Biosynthesis and Post-translational Processing of the Precursor to Brain-derived Neurotrophic Factor

Journal of Biological Chemistry

Volumn 276, Issue 16, 2001, Pages 12660-12666

  Mowla, S Javad ^a   Farhadi, Hooman F ^a   Pareek, Sangeeta ^a   Atwal, Jasvinder K ^a   Morris, Stephen J ^a   Seidah, Nabil G ^b   Murphyl, Richard A ^c  

^a MCGILL UNIVERSITY   (Canada)

^b CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; BRAIN; ELECTROPHORESIS; ENZYME INHIBITION; IMMUNOLOGY; MUTAGENESIS; NEUROLOGY;

IMMUNOPRECIPITATION; PHOSPHORYLATION;

BIOCHEMISTRY;

ALPHA 1 ANTITRYPSIN PORTLAND; ARGINYLGLYCYLLEUCYLTHREONINE; BRAIN DERIVED GROWTH FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; ENZYME; ENZYME INHIBITOR; FURIN LIKE ENZYME; PEPTIDE FRAGMENT; PROBRAIN DERIVED GROWTH FACTOR; PROTEIN PRECURSOR; SERYLLEUCINE; UNCLASSIFIED DRUG; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR PRECURSOR; BRAIN-DERIVED NEUROTROPHIC FACTOR PRECURSOR; GLYCOSIDASE; RECOMBINANT PROTEIN;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; EXTRACELLULAR SPACE; GENETIC CODE; GOLGI COMPLEX; IMMUNOPRECIPITATION; MOUSE; MUTAGENESIS; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN GLYCOSYLATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN SECRETION; PROTEIN SYNTHESIS; SECRETORY VESICLE; SULFATION; VACCINIA VIRUS; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; CELL STRAIN COS1; CERCOPITHECUS; DRUG EFFECT; EMBRYO; GENETIC TRANSFECTION; GENETICS; GLIA; GLYCOSYLATION; HIPPOCAMPUS; HUMAN; METABOLISM; MOLECULAR GENETICS; NERVE CELL; PHOSPHORYLATION; PHYSIOLOGY; SITE DIRECTED MUTAGENESIS;

ANIMALIA; VACCINIA VIRUS; VACCINIA;

AMINO ACID SEQUENCE; ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL LINE; CERCOPITHECUS AETHIOPS; COS CELLS; EMBRYO; GLYCOSIDE HYDROLASES; GLYCOSYLATION; HIPPOCAMPUS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NEUROGLIA; NEURONS; PHOSPHORYLATION; PROTEIN PRECURSORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTOR, TRKB; RECOMBINANT PROTEINS; TRANSFECTION; VACCINIA VIRUS;

EID: 0035918236     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M008104200     Document Type: Article

References (30)

1. Snider, D. W. (1994) Cell 77, 625-638
2. Maisonpierre, P. C., Belluscio, L., Squito, S., Ip, N. Y., Furth, M. E., Lindsay, R. M., and Yancoupoulos, G. D. (1990) Science 247, 1373-1520
3. Maisonpierre, P. C., Le Beau, M. M., Espinosa, R., III, Ip, N. Y., Belluscia, L., De La Monte, S. M., Squinto, S., Furth, M. E., and Yancopoulos, G. D. (1991) Genomics 10, 558-568
4. Barker, P. A. (1998) Cell Death Differ. 5, 346-356
5. Kaplan, D. R., Hemstead, B. L., Martin-Zanca, D., Chao, M. V., and Parada, L. F. (1991) Science 252, 545-558
6. Edwards, R. H., Selby, M. J., Mobley, W. C., Weinrich, S. L., Hruby, D. E., and Rutter, W. J. (1988) Mol. Cell. Biol. 8, 2456-2464
7. Seidah, N. G., Benjannet, S., Pareek, S., Savaria, D., Hamlin, J., Goulet, B., Laliberte, J., Lazure, C., Chretien, M., and Murphy, R. A. (1996) Biochem. J. 314, 951-960
8. Mowla, S. J., Pareek, S., Farhadi, H. F., Petrecca, K., Fawcett, J. P., Seidah, N. G., Morris, S. J., Sossin, W. S., and Murphy, R. A. (1999) J. Neurosci. 19, 2069-2080
9. Farhadi, H. F., Mowla, S. J., Petrecca, K., Morris, S. J., Seidah, N. G., and Murphy, R. A. (2000) J. Neurosci. 20, 4059-4068
10. Fawcett, J. P., Aloyz, R., McClean, J. H., Pareek, S., Miller, F. D., McPherson, P. S., and Murphy, R. A. (1997) J. Biol. Chem. 272, 8837-8840
11. Anderson, E. D., Thomas, L., Hayflick, J. S., and Thomas, G. (1993) J. Biol. Chem. 268, 24887-24891
12. Seidah, N. G., Benjannet, S., Pareek, S., Chretien, M., and Murphy, R. A. (1996) FEBS Lett. 379, 248-250
13. Yan, Q., Rosenfeld, R. D., Matheson, C. R., Hawkins, N., Lopez, O. T., Bennett, L., and Welcher, A. A. (1997) Neuroscience 78, 431-448
14. Benjannet, S., Reudelhuber, T., Mercure, C., Rondeau, N., Chretien, M., and Seidah, N. G. (1992) J. Biol. Chem. 267, 11417-11423
15. Takahashi, S., Kasal, K., Hatsuzawa, K., Kitamura, N., Misumi, Y., Ikehara, Y., Murakami, K., and Nakayama, K. (1993) Biochem. Biophys. Res. Commun. 195, 1019-1026
16. Hempstead, B. L., Rabin, S. J., Kaplan, L., Reid, S., Parada, L. F., and Kaplan, D. R. (1992) Neuron 9, 883-896
17. Baeuerle, P. A., and Huttner, W. B. (1986) Biochem. Biophys Res. Commun. 141, 870-877
18. Fernandez, C. J., Haugwitz, M., Baton, B., and Moore, H. P. (1997) Mol. Biol. Cell 8, 2171-2185
19. Seidah, N. G., Mowla, S. J., Hamelin, J., Mamarbachi, A. M., Benjannet, S., Toure, B. B., Basak, A., Munzer, J. S., Marcinkiewicz, J., Zhong, M., Barale, J. C., Lazure, C., Murphy, R. A., Chretien, M., and Marcinkiewicz, M. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 1321-1326
20. Crino, P. B., and Eberwine, J. (1996) Neuron 17, 1173-1187
21. Tongiori, E., Righi, M., and Catteneo, A. (1997) J. Neurosci. 17, 9492-9505
22. Kolbeck, R., Jungbluth, S., and Barde, Y. A. (1994) Eur. J. Biochem. 225, 995-1003
23. Edwards, R. H., Selby, M. J., Garcia, P. D., and Rutter, W. J. (1988) J. Biol. Chem. 263, 6810-6815
24. Kornfeld, R., and Kornfeld, S. (1985) Annu. Rev. Biochem. 54, 5543-5551
25. Van Kupperfeld, F. J., Van Horssen, A. M., and Martens, G. J. (1997) Mol. Cell. Endocrinol. 136, 29-35
26. Mowla, S. J., Zhong, M., Mamarbachi, A. M., Seidah, N. G., and Murphy, R. A. (1999) Soc. Neurosci. Abstr. 709, 6
27. Brechler, V., Chu, W. N., Baxter, J. D., Thibault, G., and Reudelhuber, T. L. (1996) J. Biol. Chem. 271, 20636-20640
28. Seidah, N. G., and Chretien, M. (1999) Brain Res. 848, 45-62
29. Brewer, G. J., Torricelli, J. R., Evege, E. K., and Price, P. J. (1993) J. Neurosci. Res. 35, 567-576
30. Jean, F., Thomas, L., Molloy, S. S., Liu, G., Jarvis, M. A., Nelson, J. A., and Thomas, G. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 2864-2869