Brain-derived neurotrophic factor gene and protein expression in pediatric and adult depressed subjects

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 34, Issue 4, 2010, Pages 645-651

  Pandey, Ghanshyam N ^a   Dwivedi, Yogesh ^a   Rizavi, Hooriyah S ^a   Ren, Xinguo ^a   Zhang, Hui ^a   Pavuluri, Mani N ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

BDNF; Depression; Lymphocytes; MRNA; Pediatric depression; Platelets

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; MESSENGER RNA; NEUROTROPHIN;

ADOLESCENT; ADULT; ARTICLE; ASIAN; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DEPRESSION; DRUG TARGETING; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE MUTATION; HAMILTON SCALE; HISPANIC; HUMAN; HUMAN CELL; LYMPHOCYTE; MALE; NEGRO; NERVE CELL; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; RACE DIFFERENCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHOOL CHILD; SEX DIFFERENCE; THROMBOCYTE;

ADOLESCENT; ADULT; BIPOLAR DISORDER; BRAIN-DERIVED NEUROTROPHIC FACTOR; CHILD; DEPRESSIVE DISORDER; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; HUMANS; LYMPHOCYTES; MALE; MIDDLE AGED; REGRESSION ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEVERITY OF ILLNESS INDEX;

EID: 77952674015     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2010.03.003     Document Type: Article

References (47)

1. Altar C.A., Whitehead R.E., Chen R., Wortwein G., Madsen T.M. Effects of electroconvulsive seizures and antidepressant drugs on brain-derived neurotrophic factor protein in rat brain. Biol Psychiatry 2003, 54:703-709.
2. Altman E.G., Hedeker D.R., Janicak P.G., Peterson J.L., Davis J.M. The Clinician-Administered Rating Scale for Mania (CARS-M): development, reliability, and validity. Biol Psychiatry 1994, 36:124-134.
3. Birmaher B., Dahl R.E., Perel J., Williamson D.E., Nelson B., Stull S., et al. Corticotropin-releasing hormone challenge in prepubertal major depression. Biol Psychiatry 1996, 39:267-277.
4. Braun A., Lommatzsch M., Mannsfeldt A., Neuhaus-Steinmetz U., Fischer A., Schnoy N., et al. Cellular sources of enhanced brain-derived neurotrophic factor production in a mouse model of allergic inflammation. Am J Respir Cell Mol Biol 1999, 21:537-546.
5. Bremner J.D., Vythilingam M., Vermetten E., Nazeer A., Adil J., Khan S., et al. Reduced volume of orbitofrontal cortex in major depression. Biol Psychiatry 2002, 51:273-279.
6. Brunoni A.R., Lopes M., Fregni F. A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression. Int J Neuropsychopharmacol 2008, 11:1169-1180.
7. Chen B., Dowlatshahi D., MacQueen G.M., Wang J.F., Young L.T. Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication. Biol Psychiatry 2001, 50:260-265.
8. Cunha A.B., Frey B.N., Andreazza A.C., Goi J.D., Rosa A.R., Goncalves C.A., et al. Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes. Neurosci Lett 2006, 398:215-219.
9. Duman R.S. Synaptic plasticity and mood disorders. Mol Psychiatry 2002, 7(Suppl 1):S29-S34.
10. Dwivedi Y., Rizavi H.S., Zhang H., Mondal A.C., Roberts R.C., Conley R.R., et al. Neurotrophin receptor activation and expression in human postmortem brain: effect of suicide. Biol Psychiatry 2009, 65:319-328.
11. Emslie G.J., Rush A.J., Weinberg W.A., Kowatch R.A., Hughes C.W., Carmody T., et al. A double-blind, randomized, placebo-controlled trial of fluoxetine in children and adolescents with depression. Arch Gen Psychiatry 1997, 54:1031-1037.
12. Fujimura H., Altar C.A., Chen R., Nakamura T., Nakahashi T., Kambayashi J., et al. Brain-derived neurotrophic factor is stored in human platelets and released by agonist stimulation. Thromb Haemost 2002, 87:728-734.
13. Gielen A., Khademi M., Muhallab S., Olsson T., Piehl F. Increased brain-derived neurotrophic factor expression in white blood cells of relapsing-remitting multiple sclerosis patients. Scand J Immunol 2003, 57:493-497.
14. Gonul A.S., Akdeniz F., Taneli F., Donat O., Eker C., Vahip S. Effect of treatment on serum brain-derived neurotrophic factor levels in depressed patients. Eur Arch Psychiatry Clin Neurosci 2005, 255:381-386.
15. Hashimoto R., Takei N., Shimazu K., Christ L., Lu B., Chuang D.M. Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: an essential step for neuroprotection against glutamate excitotoxicity. Neuropharmacology 2002, 43:1173-1179.
16. Hashimoto K., Shimizu E., Iyo M. Critical role of brain-derived neurotrophic factor in mood disorders. Brain Res Brain Res Rev 2004, 45:104-114.
17. Hazell P., O'Connell D., Heathcote D., Robertson J., Henry D. Efficacy of tricyclic drugs in treating child and adolescent depression: a meta-analysis. BMJ 1995, 310:897-901.
18. Huang E.J., Reichardt L.F. Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 2001, 24:677-736.
19. Iga J., Ueno S., Ohmori T. Molecular assessment of depression from mRNAs in the peripheral leukocytes. Ann Med 2008, 40:336-342.
20. Kang H., Schuman E.M. Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus. Science 1995, 267:1658-1662.
21. Karege F., Perret G., Bondolfi G., Schwald M., Bertschy G., Aubry J.M. Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry Res 2002, 109:143-148.
22. Karege F., Bondolfi G., Gervasoni N., Schwald M., Aubry J.M., Bertschy G. Low brain-derived neurotrophic factor (BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivity. Biol Psychiatry 2005, 57:1068-1072.
23. Karege F., Vaudan G., Schwald M., Perroud N., La Harpe R. Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs. Brain Res Mol Brain Res 2005, 136:29-37.
24. Kaufman J., Martin A., King R.A., Charney D. Are child-, adolescent-, and adult-onset depression one and the same disorder?. Biol Psychiatry 2001, 49:980-1001.
25. Kerschensteiner M., Gallmeier E., Behrens L., Leal V.V., Misgeld T., Klinkert W.E., et al. Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: a neuroprotective role of inflammation?. J Exp Med 1999, 189:865-870.
26. Lee B.H., Kim Y.K. Reduced platelet BDNF level in patients with major depression. Prog Neuropsychopharmacol Biol Psychiatry 2009, 33:849-853.
27. Lommatzsch M., Zingler D., Schuhbaeck K., Schloetcke K., Zingler C., Schuff-Werner P., et al. The impact of age, weight and gender on BDNF levels in human platelets and plasma. Neurobiol Aging 2005, 26:115-123.
28. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J Biol Chem 1951, 193:265-275.
29. Machado-Vieira R., Dietrich M.O., Leke R., Cereser V.H., Zanatto V., Kapczinski F., et al. Decreased plasma brain derived neurotrophic factor levels in unmedicated bipolar patients during manic episode. Biol Psychiatry 2007, 61:142-144.
30. Nakahashi T., Fujimura H., Altar C.A., Li J., Kambayashi J., Tandon N.N., et al. Vascular endothelial cells synthesize and secrete brain-derived neurotrophic factor. FEBS Lett 2000, 470:113-117.
31. Nibuya M., Morinobu S., Duman R.S. Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J Neuroscience 1995, 15:7539-7547.
32. Noga O., Englmann C., Hanf G., Grutzkau A., Seybold J., Kunkel G. The production, storage and release of the neurotrophins nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 by human peripheral eosinophils in allergics and non-allergics. Clin Exp Allergy 2003, 33:649-654.
33. Otsuki K., Uchida S., Watanuki T., Wakabayashi Y., Fujimoto M., Matsubara T., et al. Altered expression of neurotrophic factors in patients with major depression. J Psychiatr Res 2008, 42:1145-1153.
34. Pan W., Banks W.A., Fasold M.B., Bluth J., Kastin A.J. Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology 1998, 37:1553-1561.
35. Pandey G.N., Dwivedi Y., SridharaRao J., Ren X., Janicak P.G., Sharma R. Protein kinase C and phospholipase C activity and expression of their specific isozymes is decreased and expression of MARCKS is increased in platelets of bipolar but not in unipolar patients. Neuropsychopharmacology 2002, 26:216-228.
36. Pandey G.N., Ren X., Rizavi H.S., Conley R.R., Roberts R.C., Dwivedi Y. Brain-derived neurotrophic factor and tyrosine kinase B receptor signalling in post-mortem brain of teenage suicide victims. Int J Neuropsychopharmacol 2008, 11:1047-1061.
37. Pandey G.N., Rizavi H.S., Dwivedi Y., Pavuluri M.N. Brain-derived neurotrophic factor gene expression in pediatric bipolar disorder: effects of treatment and clinical response. J Am Acad Child Adolesc Psychiatry 2008, 47:1077-1085.
38. Poznanski E.O., Grossman J.A., Buchsbaum Y., Banegas M., Freeman L., Gibbons R. Preliminary studies of the reliability and validity of the children's depression rating scale. J Am Acad Child Psychiatry 1984, 23:191-197.
39. Radka S.F., Holst P.A., Fritsche M., Altar C.A. Presence of brain-derived neurotrophic factor in brain and human and rat but not mouse serum detected by a sensitive and specific immunoassay. Brain Res 1996, 709:122-301.
40. Rajkowska G. Cell pathology in mood disorders. Semin Clin Neuropsychiatry 2002, 7:281-292.
41. Rajkowska G. Depression: what we can learn from postmortem studies. Neuroscientist 2003, 9:273-284.
42. Schinder A.F., Poo M. The neurotrophin hypothesis for synaptic plasticity. Trends Neurosci 2000, 23:639-645.
43. Sen S., Duman R., Sanacora G. Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications. Biol Psychiatry 2008, 64:527-532.
44. Sheline Y.I., Sanghavi M., Mintun M.A., Gado M.H. Depression duration but not age predicts hippocampal volume loss in medically healthy women with recurrent major depression. J Neurosci 1999, 19:5034-5043.
45. Shimizu E., Hashimoto K., Okamura N., Koike K., Komatsu N., Kumakiri C., et al. Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biol Psychiatry 2003, 54:70-75.
46. Thoenen H. Neurotrophins and neuronal plasticity. Science 1995, 270:593-598.
47. Williams J.B. A structured interview guide for the Hamilton Depression Rating Scale. Arch Gen Psychiatry 1988, 45:742-747.