Serum levels of brain-derived neurotrophic factor in major depressive disorder: State-trait issues, clinical features and pharmacological treatment

Molecular Psychiatry

Volumn 16, Issue 11, 2011, Pages 1088-1095

  Molendijk, M L ^a   Bus, B A A ^b   Spinhoven, Ph ^a,c   Penninx, B W J H ^c,d,e   Kenis, G ^f   Prickaerts, J ^f   Voshaar, R C Oude ^b,e   Elzinga, B M ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^d VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^e UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^f MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

antidepressants; BDNF; brain derived neurotrophic factor; depression

Indexed keywords

ANTIDEPRESSANT AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; HYPERICUM PERFORATUM EXTRACT; NORADRENERGIC AND SPECIFIC SEROTONERGIC ANTIDEPRESSANT; SEROTONIN NORADRENALIN REUPTAKE INHIBITOR; SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE SEVERITY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PSYCHOPHARMACOTHERAPY; RECURRENT DISEASE; REMISSION; UPREGULATION;

ADULT; ANTIDEPRESSIVE AGENTS, TRICYCLIC; ANXIETY DISORDERS; BIOLOGICAL MARKERS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CONVALESCENCE; DEPRESSIVE DISORDER, MAJOR; DRUG MONITORING; FEMALE; HUMANS; HYPERICUM; MALE; MIDDLE AGED; MODELS, NEUROLOGICAL; MODELS, PSYCHOLOGICAL; PHYTOTHERAPY; PLANT EXTRACTS; RECURRENCE; SEROTONIN UPTAKE INHIBITORS; SEVERITY OF ILLNESS INDEX;

EID: 80054848287     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2010.98     Document Type: Article

References (55)

1. Duman RS, Malberg J, Nakagawa S, D'Sa C. Neuronal plasticity and survival in mood disorders. Biol Psychiatry 2000; 48: 732-739.
2. Sutton MA, Schuman EM. Dendritic protein synthesis, synaptic plasticity, and memory. Cell 2006; 127: 49-58. (Pubitemid 44466643)
3. Duman RS, Monteggia LM. A neurotrophic model for stress-related mood disorders. Biol Psychiatry 2000; 59: 1116-1127.
4. Duman RS, Heninger GR, Nestler EJ. A molecular and cellular theory of depression. Arch Gen Psychiatry 1997; 54: 597-606. (Pubitemid 27306570)
5. Dwivedi Y, Rizavi HS, Conley RR, Roberts RC, Tamminga CA, Pandey GN. Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brains of suicide victims. Arch Gen Psychiatry 2003; 60: 804-815. (Pubitemid 36960912)
6. Sen S, Duman R, Sanacora G. Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications. Biol Psychiatry 2008; 64: 527-532.
7. Brunoni AR, Lopes M, Fregni F. A systematic review and meta-analyses of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression. Int J Neuropsychopharmacol 2008; 11: 1169-1180.
8. Angelucci F, Brene S, Mathe AA. BDNF in schizophrenia, depression and corresponding animal models. Mol Psychiatry 2005; 10: 345-352.
9. Nemeroff CB, Owens MJ. Treatment of mood disorders. Nat Neurosci 2002; 6: 1068-1070. (Pubitemid 35247201)
10. Basterzi AD, Yazici K, Aslan E, Delialioglu N, Tasdelen B, Acar ST et al. Effects of fluoxetine and venlafaxine on serum brain-derived neurotrophic factor levels in depressed patients. Prog Neuro-Psychopharmacol Biol Psychiatry 2009; 33: 281-285.
11. Matrisciano F, Bonaccorso S, Ricciardi A, Scaccianoce S, Panaccione I, Wang L et al. Changes in BDNF serum levels in patients with major depression disorder (MDD) after 6 months treatment with sertraline, ecitalopram, or venlafaxine. J Psych Res 2009; 43: 247-254.
12. Ziegenhorn AA, Schulte-Hebruggen O, Danker-Hopfe H, Malbranc M, Hartung H-D, Anders D. Serun neurotrophins - a study on the time course and influencing factors in a large old sample. Neurobiol Aging 2007; 28: 1436-1445. (Pubitemid 47090171)
13. Groves JO. Is it time to reassess the BDNF hypothesis of depression? Mol Psychiatry 2007; 12: 1079-1088. (Pubitemid 350191365)
14. Trajkovska V, Vinberg M, Aznar S, Knudsen GM, Kessing LV. Whole blood BDNF levels in healthy twins discordant for affective disorder: association to life events and neuroticism. J Affect Disord 2008; 108: 165-169. (Pubitemid 351418011)
15. Monteleone P, Serritella C, Martiadis V, Maj M. Decreased levels of brainderived neurotrophic factor in both depressed and euthymic patients with unipolar depression and in euthymic patients with bipolar I and II disorders. Bipolar Disord 2008; 10: 95-100.
16. Lee B-H, Kim Y, Park S-H, Kim Y-K. Decreased plasma BDNF level in depressive patients. J Affect Dis 2007; 101: 239-244. (Pubitemid 46879923)
17. Karege F, Perret G, Bondolfi G, Schwald M, Bertschy G, Aubry JM. Decreased serum brain-derived neurotrophic factor in major depressed patients. Psychiatry Res 2002; 109: 143-148. (Pubitemid 34258493)
18. Penninx BW, Beekman AT, Smit JH, Nolen WA, Spinhoven P, Cuijpers P, et al., NESDA Research Consortium. The Netherlands Study of Depression and Anxiety (NESDA): rational, objectives and methods. Int J Methods Psychiatr Res 2008; 17: 121-140.
19. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th edn. American Psychiatric Association: Washington, DC, 1994.
20. Wittchen HU, Robins LN, Cottler LB, Sartorius N, Burke JD, Regier D. Cross-cultural feasibility, reliability and sources of variance of the Composite International Diagnostic Interview (CIDI). The multicentere WHO/ADAMHA field trials. Br J Psychiatry 1991; 159: 645-653.
21. Rush AJ, Gullion CM, Basco MR, Jarrett RB, Trivedi MH. The inventory of depressive symptomatology (IDS): psychometric properties. Psychol Med 1996; 26: 477-486. (Pubitemid 26142491)
22. World Health Organization (WHO) Collaborating Centre for Drug Statistics Methodology. 2008; http://www.whocc.no/atcddd/. Accessed March 2010.
23. Lyketsos CG, Nestadt G, Cwi J, Heithoff K, Eaton WW. The life chart interview: a standardized method to describe the course of psychopathology. Int J Methods Psychiatr Res 1994; 4: 143-155.
24. Beck AT, Kovacs M, Weissman A. Assessment of suicidal intention: the Scale for Suicide Ideation. J Consult Clin Psychol 1979; 47: 343-352. (Pubitemid 9157284)
25. Suwa M, Kishimoto H, Nofuji Y, Sasaki H, Radak Z, Kumagai S. Serum brain-derived neurotrophic factor level is increased and associated with obesity in newly diagnosed female patients with type 2 diabetes mellitus. Metabolism 2006; 55: 852-857. (Pubitemid 43902888)
26. Rojas-Vega S, Strüder HK, Wahrmann BV, Schmidt A, Bloch W, Hollmann W. Acute BDNF and cortisol response to low intensity exercise and following ramp incremental exercise to exhaustion in humans. Brain Res 2006; 1121: 59-65. (Pubitemid 44708897)
27. Kim TS, Kim DJ, Lee H, Kim YK. Increased plasma brain-derived neurotrophic factor levels in chronic smokers following unaided smoking cessation. Neurosci Lett 2007; 423: 53-57. (Pubitemid 47176776)
28. Simon GE, von Korff M, Saunders K, Miglioretti DL, Crane PK, van Belle G et al. Association between obesity and psychiatric disorders in the US adult population. Arch Gen Psychiatry 2006; 63: 824-830.
29. Harris AHS, Cronkite R, Moos R. Physical activity, exercise coping, and depression in a 10-year cohort study of depressed patients. J Affect Disord 2006; 93: 79-85. (Pubitemid 43816052)
30. Kendler KS, Neale MC, MacLean CJ, Heath AC, Eaves LJ, Kessler RC. Smoking and major depression. Arch Gen Psychiatry 1993; 50: 36-43.
31. Craig CL, Marshall AL, Sjostrom M, Bauman AE, Booth ML, Ainsworth BE et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc 2003; 35: 1381-1395. (Pubitemid 36936159)
32. Begliuomini S, Lenzi E, Ninni F, Casarosa E, Merlini S, Pluchino N et al. Plasma brain-derived neurorophic factor daily variations in men: correlation with cortisol circadian rhythm. J Endocrinol 2008; 197: 429-435. (Pubitemid 351696256)
33. Trajkovska V, Marcussen AB, Vinberg M, Hartvig P, Aznar S, Knudsen GM. Measurements of brain-derived neurotrophic factor: methodological aspects and demographical data. Brain Res Bull 2007; 73: 143-149. (Pubitemid 46722657)
34. Cohen J. Statistical Power Analysis for the Behavioral Sciences. Lawrence Erlbaum Associates: Hillsdale, NJ, 1988.
35. Shimuzu E, Hashimoto K, Okamura N, Koike K, Komatsu N, Kumakiri C et al. Alternations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biol Psychiatry 2003; 54: 70-75. (Pubitemid 36776725)
36. Deveci A, Aydemir O, Taskin O, Taneli F, Esen-Danaci A. Serum BDNF levels in suicide attempters related to psychosocial stressors: a comparative study with depression. Neuropsychobiol 2007; 56: 93-97. (Pubitemid 351340019)
37. Kim Y-K, Lee H-P, Won S-D, Park E-U, Lee H-Y, Lee B-H et al. Low plasma BDNF is associated with suicidal behavior in major depression. Progress Neuro-Psychopharmacol Biol Psychiatry 2007; 31: 78-85. (Pubitemid 44959250)
38. Monteleone P, Fabrazzo M, Martiadis V, Serritella C, Pannuto M, Maj M. Circulating brain-derived neurotrophic factor is decreased in women with anorexia and bulimia nervosa but not in women with binge eating disorder: relationships to co-morbid depression, psychopathology and hormonal variables. Psychol Med 2005; 35: 897-905. (Pubitemid 40873390)
39. Nakazato M, Hashimoto K, Shimuzu E, Kumakiri C, Koizumi H, Okamura N et al. Decreased levels of serum brain-derived neurotrophic factor in female patients with eating disorders. Biol Psychiatry 2003; 54: 485-490. (Pubitemid 37289455)
40. Paykel ES. The clinical interview for depression development, reliability and validity. J Affect Disord 1985; 8: 85-96. (Pubitemid 15068952)
41. Paykel ES, Ramana R, Cooper Z, Hayhurst H, Kerr J, Barocka A. Residual symptoms after partial remission: an important outcome in depression. Psychol Med 1995; 25: 1171-1180.
42. Kachur SG, Hannan CL, Ward KE. Antidepressant-induced weight gain. Med Health Res 2005; 88: 359-361.
43. Antilla SAK, Leinonen EVJ. A review of the pharmacological and clinical profile of mirtazapine. CNS Drug Rev 2001; 7: 249-264. (Pubitemid 34016084)
44. Kauer-Sant'Anna M, Tramontina J, Andreazza AC, Cereser K, da Costa S, Santin A et al. Traumatic life events in bipolar disorder: impact on BDNF levels and psychopathology. Bipolar Disord 2007; 9(S1): 128-135.
45. Grassi-Oliveira R, Stein LM, Lopes RP, Teixeira AL, Bauer ME. Low plasma Brainderived neurotrophic factor and childhood physical neglect are associated with verbal memory impairment in major depression - acpreliminary report. Biol Psychiatry 2008; 64: 281-285.
46. Gatt JM, Nemeroff CB, Dobson-Stone C, Paul RH, Bryant RH, Schofield R et al. Interactions between BDNF val66met polymorphism predicts brain and arousal pathways to syndromal depression and anxiety. Mol Psychiatry 2009; 14: 681-695.
47. Mattson MP, Maudsley S, Martin B. BDNF and 5-HT: a dynamic duo in age related neuronal plasticity and neurodegenerative disorders. Trends Neurosci 2004; 27: 589-594. (Pubitemid 39221394)
48. Martinowich K, Lu B. Interaction between BDNF and serotonin: role in mood disorders. Neuropsychopharmacol 2008; 33: 73-83. (Pubitemid 350191318)
49. Mann JJ. The medical management of depression. N Engl J Med 2005; 353: 1819-1834.
50. Gaster B, Holroyd J. St John's wort for depression. Arch Intern Med 2000; 160: 152-156.
51. Kent JM. SNaRIs, NaSSAs, and NaRIs: new agents for the treatment of depression. Lancet 2000; 355: 911-918. (Pubitemid 30137678)
52. Berton O, Nestler EJ. New approaches to antidepressant drug discovery. Nat Rev Neurosci 2006; 7: 137-151. (Pubitemid 43151600)
53. Sartorius A, Hellweg R, Litzke J, Vogt M, Dormann C, Vollmayr B et al. Correlations and discrepancies between serum and brain tissue levels of neurotrophins after electroconvulsive treatment in rats. Pharmacopsychiatry 2009; 42: 270-276.
54. Karege F, Schwald M, Cisse M. Postnatal developmental profile of brain derived neurotrophic factor in rat brain and platelets. Neurosci Lett 2002; 328: 261-264. (Pubitemid 34876661)
55. Klein AB, Williamson R, Santini MA, Clemmensen C, Ettrup A, Rios M et al. Blood BDNF concentrations reflect brain-tissue BDNF levels across species. Int J Neuropsychopharmacol 2010; e-pub ahead of print 7 July 2010; doi:10.1017/S1461145710000738.