Raphe-mediated signals control the hippocampal response to SRI antidepressants via miR-16

Translational Psychiatry

Volumn 1, Issue , 2011, Pages

  Launay, J M ^a,b   Mouillet Richard, S ^c,d   Baudry, A ^c,d   Pietri, M ^c,d   Kellermann, O ^c,d  

^a HÔPITAL LARIBOISIÈRE   (France)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

^c INSERM   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

antidepressant; hippocampus; locus coeruleus; microRNA; neurogenesis; raphe

Indexed keywords

FLUOXETINE; MICRORNA; MIRN16 MICRORNA, HUMAN; SEROTONIN UPTAKE INHIBITOR;

ADULT; ANIMAL; ANIMAL BEHAVIOR; ARTICLE; DRUG EFFECT; FEMALE; GENETICS; HIPPOCAMPUS; HUMAN; LOCUS CERULEUS; MAJOR DEPRESSION; MALE; METABOLISM; MOUSE; PHYSIOLOGY; RAPHE NUCLEUS; SIGNAL TRANSDUCTION;

ADULT; ANIMALS; BEHAVIOR, ANIMAL; DEPRESSIVE DISORDER, MAJOR; FEMALE; FLUOXETINE; HIPPOCAMPUS; HUMANS; LOCUS COERULEUS; MALE; MICE; MICRORNAS; RAPHE NUCLEI; SEROTONIN UPTAKE INHIBITORS; SIGNAL TRANSDUCTION;

EID: 82055164291     PISSN: None     EISSN: 21583188     Source Type: Journal    
DOI: 10.1038/tp.2011.54     Document Type: Article

References (29)

1. Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S et al. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 2003; 301: 805-809. (Pubitemid 36962615)
2. Duman RS. Depression: A case of neuronal life and death? Biol Psychiatry 2004; 56: 140-145.
3. Drzyzga LR, Marcinowska A, Obuchowicz E. Antiapoptotic and neurotrophic effects of antidepressants: A review of clinical and experimental studies. Brain Res Bull 2009; 79: 248-257.
4. Macqueen G, Frodl T. The hippocampus in major depression: Evidence for the convergence of the bench and bedside in psychiatric research? Mol Psychiatry 2010; 16: 252-264.
5. Perera TD, Dwork AJ, Keegan KA, Thirumangalakudi L, Lipira CM, Joyce N et al. Necessity of hippocampal neurogenesis for the therapeutic action of antidepressants in adult nonhuman primates. PLoS One 2011; 6: E17600.
6. Baudry A, Mouillet-Richard S, Launay JM, Kellermann O. New views on antidepressant action. Curr Opin Neurobiol 2011; 21: 1-8.
7. Baudry A, Mouillet-Richard S, Schneider B, Launay JM, Kellermann O. MiR-16 Targets the Serotonin Transporter: A New Facet for Adaptive Responses to Antidepressants. Science 2010; 329: 1537-1541.
8. Cimmino A, Calin GA, Fabbri M, Iorio MV, Ferracin M, Shimizu M et al. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci USA 2005; 102: 13944-13949. (Pubitemid 41377683)
9. Kuhn HG, Biebl M, Wilhelm D, Li M, Friedlander RM, Winkler J. Increased generation of granule cells in adult Bcl-2-overexpressing mice: A role for cell death during continued hippocampal neurogenesis. Eur J Neurosci 2005; 22: 1907-1915. (Pubitemid 41579381)
10. Perera TD, Coplan JD, Lisanby SH, Lipira CM, Arif M, Carpio C et al. Antidepressantinduced neurogenesis in the hippocampus of adult nonhuman primates. J Neurosci 2007; 27: 4894-4901. (Pubitemid 46699055)
11. Hagg T. Molecular regulation of adult CNS neurogenesis: An integrated view. Trends Neurosci 2005; 28: 589-595. (Pubitemid 41476689)
12. Fritschy JM, Grzanna R. Selective effects of DSP-4 on locus coeruleus axons: Are there pharmacologically different types of noradrenergic axons in the central nervous system? Prog Brain Res 1991; 88: 257-268.
13. Launay JM, Schneider B, Loric S, Da Prada M, Kellermann O. Serotonin transport and serotonin transporter-mediated antidepressant recognition are controlled by 5-HT2B receptor signaling in serotonergic neuronal cells. FASEB J 2006; 20: 1843-1854. (Pubitemid 44933798)
14. Egeland M, Warner-Schmidt J, Greengard P, Svenningsson P. Neurogenic effects of fluoxetine are attenuated in p11 (S100A10) knockout mice. Biol Psychiatry 2010; 67: 1048-1056.
15. Surget A, Wang Y, Leman S, Ibarguen-Vargas Y, Edgar N, Griebel G et al. Corticolimbic transcriptome changes are state-dependent and region-specific in a rodent model of depression and of antidepressant reversal. Neuropsychopharmacology 2009; 34: 1363-1380.
16. Mouillet-Richard S, Mutel V, Loric S, Tournois C, Launay JM, Kellermann O. Regulation by neurotransmitter receptors of serotonergic or catecholaminergic neuronal cell differentiation. J Biol Chem 2000; 275: 9186-9192. (Pubitemid 30185135)
17. Bafico A, Gazit A, Wu-Morgan SS, Yaniv A, Aaronson SA. Characterization of Wnt-1 and Wnt-2 induced growth alterations and signaling pathways in NIH3T3 fibroblasts. Oncogene 1998; 16: 2819-2825. (Pubitemid 28279349)
18. Bell-Parikh LC, Ide T, Lawson JA, McNamara P, Reilly M, FitzGerald GA. Biosynthesis of 15-deoxy-delta12,14-PGJ2 and the ligation of PPARgamma. J Clin Invest 2003; 112: 945-955.
19. Chou TC. Preclinical versus clinical drug combination studies. Leuk Lymphoma 2008; 49: 2059-2080.
20. Gutierrez R. The dual glutamatergic-GABAergic phenotype of hippocampal granule cells. Trends Neurosci 2005; 28: 297-303. (Pubitemid 40775774)
21. Couillard-Despres S, Winner B, Schaubeck S, Aigner R, Vroemen M, Weidner N et al. Doublecortin expression levels in adult brain reflect neurogenesis. Eur J Neurosci 2005; 21: 1-14. (Pubitemid 40193870)
22. Wang JW, David DJ, Monckton JE, Battaglia F, Hen R. Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells. J Neurosci 2008; 28: 1374-1384. (Pubitemid 351231535)
23. Wayman GA, Impey S, Marks D, Saneyoshi T, Grant WF, Derkach V et al. Activitydependent dendritic arborization mediated by CaM-kinase I activation and enhanced CREB-dependent transcription of Wnt-2. Neuron 2006; 50: 897-909. (Pubitemid 43850689)
24. Martinowich K, Lu B. Interaction between BDNF and serotonin: Role in mood disorders. Neuropsychopharmacology 2008; 33: 73-83. (Pubitemid 350191318)
25. Sairanen M, Lucas G, Ernfors P, Castren M, Castren E. Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrus. J Neurosci 2005; 25: 1089-1094. (Pubitemid 40268949)
26. Okamoto H, Voleti B, Banasr M, Sarhan M, Duric V, Girgenti MJ et al. Wnt2 expression and signaling is increased by different classes of antidepressant treatments. Biol Psychiatry 2010; 68: 521-527.
27. Taliaz D, Stall N, Dar DE, Zangen A. Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis. Mol Psychiatry 2010; 15: 80-92.
28. Garcia-Bueno B, Perez-Nievas BG, Leza JC. Is there a role for the nuclear receptor PPARgamma in neuropsychiatric diseases? Int J Neuropsychopharmacol 2010; 13: 1411-1429.
29. Cryan JF, O'Leary OF, Jin SH, Friedland JC, Ouyang M, Hirsch BR et al. Norepinephrinedeficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitors. Proc Natl Acad Sci USA 2004; 101: 8186-8191. (Pubitemid 38698075)