Serum BDNF concentrations as peripheral manifestations of depression: Evidence from a systematic review and meta-analyses on 179 associations (N=9484)

Molecular Psychiatry

Volumn 19, Issue 7, 2014, Pages 791-800

  Molendijk, M L ^a,b   Spinhoven, P ^a,b   Polak, M ^a   Bus, B A A ^c   Penninx, B W J H ^b,d,e   Elzinga, B M ^a,b  

^a LEIDEN UNIVERSITY   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITY OF AMSTERDAM   (Netherlands)

^e UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

antidepressants; BDNF; biomarker; depression; meta analysis

Indexed keywords

ANTIDEPRESSANT AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; BIOLOGICAL MARKER;

ARTICLE; DEPRESSION; DISEASE SEVERITY; HUMAN; META ANALYSIS; PRIORITY JOURNAL; SYMPTOM; SYSTEMATIC REVIEW; BLOOD; CASE CONTROL STUDY; PSYCHOLOGICAL RATING SCALE; PUBLISHING; STATISTICS AND NUMERICAL DATA;

ANTIDEPRESSIVE AGENTS; BIOLOGICAL MARKERS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CASE-CONTROL STUDIES; DEPRESSION; HUMANS; PSYCHIATRIC STATUS RATING SCALES; PUBLICATION BIAS;

EID: 84903584769     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2013.105     Document Type: Article

References (105)

1. Duman RS, Heninger GR, Nestler EJ. A molecular and cellular theory of depression. Arch Gen Psychiatry 1997; 54: 597-606.
2. Park H, Poo M-M. Neurotrophin regulation of neuronal circuit development and function. Nat Rev Neurosci 2013; 14: 7-23.
3. Duman RS, Monteggia LM. A neurotrophic model for stress-related mood disorders. Biol Psychiatry 2006; 59: 1116-1127.
4. Taliaz D, Stall N, Dar DE, Zangen A. Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis. Mol Psychiatry 2010; 15: 80-92.
5. Thompson Ray M, Weickert CS, Wyatt E, Webster MJ. Decreased BDNF, trkB-TK+ and GAD mRNA expression in the hippocampus of individuals with schizophrenia and mood disorders. J Psychiatry Neurosci 2011; 36: 195-203.
6. Karege F, Perret G, Bondolfi G, Schwald M, Bertschy G, Aubry JM. Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry Res 2002; 109: 143-148.
7. Shimizu E, Hashimoto K, Okamura N, Koike K, Komatsu N, Kumakiri C et al. Alternations of serum concentrations of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biol Psychiatry 2003; 54: 70-75.
8. Brunoni AR, Lopes M, Fregni F. A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression. Int J Neuropsychopharmacol 2008; 11: 1169-1180.
9. Sen S, Duman R, Sanacora G. Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications. Biol Psychiatry 2008; 64: 527-532.
10. Bocchio-Chiavetto L, Bagnardi V, Zanardini R, Molteni R, Nielsen MG, Placentino A et al. Serum and plasma BDNF levels in major depression: a replication study and meta-analyses. W J Biol Psychiatry 2010; 11: 763-773.
11. Basterzi AD, Yazici K, Aslan E, Delialioglu N, Tasdelen B, Acar ST et al. Effects of fluoxetine and venlafaxine on serum brain-derived neurotrophic factor concentrations in depressed patients. Prog Neuro-Psychopharmacol Biol Psychiatry 2009; 33: 281-285.
12. Elfving B, Buttenschon HN, Foldager L, Poulsen PHP, Andersen JH, Grynderup MB et al. Depression, the val66met polymorphism, age, and gender influence the serum BDNF level. J Psychiatric Res 2012; 46: 1118-1125.
13. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the prisma statement. Ann Intern Med 2009; 151: 264-269.
14. Wells GA, Shea B, O'Connel D. The Newcastle-Ottawa Scale (NOS) for assessing the quality non-randomised studies in meta-analyses. Ottawa Healthcare Institute. http://www.ohri.ca, accessed 7 February 2013.
15. The Cochrane Collaboration Handbookhttp://www.cochrane.org/, accessed 29 June 2013.
16. Borenstein M, Hedges LV, Higgins JPT. Introduction to Meta-Analyses. Wiley: Chicester, NH, USA, 2009.
17. Cohen J. Statistical Power Analysis for the Behavioral Sciences. Lawrence Erlbaum Associates: Hillsdale, NJ, USA, 1988.
18. Mosteller F, Colditz GA. Understanding research synthesis (meta-analysis). Annu Rev Public Health 1996; 17: 1-23.
19. Higgins JPT, Thompson SG. Quantifying heterogeneity in meta-analysis. Statist Med 2002; 21: 1539-155.
20. Hamilton M. A rating scale for depression. J Neurol Neurosug Psychiatry 1960; 23: 56-62.
21. Rush AJ, Gullion CM, Basco MR, Jarrett RB, Trivedi MH. The inventory of depressive symptomatology (IDS): psychometric properties. Psychol Med 1996; 26: 477-486.
22. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997; 315: 629-634.
23. Duval S, Tweedie RL. A nonparametric 'trim and fill' method of accounting for publication bias in meta-analysis. J Am Stat Soc 2000; 95: 89-98.
24. Peters JL, Sutton AJ, Jones DR, Abrams KR, Rushton L. Performance of the trim and fill method in the presence of publication bias and between-study heterogeneity. Statist Med 2007; 26: 4544-4562.
25. Faul F, Erdfelder E, Buchner A, Lang AG. Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Beh Res Methods 2009; 41: 1149-1160.
26. Gervasoni N, Aubry JM, Bondolfi G, Osiek C, Schwald M, Bertschy G et al. Partial normalization of serum brain-derived neurotrophic factor in remitted patients after a major depressive episode. Neuropsychobiol 2005; 51: 234-238.
27. Gönü l AS, Kitis O, Eker MC, Eker OD, Ozan E, Coburn K. Association of the brainderived neurotrophic factor val66met polymorphism with hippocampus volumes in drug-free depressed patients. W J Biol Psychiatry 2011; 12: 110-118.
28. Karege F, Bondolfi G, Gervasoni N, Schwald M, Aubry J-M, Bertschy G. Low brainderived neurotrophic factor levels in serum of depressed patients probably result from lower platelet BDNF release unrelated to platelet reactivity. Biol Psychiatry 2005; 57: 1068-1072.
29. Aydemir C, Yalcin ES, Aksaray S, Kisa C, Yildirim SG, Uzbay T et al. Brain-derived neurotrophic factor (BDNF) changes in the serum of depressed women. Prog Neuropsychopharmacol Biol Psychiatry 2006; 30: 1256-1260.
30. Zanardini R, Gazzoli A, Ventriglia M, Perez J, Bignotti S, Rossini PM et al. Effect of repetitive transcranial magnetic stimulation on serum brain-derived neurotrophic factor in drug resistant depressed patients. J Affect Disord 2006; 91: 83-86.
31. Lommatzsch M, Hornych K, Zingler C, Schuff-Werner P, Hoppner J, Virchow JC et al. Maternal serum concentrations of BDNF and depression in the perinatal period. Psychoendocrinol 2006; 31: 388-394.
32. Bocchi-Chiavetto L, Zanardini R, Bortolomasi M, Abate M, Segala M, Giacopuzzi M et al. Electroconvulsive therapy (ECT) increases serum brain-derived neurotrophic factor in drug resistant depressed patients. Eur Neuropsychopharmacol 2006; 16: 56-59.
33. Lang UE, Bajbouj M, Gallinat J, Hellweg R. Brain-derived neurotrophic factor serum concentrations in depressive patients during vagus nerve stimulation and repetetive transcranial magnetic stimulation. Psychopharmacol 2006; 187: 56-59.
34. Aydemir O, Deveci A, Taskin OE, Taneli F, Esen-Danaci A. Serum brain-derived neurotrophic factor level in dysthymia: a comparative study with major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry 2007; 31: 1023- 1026.
35. Yoshimura R, Mitoma M, Sugita A, Hori H, Okamoto T, Umene W et al. Effects of paroxetine or milnacipran on serum brain-derived neurotrophic factor in depressed patients. Prog Neuropsychopharmacol Biol Psychiatry 2007; 31: 1034- 1037.
36. Ziegenhorn AA, Schulte-Hebruggen O, Danker-Hopfe H, Malbranc M, Hartung H-D, Anders D. Serum neurotrophins-a study on the time course and influencing factors in a large old sample. Neurobiol Aging 2007; 28: 1436-1445.
37. Hellweg R, Ziegenhorn A, Heuser I, Deuschle M. Serum concentrations of nerve growth factor and brain-derived neurotrophic factor in depressed patients before and after antidepressant treatment. Pharmacopsychiatry 2008; 41: 66-71.
38. Okamoto T, Yoshimura R, Ikenouchi-Sugita A, Hori H, Umene-Nakano W, Inoue Y et al. Efficacy of electroconvulsive therapy is associated with changing blood levels of homovanilic acid and brain-derived neurotrophic factor in refractory depressed patients: a pilot study. Prog Neuropsychopharmacol Biol Psychiatry 2008; 32: 1185-1190.
39. Stanek K, Gunstad J, Leahey T, Glickman E, Alexander T, Spitznagel MB et al. Serum brain-derived neurotrophic factor is associated with reduced appetite in healthy older adults. J Health Aging 2008; 12: 183-185.
40. Huang TL, Lee CT, Liu YL. Serum brain-derived neurotrophic factor levels in patients with major depression: effects of antidepressants. J Psychiatr Res 2008; 42: 521-525.
41. Piccinni A, Marazziti D, Catena M, Domenici L, Del Debbio A, Bianchi C et al. Plasma and serum brain-derived neurotrophic factor (BDNF) in depressed patients during 1 year of antidepressant treatment. J Affect Disord 2008; 105: 279-283.
42. Matrisciano F, Bonaccorso S, Ricciardi A, Scaccianoce S, Panaccione I, Wang L et al. Changes in BDNF serum concentrations in patients with major depression disorder (MDD) after 6 months treatment with sertraline, ecitalopram, or venlafaxine. J Psych Res 2009; 43: 247-254.
43. Gorgulu Y, Caliyurt O. Rapid antidepressant effect of sleep deprivation therapy correlates with serum BDNF changes in major depression. Brain Res Bull 2009; 80: 158-162.
44. Gronli O, Stensland GO, Wynn R, Olstad R. Neurotrophic factors in serum following ECT: a pilot study. World J Biol Psychiatry 2009; 10: 295-301.
45. Umene-Nakano W, Yoshimura R, Ikenouchi-Sugita A, Hori H, Hayashi K, Ueda N et al. Serum levels of brain-derived neurotrophic factor in comorbidity of depression and alcohol dependence. Hum Psychopharmacol Clin Exp 2009; 24: 409-413.
46. Fernandes B, Gama CS, Massuda R, Torres M, Camargo D, Kunz M et al. Serum brain-derived neurotrophic factor is not associated with response to electroconvulsive therapy: a pilot in drug resistant depressed patients. Neurosci Lett 2009; 453: 195-198.
47. Lee JG, Shin BS, You YS, Kim JE, Yoon SW, Jeon DW et al. Decreased serum brainderived neurotrophic factor levels in elderly Korean with dementia. Psychiatry Invest 2009; 6: 299-305.
48. Ozan E, Okur H, Eker C, Eker DE, Gönü l AS, Akarsu N. The effect of depression, BDNF gene val66met polymorphism and gender on serum BDNF levels. Brain Res Bull 2010; 81: 61-65.
49. Diniz BS, Teixeira AL, Talib LL, Mendoca VA, Gattaz WF, Forlenza OV. Serum brain-derived neurotrophic factor level is reduced in antidepressant-free patients with late-life depression. W J Biol Psychiatry 2010; 11: 550-555.
50. Eker C, Kitis O, Taneli F, Eker DE, Ozan E, Yucel K et al. Correlation of serum BDNF levels with hippocampal volumes in first episode, medication-free depressed patients. Eur Arch Psychiatry Clin Neurosci 2010; 260: 527-533.
51. Hu Y, Yu X, Yang F, Si T, Wang W, Tan Y et al. The brain-derived neurotrophic factor is associated with the therapeutic efficacy of modified electroconvulsive therapy in Chinese patient with depression. J ECT 2010; 26: 121-125.
52. Zhou Z, Lu T, Xu G, Yue X, Zhu W, Ma M et al. Decreased serum brain-derived neurotrophic factor (BDNF) is associated with post-stroke depression but not with BDNF gene val66met polymorphism. Clin Chem Lab Med 2011; 49: 185-189.
53. Su SC, Sun MT, Wen MJ, Lin CJ, Chen YC, Hung YJ. Brain-derived neurotrophic factor, adiponectin, and proinflammatory markers in various subtypes of depression in young men. Int J Psychiatry Med 2011; 42: 211-226.
54. Rojas PS, Fritsch R, Rojas RA, Jara P, Fiedler JL. Serum brain-derived neurotrophic factor and glucocorticoid receptor levels in lymphocytes as markers of antidepressant response in major depressive patients: a pilot study. Psychiatry Res 2011; 189: 239-245.
55. Gorgulu Y, Caliyurt O. Rapid antidepressant effects of sleep deprivation therapy correlates with serum BDNF changes in major depression. Brain Res Bull 2009; 80: 158-162.
56. Yoshimura R, Kishi T, Suzuki A, Umene-Nakano W, Ikenouchi-Sugita A, Hori H et al. The brain-derived neurotrophic factor (BDNF) polymorphism val66met is associated with neither serum BDNF level nor response to selective serotonin reuptake inhibitors in depressed Japanese patients. Prog Neuropsychopharmacol Biol Psychiatry 2011; 35: 1022-1025.
57. Wolkowitz OM, Wolf J, Shelly W, Rosser R, Burke HM, Lerner GK et al. Serum BDNF levels before treatment predict SSRI response in depression. Prog Neuropsychopharmacol Biol Psychiatry 2011; 15: 1623-1630.
58. Kobayakawa M, Inagaki M, Fujimori M, Hamazaki K, Hamazaki T, Akechi T et al. Serum brain-derived neurotrophic factor and antidepressant-naive major depression after lung cancer diagnosis. Jpn J Clin Oncol 2011; 4: 1233-1237.
59. Terracciano A, Lobina M, Piras MG, Cannas A, Meirelles O, Mulas A et al. Lower serum BDNF associated with higher neuroticism and depressive symptoms. Psychosom Med 2011; 74: 638-642.
60. Molendijk ML, Bus BAA, Spinhoven P, Penninx BJWH, Kenis G, Prickaerts J et al. Serum concentrations of brain-derived neurotrophic factor in major depressive disorder: state and trait issues, clinical features, and pharmacological treatment. Mol Psychiatry 2011; 16: 1088-1095.
61. Toups MSP, Greer TL, Kurian BT, Grannemann BD, Carmody TJ, Huebinger R et al. Effects of serum brain-derived neurotrophic factor on exercise augmentation treatment of depression. J Psychiatric Res 2011; 45: 1301-1306.
62. Satomura E, Baba H, Nakano Y, Maeshima H, Suzuki T, Arai H. Correlations between brain-derived neurotrophic factor and clinical symptoms inmedicated patients with major depression. J Affect Disord 2011; 135: 332-335.
63. Sö zeri-Varma G, Enli Y, Toker-Ug? urlu T, Alaçam H, Kalkan-Oguzhanog lu N. Decreased serum BDNF levels in major depressive patients. Neurol Psychiatry Brain Res 2011; 17: 84-88.
64. Bus BAA, Tendolkar I, Franke B, de Graaf J, Den Heijer M, Buitelaar JK et al. Serum brain-derived neurotrophic factor: determinants and relationship with depressive symptoms in a community population of middle-aged and elderly people. W J Biol Psychiatry 2012; 13: 39-47.
65. Gedge L, Beaudoin A, Lazowski L, Toit R, Jokic R, Milev R. Effects of electroconvulsive therapy and repetetive transcranial magnetic stimulation on serum brain-derived neurotrophic factor levels in patients with depression. Front Psychiatry 2012; 3: 1-8.
66. Gazal M, Motta LS, Wiener CD, Fernandes JC, Quevedo LA, Jansen K et al. Brainderived neurotrophic factor in post-partum depressive mothers. Neurochem Res 2012; 37: 583-587.
67. Birkenhäger TK, Geldermans S, Van den Broek WW, van Beveren N, Fekkes D. Serum brain-derived neurotrophic factor level in relation to illness severity and episode duration in patients with major depression. J Psychiatr Res 2012; 46: 285-289.
68. Deuschle M, Gilles M, Scharnholz B, Lederbogen F, Lang U, Hellweg R. Changes of serum concentrations of brain-derived neurotrophic factor (BDNF) during treatment with venlafaxine and mirtazapine: role of medication and response to treatment. Pharmacopsychiatry 2013; 46: 54-58.
69. Harvey BH, Hamer M, Louw R, van der Westhuizen FH, Malan L. Metabolic and glutathione redox markers associated with brain-derived neurotrophic factor in depressed African men and women: evidence for counter-regulation. Neuropsychobiol 2012; 67: 33-40.
70. Oral E, Canpolat S, Yildirim S, Gulec M, Aliyev E, Aydin N. et al. Cognitive functions and serum levels of brain-derived neurotrophic factor in patients with major depressive disorder. Brain Res Bull 2012; 88: 454-459.
71. Karlović D, Serretti A, Jevtović S, Vrkić N, S? eric V, Peles? AM. Diagnostic accuracy of serum brain derived neurotrophic factor concentration in antidepressant naïve patients with first major depression episode. J Psychiatric Res 2012; 47: 162-167.
72. Jeon HJ, Kang E-S, Lee EH, Jeong E-H, Jeon JR, Mischoulon D et al. Childhood trauma and platelet brain-derived neurotrophic factor (BDNF) after a three month follow-up in patients with major depressive disorder. J Psychiatric Res 2012; 46: 966-972.
73. Yoshida T, Ishikawa M, Niitsu T, Nakazato M, Watanabe H, Shiraishi T et al. Decreased serum levels of mature brain-derived neurotrophic factor, but not Its precursor proBDNF, in patients with major depressive disorder. PLoS ONE 2012; 7: e42676.
74. Gazal M, Motta LS, Wiener CD, Fernandes JC, Quevedo LA, Jansen K et al. Brainderived neurotrophic factor in post-partum depressive mothers. Neurochem Res 2012; 37: 583-587.
75. Oral E, Canpolat S, Yildirim S, Gulec M, Aliyev E, Aydin N. Cognitive functions and serum brain derived neurotrophic factor in patients with major depressive disorder. Brain Res Bull 2012; 88: 454-459.
76. Papakostas GI, Shelton RC, Kinrys G, Henry ME, Bakow BR, Lipkin SH et al. Assessment of multi-assay, serum-based biological diagnostic test for major depressive disorder: a pilot and replication study. Mol Psychiatry 2013; 18: 332-339.
77. Gonul AS, Akdeniz F, Taneli F, Donat O, Eker C, Vahip S. Effect of treatment on serum brain-derived neurotrophic factor levels in depressed patients. Eur Arch Psychiatry Clin Neurosci 2005; 255: 381-386.
78. Sasaki T, Niitsu T, Hashimoto T, Kanahara N, Shiina A, Hasegawa T et al. Decreased levels of between brain-derived neurotrophic factor in male pediatric patients with depression. Open Clin Chem J 2011; 4: 28-33.
79. Bus BAA, Molendijk ML, Penninx BJWH, Buitelaar JK, Kenis G, Prickaerts J et al. Determinants of serum brain-derived neurotrophic factor. Psychoneuroendocrinol 2011; 36: 228-239.
80. Giese M, Unternaher E, Huttig H, Beck J, Brand S, Calabrese P et al. BDNF: an indicator of insomnia? Mol Psychiatry advance online publication, 12 February 2013; doi:10.1038/mp.2013.10.
81. Molendijk ML, Haffmans JPM, Bus BAA, Spinhoven P, Penninx BWJH, Prickaerts J et al. BDNF concentrations show strong seasonal variation and correlations with the amount of ambient sunlight. PLoS One 2012; 7: e48046.
82. Elzinga BM, Molendijk ML, Oude Voshaar RC, Bus AA, Prickaerts J, Spinhoven P et al. The impact of childhood abuse and recent stress on serum brain-derived neurotrophic factor and the moderating role of BDNF val66met. Psychopharmacol 2011; 214: 319-328.
83. Rush AJ. The varied clinical presentations of major depressive disorders. J Clin Psychiatry 2007; 68: S4-S10.
84. Sterne JAC, Davey Smith G. Sifting the evidence - what's wrong with significance tests? BMJ 2001; 322: 226-231.
85. Dickersin K. The existence of publication bias and risk factors for its occurrence. JAMA 1990; 263: 1385-1359.
86. Munafo MR, Flint J. Meta-analysis of genetic association studies. Trends Gen 2004; 20: 439-444.
87. Ioannidis JPA. Why most published research findings are false. PLoS MED 2005; 2: e124 89.
88. Kapur S, Phillips AG, Insel TR. Why has it taken so long for biological psychiatry to develop clinical tests and what to do about it? Mol Psychiatry 2012; 17: 1174- 1179.
89. Schmidt HD, Shelton RC, Duman RS. Functional biomarkers of depression: diagnosis, treatment, and pathophysiology. Neuropsychopharmacol 2011; 36: 2375-2394.
90. Groves JO. Is it time to reassess the BDNF hypothesis of depression? Mol Psychiatry 2007; 12: 1079-1088.
91. Gass P, Hellweg R. Peripheral brain-derived neurotrophic factor (BDNF) levels as a biomarker for affective disorders. Int J Neuropsychopharmacol 2010; 13: 1-4.
92. Green MJ, Matheson SL, Sheperd A, Weickert CS, Carr VJ. Brain-derived neurotrophic factor levels in schizophrenia: a systematic review with meta-analysis. Mol Psychiatry 2011; 16: 960-972.
93. Fernandes BS, Gama CS, Cereser KM, Yatham LN, Fries GR, Colpo G et al. Brainderived neurotrophic factor as a state marker of mood episodes in bipolar disorders: a systematic review and meta-regression analysis. J Psychiatric Res 2011; 45: 995-1004.
94. Monteleone P, Fabrazzo M, Martiadis V, Serritella C, Pannuto M, Maj M. Circulating brain-derived neurotrophic factor is decreased in women with anorexia and bulimia nervosa but not in women with binge eating disorder: relationships to co-morbid depression, psychopathology and hormonal variables. Psychol Med 2005; 35: 897-905.
95. Molendijk ML, Bus BAA, Spinhoven P, Penninx BWJH, Prickaerts J, Oude Voshaar RC et al. Gender specific associations of serum BDNF concentrations in anxiety. W J Biol Psychiatry 2012; 13: 535-543.
96. Penninx BWJH, Milaneschi Y, Lamers F, Vogelzangs N. Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile. BMC Med 2013; 11: 129.
97. Dawood T, Anderson J, Barton D, Lambert E, Esler M, Hotchkin E et al. Reduced overflow of BDNF from the brain is linked with suicide risk in depressive illness. Mol Psychiatry 2007; 12: 981-983.
98. Klein AB, Williamson R, Santini MA, Clemmensen C, Ettrup A, Rios M et al. Blood BDNF concentrations reflect brain-tissue BDNF concentrations across species. Int J Neuropsychopharmacol 2011; 14: 347-353.
99. Cassiman D, Denef C, Desmet VJ, Roskams T. Human and rat hepatic stellate cells express neurotrophins and neurotrophin receptors. Hepatology 2001; 33: 148-158.
100. Karege F, Schwald M, Cisse M. Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets. Neurosci Lett 2002; 328: 261-264.
101. Sanderson S, Tatt ID, Higgings JPT. Tools for assessing quality and susceptibility to bias in observational studies in epidemiology: a systematic review and annotated bibliography. Int J Epidemiol 2007; 36: 666-676.
102. aan het Rot M, Zarate CA, Charney DS, Mathew SJ. Ketamine for depression: where do wego from here? Biol Psychiatry 2012; 72: 537-547.
103. Machado-Vieira R, Yuan P, Brutsche N, Diaz-Granados N, Luckenbaugh D, Manji HK et al. Brain-derived neurotrophic factor and initial antidepressant response to an N-methyl-D- aspartate antagonist. J Clin Psychiatry 2009; 70: 1662-1666.
104. Lang UE, Bajbouj M, Gallinat J, Hellweg R. Brain-derived neurotrophic factor serumconcentrations in depressive patients during vagus nerve stimulation and repetetive transcranial magnetic stimulation. Psychopharmacol 2006; 187: 56-59.
105. Yoshida T, Ishikawa M, Masaomi I, Hashimoto K. Serum levels of mature brainderived neurotrophic factor (BDNF) and its precursor proBDNF in healthy subjects. Open ClinChem 2012; 5: 7-12.