Genomic Loss of Tumor Suppressor miRNA-204 Promotes Cancer Cell Migration and Invasion by Activating AKT/mTOR/Rac1 Signaling and Actin Reorganization

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Imam, J Saadi ^a   Plyler, Jason R ^a,b   Bansal, Hima ^a   Prajapati, Suresh ^a   Bansal, Sanjay ^a   Rebeles, Jennifer ^a   Chen, Hung I Harry ^a   Chang, Yao Fu ^a,b   Panneerdoss, Subbarayalu ^a   Zoghi, Behyar ^a   Buddavarapu, Kalyan C ^a   Broaddus, Russell ^c   Hornsby, Peter ^a   Tomlinson, Gail ^a   Dome, Jeffrey ^d   Vadlamudi, Ratna K ^b   Pertsemlidis, Alexander ^a   Chen, Yidong ^a   Rao, Manjeet K ^a,b  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b Mays Cancer Center at UT Health San Antonio   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^d CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN; MICRORNA; MICRORNA 204; PROTEIN KINASE B; RAC1 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER INHIBITION; CANCER INVASION; CARCINOGENESIS; CELL MIGRATION; CONTROLLED STUDY; DRUG MECHANISM; EMBRYO; ENZYME ACTIVATION; FEMALE; GENE DELETION; GENE LOSS; GENE OVEREXPRESSION; GENE TARGETING; HUMAN; HUMAN TISSUE; IN VIVO STUDY; KIDNEY CANCER; LUNG METASTASIS; MALE; METASTASIS INHIBITION; MOLECULARLY TARGETED THERAPY; MOUSE; NONHUMAN; OVARY CANCER; PRIMARY TUMOR; PROTEIN DEPLETION; PROTEIN EXPRESSION; RNA ANALYSIS;

ACTINS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOME, HUMAN; HUMANS; MICRORNAS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASMS; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; RAC1 GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84871377399     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0052397     Document Type: Article

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