Genetic epistasis between the brain-derived neurotrophic factor Val66Met polymorphism and the 5-HTT promoter polymorphism moderates the susceptibility to depressive disorders after childhood abuse

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 36, Issue 2, 2012, Pages 264-270

  Grabe, Hans Jörgen ^a   Schwahn, Christian ^a   Mahler, Jessie ^a   Appel, Katja ^a   Schulz, Andrea ^a   Spitzer, Carsten ^b   Fenske, Kristin ^a   Barnow, Sven ^c   Freyberger, Harald Jürgen ^a   Teumer, Alexander ^a   Petersmann, Astrid ^a   Biffar, Reiner ^a   Rosskopf, Dieter ^a   John, Ulrich ^a   Völzke, Henry ^a  

^a UNIVERSITY OF GREIFSWALD   (Germany)

^b UNIVERSITY OF HAMBURG   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Brain derived neurotrophic factor; Childhood abuse; Depression; Gene environment interaction; Serotonin transporter promoter polymorphism

Indexed keywords

ADULT; AGED; ARTICLE; BECK DEPRESSION INVENTORY; BRAIN DERIVED NEUROTROPHIC FACTOR GENE; CAUCASIAN; CHILD ABUSE; CHILDHOOD TRAUMA QUESTIONNAIRE; CONTROLLED STUDY; DEPRESSION; FEMALE; GENE; GENETIC EPISTASIS; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; GERMANY; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; PROMOTER REGION; QUESTIONNAIRE; SEROTONIN TRANSPORTER GENE; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; AGED, 80 AND OVER; ALLELES; BRAIN-DERIVED NEUROTROPHIC FACTOR; CHILD; CHILD ABUSE; DEPRESSIVE DISORDER; EPISTASIS, GENETIC; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE-ENVIRONMENT INTERACTION; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; PSYCHIATRIC STATUS RATING SCALES; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEX CHARACTERISTICS;

EID: 84855354000     PISSN: 02785846     EISSN: 18784216     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2011.09.010     Document Type: Article

References (44)

1. Adachi M., Barrot M., Autry A.E., Theobald D., Monteggia L.M. Selective loss of brain-derived neurotrophic factor in the dentate gyrus attenuates antidepressant efficacy. Biol Psychiatry 2008, 63:642-649.
2. Aguilera M., Arias B., Wichers M., Barrantes-Vidal N., Moya J., Villa H., et al. Early adversity and 5-HTT/BDNF genes: new evidence of gene-environment interactions on depressive symptoms in a general population. Psychol Med 2009, 39:1425-1432.
3. Appel K., Schwahn C., Mahler J., Schulz A., Spitzer C., Fenske K., et al. Moderation of adult depression by a polymorphism in the FKBP5 gene and childhood physical abuse in the general population. Neuropsychopharmacology 2011, 36:1982-1991.
4. Beck A.T., Steer R.A. Beck Depression Inventory - Manual 1987, The Psychological Corporation, San Antonio.
5. Bernstein D.P., Stein J.A., Newcomb M.D., Walker E., Pogge D., Ahluvalia T., et al. Development and validation of a brief screening version of the Childhood Trauma Questionnaire. Child Abuse Negl 2003, 27:169-190.
6. Caspi A., Sugden K., Moffitt T.E., Taylor A., Craig I.W., Harrington H., et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 2003, 301:386-389.
7. Deltheil T., Guiard B.P., Guilloux J.P., Nicolas L., Delomenie C., Reperant C., et al. Consequences of changes in BDNF levels on serotonin neurotransmission, 5-HT transporter expression and function: studies in adult mice hippocampus. Pharmacol Biochem Behav 2008, 90:174-183.
8. Egan M.F., Kojima M., Callicott J.H., Goldberg T.E., Kolachana B.S., Bertolino A., et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 2003, 112:257-269.
9. Elzinga B.M., Molendijk M.L., Oude Voshaar R.C., Bus B.A., Prickaerts J., Spinhoven P., et al. The impact of childhood abuse and recent stress on serum brain-derived neurotrophic factor and the moderating role of BDNF Val66Met. Psychopharmacology (Berl) 2011, 214:319-328.
10. Gerritsen L., Tendolkar I., Franke B., Vasquez A.A., Kooijman S., Buitelaar J., et al. BDNF Val66Met genotype modulates the effect of childhood adversity on subgenual anterior cingulate cortex volume in healthy subjects. Mol Psychiatry 2011, [Epub ahead of print].
11. Grabe H.J., Lange M., Wolff B., Volzke H., Lucht M., Freyberger H.J., et al. Mental and physical distress is modulated by a polymorphism in the 5-HT transporter gene interacting with social stressors and chronic disease burden. Mol Psychiatry 2005, 10:220-224.
12. Grabe H.J., Schwahn C., Appel K., Mahler J., Schulz A., Spitzer C., et al. Update on the 2005 paper: moderation of mental and physical distress by polymorphisms in the 5-HT transporter gene by interacting with social stressors and chronic disease burden. Mol Psychiatry 2010, 16(6):354-356.
13. Greenland S. Introduction to Regression Models. Modern Epidemiology 2008, 381-417. Lippincott Williams & Wilkins, Philadelphia. K.J. Rothman, S. Greenland, T.L. Lash (Eds.).
14. Heils A., Teufel A., Petri S., Seemann M., Bengel D., Balling U., et al. Functional promoter and polyadenylation site mapping of the human serotonin (5-HT) transporter gene. J Neural Transm Gen Sect 1995, 102:247-254.
15. Heim C., Nemeroff C.B. The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies. Biol Psychiatry 2001, 49:1023-1039.
16. Hu X.Z., Lipsky R.H., Zhu G., Akhtar L.A., Taubman J., Greenberg B.D., et al. Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet 2006, 78:815-826.
17. John U., Greiner B., Hensel E., Ludemann J., Piek M., Sauer S., et al. Study of Health in Pomerania (SHIP): a health examination survey in an east German region: objectives and design. Soz Praventivmed 2001, 46:186-194.
18. Juhasz G., Dunham J.S., McKie S., Thomas E., Downey D., Chase D., et al. The CREB1-BDNF-NTRK2 pathway in depression: multiple gene-cognition-environment interactions. Biol Psychiatry 2011, 69:762-771.
19. Kato M., Serretti A. Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder. Mol Psychiatry 2010, 15:473-500.
20. Kaufman J., Yang B.Z., Douglas-Palumberi H., Grasso D., Lipschitz D., Houshyar S., et al. Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children. Biol Psychiatry 2006, 59:673-680.
21. Kim J.M., Stewart R., Kim S.W., Yang S.J., Shin I.S., Kim Y.H., et al. Interactions between life stressors and susceptibility genes (5-HTTLPR and BDNF) on depression in Korean elders. Biol Psychiatry 2007, 62:423-428.
22. Lavebratt C., Aberg E., Sjoholm L.K., Forsell Y. Variations in FKBP5 and BDNF genes are suggestively associated with depression in a Swedish population-based cohort. J Affect Disord 2011, 125:249-255.
23. Licinio J., Dong C., Wong M.L. Novel sequence variations in the brain-derived neurotrophic factor gene and association with major depression and antidepressant treatment response. Arch Gen Psychiatry 2009, 66:488-497.
24. Lucht M.J., Barnow S., Sonnenfeld C., Rosenberger A., Grabe H.J., Schroeder W., et al. Associations between the oxytocin receptor gene (OXTR) and affect, loneliness and intelligence in normal subjects. Prog Neuropsychopharmacol Biol Psychiatry 2009, 33:860-866.
25. Martinowich K., Lu B. Interaction between BDNF and serotonin: role in mood disorders. Neuropsychopharmacology 2008, 33:73-83.
26. Molteni R., Cattaneo A., Calabrese F., Macchi F., Olivier J.D., Racagni G., et al. Reduced function of the serotonin transporter is associated with decreased expression of BDNF in rodents as well as in humans. Neurobiol Dis 2010, 37:747-755.
27. Nederhof E., Bouma E.M., Oldehinkel A.J., Ormel J. Interaction between childhood adversity, brain-derived neurotrophic factor val/met and serotonin transporter promoter polymorphism on depression: the TRAILS study. Biol Psychiatry 2010, 68:209-212.
28. Perroud N., Salzmann A., Saiz P.A., Baca-Garcia E., Sarchiapone M., Garcia-Portilla M.P., et al. Rare genotype combination of the serotonin transporter gene associated with treatment response in severe personality disorder. Am J Med Genet B Neuropsychiatr Genet 2010, 153B:1494-1497.
29. Persons J.B., Perloff J.M. The relationship between attributions and depression varies across attributional dimensions and across samples. J Psychopathol Behav Assess 1989, 11:47-60.
30. Pezawas L., Meyer-Lindenberg A., Drabant E.M., Verchinski B.A., Munoz K.E., Kolachana B.S., et al. 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nat Neurosci 2005, 8:828-834.
31. Pezawas L., Meyer-Lindenberg A., Goldman A.L., Verchinski B.A., Chen G., Kolachana B.S., et al. Evidence of biologic epistasis between BDNF and SLC6A4 and implications for depression. Mol Psychiatry 2008, 13:709-716.
32. Santarelli L., Saxe M., Gross C., Surget A., Battaglia F., Dulawa S., et al. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 2003, 301:805-809.
33. Schumacher J., Jamra R.A., Becker T., Ohlraun S., Klopp N., Binder E.B., et al. Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression. Biol Psychiatry 2005, 58:307-314.
34. Snyder J.S., Soumier A., Brewer M., Pickel J., Cameron H.A. Adult hippocampal neurogenesis buffers stress responses and depressive behaviour. Nature 2011, 476:458-461.
35. Strauss J., Barr C.L., George C.J., Devlin B., Vetro A., Kiss E., et al. Brain-derived neurotrophic factor variants are associated with childhood-onset mood disorder: confirmation in a Hungarian sample. Mol Psychiatry 2005, 10:861-867.
36. Suchanek R., Owczarek A., Kowalczyk M., Kucia K., Kowalski J. Association between C-281A and val66met functional polymorphisms of BDNF gene and risk of recurrent major depressive disorder in Polish population. J Mol Neurosci 2011, 43:524-530.
37. Sullivan P.F., Neale M.C., Kendler K.S. Genetic epidemiology of major depression: review and meta-analysis. Am J Psychiatry 2000, 157:1552-1562.
38. Taliaz D., Stall N., Dar D.E., Zangen A. Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis. Mol Psychiatry 2010, 15:80-92.
39. Uher R., McGuffin P. The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update. Mol Psychiatry 2010, 15:18-22.
40. Verhagen M., van der Meij A., van Deurzen P.A., Janzing J.G., Arias-Vasquez A., Buitelaar J.K., et al. Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity. Mol Psychiatry 2010, 15:260-271.
41. Völzke H., Alte D., Schmidt C.O., Radke D., Lorbeer R., Friedrich N., et al. Cohort Profile: The Study of Health in Pomerania. Int J Epidemiol 2010, 40(2):294-307.
42. Wichers M., Kenis G., Jacobs N., Mengelers R., Derom C., Vlietinck R., et al. The BDNF Val(66)Met x 5-HTTLPR x child adversity interaction and depressive symptoms: an attempt at replication. Am J Med Genet B Neuropsychiatr Genet 2008, 147:120-123.
43. Wingenfeld K., Spitzer C., Mensebach C., Grabe H., Hill A., Gast U., et al. The German Version of the Childhood Trauma Questionnaire (CTQ):Preliminary Psychometric Properties. Psychother Psychosom Med Psychol 2010, 60(11):442-450.
44. Wittchen H., Höfler M., Gander F., Pfister H., Storz S., Üstün B., et al. Screening for mental disorders: performance of the Composite International Diagnostic-Screener (CID-S). Int J Methods Psychiatr Res 1999, 8:59-70.