998) Neuropharmacology , vol.37 , pp. 1553-1561
    • Pan, W.1    Banks, W.A.2    Fasold, M.B.3    Bluth, J.4    Kastin, A.J.5
  • 105
    • 34548028287 scopus 로고    scopus 로고
    • Correlation between serum brain-derived neurotrophic factor level and an in vivo marker of cortical integ-rity
    • Lang UE, Hellweg R, Seifert F, Schubert F, Gallinat J. Correlation between serum brain-derived neurotrophic factor level and an in vivo marker of cortical integ-rity. Biological psychiatry 2007; 62: 530–535.
    • (2007) Biological Psychiatry , vol.62 , pp. 530-535
    • Lang, U.E.1    Hellweg, R.2    Seifert, F.3    Schubert, F.4    Gallinat, J.5
  • 106
    • 0036214689 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation
    • Fujimura H, Altar CA, Chen R, Nakamura T, Nakahashi T, Kambayashi J et al. Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation. Thromb Haemostasis 2002; 87: 728–734.
    • (2002) Thromb Haemostasis , vol.87 , pp. 728-734
    • Fujimura, H.1    Altar, C.A.2    Chen, R.3    Nakamura, T.4    Nakahashi, T.5    Kambayashi, J.6
  • 108
    • 67649173089 scopus 로고    scopus 로고
    • Reduced platelet BDNF level in patients with major depression
    • Lee BH, Kim YK. Reduced platelet BDNF level in patients with major depression. Progr Neuropsychopharmacol Biol Psychiatry 2009; 33: 849–853.
    • (2009) Progr Neuropsychopharmacol Biol Psychiatry , vol.33 , pp. 849-853
    • Lee, B.H.1    Kim, Y.K.2
  • 109
    • 77952676942 scopus 로고    scopus 로고
    • Analysis of whole genome biomarker expression in blood and brain
    • Rollins B, Martin MV, Morgan L, Vawter MP. Analysis of whole genome biomarker expression in blood and brain. Am J Med Genet B 2010; 153B: 919–936.
    • (2010) Am J Med Genet B , vol.153B , pp. 919-936
    • Rollins, B.1    Martin, M.V.2    Morgan, L.3    Vawter, M.P.4
  • 110
    • 33646010307 scopus 로고    scopus 로고
    • Evaluating the comparability of gene expression in blood and brain
    • Sullivan PF, Fan C, Perou CM. Evaluating the comparability of gene expression in blood and brain. Am J Med Genet B 2006; 141B: 261–268.
    • (2006) Am J Med Genet B , vol.141B , pp. 261-268
    • Sullivan, P.F.1    Fan, C.2    Perou, C.M.3
  • 111
    • 84885705541 scopus 로고    scopus 로고
    • On the outside, looking in: A review and evaluation of the comparability of blood and brain ‘-omes’
    • Tylee DS, Kawaguchi DM, Glatt SJ. On the outside, looking in: a review and evaluation of the comparability of blood and brain ‘-omes’. Am J Med Genet B 2013; 162B: 595–603.
    • Am J Med Genet B 2013 , vol.162B , pp. 595-603
    • Tylee, D.S.1    Kawaguchi, D.M.2    Glatt, S.J.3
  • 112
    • 84874424599 scopus 로고    scopus 로고
    • Gene expression analysis reveals schizophrenia-associated dysregulation of immune pathways in peripheral blood mononuclear cells
    • Gardiner EJ, Cairns MJ, Liu B, Beveridge NJ, Carr V, Kelly B et al. Gene expression analysis reveals schizophrenia-associated dysregulation of immune pathways in peripheral blood mononuclear cells. J Psychiatr Res 2013; 47: 425–437.
    • (2013) J Psychiatr Res , vol.47 , pp. 425-437
    • Gardiner, E.J.1    Cairns, M.J.2    Liu, B.3    Beveridge, N.J.4    Carr, V.5    Kelly, B.6
  • 113
    • 80054850997 scopus 로고    scopus 로고
    • Similarities and differences in peripheral blood gene-expression signatures of individuals with schizophrenia and their first-degree biological relatives
    • Glatt SJ, Stone WS, Nossova N, Liew CC, Seidman LJ, Tsuang MT. Similarities and differences in peripheral blood gene-expression signatures of individuals with schizophrenia and their first-degree biological relatives. Am J Med Genet B 2011; 156B: 869–887.
    • (2011) Am J Med Genet B , vol.156B , pp. 869-887
    • Glatt, S.J.1    Stone, W.S.2    Nossova, N.3    Liew, C.C.4    Seidman, L.J.5    Tsuang, M.T.6
  • 115
    • 84868308595 scopus 로고    scopus 로고
    • Serum BDNF concentrations show strong seasonal variation and correlations with the amount of ambient sunlight
    • Molendijk ML, Haffmans JP, Bus BA, Spinhoven P, Penninx BW, Prickaerts J et al. Serum BDNF concentrations show strong seasonal variation and correlations with the amount of ambient sunlight. PLoS One 2012; 7: e48046.
    • (2012) Plos One , vol.7
    • Molendijk, M.L.1    Haffmans, J.P.2    Bus, B.A.3    Spinhoven, P.4    Penninx, B.W.5    Prickaerts, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.